Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 192289772

GI number: 192289772

Start: 1433891

End: 1436005

Strand: Reverse

Name: uvrC [H]

Synonym: Rpal_1362

Alternate gene names: 192289772

Gene position: 1436005-1433891 (Counterclockwise)

Preceding gene: 192289774

Following gene: 192289771

Centisome position: 25.0

GC content: 68.09

Gene sequence:

>2115_bases
ATGATTCATGATCCCGCCGAGCCGCCTGCGGCCGCGGCCGAACCACCGCTCGACACGGCCTCCCCTGACGGCGCTGCGCC
CGTCGCGGACACGCGCCCGGCTGCGGGCAACCAGGACATCGACGCGGCGACCGCCTCGCTTGCGGTCGAGGAGGACGACG
AGGCGCGGCTGCCGGAGGTGGAGGACGAGCAGGAAGCTGAGCCGGCGCAGGCCGGTGCCGGGCCGATGGCGGTGGGCCGG
TCGGCGATCGCGCGCGCGGTGCGGCTCGCCCCGACCTCACCTGGCGTCTACCGGATGCTGAACGCCGAGCGCGACGTGCT
CTACGTCGGTAAGGCCAAGAATGTGAAGAAGCGGCTGGCGTCCTACGCCCGCCCCACAGGCCAGGTGCTGCGGATCGCAC
GGATGATCGCGCTCACCGTCGAGGTCGAGGTGATCTCCACCACGACCGAGACTGAGGCGCTGCTGCTCGAAGCCAACCTG
ATCAAGCAGCTCCGGCCGCGCTTCAACGTCCAGCTCCGTGACGACAAGTCGTTTCCCTACATCCTGATCACCGGCGACCA
TTGGGCGCCGCAGATCCTCAAGCATCGCGGCGCGCAGAGCCGCCCCGGACGGTATTTCGGTCCGTTTGCCTCGGCCGGTG
CGGTGAACCGCACCATCACGGCGCTGCAGCGCGCGTTCCTGGTGCGGTCCTGCACCGACTCGTTCTTCGAGAGCCGAACC
CGCCCCTGCCTGCTCTATCAAATCCGGCGGTGCGCCGGCCCGTGCACCGGTGAGGTCGACTTCCCCGGTTACAGTGAGCT
GGTGCGCGAGGCGACCGACTTCCTGTCTGGCCGCAGCCGGGCGGTGAAGGAGCTGCTGGCGGCCGAGATGGAGAAAGCGT
CGGGCGAGCTCGAATTCGAGACCGCGGCGCTGTACCGCGACCGTCTCGCCGCGCTGTCGGCGATCCAGTCCCAGCAGGGC
ATCAATCCACGCACCGTCGAAGAGGCCGATGTGTTCGCCATCCATCAGGACGGCGGCTACTCGTGCGTCGAAGTGTTCTT
CTTCCGCACCGGCCAGAACTGGGGCAACCGCGCCTACTTCCCGCGCGCCGAGAAGTCGTTCACGCCGGCCGAAGTGCTCG
GCGCCTTCGTGGCGCAGTTCTATGACGACAAGCCGCCGCCGAAGCTGATCCTGTTGTCGCACGAGATCGAGGAGGCCGAG
CTGCTCGCCGACGCGCTGTGCGTCAAGGCCGGGCACAAGGTCGAGATCACGGTGCCCAAGCGCGGCGAGAAGAAGGAACT
GGTCGCCCACGCCCAGACCAACGCGCGCGAAGCGCTCGGCCGCAAGCTCGCCGACACCGCCACCCAGGCCCGGCTGCTGG
AAAACCTCGCCACCACGCTCGGCCTGCCGAAGACGCCGCAGCGGATCGAGGTGTACGACAACAGCCACATCCAGGGCACC
AACGCGGTCGGCGCGATGATCGTCGCCGGCCCGGACGGCTTCATCAAGAACCAGTACCGCAAATTCAACATTCGCTCCGA
AGGCCTCACGCCGGGCGACGACTACGCGATGATGCGCGAGGTGCTGCAGCGGCGGTTCAAGCGGCTGGTGACGTCACAGG
CCGAAGGCGACGGCGAGGCCGCCGCGAAGGCCAAGCCGAAGGATGACGATGTTCCGCAGTGGCCCGACCTCGTGATCATC
GACGGCGGCCGCGGCCAGCTCAACGCCGCGCGCGAAGCATTGTCCGGCATCGGCTTGACCGACCAGGTCACCCTGCTCGG
CGTCGCCAAGGGCCCGGACCGCGACGCCGGGCGCGAAACACTGTTCCTGCCGGACCGCGACGCGATCAAGCTCGAGCCGC
GCGACCCTGTGCTGTATTTCATCCAGCGGCTGCGCGACGAGGCGCATCGTTTCGTGATCGGGTCGCATCGCACGCTGCGC
AAGAAGGACATCCGCGAGGCCGGCCTGCAGGAGATCCCCGGCATCGGCCCGACGCGCAAGCGCGCGCTGCTGCTGCATTT
CGGCACGCTGAAGGAAATCGAGCGGGCCTCGATCGCCGATCTCGGCAAAGTTCCAGGCATCAGCGCCGAGAGTGCCAAGC
GAATCTTCGAGTTTTTCCATGCCCGTCCGGACTGA

Upstream 100 bases:

>100_bases
CGGCAACACCATGGCAAGTCAGCGGAATTTCGGGCGGGGTCGGTTCCGCCGCGGCCCCGCGCTGGCAACCGCGGAAGCGA
GCGCATAGGTTGGGGCCGCC

Downstream 100 bases:

>100_bases
CGCACCGGCAGCCCCCGACCAAAGTCGGCGGCGCCGAAGGCGGCCGCGCCCAATGCGGATTTCACCTTTTCCTGATACGG
AACGAGAGCACCCGGGTCGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MIHDPAEPPAAAAEPPLDTASPDGAAPVADTRPAAGNQDIDAATASLAVEEDDEARLPEVEDEQEAEPAQAGAGPMAVGR
SAIARAVRLAPTSPGVYRMLNAERDVLYVGKAKNVKKRLASYARPTGQVLRIARMIALTVEVEVISTTTETEALLLEANL
IKQLRPRFNVQLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLVRSCTDSFFESRT
RPCLLYQIRRCAGPCTGEVDFPGYSELVREATDFLSGRSRAVKELLAAEMEKASGELEFETAALYRDRLAALSAIQSQQG
INPRTVEEADVFAIHQDGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPAEVLGAFVAQFYDDKPPPKLILLSHEIEEAE
LLADALCVKAGHKVEITVPKRGEKKELVAHAQTNAREALGRKLADTATQARLLENLATTLGLPKTPQRIEVYDNSHIQGT
NAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLQRRFKRLVTSQAEGDGEAAAKAKPKDDDVPQWPDLVII
DGGRGQLNAAREALSGIGLTDQVTLLGVAKGPDRDAGRETLFLPDRDAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRTLR
KKDIREAGLQEIPGIGPTRKRALLLHFGTLKEIERASIADLGKVPGISAESAKRIFEFFHARPD

Sequences:

>Translated_704_residues
MIHDPAEPPAAAAEPPLDTASPDGAAPVADTRPAAGNQDIDAATASLAVEEDDEARLPEVEDEQEAEPAQAGAGPMAVGR
SAIARAVRLAPTSPGVYRMLNAERDVLYVGKAKNVKKRLASYARPTGQVLRIARMIALTVEVEVISTTTETEALLLEANL
IKQLRPRFNVQLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLVRSCTDSFFESRT
RPCLLYQIRRCAGPCTGEVDFPGYSELVREATDFLSGRSRAVKELLAAEMEKASGELEFETAALYRDRLAALSAIQSQQG
INPRTVEEADVFAIHQDGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPAEVLGAFVAQFYDDKPPPKLILLSHEIEEAE
LLADALCVKAGHKVEITVPKRGEKKELVAHAQTNAREALGRKLADTATQARLLENLATTLGLPKTPQRIEVYDNSHIQGT
NAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLQRRFKRLVTSQAEGDGEAAAKAKPKDDDVPQWPDLVII
DGGRGQLNAAREALSGIGLTDQVTLLGVAKGPDRDAGRETLFLPDRDAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRTLR
KKDIREAGLQEIPGIGPTRKRALLLHFGTLKEIERASIADLGKVPGISAESAKRIFEFFHARPD
>Mature_704_residues
MIHDPAEPPAAAAEPPLDTASPDGAAPVADTRPAAGNQDIDAATASLAVEEDDEARLPEVEDEQEAEPAQAGAGPMAVGR
SAIARAVRLAPTSPGVYRMLNAERDVLYVGKAKNVKKRLASYARPTGQVLRIARMIALTVEVEVISTTTETEALLLEANL
IKQLRPRFNVQLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLVRSCTDSFFESRT
RPCLLYQIRRCAGPCTGEVDFPGYSELVREATDFLSGRSRAVKELLAAEMEKASGELEFETAALYRDRLAALSAIQSQQG
INPRTVEEADVFAIHQDGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPAEVLGAFVAQFYDDKPPPKLILLSHEIEEAE
LLADALCVKAGHKVEITVPKRGEKKELVAHAQTNAREALGRKLADTATQARLLENLATTLGLPKTPQRIEVYDNSHIQGT
NAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLQRRFKRLVTSQAEGDGEAAAKAKPKDDDVPQWPDLVII
DGGRGQLNAAREALSGIGLTDQVTLLGVAKGPDRDAGRETLFLPDRDAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRTLR
KKDIREAGLQEIPGIGPTRKRALLLHFGTLKEIERASIADLGKVPGISAESAKRIFEFFHARPD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=619, Percent_Identity=40.2261712439418, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 77234; Mature: 77234

