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The map label for this gene is cah [H]

Identifier: 192289290

GI number: 192289290

Start: 915262

End: 916020

Strand: Reverse

Name: cah [H]

Synonym: Rpal_0862

Alternate gene names: 192289290

Gene position: 916020-915262 (Counterclockwise)

Preceding gene: 192289291

Following gene: 192289288

Centisome position: 15.95

GC content: 64.3

Gene sequence:

>759_bases
ATGGACCGTCGCAATATCCTGAAGGCCTTTGCTGGCCTCGCTCTATGTCCGCTTTGCGCCACCGCCGGCGCTGCCGCCGA
AGGCGCCCACCATTGGGGCTACGAGGGTGAAGGCGGCCCGGCCAAGTGGGGCGAGATCGATCCCGCCAACCAGATCTGCT
CGATCGGGGTGCAGCAATCGCCGGTCGATATCCGCTCCACCGTCAGCGCCAATCTGTTTCCGCTGCAGGTGCAGTGGGCC
GACACGGCCGATACCATCATCAACAACGGCCACACCATCCAGCTCAACGTGGCCGAAGGCTCGACGCTCAAGCTCGGCGG
CGCGACCTTCAAGCTGGTGCAATTCCATTTCCATCGCCCCAGCGAGCATCAGATCGATGGCAAGTCGTTCCCGATGGAAG
TGCACTTCGTCCACCGCATGGATTCCGGCACGCTCGGCGTGGTCGGCGTGCTGATGCAGGAAGGCGCCGCCAACGCGGCG
TTCGCCAAGATCGTAGCGACCATGCCGCAGAGCGAAGGCCCAGCCGTGAAGGCCGATGCTGGGATCAATCCGAATGCGCT
GCTGCCCGCCAAGCTCGGCTACTACCGCTACGAAGGTTCGCTGACGACGCCGCCGTGCTCGGAGGTCGTCGACTGGATGG
TGCTGACCGATCCGATCACCGTCGCGGCCGAGGACGTTGCGGCGTTCGCCAAGCTGTATCCGATGAACGCGCGCCCGGTG
CAGAAGGACAACCGCCGCTTCGTGCTGCAGTCCAACTAA

Upstream 100 bases:

>100_bases
GGGCCAGTCAGTAACCGTAAAGCGTCGTTCATTCGTCCCACTTCCCTTTGCTCCGGCGTCGGGCAATGCTAGTTCCCGCG
CATCAACCCCGGAGACGTCG

Downstream 100 bases:

>100_bases
GCGGCACCACACGCTGTCAACGACAAAGGCCTGACGCGGGCACCGCGTCAGGCCTTTTCGTTCTCAGAAAAAGACAATCG
GACTGAACGCTCAGCCGCCG

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MDRRNILKAFAGLALCPLCATAGAAAEGAHHWGYEGEGGPAKWGEIDPANQICSIGVQQSPVDIRSTVSANLFPLQVQWA
DTADTIINNGHTIQLNVAEGSTLKLGGATFKLVQFHFHRPSEHQIDGKSFPMEVHFVHRMDSGTLGVVGVLMQEGAANAA
FAKIVATMPQSEGPAVKADAGINPNALLPAKLGYYRYEGSLTTPPCSEVVDWMVLTDPITVAAEDVAAFAKLYPMNARPV
QKDNRRFVLQSN

Sequences:

>Translated_252_residues
MDRRNILKAFAGLALCPLCATAGAAAEGAHHWGYEGEGGPAKWGEIDPANQICSIGVQQSPVDIRSTVSANLFPLQVQWA
DTADTIINNGHTIQLNVAEGSTLKLGGATFKLVQFHFHRPSEHQIDGKSFPMEVHFVHRMDSGTLGVVGVLMQEGAANAA
FAKIVATMPQSEGPAVKADAGINPNALLPAKLGYYRYEGSLTTPPCSEVVDWMVLTDPITVAAEDVAAFAKLYPMNARPV
QKDNRRFVLQSN
>Mature_252_residues
MDRRNILKAFAGLALCPLCATAGAAAEGAHHWGYEGEGGPAKWGEIDPANQICSIGVQQSPVDIRSTVSANLFPLQVQWA
DTADTIINNGHTIQLNVAEGSTLKLGGATFKLVQFHFHRPSEHQIDGKSFPMEVHFVHRMDSGTLGVVGVLMQEGAANAA
FAKIVATMPQSEGPAVKADAGINPNALLPAKLGYYRYEGSLTTPPCSEVVDWMVLTDPITVAAEDVAAFAKLYPMNARPV
QKDNRRFVLQSN

