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The map label for this gene is norM

Identifier: 192289446

GI number: 192289446

Start: 1081923

End: 1083347

Strand: Reverse

Name: norM

Synonym: Rpal_1019

Alternate gene names: 192289446

Gene position: 1083347-1081923 (Counterclockwise)

Preceding gene: 192289447

Following gene: 192289445

Centisome position: 18.86

GC content: 68.98

Gene sequence:

>1425_bases
ATGGTGCGCGCCATGACCGCACCTGGTTCCAACATCGCCGCCGGCGCGCTTGCGCCGGCGAAATCGTCTGCGTGGCGGAC
AGAGCTGATCGAAACGCTGTGGCTCGCGTGGCCGATGGCGCTGACCCAGCTCGGCCAGATCGCGATGATGACCACCGATC
TGGCGCTGATCGGCCGGCTCGGCGATGCCGCCGTGGCCGCGGCGGCGCTGGCGCATTTCGTGCTGTTCTCGACCTTCACG
ATGGGGCTGGGTCTGGTCTCCGCGGTGACGCCGCTGGCCGCACAGGCGTTCGGCGCCCGCGCGCCGCGTCAGGTGCGTGC
TTCACTGCGCGTCGGCCTATGGGCGGGCGTGATCGCCGGCGTGCCGCTCACCCTCGGCCAGCTCTATGGCGAAGAGCTGC
TGGTCGCGCTCGGCCAAAATCCTGCGACCTCGCGGCTTGCCGGTGATTACCTCGACGGGCTGGCATGGTCGCTGGTGCCG
GGCTGGCTGTTCATCGCGCTGCGCGGCTTGATGGGCGCGGTGAACCGGCCCGAGCCGGCGCTGTGGATCATGCTGACCGC
GATCCCGATCAACCTCGGCCTCGCTTACGTGCTGATCCACGGCTCGTTCGGCCTGCCGCGGCTGGAAATCTTCGGCGCCG
GCCTCGCCACCAGCATCGTGTCGTGGGCGATGTGTATCGCCGCCGCCGTGGTGTGCGTGACGATGCGCCCGTTCCGGAAA
TACCAAGTGTTCGGCGAACTGTTCCGGTTCGACGGCGAGCTGATGCGCCGGCTGCTGCAGCTCGGCCTGCCGATCTCTGG
CGCTTCCGTGCTGGAATACGGAGTGTTCGGCGCCGCCGCGCTGCTGATGGGCAAGTTCGGCACCACCGCACTCGCCGCGC
ATCAGATCGCCCTGCAGGTAGCCGCGATCATGTTCATGGTGCCGATGGGGATCTCGGTCGCCGCTACGGTGCGGGTCGGC
CATGCGGTCGGCCGCGGCGATCCGCCGTCCGCGCGACGCGCCGGCTTTGCGGCGATCGGCCTCGGCTTCGTGTTCATGGC
CGCGATGACCCTGCTGGTTGCGCTGACGCGGCATCAGATCCCGCAGCTGTTCCTCGGCGATTCCGACACCTCGATCGAAA
CCGCGACGCTGACCGCGGCACTGCTGATCGTCGGCGCGAGCTTCTTCATTGCCGACGGCCTGCAGGTCGTCGCCAACGGC
GCACTGCGCGGCCGCAACGACACCAAGGTGCCGCTGCTGTTCGCGGTGCTCGGGTTCTGGGTGATCGGTTTTCCGTTCTG
CTGGGTGCTCGGCTTCCACACCGACCTCGGACCGTTCGGTGTCTGGATCGGGCTCGCGGTCGGCCTCGTCGTCTATGCGG
CGCTGCTGGTGTGGCGATTCCACCGGCTGACGCGCGACGCGATGGCCGCGGCCGTCGCCGCCTGA

Upstream 100 bases:

>100_bases
GCAATGTCGAGTTCTTCCTCGGTGCGAAGCGCGGCTGAAGGCGTCCTGGGCGCGACGACTTGGCCGGAACCAAAGTCTTA
CTCCGGCCGCAACTTCGGCT

Downstream 100 bases:

