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The map label for this gene is gltR [H]

Identifier: 192290339

GI number: 192290339

Start: 2099535

End: 2100485

Strand: Reverse

Name: gltR [H]

Synonym: Rpal_1946

Alternate gene names: 192290339

Gene position: 2100485-2099535 (Counterclockwise)

Preceding gene: 192290349

Following gene: 192290338

Centisome position: 36.57

GC content: 65.72

Gene sequence:

>951_bases
ATGGTGGACTTCAAAGCGCTCGAAACATTCATCTGGGTCGTGACGCTCGGCAGCTTCCGCGGCGCGGCGCACAAGCTGAA
CACGACGCAGCCGGCGATCTCGCAGCGGATCGCACAACTGGAGCGGGAGCTCGGGGTGCGGCTGCTGCAGCGCGACCACC
GAGTCGCCTCGCCGACGCCGAGCGGTCGGCAGTTGATGCTGTATGCCGAGAAGCTGATCCGGCTGCGGACCGAGATGATG
GCGGCGGTGAGCGATCAGTCGAGCATGCGGGGCGTGCTGCGGCTGGGCGTCGCCGAGACCATCGTCCACACTTGGCTGCC
ACGGCTGATCGAGCAGGTGAACCGGGTCTATCCCAACTTGTCGCTGGAGATCGAAGTCGACATCACCCCGAACCTGCGCG
CGCGGCTGTTGGCGCAGGAGATCGAGCTGGCGTTCCTGCTCGGCCCGATGACGGCGTCCACCGTGCGCAGCCGGGTGCTG
TGCGAGTATCCGATCGGCTTCCTCGCCAGCCCCTCGCTCGGCCTCGGCAACGGTCCGCTGACGGTGGCGGATCTGGCGAA
ATTCCCGATCATCACCTTCCCGCGCAAGACGCAGCCTTATGAGATCGTTCGCTCGCTGTTCAACAAGCCGGAGCTCCCGC
CGATCCGCCTGCATGCCTCCGCATCACTCGGCACGGTGATCCACATGGCGATCGAGGGCCTCGGCATCGCGGTGATCCCG
ACCGCGATCGTCGAGAACGAACTTGCCGAAGGCCGGCTGCAACTTCTGCAGACCGACCTGAAGATCTCACCGCTGCGGTT
CTCCGCAAGCTGGCTCGCCTCCCCCGACACGGTGGCGATCGAGCGCGTCGCCGAACTCGCGGCCGAGATCGCGCACACCG
GCGGCTTCATGCCCGATCCTGCAATGCAGCTCCGCGATATTGCTCACGTCGTTGAACCGGCGATTGGTTGA

Upstream 100 bases:

>100_bases
AGTCTCTCGACAGTACAGGAGCCGAAGCCTAGTATAATGTCTAATCTTTGTTTCTGATCGGAAACAATAAACTTGTCTTA
TCGACTGAAGGAGTCGACCG

Downstream 100 bases:

>100_bases
CGCGCGCCCAGCCGGCTTGACACACTTTCGTTCTGCCTCGCGCGTCCGCGCTGAATTACCGGAGTGACTATGACCAAGAC
TGCCTCGAACCTGCAGATCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MVDFKALETFIWVVTLGSFRGAAHKLNTTQPAISQRIAQLERELGVRLLQRDHRVASPTPSGRQLMLYAEKLIRLRTEMM
AAVSDQSSMRGVLRLGVAETIVHTWLPRLIEQVNRVYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CEYPIGFLASPSLGLGNGPLTVADLAKFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIEGLGIAVIP
TAIVENELAEGRLQLLQTDLKISPLRFSASWLASPDTVAIERVAELAAEIAHTGGFMPDPAMQLRDIAHVVEPAIG

Sequences:

>Translated_316_residues
MVDFKALETFIWVVTLGSFRGAAHKLNTTQPAISQRIAQLERELGVRLLQRDHRVASPTPSGRQLMLYAEKLIRLRTEMM
AAVSDQSSMRGVLRLGVAETIVHTWLPRLIEQVNRVYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CEYPIGFLASPSLGLGNGPLTVADLAKFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIEGLGIAVIP
TAIVENELAEGRLQLLQTDLKISPLRFSASWLASPDTVAIERVAELAAEIAHTGGFMPDPAMQLRDIAHVVEPAIG
>Mature_316_residues
MVDFKALETFIWVVTLGSFRGAAHKLNTTQPAISQRIAQLERELGVRLLQRDHRVASPTPSGRQLMLYAEKLIRLRTEMM
AAVSDQSSMRGVLRLGVAETIVHTWLPRLIEQVNRVYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CEYPIGFLASPSLGLGNGPLTVADLAKFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIEGLGIAVIP
TAIVENELAEGRLQLLQTDLKISPLRFSASWLASPDTVAIERVAELAAEIAHTGGFMPDPAMQLRDIAHVVEPAIG

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=277, Percent_Identity=29.6028880866426, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788626, Length=247, Percent_Identity=26.7206477732794, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788481, Length=255, Percent_Identity=27.4509803921569, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693105, Length=154, Percent_Identity=29.8701298701299, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789639, Length=263, Percent_Identity=27.7566539923954, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787806, Length=252, Percent_Identity=24.6031746031746, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787879, Length=256, Percent_Identity=25, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=249, Percent_Identity=28.1124497991968, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=281, Percent_Identity=27.0462633451957, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081978, Length=256, Percent_Identity=25.390625, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788297, Length=161, Percent_Identity=27.3291925465839, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082132, Length=173, Percent_Identity=26.0115606936416, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI157672245, Length=147, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787589, Length=254, Percent_Identity=25.9842519685039, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34750; Mature: 34750

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDFKALETFIWVVTLGSFRGAAHKLNTTQPAISQRIAQLERELGVRLLQRDHRVASPTP
CCCHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SGRQLMLYAEKLIRLRTEMMAAVSDQSSMRGVLRLGVAETIVHTWLPRLIEQVNRVYPNL
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVLCEYPIGFLASPSLGLGNGPL
EEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
TVADLAKFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIEGLGIAVIP
HHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHH
TAIVENELAEGRLQLLQTDLKISPLRFSASWLASPDTVAIERVAELAAEIAHTGGFMPDP
HHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AMQLRDIAHVVEPAIG
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVDFKALETFIWVVTLGSFRGAAHKLNTTQPAISQRIAQLERELGVRLLQRDHRVASPTP
CCCHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SGRQLMLYAEKLIRLRTEMMAAVSDQSSMRGVLRLGVAETIVHTWLPRLIEQVNRVYPNL
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVLCEYPIGFLASPSLGLGNGPL
EEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
TVADLAKFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIEGLGIAVIP
HHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHH
TAIVENELAEGRLQLLQTDLKISPLRFSASWLASPDTVAIERVAELAAEIAHTGGFMPDP
HHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AMQLRDIAHVVEPAIG
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]