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The map label for this gene is hisC [H]

Identifier: 193213877

GI number: 193213877

Start: 186419

End: 187516

Strand: Direct

Name: hisC [H]

Synonym: Ctha_0158

Alternate gene names: 193213877

Gene position: 186419-187516 (Clockwise)

Preceding gene: 193213871

Following gene: 193213878

Centisome position: 5.66

GC content: 45.81

Gene sequence:

>1098_bases
ATGCAAAAAGATTTTTCAAACGATTTAGAATTTCGAGCATTTCTAAATCCTGCCGTTAGGAATATGTCTGCCTATCATAT
TTCTGGTGGACAAAACGCGGAAATCAAGCTAAACCAAAACGAAAATCCGTTAGACCTGCCCGATTGGCTGAAGGAAAAAA
TATTGGCGGACTTTGCCAAAGAGCAATGGAATCGCTATCCCGAAATTTTCCCAAACCAAGCCACACGGAAATATGCAGAG
TTTTTAGACGTTCCCGCCGAATGCGTGCTGATGGGAAACGGTTCTAACGAGTTGCTTTACACGATTTTCATGGCGACCCT
TACAAAAGGCGCGTCGGTGCTGATTCCGCAGCCGTCGTTTTCACTTTATGAAAAAATCGCTGACATCTTAAACGCCGATG
TCATTGCCGTGCCGATGACCAGCTCGTTTGAGTTTCAACCGGAACGCATCATTGCGGAAGCGAAGAACAGCCAGCCAAAT
CTCATCGTGCTTTCCACGCCGAACAATCCGACGAGCAAGTCGCTTTCTTATGAGCAAATCAAGCAAATTGTCACCGAAAC
CGATTCCATCGTTTTGGCTGACGAGGCGTATATCGAATTTTCCAAGCAAAAATCCGCGCTGGATCTGATCTATGAACACA
GCAACTTGCTCGTGCTTCGAACCATGTCGAAGGCGTTTTCGCTTGCGGGCGTGCGGGTCGGTTTTGCCATCAGCCATCCT
GAACTGTTGAAGGAAATCTCAAAGCCGAAGATTCCATTTGCGTCGAATCGCTTGGCGGAGCTTTGCCTGATTCATGTGCT
CGAAAATTATTCAGTTATTGACGAACGCGTAAAAATGCTGCTCGGCGAGCGCGAACGAATGGCGGGCATATTGGCAAAAA
TGAACGGCATCTTTTTGCACGAAAGCGACACGAACTTTTTCATCATTGAAGTTGAACAACCCGGCGAAGTATTTAATCGG
TTGAAAGCCAAAGACATCATCGTGCGAAATGTTTCGAGCTACCCGATGATGGAAAAATGCCTGCGCATCAATGTGGGAAC
AAAAGCGGAAAACGACCGATTTTTGTCGGAATTGGAAAAAATTATGAATGAAGGTTAA

Upstream 100 bases:

>100_bases
ACGCGTCTAAACAACCCCAGACATCGCGCAGCCTGTCTGGAATAACGCTGGAGCTTTTGTATCTTTGCGCTTTAAGATTT
AACCAGTCAATGCTTTTGAC

Downstream 100 bases:

>100_bases
GGATTTAGTAGAAAAATGTTGAGGAAATTACATGGTTCTGAAATGGGGCGCTTAGAGCCGGACGCGTTTCGCGAAAGCCA
AAAACATCCGATTTATGTGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQKDFSNDLEFRAFLNPAVRNMSAYHISGGQNAEIKLNQNENPLDLPDWLKEKILADFAKEQWNRYPEIFPNQATRKYAE
FLDVPAECVLMGNGSNELLYTIFMATLTKGASVLIPQPSFSLYEKIADILNADVIAVPMTSSFEFQPERIIAEAKNSQPN
LIVLSTPNNPTSKSLSYEQIKQIVTETDSIVLADEAYIEFSKQKSALDLIYEHSNLLVLRTMSKAFSLAGVRVGFAISHP
ELLKEISKPKIPFASNRLAELCLIHVLENYSVIDERVKMLLGERERMAGILAKMNGIFLHESDTNFFIIEVEQPGEVFNR
LKAKDIIVRNVSSYPMMEKCLRINVGTKAENDRFLSELEKIMNEG

Sequences:

