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The map label for this gene is pdxH

Identifier: 192289799

GI number: 192289799

Start: 1462588

End: 1463226

Strand: Reverse

Name: pdxH

Synonym: Rpal_1389

Alternate gene names: 192289799

Gene position: 1463226-1462588 (Counterclockwise)

Preceding gene: 192289806

Following gene: 192289798

Centisome position: 25.47

GC content: 63.85

Gene sequence:

>639_bases
ATGAGCGACCCTACGATCAGACCACAGAGTGAGTTAACGCCCGGTGATTTCACTGCGGCAGAGAATCCGTTTGCGCTGTT
CGCTGAATGGCTTGCGGAAGCCAACAAGTCCGAACCCAACGATCCGAACGCGATGGCGCTGGCGACGGTCGATCCGGACG
GCCTGCCCGACGTGCGCATGGTTCTAATGAAGGGCTATGACGAGCACGGTTTCGTGTTCTACAGCCACATTGCTAGTCAG
AAGGGCCGCGAGCTGGCCGCCAATCCGAAGGCCGCGCTGCTGTTTCATTGGAAATCGCTGCGCCGGCAGATTCGGATTCG
CGGCACCGTGACCCCGGTGACCGACACCGAGGCCGACGCCTATTTCGCGACCCGGCCGAAGCAGGCGCAGATCGGCGCCT
GGGCGAGCAAGCAGTCGCAGCCGCTGGAAAGCCGGTTCGCGTTCGAGCAGGCGATCGCCAAGGTGACGGCGCGCCATCTG
ATCGGCGACGTCCCGCGGCCGCCTGGCTGGAGCGGCTGGCGGATCACGCCGAGCCGGATCGAGTTTTGGCACGACCGTCC
GTTCCGCCTGCACGACCGCATCGAATTTCGCCGGGACACCCCGGATCACCCCTGGACCAAGACAAGGCTGTATCCATGA

Upstream 100 bases:

>100_bases
CCGATAGGCCAATGCGTTGCCGTGTCCTATATAGGTCGAGCCTATATAGGACCCGCAGCGCGTTCCGGACCGCGGTGAAG
CACAAGTCGGATTCCCTCGC

Downstream 100 bases:

>100_bases
GCCCCGACTCCCAAAAGCCGCGCCCGCCCGAGAGCAACGCGCCGCGCCGGACCATGATCCTGACCGGCGCCAGCCGCGGC
ATCGGCCACGCCACGGTGAT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRMVLMKGYDEHGFVFYSHIASQ
KGRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHL
IGDVPRPPGWSGWRITPSRIEFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP

Sequences:

>Translated_212_residues
MSDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRMVLMKGYDEHGFVFYSHIASQ
KGRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHL
IGDVPRPPGWSGWRITPSRIEFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP
>Mature_211_residues
SDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRMVLMKGYDEHGFVFYSHIASQK
GRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHLI
GDVPRPPGWSGWRITPSRIEFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=181, Percent_Identity=40.8839779005525, Blast_Score=151, Evalue=3e-37,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=39.7905759162304, Blast_Score=160, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=197, Percent_Identity=38.0710659898477, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319509, Length=207, Percent_Identity=39.1304347826087, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644901, Length=185, Percent_Identity=41.0810810810811, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551845, Length=185, Percent_Identity=41.0810810810811, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=30.3571428571429, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_RHOPA (Q6NAI9)

Other databases:

- EMBL:   BX572596
- RefSeq:   NP_946547.1
- ProteinModelPortal:   Q6NAI9
- SMR:   Q6NAI9
- GeneID:   2691450
- GenomeReviews:   BX571963_GR
- KEGG:   rpa:RPA1196
- NMPDR:   fig|258594.1.peg.1191
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   PRK05679
- BioCyc:   RPAL258594:RPA1196-MONOMER
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24204; Mature: 24072

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 59-59 BINDING 62-62 BINDING 64-64 BINDING 81-81 BINDING 121-121 BINDING 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRM
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHH
VLMKGYDEHGFVFYSHIASQKGRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADA
HHHHCCCCCCCEEEEHHHHHCCCEECCCCCEEEEHHHHHHHHEEEECEEECCCCCCCCCC
YFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHLIGDVPRPPGWSGWRITPSRI
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHH
EFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP
HHCCCCCCEECCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDPTIRPQSELTPGDFTAAENPFALFAEWLAEANKSEPNDPNAMALATVDPDGLPDVRM
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHH
VLMKGYDEHGFVFYSHIASQKGRELAANPKAALLFHWKSLRRQIRIRGTVTPVTDTEADA
HHHHCCCCCCCEEEEHHHHHCCCEECCCCCEEEEHHHHHHHHEEEECEEECCCCCCCCCC
YFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVTARHLIGDVPRPPGWSGWRITPSRI
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHH
EFWHDRPFRLHDRIEFRRDTPDHPWTKTRLYP
HHCCCCCCEECCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA