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The map label for this gene is dxs

Identifier: 192289449

GI number: 192289449

Start: 1084939

End: 1086864

Strand: Reverse

Name: dxs

Synonym: Rpal_1022

Alternate gene names: 192289449

Gene position: 1086864-1084939 (Counterclockwise)

Preceding gene: 192289450

Following gene: 192289448

Centisome position: 18.92

GC content: 65.73

Gene sequence:

>1926_bases
GTGACCGAATTTAGTAAAACACCGCTTCTCGACACCATTCGCACACCGGAAGATCTGCGCAAGCTGCGGATCGATCAGGT
TCGGCAGGTCGCCGACGAATTGCGATTGGAGACGATCGACGCGGTATCGGTCACCGGCGGGCATTTTGGCGCCGGGCTCG
GCGTGGTCGAACTGACCACCGCACTGCACTATGTGTTCGACACCCCGCGCGACCGGCTGATCTGGGACGTTGGCCACCAG
GCCTACCCGCACAAGATCCTGACCGGCCGGCGCGACCGCATCCGCACCCTGCGCACCGGCGGCGGCCTGTCCGGCTTCAC
CAAGCGCACCGAGAGCGACCATGACCCGTTCGGCGCCGGCCACTCCTCGACCTCGATCTCGGCCGGCCTCGGCATGGCGG
TCGCCAGCGAACTCGCCGGCAAGAAGAACAACGTCATCGCGGTGATCGGCGACGGTTCGATCTCGGCCGGCATGGCCTAC
GAGGCGATGAACAACGCCGGCGCGATGAACTCCCGGCTGATCGTCATCCTCAATGACAACAACATGTCGATCGCCCCGCC
GGTCGGCGCGATGTCCGCCTATCTGTCGCGGCTGTACTCGGGCAAGACCTATCGGTCGCTGCGCGAGGCCGGCAAGCAGA
TTGGGAAGCACCTACCGAAGCTGATCGCCGACCGCGCCGCCCGCGCCGAGGAATATTCCCGCGGCTTCATGATGGGCGGC
GGCACCCTGTTCGAGGAACTCGGTTTCTACTACGTCGGCCCGGTCGACGGCCACAATCTCGACCACCTGCTGCCGATCCT
GCAGAACGTCCGTGATGCCGACACCGGCCCGTTCCTGATCCACGTCGTCACCCAGAAGGGCAAGGGCTACGGCCCGGCCG
AAGCGGCGGCCGACAAGTATCACGCGGTGGTCAAGTTCGATATCGCCACCGGCGCCCAGGCCAAGGCCAAGTCGAACGCG
CCGTCCTATCAGAACGTGTTCGGCCAGAGCCTGGTCAAGGAAGCCCAGAAGGACGACAAGATCGTCGGCATCACCGCGGC
GATGCCGTCGGGCACCGGCATCGACATCTTCGAGAAGGCCTTCCCGAAGCGCACGTTCGACGTCGGCATTGCCGAACAGC
ACGCCGTGACCTTCGCGGCCGGCCTCGCCACCGAAGGCTACAAGCCGTTCTGCGCGATCTACTCGACCTTCCTGCAGCGC
GCCTACGACCAGATCGTGCACGACGTCGCGATCCAGAAGCTGCCGGTGCGCTTTGCGATCGACCGCGCGGGCCTGGTCGG
TGCCGACGGCGCCACCCACGCCGGTTCGTTCGATAATGCCTATCTCGGCTGCCTGCCCAACATGGTGATCATGGCTGCGG
CCGACGAAGCCGAGCTGGTGCACATGGTCGCCACCCAGGTGGCGATCGACGACCGTCCGAGCGCGGTGCGCTATCCGCGC
GGCGAAGGCCGCGGTGTCGAGATGCCGGAAGTCGGCATTCCGCTGGAAATCGGCAAGGGCCGCGTCATCCGCCAGGGTAA
CAAGGTCGCGCTGCTGTCGTTCGGTACCCGGCTCGCGGAGGCCGAGAAGGCCGCCGACGAACTCGCCACTCTCGGCCTCT
CCACCACCGTCGCCGACGCCCGCTTCATGAAGCCGCTCGACGTCGAGCTGGTGCTGAAGCTCGCCCGCGACCACGAAGTG
CTGCTCACCATCGAAGAAGGTTCGATCGGCGGTTTCGGCAGCCACGTGATGCAGACGCTGGCCGAACACGGCATGCTCGA
CGGCGAAGTGAAGATGCGGGCGCTGGTGCTGCCCGACGTATTCATGGATCACGACAACCCGGTGGCGATGTACGCCCGCG
CCGGCCTCGACGCCAAGGCAATCGTCAAGAAGGTGTTCGACGTGCTCGGCAAGGATGCCGCGACCGAGACCTCGAAGCTG
GCCTGA

