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The map label for this gene is metC [H]

Identifier: 192291209

GI number: 192291209

Start: 3082416

End: 3083612

Strand: Reverse

Name: metC [H]

Synonym: Rpal_2831

Alternate gene names: 192291209

Gene position: 3083612-3082416 (Counterclockwise)

Preceding gene: 192291214

Following gene: 192291199

Centisome position: 53.68

GC content: 66.58

Gene sequence:

>1197_bases
ATGGACGCCTCCGACTCCAGCGGGACACCCGCGCCGCTCAGCACGCAGACCCGCCTCGTCACCGCGGGGCGCGACACTGC
GGCGCAGAAGGGCTTCGTCAATCCTCCGGTGGTGCACGGTTCGACGGTGCTGTATCCGACCGCGGCCGATCTGCACGCCC
ATCGCGGCGAGTACTCCTATGGACGGCACGGCACCCCGACCACCAAGGCGCTGCAGCAGGCGTTGATCGCGCTTGAAGGT
CCGCAGTGTGCCGGCGTCGGCATCACCCCCTCCGGCGTGTCGGCGATCTCGACCGCCCTGCTCGCCGTGGTCAAAGCCGG
CGATCATGTGCTGGTCTGTGACAACGCCTATCGCCCGACCCGGCTGTTCTGCGATCAAATGCTGAATCGGCTCGGCGTCG
AGACCAGTTATTTCGATCCGCTGATCGGCGCCGGCATCGCGTCGCATCTTCGGCCGAACACCGTGGCGGTGGTGGTCGAG
GCGCCGGGATCGCAGTCGTTCGAGATGCCGGACATCCCGGCGATCGCCGCGGTCGCCAAGCAGCACGGTGCGCTGGTGAT
CGACGACAACACCTGGGCGACGCCGCTGTATCATCGCTCGCTGGAACAAGGCGTGGATATCTCGATCCAGGCCGCGACCA
AATATATCGGTGGTCACTCCGACATCATGTTCGGCACCATCTCGGCCAATGCCGCCGCGTGGCCGAAGGTGTCGGAAGCG
ATCCGGCTGCTCGGCGTCTGCGCCGGACCGGACGATGTGTTCCTGGCGCTGCGCGGTCTGCGCACCCTGGAGGTGCGTCT
CGCCCGACACTATCAGGCGGGCCTGGAGATGGCGCGCTGGCTCGCGGCGCGTCCCGAGGTACAGCGCGTGCTGCATCCCG
GGCTCGACACCGATCCCGGCCATGCGATCTGGAAGCGCGACTTCACCGGCGCCTCCGGGCTGTTCTCGATCGTGCTGCAA
CCGGCGCCGCAGGCTGCCGTCGATGCGCTGCTCGACACCGTGTCGCTGTTTGGGATGGGCTATTCCTGGGGCGGCTTCGA
AAGCCTGGTGATCCCGTTCGACTGCGCCTCGTACCGGACCGCGACGCATTGGAACCCGGGCGGCCCGGCGCTGCGGCTAC
ATATCGGGCTCGAAAGCGTCGATGATCTAATAGCCGATCTAGAGCAGGGCCTTACAGCTTTTGCTGCCCTTCAATGA

Upstream 100 bases:

>100_bases
ACGGCCGTCTTCCAGAAGCTGCTATTACCCCCATTCGTCGAAGTAGCCGAAGCACAGGCACAAGCGCTGTCACATTCGGC
ACAACCACCAGCGAGCCACC

Downstream 100 bases:

>100_bases
GGCCCTAAGAACGTCAGCCAACCCCGACCGACAAAAAGAACAGGATAATGATTGGCGGTACCCGAAGTTCAGAGCAAGAG
TCACAGTTGGCCGCCAATAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSYGRHGTPTTKALQQALIALEG
PQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPTRLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVE
APGSQSFEMPDIPAIAAVAKQHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTISANAAAWPKVSEA
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLEMARWLAARPEVQRVLHPGLDTDPGHAIWKRDFTGASGLFSIVLQ
PAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRTATHWNPGGPALRLHIGLESVDDLIADLEQGLTAFAALQ

Sequences:

>Translated_398_residues
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSYGRHGTPTTKALQQALIALEG
PQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPTRLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVE
APGSQSFEMPDIPAIAAVAKQHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTISANAAAWPKVSEA
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLEMARWLAARPEVQRVLHPGLDTDPGHAIWKRDFTGASGLFSIVLQ
PAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRTATHWNPGGPALRLHIGLESVDDLIADLEQGLTAFAALQ
>Mature_398_residues
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSYGRHGTPTTKALQQALIALEG
PQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPTRLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVE
APGSQSFEMPDIPAIAAVAKQHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTISANAAAWPKVSEA
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLEMARWLAARPEVQRVLHPGLDTDPGHAIWKRDFTGASGLFSIVLQ
PAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRTATHWNPGGPALRLHIGLESVDDLIADLEQGLTAFAALQ

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=354, Percent_Identity=31.3559322033898, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI299473759, Length=353, Percent_Identity=28.8951841359773, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI25453487, Length=350, Percent_Identity=28.5714285714286, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1789383, Length=386, Percent_Identity=46.3730569948187, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790375, Length=388, Percent_Identity=30.6701030927835, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71980708, Length=368, Percent_Identity=29.8913043478261, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17560056, Length=297, Percent_Identity=34.006734006734, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=321, Percent_Identity=31.1526479750779, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=330, Percent_Identity=45.1515151515152, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6319307, Length=355, Percent_Identity=30.1408450704225, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323333, Length=392, Percent_Identity=25.765306122449, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=242, Percent_Identity=31.404958677686, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=383, Percent_Identity=25.3263707571802, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922554, Length=356, Percent_Identity=33.4269662921348, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42126; Mature: 42126

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSY
CCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEECHHHHHHCCCCCCC
GRHGTPTTKALQQALIALEGPQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPT
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCH
RLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVEAPGSQSFEMPDIPAIAAVAK
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHH
QHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTISANAAAWPKVSEA
HCCCEEEECCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHH
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLEMARWLAARPEVQRVLHPGLDTDPG
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
HAIWKRDFTGASGLFSIVLQPAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRT
CEEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
ATHWNPGGPALRLHIGLESVDDLIADLEQGLTAFAALQ
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSY
CCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEECHHHHHHCCCCCCC
GRHGTPTTKALQQALIALEGPQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPT
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCH
RLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVEAPGSQSFEMPDIPAIAAVAK
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHH
QHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTISANAAAWPKVSEA
HCCCEEEECCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHH
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLEMARWLAARPEVQRVLHPGLDTDPG
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
HAIWKRDFTGASGLFSIVLQPAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRT
CEEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
ATHWNPGGPALRLHIGLESVDDLIADLEQGLTAFAALQ
CCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]