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=231, Percent_Identity=35.4978354978355, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4885101, Length=233, Percent_Identity=36.0515021459227, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI258679498, Length=246, Percent_Identity=32.9268292682927, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI192447434, Length=246, Percent_Identity=32.9268292682927, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI192447432, Length=246, Percent_Identity=32.9268292682927, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI192447430, Length=246, Percent_Identity=32.9268292682927, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4502517, Length=246, Percent_Identity=32.9268292682927, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI169636420, Length=229, Percent_Identity=34.061135371179, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI45935383, Length=292, Percent_Identity=29.7945205479452, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4502515, Length=292, Percent_Identity=29.7945205479452, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4885099, Length=268, Percent_Identity=31.7164179104478, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI6912284, Length=270, Percent_Identity=34.0740740740741, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI38348436, Length=230, Percent_Identity=30.8695652173913, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI62240989, Length=172, Percent_Identity=36.6279069767442, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4502521, Length=235, Percent_Identity=30.6382978723404, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI6005723, Length=205, Percent_Identity=30.7317073170732, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4502519, Length=278, Percent_Identity=30.2158273381295, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI22027500, Length=227, Percent_Identity=30.8370044052863, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI194097398, Length=271, Percent_Identity=27.6752767527675, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI91208428, Length=237, Percent_Identity=29.1139240506329, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI70167127, Length=258, Percent_Identity=28.6821705426357, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI130979954, Length=281, Percent_Identity=23.4875444839858, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI130979679, Length=281, Percent_Identity=23.4875444839858, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI9910366, Length=281, Percent_Identity=23.4875444839858, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17568715, Length=247, Percent_Identity=32.7935222672065, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71995280, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17569163, Length=227, Percent_Identity=28.6343612334802, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17569165, Length=228, Percent_Identity=29.3859649122807, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564019, Length=228, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737413, Length=245, Percent_Identity=33.469387755102, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24645604, Length=277, Percent_Identity=29.2418772563177, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18858185, Length=237, Percent_Identity=26.5822784810127, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221329761, Length=281, Percent_Identity=27.0462633451957, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI116008410, Length=253, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358169, Length=268, Percent_Identity=28.7313432835821, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161079350, Length=266, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650523, Length=278, Percent_Identity=25.8992805755396, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573346, Length=258, Percent_Identity=25.1937984496124, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27008; Mature: 27008

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRNILKAFAGLALCPLCATAGAAAEGAHHWGYEGEGGPAKWGEIDPANQICSIGVQQS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PVDIRSTVSANLFPLQVQWADTADTIINNGHTIQLNVAEGSTLKLGGATFKLVQFHFHRP
CCHHHHHCCCCEEEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEECCC
SEHQIDGKSFPMEVHFVHRMDSGTLGVVGVLMQEGAANAAFAKIVATMPQSEGPAVKADA
CCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECC
GINPNALLPAKLGYYRYEGSLTTPPCSEVVDWMVLTDPITVAAEDVAAFAKLYPMNARPV
CCCCCEEECCCCCEEEECCCCCCCCHHHHHHEEEECCCCEEHHHHHHHHHHHCCCCCCCC
QKDNRRFVLQSN
CCCCCEEEEECC
>Mature Secondary Structure
MDRRNILKAFAGLALCPLCATAGAAAEGAHHWGYEGEGGPAKWGEIDPANQICSIGVQQS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PVDIRSTVSANLFPLQVQWADTADTIINNGHTIQLNVAEGSTLKLGGATFKLVQFHFHRP
CCHHHHHCCCCEEEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEECCC
SEHQIDGKSFPMEVHFVHRMDSGTLGVVGVLMQEGAANAAFAKIVATMPQSEGPAVKADA
CCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECC
GINPNALLPAKLGYYRYEGSLTTPPCSEVVDWMVLTDPITVAAEDVAAFAKLYPMNARPV
CCCCCEEECCCCCEEEECCCCCCCCHHHHHHEEEECCCCEEHHHHHHHHHHHCCCCCCCC
QKDNRRFVLQSN
CCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]