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHDPAEPPAAAAEPPLDTASPDGAAPVADTRPAAGNQDIDAATASLAVEEDDEARLPEV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCCCCCCCC
EDEQEAEPAQAGAGPMAVGRSAIARAVRLAPTSPGVYRMLNAERDVLYVGKAKNVKKRLA
CCHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHH
SYARPTGQVLRIARMIALTVEVEVISTTTETEALLLEANLIKQLRPRFNVQLRDDKSFPY
HHCCCHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCE
ILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLVRSCTDSFFESRT
EEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPCLLYQIRRCAGPCTGEVDFPGYSELVREATDFLSGRSRAVKELLAAEMEKASGELEFE
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEHH
TAALYRDRLAALSAIQSQQGINPRTVEEADVFAIHQDGGYSCVEVFFFRTGQNWGNRAYF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHEEEECCCCCCCCCCCC
PRAEKSFTPAEVLGAFVAQFYDDKPPPKLILLSHEIEEAELLADALCVKAGHKVEITVPK
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECC
RGEKKELVAHAQTNAREALGRKLADTATQARLLENLATTLGLPKTPQRIEVYDNSHIQGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLQRRFKRLVTSQAEGDGEA
CCCEEEEEECCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AAKAKPKDDDVPQWPDLVIIDGGRGQLNAAREALSGIGLTDQVTLLGVAKGPDRDAGRET
HCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCE
LFLPDRDAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRTLRKKDIREAGLQEIPGIGPTRK
EECCCCCCEEECCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
RALLLHFGTLKEIERASIADLGKVPGISAESAKRIFEFFHARPD
CEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIHDPAEPPAAAAEPPLDTASPDGAAPVADTRPAAGNQDIDAATASLAVEEDDEARLPEV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCCCCCCCC
EDEQEAEPAQAGAGPMAVGRSAIARAVRLAPTSPGVYRMLNAERDVLYVGKAKNVKKRLA
CCHHHCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCCHHHHHHHH
SYARPTGQVLRIARMIALTVEVEVISTTTETEALLLEANLIKQLRPRFNVQLRDDKSFPY
HHCCCHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCE
ILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLVRSCTDSFFESRT
EEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPCLLYQIRRCAGPCTGEVDFPGYSELVREATDFLSGRSRAVKELLAAEMEKASGELEFE
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEHH
TAALYRDRLAALSAIQSQQGINPRTVEEADVFAIHQDGGYSCVEVFFFRTGQNWGNRAYF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHEEEECCCCCCCCCCCC
PRAEKSFTPAEVLGAFVAQFYDDKPPPKLILLSHEIEEAELLADALCVKAGHKVEITVPK
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECC
RGEKKELVAHAQTNAREALGRKLADTATQARLLENLATTLGLPKTPQRIEVYDNSHIQGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NAVGAMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLQRRFKRLVTSQAEGDGEA
CCCEEEEEECCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AAKAKPKDDDVPQWPDLVIIDGGRGQLNAAREALSGIGLTDQVTLLGVAKGPDRDAGRET
HCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCE
LFLPDRDAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRTLRKKDIREAGLQEIPGIGPTRK
EECCCCCCEEECCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
RALLLHFGTLKEIERASIADLGKVPGISAESAKRIFEFFHARPD
CEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA