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The map label for this gene is idsA [H]

Identifier: 193214123

GI number: 193214123

Start: 468231

End: 469238

Strand: Direct

Name: idsA [H]

Synonym: Ctha_0404

Alternate gene names: 193214123

Gene position: 468231-469238 (Clockwise)

Preceding gene: 193214122

Following gene: 193214137

Centisome position: 14.22

GC content: 45.24

Gene sequence:

>1008_bases
ATGAAAACGACAACAACGGAAAATATCGGGATGGATATTCAACAAAAGTATCTTGAGTTTCACACGCGAATCAATGAAGA
ACTTCAACAATGCTTGTTGGGAAAAGAACCCAAATCGCTTTATGAGCCGGCAACTTACATTTTAACGGGAAAAGGAAAAC
GCGTTCGCCCTGTTCTGGTTCTACTTGGCGCTGAAAGCATTTGTGGAACATCCGATCATGCGCTGAACCTCGCCCTGTCG
GTTGAAGTGCTTCACAACTTCACGCTCATCCATGACGATATTATGGACAACGCCGCGTTGCGCCATGGCCGTGAAACCGT
TCATTTGAAATGGAATGAAAATGCGGCGATTCTTTCCGGCGACATGATGCTTGCCTTTGCTTATGAACTTGCACTGAAAA
CGAATTCCTCACGCCTTACCAAAATTCTTGACGTCATTACGCAAAGCACTATTGTCATTTGCGAAGGTCAAACCTATGAT
ATGGATTTTGAGAAGCGCACCGATGTTACCATGTCCGAGTACCTCGACATGATTTCCAAAAAAACAGGCCGCTTAATTGC
CGCATCGCTTGAGCTTGGCGGACTTGCTGCCGAAGCGACCGATGAGCAGTTGGCCATTTTAACAGAATACGGCGAGCTTA
TTGGACAAGCCTTTCAAGTTCAAGACGACTTGCTCGACATCATGGCCGATGATAAAAAATTTGGAAAAGTCCCTGGCGGC
GATTTGATGGAAGGGAAAAAAACCTTCTTGCTGCTTCGCGCTTTGGAGCTTACAACGGGCGAAGATCATCTGCTGCTTCA
ATCTGTCATTGATAATCACGGGATCGCTCAAGAGCGTATTCCTGAAATCAAGGACATTTACGAGCGCTGCGGCATCCTAA
ATGAAGCGCAAGAACTTATTAATAGCAATTTTGAAAAAGCCGTTACACTTTCAGAAAAACTTCCTAACGAAGCTGGCCGC
GAAGCTTTAGTTGGATTTACGGCAATGGTCATGAAACGCGATTCTTAA

Upstream 100 bases:

>100_bases
ACATTTGAAATTAAGCCGCTGCAGCGATCATAGCTTTTTTGCGATTTTGTTGAAATACAATTTCATGCACGTCTTTAAAA
ACCGAAACCAAACAGCTTTA

Downstream 100 bases:

>100_bases
CCTTCTTTTACTTGGCAATTGACCAGCGATTTGGTCAATTGCCTTTTTATTTTCAAAACTTCTCACTTTCAGCAGCTCGT
CCCAAAGCAACTTGTCCAAT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKTTTTENIGMDIQQKYLEFHTRINEELQQCLLGKEPKSLYEPATYILTGKGKRVRPVLVLLGAESICGTSDHALNLALS
VEVLHNFTLIHDDIMDNAALRHGRETVHLKWNENAAILSGDMMLAFAYELALKTNSSRLTKILDVITQSTIVICEGQTYD
MDFEKRTDVTMSEYLDMISKKTGRLIAASLELGGLAAEATDEQLAILTEYGELIGQAFQVQDDLLDIMADDKKFGKVPGG
DLMEGKKTFLLLRALELTTGEDHLLLQSVIDNHGIAQERIPEIKDIYERCGILNEAQELINSNFEKAVTLSEKLPNEAGR
EALVGFTAMVMKRDS

Sequences:

>Translated_335_residues
MKTTTTENIGMDIQQKYLEFHTRINEELQQCLLGKEPKSLYEPATYILTGKGKRVRPVLVLLGAESICGTSDHALNLALS
VEVLHNFTLIHDDIMDNAALRHGRETVHLKWNENAAILSGDMMLAFAYELALKTNSSRLTKILDVITQSTIVICEGQTYD
MDFEKRTDVTMSEYLDMISKKTGRLIAASLELGGLAAEATDEQLAILTEYGELIGQAFQVQDDLLDIMADDKKFGKVPGG
DLMEGKKTFLLLRALELTTGEDHLLLQSVIDNHGIAQERIPEIKDIYERCGILNEAQELINSNFEKAVTLSEKLPNEAGR
EALVGFTAMVMKRDS
>Mature_335_residues
MKTTTTENIGMDIQQKYLEFHTRINEELQQCLLGKEPKSLYEPATYILTGKGKRVRPVLVLLGAESICGTSDHALNLALS
VEVLHNFTLIHDDIMDNAALRHGRETVHLKWNENAAILSGDMMLAFAYELALKTNSSRLTKILDVITQSTIVICEGQTYD
MDFEKRTDVTMSEYLDMISKKTGRLIAASLELGGLAAEATDEQLAILTEYGELIGQAFQVQDDLLDIMADDKKFGKVPGG
DLMEGKKTFLLLRALELTTGEDHLLLQSVIDNHGIAQERIPEIKDIYERCGILNEAQELINSNFEKAVTLSEKLPNEAGR
EALVGFTAMVMKRDS

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=303, Percent_Identity=27.3927392739274, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI209571582, Length=281, Percent_Identity=25.9786476868327, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4503685, Length=281, Percent_Identity=25.9786476868327, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI209571584, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4758430, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI83700220, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789578, Length=289, Percent_Identity=31.8339100346021, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1786623, Length=216, Percent_Identity=36.5740740740741, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=257, Percent_Identity=29.1828793774319, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325188, Length=226, Percent_Identity=29.646017699115, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24651612, Length=288, Percent_Identity=27.4305555555556, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137582, Length=261, Percent_Identity=27.5862068965517, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281365769, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24660002, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 37309; Mature: 37309

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00052 RIBOSOMAL_S7 ; PS00687 ALDEHYDE_DEHYDR_GLU ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTTTENIGMDIQQKYLEFHTRINEELQQCLLGKEPKSLYEPATYILTGKGKRVRPVLV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCCCCCEEEE
LLGAESICGTSDHALNLALSVEVLHNFTLIHDDIMDNAALRHGRETVHLKWNENAAILSG
EECCCHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEC
DMMLAFAYELALKTNSSRLTKILDVITQSTIVICEGQTYDMDFEKRTDVTMSEYLDMISK
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCEECCCCHHCCCCCHHHHHHHHHH
KTGRLIAASLELGGLAAEATDEQLAILTEYGELIGQAFQVQDDLLDIMADDKKFGKVPGG
CCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
DLMEGKKTFLLLRALELTTGEDHLLLQSVIDNHGIAQERIPEIKDIYERCGILNEAQELI
CCCCCHHHHHHEEHHHHCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCHHHHHHHH
NSNFEKAVTLSEKLPNEAGREALVGFTAMVMKRDS
HCCHHHHEEHHHHCCCHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKTTTTENIGMDIQQKYLEFHTRINEELQQCLLGKEPKSLYEPATYILTGKGKRVRPVLV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEECCCCCCCEEEE
LLGAESICGTSDHALNLALSVEVLHNFTLIHDDIMDNAALRHGRETVHLKWNENAAILSG
EECCCHHCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEC
DMMLAFAYELALKTNSSRLTKILDVITQSTIVICEGQTYDMDFEKRTDVTMSEYLDMISK
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCEECCCCHHCCCCCHHHHHHHHHH
KTGRLIAASLELGGLAAEATDEQLAILTEYGELIGQAFQVQDDLLDIMADDKKFGKVPGG
CCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
DLMEGKKTFLLLRALELTTGEDHLLLQSVIDNHGIAQERIPEIKDIYERCGILNEAQELI
CCCCCHHHHHHEEHHHHCCCCCHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCHHHHHHHH
NSNFEKAVTLSEKLPNEAGREALVGFTAMVMKRDS
HCCHHHHEEHHHHCCCHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7979381 [H]