Upstream 100 bases:

>100_bases
CGTAGGAGTGCGGGAGCCGGGTGAGGCTCGCGCAGACTGGACACTCGGACCATTCGTCGAGGGACTCACCACCCTATAGT
TATAAGACTGGAATATCGCC

Downstream 100 bases:

>100_bases
GGCGCTGACACGCGCGCCCCTGGCAGAGATTTCCCGGGCTGCGCCGGCGTGCTCTGACCCTCCCCTGGAGGGGGAGGGTC
GGCACGCAGCCCGCGCAGCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MTEFSKTPLLDTIRTPEDLRKLRIDQVRQVADELRLETIDAVSVTGGHFGAGLGVVELTTALHYVFDTPRDRLIWDVGHQ
AYPHKILTGRRDRIRTLRTGGGLSGFTKRTESDHDPFGAGHSSTSISAGLGMAVASELAGKKNNVIAVIGDGSISAGMAY
EAMNNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGG
GTLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAAADKYHAVVKFDIATGAQAKAKSNA
PSYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKAFPKRTFDVGIAEQHAVTFAAGLATEGYKPFCAIYSTFLQR
AYDQIVHDVAIQKLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAAADEAELVHMVATQVAIDDRPSAVRYPR
GEGRGVEMPEVGIPLEIGKGRVIRQGNKVALLSFGTRLAEAEKAADELATLGLSTTVADARFMKPLDVELVLKLARDHEV
LLTIEEGSIGGFGSHVMQTLAEHGMLDGEVKMRALVLPDVFMDHDNPVAMYARAGLDAKAIVKKVFDVLGKDAATETSKL
A

Sequences:

>Translated_641_residues
MTEFSKTPLLDTIRTPEDLRKLRIDQVRQVADELRLETIDAVSVTGGHFGAGLGVVELTTALHYVFDTPRDRLIWDVGHQ
AYPHKILTGRRDRIRTLRTGGGLSGFTKRTESDHDPFGAGHSSTSISAGLGMAVASELAGKKNNVIAVIGDGSISAGMAY
EAMNNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGG
GTLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAAADKYHAVVKFDIATGAQAKAKSNA
PSYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKAFPKRTFDVGIAEQHAVTFAAGLATEGYKPFCAIYSTFLQR
AYDQIVHDVAIQKLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAAADEAELVHMVATQVAIDDRPSAVRYPR
GEGRGVEMPEVGIPLEIGKGRVIRQGNKVALLSFGTRLAEAEKAADELATLGLSTTVADARFMKPLDVELVLKLARDHEV
LLTIEEGSIGGFGSHVMQTLAEHGMLDGEVKMRALVLPDVFMDHDNPVAMYARAGLDAKAIVKKVFDVLGKDAATETSKL
A
>Mature_640_residues
TEFSKTPLLDTIRTPEDLRKLRIDQVRQVADELRLETIDAVSVTGGHFGAGLGVVELTTALHYVFDTPRDRLIWDVGHQA
YPHKILTGRRDRIRTLRTGGGLSGFTKRTESDHDPFGAGHSSTSISAGLGMAVASELAGKKNNVIAVIGDGSISAGMAYE
AMNNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGG
TLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAAADKYHAVVKFDIATGAQAKAKSNAP
SYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKAFPKRTFDVGIAEQHAVTFAAGLATEGYKPFCAIYSTFLQRA
YDQIVHDVAIQKLPVRFAIDRAGLVGADGATHAGSFDNAYLGCLPNMVIMAAADEAELVHMVATQVAIDDRPSAVRYPRG
EGRGVEMPEVGIPLEIGKGRVIRQGNKVALLSFGTRLAEAEKAADELATLGLSTTVADARFMKPLDVELVLKLARDHEVL
LTIEEGSIGGFGSHVMQTLAEHGMLDGEVKMRALVLPDVFMDHDNPVAMYARAGLDAKAIVKKVFDVLGKDAATETSKLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=602, Percent_Identity=24.0863787375415, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4507521, Length=602, Percent_Identity=24.0863787375415, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI133778974, Length=601, Percent_Identity=23.2945091514143, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637459, Length=498, Percent_Identity=23.0923694779116, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637461, Length=498, Percent_Identity=23.0923694779116, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI225637463, Length=502, Percent_Identity=23.3067729083665, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=52.7910685805423, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=432, Percent_Identity=25.462962962963, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17538422, Length=299, Percent_Identity=23.7458193979933, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45551847, Length=678, Percent_Identity=23.3038348082596, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45550715, Length=678, Percent_Identity=23.3038348082596, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24645119, Length=318, Percent_Identity=27.3584905660377, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666278, Length=272, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_RHOPA (Q6NB76)

