Click here to switch to the map view.

The map label for this gene is glcK [H]

Identifier: 193214493

GI number: 193214493

Start: 924761

End: 925723

Strand: Direct

Name: glcK [H]

Synonym: Ctha_0777

Alternate gene names: 193214493

Gene position: 924761-925723 (Clockwise)

Preceding gene: 193214492

Following gene: 193214494

Centisome position: 28.08

GC content: 54.93

Gene sequence:

>963_bases
ATGGAAAAAGTTGCACTCGGCATAGACCTTGGCGGGACAGCTATCAAGTTTGCCGCCGTCACCGAAACCGGAAACATCAT
CGCCACGCATCACGCGCCAACAGAAGCCGAACATGGCCTTGAGCATGTTATAGAAAACATGATGCGCGGCATTGCCGAAC
TGATCGCTCAAACCAAATCGGTAGAACTTTCGGGAATTGGCATCGGCGTGCCAGGCGTCGTCAGCTTGGATGGCGGCACG
GTGAGTCATCCGCCGAACTTGCCGGGTTGGGAAGTCGTTCGTCTCGGCGATGCTATTGCTGAAAAATTTCGTCAGGTTTA
TGGCGCAACAAAGCCCGTTTTTGTGGAAAACGACGCCAACCTTGCGGCGCTCGGCGAAGCGCGTTTCGGCGCGGGCACTG
CGCTAAACGATTTTATCATGATCACGCTTGGCACGGGAATTGGCGCGGGGATTATCATTAACCGAAAAATTTTTCGCGGC
ACAACGGGTGCTGCAGGCGAATTCGGTCACATCCCGATTGATTACAACAGTGAAACTGCGCACGCGGGCATTCACGGTTC
GGTGGAGGGTTTCATCGGGCAACGGCACATTGCGGAGTATGCGCGCAAACTGGCGAAAAATCATCCCGACTCGCTTCTGC
ATCAGCTTTGCCCCGATCTCTCACAACTTGAGCCGAAGCATATTACAGCGGCTGCAGAACAAGGCGACCCGCTCGCGTTG
GCTATTTGGCAATGGGTTGCCGAAATTTTGGGCGCGGGACTTGGCGCGATTGTCTCTATCTTGGACATTCGCAAATTCGT
GATTGGCGGCGGCGTGGCGGGCGCGGGCAAATATTTGTTTGAACCTTGCCTTGGCGCACTGAAGCGATTCACGCTGAGCT
CCATGCACGAAGGAATTGAACTTTTACCGGCCAAGCTTGGCAATCAAGCTGGCGTAATGGGCGCGGCGGCGCAGGCTTTG
TAA

Upstream 100 bases:

>100_bases
ACCAGCCTCAGAATGACATGAATTACATGCTTTAGCTATAAATCATCTTTGTCAAATAGCCCTAAGTTCCTTTCACCGAA
TCGTTTATCCAAAATTTCCC

Downstream 100 bases:

>100_bases
TTTTTATTGCTCAATTGTATTTGTCATGATTCCGATAGAACTTCAGAGTATAGTTAGTAACCTGATTGACCAGCCAATCA
CATTGACCGCATTTCATAGT

Product: ROK family protein

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MEKVALGIDLGGTAIKFAAVTETGNIIATHHAPTEAEHGLEHVIENMMRGIAELIAQTKSVELSGIGIGVPGVVSLDGGT
VSHPPNLPGWEVVRLGDAIAEKFRQVYGATKPVFVENDANLAALGEARFGAGTALNDFIMITLGTGIGAGIIINRKIFRG
TTGAAGEFGHIPIDYNSETAHAGIHGSVEGFIGQRHIAEYARKLAKNHPDSLLHQLCPDLSQLEPKHITAAAEQGDPLAL
AIWQWVAEILGAGLGAIVSILDIRKFVIGGGVAGAGKYLFEPCLGALKRFTLSSMHEGIELLPAKLGNQAGVMGAAAQAL

Sequences:

>Translated_320_residues
MEKVALGIDLGGTAIKFAAVTETGNIIATHHAPTEAEHGLEHVIENMMRGIAELIAQTKSVELSGIGIGVPGVVSLDGGT
VSHPPNLPGWEVVRLGDAIAEKFRQVYGATKPVFVENDANLAALGEARFGAGTALNDFIMITLGTGIGAGIIINRKIFRG
TTGAAGEFGHIPIDYNSETAHAGIHGSVEGFIGQRHIAEYARKLAKNHPDSLLHQLCPDLSQLEPKHITAAAEQGDPLAL
AIWQWVAEILGAGLGAIVSILDIRKFVIGGGVAGAGKYLFEPCLGALKRFTLSSMHEGIELLPAKLGNQAGVMGAAAQAL
>Mature_320_residues
MEKVALGIDLGGTAIKFAAVTETGNIIATHHAPTEAEHGLEHVIENMMRGIAELIAQTKSVELSGIGIGVPGVVSLDGGT
VSHPPNLPGWEVVRLGDAIAEKFRQVYGATKPVFVENDANLAALGEARFGAGTALNDFIMITLGTGIGAGIIINRKIFRG
TTGAAGEFGHIPIDYNSETAHAGIHGSVEGFIGQRHIAEYARKLAKNHPDSLLHQLCPDLSQLEPKHITAAAEQGDPLAL
AIWQWVAEILGAGLGAIVSILDIRKFVIGGGVAGAGKYLFEPCLGALKRFTLSSMHEGIELLPAKLGNQAGVMGAAAQAL

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=276, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI298566325, Length=276, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4885285, Length=276, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI190014632, Length=276, Percent_Identity=28.9855072463768, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1786891, Length=297, Percent_Identity=30.6397306397306, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87081733, Length=324, Percent_Identity=27.7777777777778, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787878, Length=260, Percent_Identity=25.3846153846154, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1787363, Length=279, Percent_Identity=27.2401433691756, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790522, Length=304, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082127, Length=173, Percent_Identity=27.1676300578035, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33330; Mature: 33330

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVALGIDLGGTAIKFAAVTETGNIIATHHAPTEAEHGLEHVIENMMRGIAELIAQTKS
CCCEEEEEECCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VELSGIGIGVPGVVSLDGGTVSHPPNLPGWEVVRLGDAIAEKFRQVYGATKPVFVENDAN
EEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
LAALGEARFGAGTALNDFIMITLGTGIGAGIIINRKIFRGTTGAAGEFGHIPIDYNSETA
EEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEECCCCCCCCCCCCEEECCCCCCC
HAGIHGSVEGFIGQRHIAEYARKLAKNHPDSLLHQLCPDLSQLEPKHITAAAEQGDPLAL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHEEEHHCCCCCCHH
AIWQWVAEILGAGLGAIVSILDIRKFVIGGGVAGAGKYLFEPCLGALKRFTLSSMHEGIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAKLGNQAGVMGAAAQAL
HHHHHCCCCCCHHHHHHHCC
>Mature Secondary Structure
MEKVALGIDLGGTAIKFAAVTETGNIIATHHAPTEAEHGLEHVIENMMRGIAELIAQTKS
CCCEEEEEECCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VELSGIGIGVPGVVSLDGGTVSHPPNLPGWEVVRLGDAIAEKFRQVYGATKPVFVENDAN
EEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
LAALGEARFGAGTALNDFIMITLGTGIGAGIIINRKIFRGTTGAAGEFGHIPIDYNSETA
EEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEECCCCCCCCCCCCEEECCCCCCC
HAGIHGSVEGFIGQRHIAEYARKLAKNHPDSLLHQLCPDLSQLEPKHITAAAEQGDPLAL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHEEEHHCCCCCCHH
AIWQWVAEILGAGLGAIVSILDIRKFVIGGGVAGAGKYLFEPCLGALKRFTLSSMHEGIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAKLGNQAGVMGAAAQAL
HHHHHCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]