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The map label for this gene is kdsA [H]

Identifier: 193214291

GI number: 193214291

Start: 669744

End: 670583

Strand: Direct

Name: kdsA [H]

Synonym: Ctha_0572

Alternate gene names: 193214291

Gene position: 669744-670583 (Clockwise)

Preceding gene: 193214278

Following gene: 193214292

Centisome position: 20.34

GC content: 50.36

Gene sequence:

>840_bases
TTGCGTACCGCTCAATTTGAAATTGCCGGCATTCCAGTCGGGACAAAGGAAAAGCTGCTTGTTTTTGCAGGCCCGTGTGT
CGTTGAAAATCGGGAGATGCTTTTCTCAACAGCGGAAGGGCTCAAAAAGGCCGCTGAAACGATCGGCTTTGATTTGATTT
TCAAGGCATCTTATAAAAAAGCCAATCGCTCTTCGTCGGGTTCATTTACGGGAATCGGCGACGAGGCCGCGCTGGCATTG
CTTGCAGAAGTGCGCCAAACCTTCGACTTGCCGATCGTCACCGATATTCATCATCCAGAAGAAGCTGCACTGGCGTCAAA
GTTTGTGGACGTCTTGCAAATTCCCGCGTTTTTATGTCGCCAAACGGAGCTTTTGGAAGCTGCCGGAAAAACCGGACTTG
CGGTTAATATTAAAAAAGGTCAGTTTATGGCGCCAGGTGATATGCGCTTGGCTGCGGAAAAAGTCGCGGCAACGGGGAAT
ACAAAAATCTTGCTCACCGAACGCGGCACAAGCTTTGGCTATCACAACCTTGTGGTGGATTTTCGCGGGTTGCCGCAAAT
GTCGGCGCTTGGCTATCCGGTCATTTTTGACGCCACGCATAGCGTGCAACTTCCGAGCGCCGGTCAAGGCATTTCATCTG
GCGAGCGCCAATATATTCAGCCGCTGGCTCGCGCTGCGGTGGCTGTGGGCGTTACAGGACTTTTCTTTGAAGTGCATCCC
ACGCCGGAAAAAGCGCTTTCTGATTCGGCCACACAGCTTCCGCTTTCCAAAGCAGAACCGCTGCTGCGCGAACTTCAAGA
AATATTTGAGATAACAAAAAAAATTCAACCATTAATCTAA

Upstream 100 bases:

>100_bases
TTTTGATTTAGGCGTTATCTTTATCGCAAAATTTGCCACCGTATGAAACGGTTAGGTTTCTACCAGGAATTTTTATTTCA
AGTTAAAGGAGTTTGCAAAG

Downstream 100 bases:

>100_bases
GACAGAGGATAGAGAAAATTGGAAATATTCGGCGTTTCAGTTTCGTCAGAAGATCCGACTTCCCGCTTGCGGCAGCTGCT
CGGCGAGATCAAGGTGATTA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MRTAQFEIAGIPVGTKEKLLVFAGPCVVENREMLFSTAEGLKKAAETIGFDLIFKASYKKANRSSSGSFTGIGDEAALAL
LAEVRQTFDLPIVTDIHHPEEAALASKFVDVLQIPAFLCRQTELLEAAGKTGLAVNIKKGQFMAPGDMRLAAEKVAATGN
TKILLTERGTSFGYHNLVVDFRGLPQMSALGYPVIFDATHSVQLPSAGQGISSGERQYIQPLARAAVAVGVTGLFFEVHP
TPEKALSDSATQLPLSKAEPLLRELQEIFEITKKIQPLI

Sequences:

>Translated_279_residues
MRTAQFEIAGIPVGTKEKLLVFAGPCVVENREMLFSTAEGLKKAAETIGFDLIFKASYKKANRSSSGSFTGIGDEAALAL
LAEVRQTFDLPIVTDIHHPEEAALASKFVDVLQIPAFLCRQTELLEAAGKTGLAVNIKKGQFMAPGDMRLAAEKVAATGN
TKILLTERGTSFGYHNLVVDFRGLPQMSALGYPVIFDATHSVQLPSAGQGISSGERQYIQPLARAAVAVGVTGLFFEVHP
TPEKALSDSATQLPLSKAEPLLRELQEIFEITKKIQPLI
>Mature_279_residues
MRTAQFEIAGIPVGTKEKLLVFAGPCVVENREMLFSTAEGLKKAAETIGFDLIFKASYKKANRSSSGSFTGIGDEAALAL
LAEVRQTFDLPIVTDIHHPEEAALASKFVDVLQIPAFLCRQTELLEAAGKTGLAVNIKKGQFMAPGDMRLAAEKVAATGN
TKILLTERGTSFGYHNLVVDFRGLPQMSALGYPVIFDATHSVQLPSAGQGISSGERQYIQPLARAAVAVGVTGLFFEVHP
TPEKALSDSATQLPLSKAEPLLRELQEIFEITKKIQPLI

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=280, Percent_Identity=41.0714285714286, Blast_Score=225, Evalue=3e-60,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30012; Mature: 30012

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAQFEIAGIPVGTKEKLLVFAGPCVVENREMLFSTAEGLKKAAETIGFDLIFKASYKK
CCCCEEEEEECCCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHCHHEEEEEHHHH
ANRSSSGSFTGIGDEAALALLAEVRQTFDLPIVTDIHHPEEAALASKFVDVLQIPAFLCR
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
QTELLEAAGKTGLAVNIKKGQFMAPGDMRLAAEKVAATGNTKILLTERGTSFGYHNLVVD
HHHHHHHCCCCCEEEEECCCCEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEE
FRGLPQMSALGYPVIFDATHSVQLPSAGQGISSGERQYIQPLARAAVAVGVTGLFFEVHP
ECCCCCHHHCCCCEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECC
TPEKALSDSATQLPLSKAEPLLRELQEIFEITKKIQPLI
CHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTAQFEIAGIPVGTKEKLLVFAGPCVVENREMLFSTAEGLKKAAETIGFDLIFKASYKK
CCCCEEEEEECCCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHHCHHEEEEEHHHH
ANRSSSGSFTGIGDEAALALLAEVRQTFDLPIVTDIHHPEEAALASKFVDVLQIPAFLCR
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
QTELLEAAGKTGLAVNIKKGQFMAPGDMRLAAEKVAATGNTKILLTERGTSFGYHNLVVD
HHHHHHHCCCCCEEEEECCCCEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEE
FRGLPQMSALGYPVIFDATHSVQLPSAGQGISSGERQYIQPLARAAVAVGVTGLFFEVHP
ECCCCCHHHCCCCEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEECC
TPEKALSDSATQLPLSKAEPLLRELQEIFEITKKIQPLI
CHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA