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The map label for this gene is hmuU [H]

Identifier: 192290794

GI number: 192290794

Start: 2598202

End: 2599284

Strand: Reverse

Name: hmuU [H]

Synonym: Rpal_2410

Alternate gene names: 192290794

Gene position: 2599284-2598202 (Counterclockwise)

Preceding gene: 192290795

Following gene: 192290793

Centisome position: 45.25

GC content: 69.53

Gene sequence:

>1083_bases
ATGAGCGTGCTGGCGCTTCCCCGCCGCAGCCGCGCCGGCGCGCCGCGCCCCGGAGCCGCGATCACGCTCACCGTGCTCGG
CGGATTGCTGATCGCCGCGATGGCGCTGGCGATGACGGTGGGCGCCGCCGGCATTCCGCTCTCCCGCCTGCCCGCAGCGC
TCGGACTGACCAGCACCGCGGGCGATGCGGCGACGACGCGCGATCAGCTCGTGCTGTGGTCGATCCGGATGCCGCGGATT
CTCACCGCTGCGATCGTCGGCAGCCTGCTCGCCGCGGCCGGCGCGCTGATGCAGGGCCTGTTCCGCAATCCGCTGGCCGA
CCCGGCGCTGGTCGGCGTCGCGAGCGGCGGCGCCTTTGGTGCGGCCGCTTCGATCGTCCTGCTCGAACATTTGCTCGGCC
CGCATCTGCGTGGCCTGCAGGAGTATCTGCTGGCGTTCGCCGCCTTCGGCGGATCGCTGATCACCACCATTGTGCTGTAC
AGGATCGCGAGCCGATCGGGCCGCACCTCGATCGCGCTGTTCCTGCTCGCCGGTCTCGCAATCGCGGCGATCGCCAACGC
CGGCCTCGGCGTTCTGGTGTTCGTGGCCGACGATCGCCAGCTCCGCGATATTACCTTCTGGATGCTCGGCTCGCTCAGCG
GCGCCAACTGGGCCAAAGCCGCGTCCACCGGTTCTGTCCTGCTGATCGCTCTGCTGGTGCTGCTGCGGATCGCGGGACGC
CTGGATCTTCTGGTCCTCGGCGAAACCGAAGCGTTTCACAGCGGTGTCGACGTCGAGCGGCTGAAGCGCATCTCGATCCT
GCTGGTGTCGGCAATGGCCGGCGTCGCGGTCGCGGTCACCGGCGTGGTCGGCTTCGTCGGTATCGTCGTGCCGCATCTGC
TGCGGCTCGTGATCGGCCCGTCGCATCGGCTGCTGTTGCCGGCCTCCGCCGTCCTCGGTGCGGTGATGCTGGTGGTCGCC
GACACTGTGGCCCGCACCATCGTGGCCCCAGCCGAGATGCCGATCGGCATTCTCACCGCCGCGATCGGTGCACCGTTCTT
CCTCGCCATCCTGCTGCGGCAGCGCAAACTGGTGGGACCATGA

Upstream 100 bases:

>100_bases
CGCCGGCTGCGGCAGTCGAGGTCGCATCGAAACTGTATCCGCAGCTCGCAGCCGAGGCCGCCGGCTTCAAGCCGAAAGCC
ACCACGGTCGATTGCCGCTC

Downstream 100 bases:

>100_bases
GCGGGGGGCTGAAAGCCGAAGCGGCCTCATTCGCCCTACCGGGCGCCACGCTGGTCGATCGCGTCGATCTCACCATCACT
CAGGGTGAGCTGGTGGCGAT

Product: iron ABC transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSVLALPRRSRAGAPRPGAAITLTVLGGLLIAAMALAMTVGAAGIPLSRLPAALGLTSTAGDAATTRDQLVLWSIRMPRI
LTAAIVGSLLAAAGALMQGLFRNPLADPALVGVASGGAFGAAASIVLLEHLLGPHLRGLQEYLLAFAAFGGSLITTIVLY
RIASRSGRTSIALFLLAGLAIAAIANAGLGVLVFVADDRQLRDITFWMLGSLSGANWAKAASTGSVLLIALLVLLRIAGR
LDLLVLGETEAFHSGVDVERLKRISILLVSAMAGVAVAVTGVVGFVGIVVPHLLRLVIGPSHRLLLPASAVLGAVMLVVA
DTVARTIVAPAEMPIGILTAAIGAPFFLAILLRQRKLVGP

Sequences:

>Translated_360_residues
MSVLALPRRSRAGAPRPGAAITLTVLGGLLIAAMALAMTVGAAGIPLSRLPAALGLTSTAGDAATTRDQLVLWSIRMPRI
LTAAIVGSLLAAAGALMQGLFRNPLADPALVGVASGGAFGAAASIVLLEHLLGPHLRGLQEYLLAFAAFGGSLITTIVLY
RIASRSGRTSIALFLLAGLAIAAIANAGLGVLVFVADDRQLRDITFWMLGSLSGANWAKAASTGSVLLIALLVLLRIAGR
LDLLVLGETEAFHSGVDVERLKRISILLVSAMAGVAVAVTGVVGFVGIVVPHLLRLVIGPSHRLLLPASAVLGAVMLVVA
DTVARTIVAPAEMPIGILTAAIGAPFFLAILLRQRKLVGP
>Mature_359_residues
SVLALPRRSRAGAPRPGAAITLTVLGGLLIAAMALAMTVGAAGIPLSRLPAALGLTSTAGDAATTRDQLVLWSIRMPRIL
TAAIVGSLLAAAGALMQGLFRNPLADPALVGVASGGAFGAAASIVLLEHLLGPHLRGLQEYLLAFAAFGGSLITTIVLYR
IASRSGRTSIALFLLAGLAIAAIANAGLGVLVFVADDRQLRDITFWMLGSLSGANWAKAASTGSVLLIALLVLLRIAGRL
DLLVLGETEAFHSGVDVERLKRISILLVSAMAGVAVAVTGVVGFVGIVVPHLLRLVIGPSHRLLLPASAVLGAVMLVVAD
TVARTIVAPAEMPIGILTAAIGAPFFLAILLRQRKLVGP

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=299, Percent_Identity=39.1304347826087, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=36.3013698630137, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790741, Length=295, Percent_Identity=33.8983050847458, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786805, Length=312, Percent_Identity=33.6538461538462, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786347, Length=292, Percent_Identity=31.8493150684932, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786804, Length=316, Percent_Identity=28.1645569620253, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36719; Mature: 36587

Theoretical pI: Translated: 12.04; Mature: 12.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLALPRRSRAGAPRPGAAITLTVLGGLLIAAMALAMTVGAAGIPLSRLPAALGLTSTA
CCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
GDAATTRDQLVLWSIRMPRILTAAIVGSLLAAAGALMQGLFRNPLADPALVGVASGGAFG
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCHH
AAASIVLLEHLLGPHLRGLQEYLLAFAAFGGSLITTIVLYRIASRSGRTSIALFLLAGLA
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAAIANAGLGVLVFVADDRQLRDITFWMLGSLSGANWAKAASTGSVLLIALLVLLRIAGR
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCC
LDLLVLGETEAFHSGVDVERLKRISILLVSAMAGVAVAVTGVVGFVGIVVPHLLRLVIGP
CEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SHRLLLPASAVLGAVMLVVADTVARTIVAPAEMPIGILTAAIGAPFFLAILLRQRKLVGP
CCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVLALPRRSRAGAPRPGAAITLTVLGGLLIAAMALAMTVGAAGIPLSRLPAALGLTSTA
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
GDAATTRDQLVLWSIRMPRILTAAIVGSLLAAAGALMQGLFRNPLADPALVGVASGGAFG
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCHH
AAASIVLLEHLLGPHLRGLQEYLLAFAAFGGSLITTIVLYRIASRSGRTSIALFLLAGLA
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAAIANAGLGVLVFVADDRQLRDITFWMLGSLSGANWAKAASTGSVLLIALLVLLRIAGR
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCC
LDLLVLGETEAFHSGVDVERLKRISILLVSAMAGVAVAVTGVVGFVGIVVPHLLRLVIGP
CEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SHRLLLPASAVLGAVMLVVADTVARTIVAPAEMPIGILTAAIGAPFFLAILLRQRKLVGP
CCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]