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The map label for this gene is 192290544

Identifier: 192290544

GI number: 192290544

Start: 2331430

End: 2332410

Strand: Reverse

Name: 192290544

Synonym: Rpal_2153

Alternate gene names: NA

Gene position: 2332410-2331430 (Counterclockwise)

Preceding gene: 192290545

Following gene: 192290543

Centisome position: 40.61

GC content: 64.93

Gene sequence:

>981_bases
ATGAAAGTCTGTATCTATGGCGCCGGCGCGATCGGCGGTTATCTCGGCGTTCAACTCGCCCAGTCCGGCGCCGCCGACGT
CAGCCTGGTGGCGCGCGGCGCGCATCTGCAGGCGATGAAGGAGAACGGGCTCAAGCTGCTGATCGGCGACGAAGAGCGGG
TGATCAAGCCCAACGCCACCGACAAGCCGGCTGAACTCGGCGTCCAGGACGTCATCATCATCTGCCTGAAGGCGCATTCG
ATCACCGGCGCGATCGATTCGATGAAGCCGTTACTCGGCTCGCACACCCGCATCGTCACCGCGGTGAACGGCGTGCCGTA
TTGGTACTTCCACAAGCACGGCGGCAACGAATTCGAAGGCCGCACGCTCGAGAGCATCGATCCGGGCGGCCGGCAGTGGA
AGGAGCTCGGCCCCGAGCGCGGCATCGGCTGCATCGTCTATCCGGCGACCGAGCTGGAGGCGCCCGGCGTGATCCGCCAC
GTCTATGGCGACAAATTCCCGATCGGCGAGCCGTCGGGCGAGACCACTTCGGACGTCGAGAACCTGTCGAAAGTATTCGA
AGCCTCCGGATTGAAGGCACCGATCCTCGACCGCATCCGTGACGAGATCTGGCTGAAGCTGTGGGGCAACGTCTGCTTCA
ATCCGATCAGCGCGCTCACCCACGCCACGCTCGACGTGATCGCCTCCGATCCGGCGACCCGCGCGCTGTCGAAGGCGATG
ATGCTGGAAGCGCAGCAGATCGCCGAGACCTTCGGCGTCAAGTTCCGCGTCGACGTCGAACGCCGCATCGAAGGCGCCCG
CAAGGTCGGCGCGCACAAGACCTCGATGCTGCAGGACCTCGAACGCGGCCGCCCGATGGAGATCGATCCGCTGGTTACCG
TGGTGCAGGAGATGGGCCGGATGACCAACATCCCCACTCCCGCGATCGACTCGGTCCTCGGCCTCGTCATCCAGCGCGCC
AAGGTGGCGGGGCTGTACTAA

Upstream 100 bases:

>100_bases
TCGACGCGGCGGGAGCGCACGCGTCGCAGGCAAATCTGGTCTCACCGCGGCGTGGCCGAATGGCCACGCCTGTCTTGTCG
TCTGTCTGATGGGAAATCGC

Downstream 100 bases:

>100_bases
TCACCCGCGCTCCCCGCCCCGTCATTCCGGGGCGCTCGCGCCAGCGAGCGAACCCGGAATCCCGAGGTTGTTAGCACGCC
TAGTCCATTGAGATTCCGGG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKVCIYGAGAIGGYLGVQLAQSGAADVSLVARGAHLQAMKENGLKLLIGDEERVIKPNATDKPAELGVQDVIIICLKAHS
ITGAIDSMKPLLGSHTRIVTAVNGVPYWYFHKHGGNEFEGRTLESIDPGGRQWKELGPERGIGCIVYPATELEAPGVIRH
VYGDKFPIGEPSGETTSDVENLSKVFEASGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALSKAM
MLEAQQIAETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTNIPTPAIDSVLGLVIQRA
KVAGLY

Sequences:

>Translated_326_residues
MKVCIYGAGAIGGYLGVQLAQSGAADVSLVARGAHLQAMKENGLKLLIGDEERVIKPNATDKPAELGVQDVIIICLKAHS
ITGAIDSMKPLLGSHTRIVTAVNGVPYWYFHKHGGNEFEGRTLESIDPGGRQWKELGPERGIGCIVYPATELEAPGVIRH
VYGDKFPIGEPSGETTSDVENLSKVFEASGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALSKAM
MLEAQQIAETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTNIPTPAIDSVLGLVIQRA
KVAGLY
>Mature_326_residues
MKVCIYGAGAIGGYLGVQLAQSGAADVSLVARGAHLQAMKENGLKLLIGDEERVIKPNATDKPAELGVQDVIIICLKAHS
ITGAIDSMKPLLGSHTRIVTAVNGVPYWYFHKHGGNEFEGRTLESIDPGGRQWKELGPERGIGCIVYPATELEAPGVIRH
VYGDKFPIGEPSGETTSDVENLSKVFEASGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALSKAM
MLEAQQIAETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGRMTNIPTPAIDSVLGLVIQRA
KVAGLY

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35297; Mature: 35297

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCIYGAGAIGGYLGVQLAQSGAADVSLVARGAHLQAMKENGLKLLIGDEERVIKPNAT
CEEEEEECCHHHHHHHHHHHHCCCCCEEHHHCCHHHHHHHHCCCEEEECCCCCEECCCCC
DKPAELGVQDVIIICLKAHSITGAIDSMKPLLGSHTRIVTAVNGVPYWYFHKHGGNEFEG
CCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCC
RTLESIDPGGRQWKELGPERGIGCIVYPATELEAPGVIRHVYGDKFPIGEPSGETTSDVE
CCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
NLSKVFEASGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALSKAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MLEAQQIAETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGR
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MTNIPTPAIDSVLGLVIQRAKVAGLY
HCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVCIYGAGAIGGYLGVQLAQSGAADVSLVARGAHLQAMKENGLKLLIGDEERVIKPNAT
CEEEEEECCHHHHHHHHHHHHCCCCCEEHHHCCHHHHHHHHCCCEEEECCCCCEECCCCC
DKPAELGVQDVIIICLKAHSITGAIDSMKPLLGSHTRIVTAVNGVPYWYFHKHGGNEFEG
CCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCC
RTLESIDPGGRQWKELGPERGIGCIVYPATELEAPGVIRHVYGDKFPIGEPSGETTSDVE
CCCCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
NLSKVFEASGLKAPILDRIRDEIWLKLWGNVCFNPISALTHATLDVIASDPATRALSKAM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MLEAQQIAETFGVKFRVDVERRIEGARKVGAHKTSMLQDLERGRPMEIDPLVTVVQEMGR
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MTNIPTPAIDSVLGLVIQRAKVAGLY
HCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]