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The map label for this gene is accC [H]

Identifier: 192291092

GI number: 192291092

Start: 2945342

End: 2946694

Strand: Reverse

Name: accC [H]

Synonym: Rpal_2713

Alternate gene names: 192291092

Gene position: 2946694-2945342 (Counterclockwise)

Preceding gene: 192291093

Following gene: 192291091

Centisome position: 51.3

GC content: 65.78

Gene sequence:

>1353_bases
ATGTTCGATAAAATCCTGATAGCTAATCGCGGCGAGATCGCCCTGCGCGTGCTGCGCGCGTGCAAGGAGCTCGGCATCGC
CACGGTCGCGGTCCACTCCACCGCCGACGCCGACGCGATGCACGTCCGCCTCGCCGACGAGAGCGTGTGCATCGGCCCGC
CGCCGTCCAAGGACAGCTACCTCAACGTGCCGGCGCTGCTCGCCGCCTGCGAGATCACCGGCGCCGATGCGGTGCATCCG
GGCTACGGCTTCCTGTCCGAGAACGCCCGCTTCGCCGAAATCCTCTCCGACCACAATCTTCACTTCATCGGACCGAAGGC
CGAACACATCCGGCTGATGGGCGACAAGATCGAGGCCAAGAAGACCGCCAAGAGGCTCGGCATTCCGGTGGTCCCGGGCT
CCGACGGCGGGGTCGGCCCCGACGACGATGCGATGGCGATCGCCAAGGAAATCGGCTTCCCGGTGCTGGTCAAAGCCGCA
GCGGGCGGCGGCGGCCGCGGCATGAAGGTCGCCCACACCGCCGACGACCTGGCGCTGGCGATCTCCACCGCCGGCAACGA
GGCCAAGGCCGCGTTCGGTGACGCCTCGGTGTATCTTGAAAAGTATTTGCAGAAGCCGCGCCACATCGAAATCCAGGTGC
TCGGTGACGGCCGTGGCGGTGCGATCCATCTCGGCGAGCGCGACTGCTCGCTGCAGCGCCGGCATCAGAAGGTGTGGGAG
GAAAGCCCCTCGCCGGTGATCAGCCCGGAGGCGCGCGCCCGGATCGGCGGCATCTGCGCCAAGGCGATGCAGGACATGCA
GTATCTCGGCGTCGGCACCATTGAATTCCTGTACGAGGACGGCGAGTTCTATTTCATCGAAATGAACACCCGCATCCAGG
TCGAGCATCCGGTCACCGAGATGATCACCGGCATCGATCTGGTGCTGGAGCAGATCCGGATTGCCGCCGGCGGCGACCTG
CCGGTGACGCAGGACGAAATCACCCTCAACGGTCATGCCATCGAGTGCCGGGTCAACGCCGAGAACCCGGTGACCTTCCG
GCCGTCGCCCGGCAAGATCTCGCGCTATCATCCGCCCGGCGGCCTCGGCATCCGGATCGATTCCGCGGTGTATCAGGGCT
ACACGATCCCGCCCTATTACGACTCGCTGGTCGGCAAGCTGATCGTCCACGGCAAGACCCGCGGCGAGTGCCTGATGCGG
CTGCGCCGCGCGCTCGACGAGATGGTGGTGGATGGCATCGAGACCACGCTGCCGCTGTTCCGGGCCCTGGTGCGTGAGCC
GTCGATCATCGACGGCGACTACCACATCCATTGGCTGGAGCAGTATCTGGCTTCAGGCGATCCTGCAGGTTAG

Upstream 100 bases:

>100_bases
GCAAGCAGCGAGCAGAAACAAGCCGCTTAGCTGCCTCTCGTTCCATTCCACCTTCGCTACTCGCCCTTCGCCTCTTTGGC
CTCACAGCGCGGTTAAGCCG

Downstream 100 bases:

>100_bases
CCGCCTAACGCGTTGCAGCGGGTTCGCTTTCGACGCGAGCTCGCTCCTTCGGCCGCGACAACTCCTCCAAAATCTCCCTC
GTCCCTCGGGAACCTTTCCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNVPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGVGPDDDAMAIAKEIGFPVLVKAA
AGGGGRGMKVAHTADDLALAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISPEARARIGGICAKAMQDMQYLGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVTQDEITLNGHAIECRVNAENPVTFRPSPGKISRYHPPGGLGIRIDSAVYQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPSIIDGDYHIHWLEQYLASGDPAG

Sequences:

>Translated_450_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNVPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGVGPDDDAMAIAKEIGFPVLVKAA
AGGGGRGMKVAHTADDLALAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISPEARARIGGICAKAMQDMQYLGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVTQDEITLNGHAIECRVNAENPVTFRPSPGKISRYHPPGGLGIRIDSAVYQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPSIIDGDYHIHWLEQYLASGDPAG
>Mature_450_residues
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSYLNVPALLAACEITGADAVHP
GYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGVGPDDDAMAIAKEIGFPVLVKAA
AGGGGRGMKVAHTADDLALAISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
ESPSPVISPEARARIGGICAKAMQDMQYLGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTEMITGIDLVLEQIRIAAGGDL
PVTQDEITLNGHAIECRVNAENPVTFRPSPGKISRYHPPGGLGIRIDSAVYQGYTIPPYYDSLVGKLIVHGKTRGECLMR
LRRALDEMVVDGIETTLPLFRALVREPSIIDGDYHIHWLEQYLASGDPAG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=449, Percent_Identity=48.1069042316258, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=48.1069042316258, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=449, Percent_Identity=48.1069042316258, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=43.8914027149321, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.4943820224719, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.4943820224719, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.4943820224719, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679974, Length=512, Percent_Identity=29.296875, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679960, Length=512, Percent_Identity=29.296875, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679971, Length=512, Percent_Identity=29.296875, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679977, Length=512, Percent_Identity=29.296875, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679967, Length=512, Percent_Identity=29.296875, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=29.7665369649805, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=61.9369369369369, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=24.6913580246914, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=46.3251670378619, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=454, Percent_Identity=42.9515418502203, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=41.3333333333333, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=28.5996055226824, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.5996055226824, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=27.9022403258656, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.6741573033708, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=42.6666666666667, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=42.0581655480984, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323863, Length=475, Percent_Identity=31.3684210526316, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=30.1343570057582, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=46.0674157303371, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=46.0674157303371, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=46.0674157303371, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=46.0674157303371, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=46.0674157303371, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.0674157303371, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.0674157303371, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.0674157303371, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.0674157303371, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.0674157303371, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=43.8202247191011, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=42.5427872860636, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI161076409, Length=507, Percent_Identity=28.5996055226824, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161076407, Length=507, Percent_Identity=28.5996055226824, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586460, Length=507, Percent_Identity=28.5996055226824, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24586458, Length=507, Percent_Identity=28.5996055226824, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48648; Mature: 48648

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNVPALLAACEITGADAVHPGYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHEEEEECCHHHHH
KTAKRLGIPVVPGSDGGVGPDDDAMAIAKEIGFPVLVKAAAGGGGRGMKVAHTADDLALA
HHHHHCCCEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEE
ISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EECCCCCCHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVISPEARARIGGICAKAMQDMQYLGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPVTQDEITLNGHAIECRVNAENPVTFRPSPGKISRYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCCCCEECCCC
GLGIRIDSAVYQGYTIPPYYDSLVGKLIVHGKTRGECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPSIIDGDYHIHWLEQYLASGDPAG
HHHHCCCCEECCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRVLRACKELGIATVAVHSTADADAMHVRLADESVCIGPPPSKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNVPALLAACEITGADAVHPGYGFLSENARFAEILSDHNLHFIGPKAEHIRLMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHEEEEECCHHHHH
KTAKRLGIPVVPGSDGGVGPDDDAMAIAKEIGFPVLVKAAAGGGGRGMKVAHTADDLALA
HHHHHCCCEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCEEEE
ISTAGNEAKAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EECCCCCCHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVISPEARARIGGICAKAMQDMQYLGVGTIEFLYEDGEFYFIEMNTRIQVEHPVTE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDLVLEQIRIAAGGDLPVTQDEITLNGHAIECRVNAENPVTFRPSPGKISRYHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCCCCEECCCC
GLGIRIDSAVYQGYTIPPYYDSLVGKLIVHGKTRGECLMRLRRALDEMVVDGIETTLPLF
CCEEEEEHHHHCCCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RALVREPSIIDGDYHIHWLEQYLASGDPAG
HHHHCCCCEECCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]