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The map label for this gene is pth [H]

Identifier: 193214407

GI number: 193214407

Start: 805608

End: 806216

Strand: Direct

Name: pth [H]

Synonym: Ctha_0690

Alternate gene names: 193214407

Gene position: 805608-806216 (Clockwise)

Preceding gene: 193214406

Following gene: 193214411

Centisome position: 24.46

GC content: 48.6

Gene sequence:

>609_bases
TTGATTCATTCTAAAAAACGCTATTTGATTGTGAAACTAATTGTGGGGCTGGGAAATCCCGGCAGTAAATACGACGGGAC
AAGACACAATATTGGATTTGAGGTTGTGGATGCGCTGGCCGCGCGGTTCGGCGAGGACTTTCGCAGCGGCAAAGGCGAAT
ACGATTTTTGCAAAACGAAACATCGCGGCGAAGAAGTGCTGCTTGTCAAGCCAACGACTTACATGAATCTTTCTGGCAAA
GCCGTTCGGCACGCGATGGCTTTCTACAAAATTTCCATCTTGGATATTTTAGTCATTTGCGACGATTTCAATTTGCCGCT
TGGCGCAGTTCGAATTCGTCCCAGCGGCACGGACGGCGGACAAAACGGTTTGAAAAATATCATTCAACTTGTTGGCCGAA
ATGATTTTGCCAGACTGCGCGTCGGCATTGGCGCGCCGAAAGTGCAAAATGCGTCGTCGTTCGTCTTGGGAAAATTTGGC
GAAAGCGAACTGCCAATTGTGGAAGAAACCGCCCGGTTTTGCGCGGATGCTGCCTGCTCATTTCTCGAAACCGATTTAAG
CAAAACCATGACGAAGTTCAACCGCAAAGCGCCTGAAGTCACTACTTGA

Upstream 100 bases:

>100_bases
CTCAGCATGACATCGTTTTGTCATTCTGAGCTTCTTGGCCAAGAATCCAAAAATTATCCGAGTGGATGCTCGCGGGCGTT
CAGCATGACAAGAAAAAAAT

Downstream 100 bases:

>100_bases
CGATCACGCTGCGCTTTCTTCGATTTTTAAATTATTGTAGCCATTTGCCTTACGATTTTTCTGACGTAGATATAAGGCAT
GCAAAATTTCTGTTTTGAGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MIHSKKRYLIVKLIVGLGNPGSKYDGTRHNIGFEVVDALAARFGEDFRSGKGEYDFCKTKHRGEEVLLVKPTTYMNLSGK
AVRHAMAFYKISILDILVICDDFNLPLGAVRIRPSGTDGGQNGLKNIIQLVGRNDFARLRVGIGAPKVQNASSFVLGKFG
ESELPIVEETARFCADAACSFLETDLSKTMTKFNRKAPEVTT

Sequences:

>Translated_202_residues
MIHSKKRYLIVKLIVGLGNPGSKYDGTRHNIGFEVVDALAARFGEDFRSGKGEYDFCKTKHRGEEVLLVKPTTYMNLSGK
AVRHAMAFYKISILDILVICDDFNLPLGAVRIRPSGTDGGQNGLKNIIQLVGRNDFARLRVGIGAPKVQNASSFVLGKFG
ESELPIVEETARFCADAACSFLETDLSKTMTKFNRKAPEVTT
>Mature_202_residues
MIHSKKRYLIVKLIVGLGNPGSKYDGTRHNIGFEVVDALAARFGEDFRSGKGEYDFCKTKHRGEEVLLVKPTTYMNLSGK
AVRHAMAFYKISILDILVICDDFNLPLGAVRIRPSGTDGGQNGLKNIIQLVGRNDFARLRVGIGAPKVQNASSFVLGKFG
ESELPIVEETARFCADAACSFLETDLSKTMTKFNRKAPEVTT

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=173, Percent_Identity=31.7919075144509, Blast_Score=85, Evalue=4e-17,
Organism=Escherichia coli, GI1787455, Length=189, Percent_Identity=40.2116402116402, Blast_Score=113, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321983, Length=166, Percent_Identity=31.9277108433735, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22217; Mature: 22217

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHSKKRYLIVKLIVGLGNPGSKYDGTRHNIGFEVVDALAARFGEDFRSGKGEYDFCKTK
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHC
HRGEEVLLVKPTTYMNLSGKAVRHAMAFYKISILDILVICDDFNLPLGAVRIRPSGTDGG
CCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCH
QNGLKNIIQLVGRNDFARLRVGIGAPKVQNASSFVLGKFGESELPIVEETARFCADAACS
HHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
FLETDLSKTMTKFNRKAPEVTT
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIHSKKRYLIVKLIVGLGNPGSKYDGTRHNIGFEVVDALAARFGEDFRSGKGEYDFCKTK
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHC
HRGEEVLLVKPTTYMNLSGKAVRHAMAFYKISILDILVICDDFNLPLGAVRIRPSGTDGG
CCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCCCCCH
QNGLKNIIQLVGRNDFARLRVGIGAPKVQNASSFVLGKFGESELPIVEETARFCADAACS
HHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
FLETDLSKTMTKFNRKAPEVTT
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA