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The map label for this gene is adhA [H]

Identifier: 192288809

GI number: 192288809

Start: 402305

End: 403288

Strand: Reverse

Name: adhA [H]

Synonym: Rpal_0378

Alternate gene names: 192288809

Gene position: 403288-402305 (Counterclockwise)

Preceding gene: 192288810

Following gene: 192288808

Centisome position: 7.02

GC content: 67.89

Gene sequence:

>984_bases
ATGGATGCGATGGTGCTGACAGCACCGGGCACGTCGCTGCAATGGCAATCGCGCGACACGCCGCAGCCGGGTGACGGCGA
GGTGCTGGTCACGGTGAGCGCTTGCGGCGTCTGCCGCACTGACCTTCACGTCGTCGATGGCGAATTGCCGAACATCCGTT
ATCCGATCATTCCCGGCCATGAGATCGTCGGCCGCGTCGCGGCGGTCGGCGCTGGCGTCACCACACATCAGATCGGTGAC
CGCGTCGGCATTCCCTGGCTCGGCCACACTTGTGGGCTGTGCCGGTACTGCCGAAGCGGCATGGAGAATCTGTGCGATGC
GCCGCTGTTCACCGGCTACACCCGCGACGGCGGATTTGCGTCTCACGCCATCGCCGACGCGCGCTACGCGTTTCCGCTCG
GCGAGGCCGGCGATGACGTTGCGATTGCGCCGCTGCTGTGCGCCGGACTGATCGGCTGGCGTTCGCTGGCGATCGCCGGA
GACGCAGAGCGGCTCGGAATCTACGGCTTCGGCGCCGCCGGCCATATCGTGGCGCAGGTCGCGCGCTGGCAAGGACGGCA
GGTGTACGCCTTCACCCGCGGCGGCGATGTCGCGGCTCAGGACTTCGCCCGCAGCCTCGGCGCAATGTGGGCCGGCGCCT
CGGAAGAATTGCCGCCCGAGCCGCTCGACGCCGCGATCATCTACGCGCCGGTCGGCAGCCTGGTGCCGGCCGCGCTGAAG
GCGGTGCGCAAAGGCGGCCGCGTGGTGTGCGCCGGCATCCATATGAGCGACATCCCGAGCTTTCCGTATGACCTGCTGTG
GGAGGAACGCCAGCTCGTTTCGGTCGCCAACCTCACCCGGCAGGACGGTGTCGATTTTCTTGAGGTGGCGCAGCAGGCCG
GCATCCGGACCGAGACCCACGCCTTCCCGCTACGTGAGGCCAACACGGTATTGAACAAACTCCGCGCCGGCGAACTGCTC
GGTGCGGCGGTGCTGGTGCCATAG

Upstream 100 bases:

>100_bases
AACTGGGTGGCGCGCGAACGGAGCTGATCGGGTCGGCTTTGATCGATAACGCCACGCGCGCTATATCCATCGTATCCGAT
CTCCGACCCAGGAGCCCGCG

Downstream 100 bases:

>100_bases
CGACGCCTCGCATCGTCATTGCGGGGCCGAAGGCGAAACAATCCAACAGCCGCGCCCGCCGAACTGGATTGCTTCGGCGG
CTTCGCCTCCTCGCAATGAC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MDAMVLTAPGTSLQWQSRDTPQPGDGEVLVTVSACGVCRTDLHVVDGELPNIRYPIIPGHEIVGRVAAVGAGVTTHQIGD
RVGIPWLGHTCGLCRYCRSGMENLCDAPLFTGYTRDGGFASHAIADARYAFPLGEAGDDVAIAPLLCAGLIGWRSLAIAG
DAERLGIYGFGAAGHIVAQVARWQGRQVYAFTRGGDVAAQDFARSLGAMWAGASEELPPEPLDAAIIYAPVGSLVPAALK
AVRKGGRVVCAGIHMSDIPSFPYDLLWEERQLVSVANLTRQDGVDFLEVAQQAGIRTETHAFPLREANTVLNKLRAGELL
GAAVLVP

Sequences:

>Translated_327_residues
MDAMVLTAPGTSLQWQSRDTPQPGDGEVLVTVSACGVCRTDLHVVDGELPNIRYPIIPGHEIVGRVAAVGAGVTTHQIGD
RVGIPWLGHTCGLCRYCRSGMENLCDAPLFTGYTRDGGFASHAIADARYAFPLGEAGDDVAIAPLLCAGLIGWRSLAIAG
DAERLGIYGFGAAGHIVAQVARWQGRQVYAFTRGGDVAAQDFARSLGAMWAGASEELPPEPLDAAIIYAPVGSLVPAALK
AVRKGGRVVCAGIHMSDIPSFPYDLLWEERQLVSVANLTRQDGVDFLEVAQQAGIRTETHAFPLREANTVLNKLRAGELL
GAAVLVP
>Mature_327_residues
MDAMVLTAPGTSLQWQSRDTPQPGDGEVLVTVSACGVCRTDLHVVDGELPNIRYPIIPGHEIVGRVAAVGAGVTTHQIGD
RVGIPWLGHTCGLCRYCRSGMENLCDAPLFTGYTRDGGFASHAIADARYAFPLGEAGDDVAIAPLLCAGLIGWRSLAIAG
DAERLGIYGFGAAGHIVAQVARWQGRQVYAFTRGGDVAAQDFARSLGAMWAGASEELPPEPLDAAIIYAPVGSLVPAALK
AVRKGGRVVCAGIHMSDIPSFPYDLLWEERQLVSVANLTRQDGVDFLEVAQQAGIRTETHAFPLREANTVLNKLRAGELL
GAAVLVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI262073058, Length=221, Percent_Identity=26.2443438914027, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI71743840, Length=221, Percent_Identity=26.2443438914027, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501933, Length=83, Percent_Identity=45.7831325301205, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI71565152, Length=96, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=83, Percent_Identity=45.7831325301205, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=32.1875, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786518, Length=199, Percent_Identity=36.6834170854271, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082401, Length=303, Percent_Identity=28.3828382838284, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=30.8035714285714, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=327, Percent_Identity=25.6880733944954, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790045, Length=252, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=26.158038147139, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788073, Length=274, Percent_Identity=28.8321167883212, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788407, Length=197, Percent_Identity=31.4720812182741, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786825, Length=94, Percent_Identity=34.0425531914894, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=25.9587020648968, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=322, Percent_Identity=25.1552795031056, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=25.5072463768116, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=260, Percent_Identity=26.5384615384615, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=127, Percent_Identity=29.9212598425197, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=345, Percent_Identity=29.5652173913043, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=200, Percent_Identity=34.5, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.0597014925373, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323961, Length=348, Percent_Identity=27.0114942528736, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=186, Percent_Identity=37.6344086021505, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323980, Length=154, Percent_Identity=30.5194805194805, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=176, Percent_Identity=31.8181818181818, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737897, Length=204, Percent_Identity=30.3921568627451, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137530, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=89, Percent_Identity=39.3258426966292, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34533; Mature: 34533

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAMVLTAPGTSLQWQSRDTPQPGDGEVLVTVSACGVCRTDLHVVDGELPNIRYPIIPGH
CCCEEEECCCCCEEECCCCCCCCCCCCEEEEEECCCCHHCCCEEECCCCCCCCCCCCCCH
EIVGRVAAVGAGVTTHQIGDRVGIPWLGHTCGLCRYCRSGMENLCDAPLFTGYTRDGGFA
HHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SHAIADARYAFPLGEAGDDVAIAPLLCAGLIGWRSLAIAGDAERLGIYGFGAAGHIVAQV
HHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECHHHHHHHHH
ARWQGRQVYAFTRGGDVAAQDFARSLGAMWAGASEELPPEPLDAAIIYAPVGSLVPAALK
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHH
AVRKGGRVVCAGIHMSDIPSFPYDLLWEERQLVSVANLTRQDGVDFLEVAQQAGIRTETH
HHHCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AFPLREANTVLNKLRAGELLGAAVLVP
CCCCHHHHHHHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MDAMVLTAPGTSLQWQSRDTPQPGDGEVLVTVSACGVCRTDLHVVDGELPNIRYPIIPGH
CCCEEEECCCCCEEECCCCCCCCCCCCEEEEEECCCCHHCCCEEECCCCCCCCCCCCCCH
EIVGRVAAVGAGVTTHQIGDRVGIPWLGHTCGLCRYCRSGMENLCDAPLFTGYTRDGGFA
HHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SHAIADARYAFPLGEAGDDVAIAPLLCAGLIGWRSLAIAGDAERLGIYGFGAAGHIVAQV
HHHHHHCHHCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECHHHHHHHHH
ARWQGRQVYAFTRGGDVAAQDFARSLGAMWAGASEELPPEPLDAAIIYAPVGSLVPAALK
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHH
AVRKGGRVVCAGIHMSDIPSFPYDLLWEERQLVSVANLTRQDGVDFLEVAQQAGIRTETH
HHHCCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AFPLREANTVLNKLRAGELLGAAVLVP
CCCCHHHHHHHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]