>100_bases
TCACTTCCGGCTTTACGGCCTGCCGGCCGGGGACTATCGCATCGCCATGATCCAAACCCTGACGATCGATCAGCTCGGCC
ACCGCGGCGACGGCGTCAGC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRLGDAAVAAAALAHFVLFSTFT
MGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAGVPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVP
GWLFIALRGLMGAVNRPEPALWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRK
YQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQVAAIMFMVPMGISVAATVRVG
HAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQIPQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANG
ALRGRNDTKVPLLFAVLGFWVIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA

Sequences:

>Translated_474_residues
MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRLGDAAVAAAALAHFVLFSTFT
MGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAGVPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVP
GWLFIALRGLMGAVNRPEPALWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRK
YQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQVAAIMFMVPMGISVAATVRVG
HAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQIPQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANG
ALRGRNDTKVPLLFAVLGFWVIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA
>Mature_474_residues
MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRLGDAAVAAAALAHFVLFSTFT
MGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAGVPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVP
GWLFIALRGLMGAVNRPEPALWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRK
YQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQVAAIMFMVPMGISVAATVRVG
HAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQIPQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANG
ALRGRNDTKVPLLFAVLGFWVIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI22907060, Length=438, Percent_Identity=25.5707762557078, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI153792564, Length=452, Percent_Identity=23.0088495575221, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI38261960, Length=199, Percent_Identity=25.1256281407035, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=32.1266968325792, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=22.4770642201835, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_RHOPA (Q6NB79)

Other databases:

- EMBL:   BX572596
- RefSeq:   NP_946302.1
- GeneID:   2689139
- GenomeReviews:   BX571963_GR
- KEGG:   rpa:RPA0949
- NMPDR:   fig|258594.1.peg.946
- HOGENOM:   HBG479615
- OMA:   TEFLAIA
- ProtClustDB:   CLSK818299
- BioCyc:   RPAL258594:RPA0949-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 49853; Mature: 49853

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c878bb4)-; HASH(0x1cb027a8)-; HASH(0x1ce2b2cc)-; HASH(0x1c6b9ec0)-; HASH(0x1cef933c)-; HASH(0x1a75fbfc)-; HASH(0x1bbeb26c)-; HASH(0x1cd3d324)-; HASH(0x1b53ae90)-; HASH(0x1b5839a4)-; HASH(0x1c42b12c)-; HASH(0x1c7b0fe0)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRL
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAAVAAAALAHFVLFSTFTMGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
VPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVPGWLFIALRGLMGAVNRPEPA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRK
EEEEEEHHHHHHCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQV
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AAIMFMVPMGISVAATVRVGHAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQI
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANGALRGRNDTKVPLLFAVLGFW
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
VIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MVRAMTAPGSNIAAGALAPAKSSAWRTELIETLWLAWPMALTQLGQIAMMTTDLALIGRL
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAAVAAAALAHFVLFSTFTMGLGLVSAVTPLAAQAFGARAPRQVRASLRVGLWAGVIAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
VPLTLGQLYGEELLVALGQNPATSRLAGDYLDGLAWSLVPGWLFIALRGLMGAVNRPEPA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LWIMLTAIPINLGLAYVLIHGSFGLPRLEIFGAGLATSIVSWAMCIAAAVVCVTMRPFRK
EEEEEEHHHHHHCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQVFGELFRFDGELMRRLLQLGLPISGASVLEYGVFGAAALLMGKFGTTALAAHQIALQV
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AAIMFMVPMGISVAATVRVGHAVGRGDPPSARRAGFAAIGLGFVFMAAMTLLVALTRHQI
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQLFLGDSDTSIETATLTAALLIVGASFFIADGLQVVANGALRGRNDTKVPLLFAVLGFW
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
VIGFPFCWVLGFHTDLGPFGVWIGLAVGLVVYAALLVWRFHRLTRDAMAAAVAA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA