Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 193214490

GI number: 193214490

Start: 919776

End: 920906

Strand: Direct

Name: hemN [H]

Synonym: Ctha_0774

Alternate gene names: 193214490

Gene position: 919776-920906 (Clockwise)

Preceding gene: 193214485

Following gene: 193214491

Centisome position: 27.93

GC content: 50.13

Gene sequence:

>1131_bases
ATGCCCGGACTGTATTTTCATATCCCGTTTTGTCGTCGTCGGTGTCATTACTGTGATTTTTATTTTACGACCAATGCGTC
GCTTATCGGGCGGTTTTTGGTTGGGCTTGAGGCTGAGATTTTCCATAAAGCGACGCTGTTTGAAAATGAAACGATCGAGA
CGATTTACTTCGGCGGGGGAACGCCTTCGCTCTTGAGCCTTGCGCAAATTGAGCGCGTTTTGGCGCTTTGTTTTGCGCAT
TTCCGAATTGCGCCCGCGCCGGAAATTACGCTGGAGGCCAATCCTGAGGATTTGAATGAGGAAAAACTTCAGGCGCTTGC
AAGTTCGCCCGTGAATCGGTTGAGTCTTGGGATTCAATCGTTTGATGCGGGAAAGTTGAAACGGCTTTCGCGCGGGCATT
CGGCGCAGGAGAGTTTCGAAATTGCCTCGCTGGCTCGCACTTTTTTCCGAAATATCAACATCGATTTGATGTTCGGCACG
CCGGATGAATCCTTGAACGATTGGCAACGAGAACTTGAAACGGCCTTGCAATTTCAGCCCGAACATCTTTCCACGTATTC
GCTGACCGTCGAGCCGAAAACCTTGCTTGCACATGACATCGGGCTTGGAAAAATTCCTGCACCGAACGAATCGCTTCAAG
TGGAGATGTTTCTTTCGGTGATGCGGCGGCTTCGTGAGGCGGGTTATCGGCACTACGAGGTGTCGAATTTTGCCAAGCCG
GCGGCGCTTTCCGCACACAACTTCGATGCGTGGCAACGCAAGCCGTATCTCGGATTCGGGCCGGCGGCGCATTCGTTCGT
TAGGCAAGGCCGAACTGAGCGGCGTTTTGCCAACGTGCGCAATTTGAAAACTTACCTCGAAAATCCCGCCAACGCCCTCT
TGTTCGAAGAAACCTTGACGGAAAAGGACATTTTAAACGAAGAAATTTTTCTTGCGCTTCGTCAGGATACTGGTTTAGGT
ATGGACGTTTTGGAGAAAAGGCGTAAATTCACACGCTCAAATTTGCTTGAAAAAGAGATCGAAGCCTTTTGCCTGCAAGG
CCTTTTGCGCCGCGATTCGGGACGCTTGCGTCTCACAGATAAAGGCTTTACACTGGCCGATTCCATAGCTGAAACATTTA
TGGTTGAGTAA

Upstream 100 bases:

>100_bases
TTCTTCATCGTCAAAAGTGAAAAATTGATCAATAAATTAGACGTCTTGCAATTTCTCACATCTCCGTATTTTCTCATTTT
TTCCAACCATCAATTTATCT

Downstream 100 bases:

>100_bases
TGGCCTTGCAAATGCAAATCAACACTGATCAGCGATTTACAAACTGAAAGAAAGTTCTGATGCACAAGAAAATAAATAGC
AGCATTGCCGTTGTCGTTCT

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MPGLYFHIPFCRRRCHYCDFYFTTNASLIGRFLVGLEAEIFHKATLFENETIETIYFGGGTPSLLSLAQIERVLALCFAH
FRIAPAPEITLEANPEDLNEEKLQALASSPVNRLSLGIQSFDAGKLKRLSRGHSAQESFEIASLARTFFRNINIDLMFGT
PDESLNDWQRELETALQFQPEHLSTYSLTVEPKTLLAHDIGLGKIPAPNESLQVEMFLSVMRRLREAGYRHYEVSNFAKP
AALSAHNFDAWQRKPYLGFGPAAHSFVRQGRTERRFANVRNLKTYLENPANALLFEETLTEKDILNEEIFLALRQDTGLG
MDVLEKRRKFTRSNLLEKEIEAFCLQGLLRRDSGRLRLTDKGFTLADSIAETFMVE

Sequences:

>Translated_376_residues
MPGLYFHIPFCRRRCHYCDFYFTTNASLIGRFLVGLEAEIFHKATLFENETIETIYFGGGTPSLLSLAQIERVLALCFAH
FRIAPAPEITLEANPEDLNEEKLQALASSPVNRLSLGIQSFDAGKLKRLSRGHSAQESFEIASLARTFFRNINIDLMFGT
PDESLNDWQRELETALQFQPEHLSTYSLTVEPKTLLAHDIGLGKIPAPNESLQVEMFLSVMRRLREAGYRHYEVSNFAKP
AALSAHNFDAWQRKPYLGFGPAAHSFVRQGRTERRFANVRNLKTYLENPANALLFEETLTEKDILNEEIFLALRQDTGLG
MDVLEKRRKFTRSNLLEKEIEAFCLQGLLRRDSGRLRLTDKGFTLADSIAETFMVE
>Mature_375_residues
PGLYFHIPFCRRRCHYCDFYFTTNASLIGRFLVGLEAEIFHKATLFENETIETIYFGGGTPSLLSLAQIERVLALCFAHF
RIAPAPEITLEANPEDLNEEKLQALASSPVNRLSLGIQSFDAGKLKRLSRGHSAQESFEIASLARTFFRNINIDLMFGTP
DESLNDWQRELETALQFQPEHLSTYSLTVEPKTLLAHDIGLGKIPAPNESLQVEMFLSVMRRLREAGYRHYEVSNFAKPA
ALSAHNFDAWQRKPYLGFGPAAHSFVRQGRTERRFANVRNLKTYLENPANALLFEETLTEKDILNEEIFLALRQDTGLGM
DVLEKRRKFTRSNLLEKEIEAFCLQGLLRRDSGRLRLTDKGFTLADSIAETFMVE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=278, Percent_Identity=38.4892086330935, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1789325, Length=391, Percent_Identity=31.7135549872123, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI87082341, Length=392, Percent_Identity=25.765306122449, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42878; Mature: 42747

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLYFHIPFCRRRCHYCDFYFTTNASLIGRFLVGLEAEIFHKATLFENETIETIYFGGG
CCCEEEECHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCC
TPSLLSLAQIERVLALCFAHFRIAPAPEITLEANPEDLNEEKLQALASSPVNRLSLGIQS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHC
FDAGKLKRLSRGHSAQESFEIASLARTFFRNINIDLMFGTPDESLNDWQRELETALQFQP
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
EHLSTYSLTVEPKTLLAHDIGLGKIPAPNESLQVEMFLSVMRRLREAGYRHYEVSNFAKP
CCCCEEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCC
AALSAHNFDAWQRKPYLGFGPAAHSFVRQGRTERRFANVRNLKTYLENPANALLFEETLT
CCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EKDILNEEIFLALRQDTGLGMDVLEKRRKFTRSNLLEKEIEAFCLQGLLRRDSGRLRLTD
HHHHCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
KGFTLADSIAETFMVE
CCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PGLYFHIPFCRRRCHYCDFYFTTNASLIGRFLVGLEAEIFHKATLFENETIETIYFGGG
CCEEEECHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCC
TPSLLSLAQIERVLALCFAHFRIAPAPEITLEANPEDLNEEKLQALASSPVNRLSLGIQS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHC
FDAGKLKRLSRGHSAQESFEIASLARTFFRNINIDLMFGTPDESLNDWQRELETALQFQP
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
EHLSTYSLTVEPKTLLAHDIGLGKIPAPNESLQVEMFLSVMRRLREAGYRHYEVSNFAKP
CCCCEEEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCC
AALSAHNFDAWQRKPYLGFGPAAHSFVRQGRTERRFANVRNLKTYLENPANALLFEETLT
CCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EKDILNEEIFLALRQDTGLGMDVLEKRRKFTRSNLLEKEIEAFCLQGLLRRDSGRLRLTD
HHHHCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
KGFTLADSIAETFMVE
CCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]