Other databases:

- EMBL:   BX572596
- RefSeq:   NP_946305.1
- ProteinModelPortal:   Q6NB76
- SMR:   Q6NB76
- GeneID:   2690243
- GenomeReviews:   BX571963_GR
- KEGG:   rpa:RPA0952
- NMPDR:   fig|258594.1.peg.949
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- ProtClustDB:   PRK05444
- BioCyc:   RPAL258594:RPA0952-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68805; Mature: 68673

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFSKTPLLDTIRTPEDLRKLRIDQVRQVADELRLETIDAVSVTGGHFGAGLGVVELTT
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHH
ALHYVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTGGGLSGFTKRTESDHDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
HSSTSISAGLGMAVASELAGKKNNVIAVIGDGSISAGMAYEAMNNAGAMNSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCC
NMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGG
CEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GTLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAAADKY
HHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHE
HAVVKFDIATGAQAKAKSNAPSYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKA
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
FPKRTFDVGIAEQHAVTFAAGLATEGYKPFCAIYSTFLQRAYDQIVHDVAIQKLPVRFAI
CCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DRAGLVGADGATHAGSFDNAYLGCLPNMVIMAAADEAELVHMVATQVAIDDRPSAVRYPR
CCCCEECCCCCCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCC
GEGRGVEMPEVGIPLEIGKGRVIRQGNKVALLSFGTRLAEAEKAADELATLGLSTTVADA
CCCCCCCCCCCCCCEEECCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHH
RFMKPLDVELVLKLARDHEVLLTIEEGSIGGFGSHVMQTLAEHGMLDGEVKMRALVLPDV
HHCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHH
FMDHDNPVAMYARAGLDAKAIVKKVFDVLGKDAATETSKLA
HHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure 
TEFSKTPLLDTIRTPEDLRKLRIDQVRQVADELRLETIDAVSVTGGHFGAGLGVVELTT
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHH
ALHYVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTGGGLSGFTKRTESDHDPFGAG
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
HSSTSISAGLGMAVASELAGKKNNVIAVIGDGSISAGMAYEAMNNAGAMNSRLIVILNDN
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCC
NMSIAPPVGAMSAYLSRLYSGKTYRSLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGG
CEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GTLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAAADKY
HHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHE
HAVVKFDIATGAQAKAKSNAPSYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKA
EEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
FPKRTFDVGIAEQHAVTFAAGLATEGYKPFCAIYSTFLQRAYDQIVHDVAIQKLPVRFAI
CCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DRAGLVGADGATHAGSFDNAYLGCLPNMVIMAAADEAELVHMVATQVAIDDRPSAVRYPR
CCCCEECCCCCCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCC
GEGRGVEMPEVGIPLEIGKGRVIRQGNKVALLSFGTRLAEAEKAADELATLGLSTTVADA
CCCCCCCCCCCCCCEEECCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHH
RFMKPLDVELVLKLARDHEVLLTIEEGSIGGFGSHVMQTLAEHGMLDGEVKMRALVLPDV
HHCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHH
FMDHDNPVAMYARAGLDAKAIVKKVFDVLGKDAATETSKLA
HHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA