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The map label for this gene is cyaB [H]

Identifier: 192290567

GI number: 192290567

Start: 2356144

End: 2358132

Strand: Reverse

Name: cyaB [H]

Synonym: Rpal_2176

Alternate gene names: 192290567

Gene position: 2358132-2356144 (Counterclockwise)

Preceding gene: 192290568

Following gene: 192290560

Centisome position: 41.05

GC content: 63.9

Gene sequence:

>1989_bases
ATGAAATTCACCACACGATTGGTCCTGCTGGTCACGGTGCTGACGGTCGGCGCCACGCTCGTGACCGCGGCGCTGCTGAC
CTGGACCACACGGCGAGCGATCATCACCGAAGCCGAAGCATCGGGTGAGAAAGTCGCGCGGCTGCTGGCGCGCAGTGCCA
GCCTCGCCGCGTCGATCCCGACCGAGGTCGAGGGGATCATTGCCGAAGAGATGATCGCCGAAGGCACCCTGCTCGGTCAT
TTCGTCGAAGCCGCCGAACGCGCCGGGATGACGCCGACCGAGATCAATCGCCGGCTGAAGTCGATCACCGACGATACCGT
GCTGGACGAGATCTGGATCACCGACGAGAAAGGTCACGCCTATCTGCACAGTCTGCCGGACGTGAACTTCACGTTCAGCA
ATTCGCCACAGCTGCAGCCTCAGGCCTACGCCTTCTACGATCTGCTCAACGGCCAGAAGAAGGTGGTCAATCAGGACGCC
CGCAAACGCGACATCGACAATCAGCATTTCAAATATGTCGGCGTCGGCGGCATCGACAAACCGCGGATCATCCAGGTCGG
ACGCAGCGCCAAATTCCTGCAGCAGCTGACGATGAAGATCGGCCTGCCGCGCACGGTCGAGAATCTGCTCGCGGACGGCG
ACATCGACGCGGTGTGGGTGTTCGACCGCAAGCTCGACGCGCTGGTCGGCCCCGGCGTGTATGGCGCCGATCGTCGCGAC
GGTCCCAACGAGAAAGAACTCGGCCCGGTGCGTCTGGTGATCGCTGACGGCCAAACACGGCACGTCGAGAGTCGCCAGAA
CCTCAGCGTGATCGCGCCGGTGCGCAACGACCAGAAGGAGATCGTCGGTGCCGCGCTGGTTCGCCTGCCGATGAACCGCG
TCTGGGCCACGGTGCAGAGCCAGGCCGAGATCGCGGCGGCGACCGCGTCGGCGATCGCCGCGCTCGGCATCCTGCTGTCG
ATCGGGGTCGCCCGCTATCAGGCAGCACCGCTGCGCCAAATCACCCGCGCGGCCGTCGCGCTGGAATCGCAGAAGTTCGA
CCCTGCCTTGCTCAAGCCGGTCTCCGCACGCCGCGACGAGCTCGGCCAACTCGCCCGAGTGTTCACCGGCATGGCCGGAC
AAGTCGCCGCGCGCGAGGAATATCTCGACTCGATGGTGAAGCAGCGCACCGAGGAATTGGAGACCCGCAACCGCAGCCTC
GAAGGCCTGTCGGCGGCGCTGTCGAAATATCTGTCGCCGCAAGTGTACTCGTCGATTTTCAGCGGTCATCAGGACGCCGA
GATCGCCTCCAAACGCAAGAAGCTGACGATCTTCCTGTCCGACATCGCCAACTTCACGGCCACCACCGACAAGCTGGAGT
CGGAAGACCTCACCGCGATGCTCAACCGCTATCTCGCCGAGATGGCGCAGATCGCGCTCAAGCACGGCGCCACCATCGAC
AAATATGTCGGTGACGCCGTGCTCGCCTTCTTCGGCGATCCGGACAGCCGCGGCGTCAAGGAGGACGCGGTCGCCTGCGT
GATGATGGCGATCGAGATGCAGGAGAAGCTGAAGCAACTCGAGATGGAGTGGATCGACGCCGGCGCCGAGCGCCCGTTCC
GGGTCCGCATCGGCATCAACACCGGCTTCTGCACCGTCGGCAATTTCGGCAGCCCGGACCGGATGGACTACACTATCGTC
GGCGGGGCCGTGAACCTCACCTCGCGCCTGGAGCAGAACTGCGAGCCCGGCTCGATCCTGATTTCGCACGTCACCTGGTC
GCTGGTGAACGACGTGATCGACGCCGAAGAGCGTCCGGCGCTCACGGTGAAAGGCTTCAGCGAGCCGGTGCGCGCCTATG
AGGTGCGCGGATTGAAGACGTCAGTATCGACCGACGTGATCCGCAAGGAGCTGCCCGGAATGCGGCTGTTCATCGACACC
GGCACGGCGGATCGGACCGAAGTAAAACAGACGCTGGTGCAGGTGGTCGAAGACCTGGACAAAAGCTGA

Upstream 100 bases:

>100_bases
CCGGTCGCAGCGCGGGGCTCGGCTGCGCGGTGTTCGCACCGCCTCGCGCGGCTCTCTGCCGGCGGCGCCCAAACGGGTGG
CGGCAAGTACAGGTTCTTCC

Downstream 100 bases:

>100_bases
GGCAACCAAGCGCTGCGGGCCAGCGCTACTTGTCCGGCTCGACGGTGATCTCTTTGAGCGCGCCGTTCGACACCACCACG
ACCACGAACACCAGCTTGTC

Product: adenylate/guanylate cyclase with integral membrane sensor

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MKFTTRLVLLVTVLTVGATLVTAALLTWTTRRAIITEAEASGEKVARLLARSASLAASIPTEVEGIIAEEMIAEGTLLGH
FVEAAERAGMTPTEINRRLKSITDDTVLDEIWITDEKGHAYLHSLPDVNFTFSNSPQLQPQAYAFYDLLNGQKKVVNQDA
RKRDIDNQHFKYVGVGGIDKPRIIQVGRSAKFLQQLTMKIGLPRTVENLLADGDIDAVWVFDRKLDALVGPGVYGADRRD
GPNEKELGPVRLVIADGQTRHVESRQNLSVIAPVRNDQKEIVGAALVRLPMNRVWATVQSQAEIAAATASAIAALGILLS
IGVARYQAAPLRQITRAAVALESQKFDPALLKPVSARRDELGQLARVFTGMAGQVAAREEYLDSMVKQRTEELETRNRSL
EGLSAALSKYLSPQVYSSIFSGHQDAEIASKRKKLTIFLSDIANFTATTDKLESEDLTAMLNRYLAEMAQIALKHGATID
KYVGDAVLAFFGDPDSRGVKEDAVACVMMAIEMQEKLKQLEMEWIDAGAERPFRVRIGINTGFCTVGNFGSPDRMDYTIV
GGAVNLTSRLEQNCEPGSILISHVTWSLVNDVIDAEERPALTVKGFSEPVRAYEVRGLKTSVSTDVIRKELPGMRLFIDT
GTADRTEVKQTLVQVVEDLDKS

Sequences:

>Translated_662_residues
MKFTTRLVLLVTVLTVGATLVTAALLTWTTRRAIITEAEASGEKVARLLARSASLAASIPTEVEGIIAEEMIAEGTLLGH
FVEAAERAGMTPTEINRRLKSITDDTVLDEIWITDEKGHAYLHSLPDVNFTFSNSPQLQPQAYAFYDLLNGQKKVVNQDA
RKRDIDNQHFKYVGVGGIDKPRIIQVGRSAKFLQQLTMKIGLPRTVENLLADGDIDAVWVFDRKLDALVGPGVYGADRRD
GPNEKELGPVRLVIADGQTRHVESRQNLSVIAPVRNDQKEIVGAALVRLPMNRVWATVQSQAEIAAATASAIAALGILLS
IGVARYQAAPLRQITRAAVALESQKFDPALLKPVSARRDELGQLARVFTGMAGQVAAREEYLDSMVKQRTEELETRNRSL
EGLSAALSKYLSPQVYSSIFSGHQDAEIASKRKKLTIFLSDIANFTATTDKLESEDLTAMLNRYLAEMAQIALKHGATID
KYVGDAVLAFFGDPDSRGVKEDAVACVMMAIEMQEKLKQLEMEWIDAGAERPFRVRIGINTGFCTVGNFGSPDRMDYTIV
GGAVNLTSRLEQNCEPGSILISHVTWSLVNDVIDAEERPALTVKGFSEPVRAYEVRGLKTSVSTDVIRKELPGMRLFIDT
GTADRTEVKQTLVQVVEDLDKS
>Mature_662_residues
MKFTTRLVLLVTVLTVGATLVTAALLTWTTRRAIITEAEASGEKVARLLARSASLAASIPTEVEGIIAEEMIAEGTLLGH
FVEAAERAGMTPTEINRRLKSITDDTVLDEIWITDEKGHAYLHSLPDVNFTFSNSPQLQPQAYAFYDLLNGQKKVVNQDA
RKRDIDNQHFKYVGVGGIDKPRIIQVGRSAKFLQQLTMKIGLPRTVENLLADGDIDAVWVFDRKLDALVGPGVYGADRRD
GPNEKELGPVRLVIADGQTRHVESRQNLSVIAPVRNDQKEIVGAALVRLPMNRVWATVQSQAEIAAATASAIAALGILLS
IGVARYQAAPLRQITRAAVALESQKFDPALLKPVSARRDELGQLARVFTGMAGQVAAREEYLDSMVKQRTEELETRNRSL
EGLSAALSKYLSPQVYSSIFSGHQDAEIASKRKKLTIFLSDIANFTATTDKLESEDLTAMLNRYLAEMAQIALKHGATID
KYVGDAVLAFFGDPDSRGVKEDAVACVMMAIEMQEKLKQLEMEWIDAGAERPFRVRIGINTGFCTVGNFGSPDRMDYTIV
GGAVNLTSRLEQNCEPGSILISHVTWSLVNDVIDAEERPALTVKGFSEPVRAYEVRGLKTSVSTDVIRKELPGMRLFIDT
GTADRTEVKQTLVQVVEDLDKS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17534659, Length=241, Percent_Identity=28.2157676348548, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17534657, Length=217, Percent_Identity=28.110599078341, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI133931199, Length=266, Percent_Identity=25.9398496240602, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24585694, Length=270, Percent_Identity=27.037037037037, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 72625; Mature: 72625

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTTRLVLLVTVLTVGATLVTAALLTWTTRRAIITEAEASGEKVARLLARSASLAASIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCC
TEVEGIIAEEMIAEGTLLGHFVEAAERAGMTPTEINRRLKSITDDTVLDEIWITDEKGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHEEEECCCCCC
YLHSLPDVNFTFSNSPQLQPQAYAFYDLLNGQKKVVNQDARKRDIDNQHFKYVGVGGIDK
HHHCCCCCCEEECCCCCCCCHHHHHHHHHCCHHHHHCCHHHHCCCCCCCEEEEECCCCCC
PRIIQVGRSAKFLQQLTMKIGLPRTVENLLADGDIDAVWVFDRKLDALVGPGVYGADRRD
CCEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCCCCCCC
GPNEKELGPVRLVIADGQTRHVESRQNLSVIAPVRNDQKEIVGAALVRLPMNRVWATVQS
CCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QAEIAAATASAIAALGILLSIGVARYQAAPLRQITRAAVALESQKFDPALLKPVSARRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
LGQLARVFTGMAGQVAAREEYLDSMVKQRTEELETRNRSLEGLSAALSKYLSPQVYSSIF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
SGHQDAEIASKRKKLTIFLSDIANFTATTDKLESEDLTAMLNRYLAEMAQIALKHGATID
CCCCCHHHHHCCCEEEEEHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KYVGDAVLAFFGDPDSRGVKEDAVACVMMAIEMQEKLKQLEMEWIDAGAERPFRVRIGIN
HHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
TGFCTVGNFGSPDRMDYTIVGGAVNLTSRLEQNCEPGSILISHVTWSLVNDVIDAEERPA
CCEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCE
LTVKGFSEPVRAYEVRGLKTSVSTDVIRKELPGMRLFIDTGTADRTEVKQTLVQVVEDLD
EEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHC
KS
CC
>Mature Secondary Structure
MKFTTRLVLLVTVLTVGATLVTAALLTWTTRRAIITEAEASGEKVARLLARSASLAASIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCC
TEVEGIIAEEMIAEGTLLGHFVEAAERAGMTPTEINRRLKSITDDTVLDEIWITDEKGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHEEEECCCCCC
YLHSLPDVNFTFSNSPQLQPQAYAFYDLLNGQKKVVNQDARKRDIDNQHFKYVGVGGIDK
HHHCCCCCCEEECCCCCCCCHHHHHHHHHCCHHHHHCCHHHHCCCCCCCEEEEECCCCCC
PRIIQVGRSAKFLQQLTMKIGLPRTVENLLADGDIDAVWVFDRKLDALVGPGVYGADRRD
CCEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCHHHHHHCCCCCCCCCCC
GPNEKELGPVRLVIADGQTRHVESRQNLSVIAPVRNDQKEIVGAALVRLPMNRVWATVQS
CCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
QAEIAAATASAIAALGILLSIGVARYQAAPLRQITRAAVALESQKFDPALLKPVSARRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHH
LGQLARVFTGMAGQVAAREEYLDSMVKQRTEELETRNRSLEGLSAALSKYLSPQVYSSIF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
SGHQDAEIASKRKKLTIFLSDIANFTATTDKLESEDLTAMLNRYLAEMAQIALKHGATID
CCCCCHHHHHCCCEEEEEHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KYVGDAVLAFFGDPDSRGVKEDAVACVMMAIEMQEKLKQLEMEWIDAGAERPFRVRIGIN
HHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
TGFCTVGNFGSPDRMDYTIVGGAVNLTSRLEQNCEPGSILISHVTWSLVNDVIDAEERPA
CCEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCE
LTVKGFSEPVRAYEVRGLKTSVSTDVIRKELPGMRLFIDTGTADRTEVKQTLVQVVEDLD
EEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]