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The map label for this gene is ytcB [H]

Identifier: 193214167

GI number: 193214167

Start: 528525

End: 529487

Strand: Direct

Name: ytcB [H]

Synonym: Ctha_0448

Alternate gene names: 193214167

Gene position: 528525-529487 (Clockwise)

Preceding gene: 193214166

Following gene: 193214168

Centisome position: 16.05

GC content: 47.77

Gene sequence:

>963_bases
ATGAATAATCAACCTGTTACCGTTATTACTGGCGGCGCTGGCTTTCTTGGCTCCCACCTCTGTGATCGCTTTATTGCCGA
AGGTCACAAAGTCATTGCCATCGATAATTTTATCACCGGTAATCCTGACAACATCGCGCATTTAATGGGCAATGAAAACT
TCAAGTTCATCAAGCACGATGTCACGGAGTTTATTTATGTTGAAGGCAAGGTCGATAACATCCTCCATTTTGCATCGCCA
GCCAGCCCAATTGATTACTTGAAACTTCCGATTCAAACACTGAAAGTCGGCTCGCTCGGCACACACAAAGCGCTTGGGCT
TGCTAAAGCAAAAGGCGCGCGCTTTTTGCTCGCCTCCACTTCTGAGGTTTATGGCGACCCGCTGGAGCATCCGCAAAAAG
AGACTTATTGGGGAAATGTGAATCCGATTGGCCTGCGTGGCGTGTATGACGAAGCCAAGCGCTTTGCCGAATCGATGACG
ATGGCCTATCATCGCTATCACAATTTGGATACGCGGATTTTGCGCATTTTTAATACTTATGGCCCGAGAATGCGCCTCAA
CGATGGTCGCGCACTTCCAGCTTTTGTGCACTCCGCGCTGAACGGCACGCCGATGACTGTTTTCGGCGATGGCTCTCAAA
CCCGCAGTTTCTGCTATGTTTCTGATTTGGTTGAAGGCATTTGGCGACTTTTAAACTCCAACGAAACTGAGCCGGTCAAC
ATCGGCAACCCCGATGAAATTACCATTTTGGATTTTGCCAAAGAAGTTCAAACGATTGTGAAGGAATTGACCGGAAAAGA
CACCGAAATTATTTTCAAAGAATTGCCCTCCGACGACCCAAAAGTCCGCAAACCCGATAACACCAAAGCCAAAGAACGCC
TTGGCTGGGAGCCGACCATCAACCGCGCGGAAGGCTTGCGCAAAACCATTTCATATTTCTTTAAGCAAGCAGGGATTATT
TAA

Upstream 100 bases:

>100_bases
CGCCAAATCAAACTTCTCAAAAGATCTCCATTTTAACAGAGCATTCCGTATCTTTGGCAACATGTGTAGCACTTTGAAAC
CTACCAACTCAATTAAGTTC

Downstream 100 bases:

>100_bases
TCAATTTGAAAAACTTCATAAACAGATAGAGAAAATTCATGGTAGTACTCGATGGAAAAAAGCTTTCACAGGAAATTAAA
GCTGAGCTAAAAACAAAAGT

Product: NAD-dependent epimerase/dehydratase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MNNQPVTVITGGAGFLGSHLCDRFIAEGHKVIAIDNFITGNPDNIAHLMGNENFKFIKHDVTEFIYVEGKVDNILHFASP
ASPIDYLKLPIQTLKVGSLGTHKALGLAKAKGARFLLASTSEVYGDPLEHPQKETYWGNVNPIGLRGVYDEAKRFAESMT
MAYHRYHNLDTRILRIFNTYGPRMRLNDGRALPAFVHSALNGTPMTVFGDGSQTRSFCYVSDLVEGIWRLLNSNETEPVN
IGNPDEITILDFAKEVQTIVKELTGKDTEIIFKELPSDDPKVRKPDNTKAKERLGWEPTINRAEGLRKTISYFFKQAGII

Sequences:

>Translated_320_residues
MNNQPVTVITGGAGFLGSHLCDRFIAEGHKVIAIDNFITGNPDNIAHLMGNENFKFIKHDVTEFIYVEGKVDNILHFASP
ASPIDYLKLPIQTLKVGSLGTHKALGLAKAKGARFLLASTSEVYGDPLEHPQKETYWGNVNPIGLRGVYDEAKRFAESMT
MAYHRYHNLDTRILRIFNTYGPRMRLNDGRALPAFVHSALNGTPMTVFGDGSQTRSFCYVSDLVEGIWRLLNSNETEPVN
IGNPDEITILDFAKEVQTIVKELTGKDTEIIFKELPSDDPKVRKPDNTKAKERLGWEPTINRAEGLRKTISYFFKQAGII
>Mature_320_residues
MNNQPVTVITGGAGFLGSHLCDRFIAEGHKVIAIDNFITGNPDNIAHLMGNENFKFIKHDVTEFIYVEGKVDNILHFASP
ASPIDYLKLPIQTLKVGSLGTHKALGLAKAKGARFLLASTSEVYGDPLEHPQKETYWGNVNPIGLRGVYDEAKRFAESMT
MAYHRYHNLDTRILRIFNTYGPRMRLNDGRALPAFVHSALNGTPMTVFGDGSQTRSFCYVSDLVEGIWRLLNSNETEPVN
IGNPDEITILDFAKEVQTIVKELTGKDTEIIFKELPSDDPKVRKPDNTKAKERLGWEPTINRAEGLRKTISYFFKQAGII

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=309, Percent_Identity=56.3106796116505, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI7657641, Length=322, Percent_Identity=27.3291925465839, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4504031, Length=349, Percent_Identity=26.0744985673352, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4507709, Length=297, Percent_Identity=25.2525252525253, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788589, Length=358, Percent_Identity=25.6983240223464, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994969, Length=334, Percent_Identity=25.748502994012, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1788353, Length=338, Percent_Identity=24.5562130177515, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786974, Length=323, Percent_Identity=22.9102167182663, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788366, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17539532, Length=307, Percent_Identity=52.7687296416938, Blast_Score=333, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17568069, Length=331, Percent_Identity=29.9093655589124, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=333, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=331, Percent_Identity=24.1691842900302, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17507723, Length=347, Percent_Identity=24.7838616714697, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982038, Length=333, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI133901788, Length=345, Percent_Identity=23.768115942029, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=345, Percent_Identity=23.768115942029, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=345, Percent_Identity=23.768115942029, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=345, Percent_Identity=23.768115942029, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=345, Percent_Identity=23.768115942029, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=254, Percent_Identity=25.5905511811024, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356223, Length=311, Percent_Identity=51.4469453376206, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI19923002, Length=330, Percent_Identity=24.5454545454545, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46

Molecular weight: Translated: 35767; Mature: 35767

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQPVTVITGGAGFLGSHLCDRFIAEGHKVIAIDNFITGNPDNIAHLMGNENFKFIKHD
CCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCHHHHHC
VTEFIYVEGKVDNILHFASPASPIDYLKLPIQTLKVGSLGTHKALGLAKAKGARFLLAST
CCEEEEEECCHHHHHHHCCCCCCHHHHHCCHHHEEECCCCCHHHHHHHHCCCCEEEEECC
SEVYGDPLEHPQKETYWGNVNPIGLRGVYDEAKRFAESMTMAYHRYHNLDTRILRIFNTY
HHHCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
GPRMRLNDGRALPAFVHSALNGTPMTVFGDGSQTRSFCYVSDLVEGIWRLLNSNETEPVN
CCEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IGNPDEITILDFAKEVQTIVKELTGKDTEIIFKELPSDDPKVRKPDNTKAKERLGWEPTI
CCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCC
NRAEGLRKTISYFFKQAGII
CHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNNQPVTVITGGAGFLGSHLCDRFIAEGHKVIAIDNFITGNPDNIAHLMGNENFKFIKHD
CCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCHHHHHC
VTEFIYVEGKVDNILHFASPASPIDYLKLPIQTLKVGSLGTHKALGLAKAKGARFLLAST
CCEEEEEECCHHHHHHHCCCCCCHHHHHCCHHHEEECCCCCHHHHHHHHCCCCEEEEECC
SEVYGDPLEHPQKETYWGNVNPIGLRGVYDEAKRFAESMTMAYHRYHNLDTRILRIFNTY
HHHCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
GPRMRLNDGRALPAFVHSALNGTPMTVFGDGSQTRSFCYVSDLVEGIWRLLNSNETEPVN
CCEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IGNPDEITILDFAKEVQTIVKELTGKDTEIIFKELPSDDPKVRKPDNTKAKERLGWEPTI
CCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCC
NRAEGLRKTISYFFKQAGII
CHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTDPglucose

Specific reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]