>Translated_365_residues
MQKDFSNDLEFRAFLNPAVRNMSAYHISGGQNAEIKLNQNENPLDLPDWLKEKILADFAKEQWNRYPEIFPNQATRKYAE
FLDVPAECVLMGNGSNELLYTIFMATLTKGASVLIPQPSFSLYEKIADILNADVIAVPMTSSFEFQPERIIAEAKNSQPN
LIVLSTPNNPTSKSLSYEQIKQIVTETDSIVLADEAYIEFSKQKSALDLIYEHSNLLVLRTMSKAFSLAGVRVGFAISHP
ELLKEISKPKIPFASNRLAELCLIHVLENYSVIDERVKMLLGERERMAGILAKMNGIFLHESDTNFFIIEVEQPGEVFNR
LKAKDIIVRNVSSYPMMEKCLRINVGTKAENDRFLSELEKIMNEG
>Mature_365_residues
MQKDFSNDLEFRAFLNPAVRNMSAYHISGGQNAEIKLNQNENPLDLPDWLKEKILADFAKEQWNRYPEIFPNQATRKYAE
FLDVPAECVLMGNGSNELLYTIFMATLTKGASVLIPQPSFSLYEKIADILNADVIAVPMTSSFEFQPERIIAEAKNSQPN
LIVLSTPNNPTSKSLSYEQIKQIVTETDSIVLADEAYIEFSKQKSALDLIYEHSNLLVLRTMSKAFSLAGVRVGFAISHP
ELLKEISKPKIPFASNRLAELCLIHVLENYSVIDERVKMLLGERERMAGILAKMNGIFLHESDTNFFIIEVEQPGEVFNR
LKAKDIIVRNVSSYPMMEKCLRINVGTKAENDRFLSELEKIMNEG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=29.512893982808, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788722, Length=188, Percent_Identity=28.1914893617021, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=25.6997455470738, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41350; Mature: 41350

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKDFSNDLEFRAFLNPAVRNMSAYHISGGQNAEIKLNQNENPLDLPDWLKEKILADFAK
CCCCCCCCCHHHHHHCHHHHCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
EQWNRYPEIFPNQATRKYAEFLDVPAECVLMGNGSNELLYTIFMATLTKGASVLIPQPSF
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCH
SLYEKIADILNADVIAVPMTSSFEFQPERIIAEAKNSQPNLIVLSTPNNPTSKSLSYEQI
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHH
KQIVTETDSIVLADEAYIEFSKQKSALDLIYEHSNLLVLRTMSKAFSLAGVRVGFAISHP
HHHHHCCCCEEEECHHHHHHHHCHHHHHHEEECCCEEEEEEHHHHHHHHCEEEEEEECCH
ELLKEISKPKIPFASNRLAELCLIHVLENYSVIDERVKMLLGERERMAGILAKMNGIFLH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEE
ESDTNFFIIEVEQPGEVFNRLKAKDIIVRNVSSYPMMEKCLRINVGTKAENDRFLSELEK
ECCCCEEEEEECCCHHHHHHHHHHHHHEECCCCCHHHHHHHEECCCCCCCCHHHHHHHHH
IMNEG
HHHCC
>Mature Secondary Structure
MQKDFSNDLEFRAFLNPAVRNMSAYHISGGQNAEIKLNQNENPLDLPDWLKEKILADFAK
CCCCCCCCCHHHHHHCHHHHCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
EQWNRYPEIFPNQATRKYAEFLDVPAECVLMGNGSNELLYTIFMATLTKGASVLIPQPSF
HHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCH
SLYEKIADILNADVIAVPMTSSFEFQPERIIAEAKNSQPNLIVLSTPNNPTSKSLSYEQI
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHH
KQIVTETDSIVLADEAYIEFSKQKSALDLIYEHSNLLVLRTMSKAFSLAGVRVGFAISHP
HHHHHCCCCEEEECHHHHHHHHCHHHHHHEEECCCEEEEEEHHHHHHHHCEEEEEEECCH
ELLKEISKPKIPFASNRLAELCLIHVLENYSVIDERVKMLLGERERMAGILAKMNGIFLH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEE
ESDTNFFIIEVEQPGEVFNRLKAKDIIVRNVSSYPMMEKCLRINVGTKAENDRFLSELEK
ECCCCEEEEEECCCHHHHHHHHHHHHHEECCCCCHHHHHHHEECCCCCCCCHHHHHHHHH
IMNEG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA