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The map label for this gene is trxC [H]

Identifier: 192288808

GI number: 192288808

Start: 401728

End: 402165

Strand: Reverse

Name: trxC [H]

Synonym: Rpal_0377

Alternate gene names: 192288808

Gene position: 402165-401728 (Counterclockwise)

Preceding gene: 192288809

Following gene: 192288806

Centisome position: 7.0

GC content: 67.81

Gene sequence:

>438_bases
ATGTCCGACCATCTCGTGGTGTGCACGCATTGCGGCGGGGTCAATCGGCTGCCGGAGCAGCGGCCGGCGCTGGACGGCAA
ATGCGGCAAGTGCGGTCATAGACTGTTCGAAGGCCATCCGGCCGACGTCAGCGGCGATCAGTTCGACAAGCAGGTGTCGC
GCAGCAGCGTGCCGGTGCTGGTCGATGTCTGGGCGCCATGGTGTGGGCCATGCCGGGCAATGGCGCCGGCCTACGAGCAG
GCAGCGCGTGAGCTGGAGCCGAATGTCCGCCTGATCAAGCTCAACTCCGACAACGAACAGCAGGTCGCCGGCCGGCTCGG
CATCCAGGGCATCCCGACCATGATCCTGTTCGACAACGGGCGCGAGCGCGCCCGGACCTCGGGCGCGATGCCGGCGGGAG
AGATCGTGCGCTGGGTGAGACAGCACCTGCCGGCGTGA

Upstream 100 bases:

>100_bases
AATCCAACAGCCGCGCCCGCCGAACTGGATTGCTTCGGCGGCTTCGCCTCCTCGCAATGACGAAGGGAACGCCTAGATAA
TCGATCGAGGAGATCCGACC

Downstream 100 bases:

>100_bases
TCACGCCGCCGGCAGCGGCAACGGCCCGCTGAGCTTGTAGCTGCGCATCGCGAACGAGGTGCGGATGTCGCGCACTGTTG
GCAGCGCCAGCAGGCCCCGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSDHLVVCTHCGGVNRLPEQRPALDGKCGKCGHRLFEGHPADVSGDQFDKQVSRSSVPVLVDVWAPWCGPCRAMAPAYEQ
AARELEPNVRLIKLNSDNEQQVAGRLGIQGIPTMILFDNGRERARTSGAMPAGEIVRWVRQHLPA

Sequences:

>Translated_145_residues
MSDHLVVCTHCGGVNRLPEQRPALDGKCGKCGHRLFEGHPADVSGDQFDKQVSRSSVPVLVDVWAPWCGPCRAMAPAYEQ
AARELEPNVRLIKLNSDNEQQVAGRLGIQGIPTMILFDNGRERARTSGAMPAGEIVRWVRQHLPA
>Mature_144_residues
SDHLVVCTHCGGVNRLPEQRPALDGKCGKCGHRLFEGHPADVSGDQFDKQVSRSSVPVLVDVWAPWCGPCRAMAPAYEQA
ARELEPNVRLIKLNSDNEQQVAGRLGIQGIPTMILFDNGRERARTSGAMPAGEIVRWVRQHLPA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=82, Percent_Identity=37.8048780487805, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20070125, Length=88, Percent_Identity=35.2272727272727, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=41.304347826087, Blast_Score=137, Evalue=3e-34,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=37.6237623762376, Blast_Score=87, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=102, Percent_Identity=35.2941176470588, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=96, Percent_Identity=36.4583333333333, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=107, Percent_Identity=35.5140186915888, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=102, Percent_Identity=30.3921568627451, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=102, Percent_Identity=30.3921568627451, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=102, Percent_Identity=30.3921568627451, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=86, Percent_Identity=34.8837209302326, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=35.5555555555556, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921434, Length=101, Percent_Identity=36.6336633663366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=99, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=30.9278350515464, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15906; Mature: 15775

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHLVVCTHCGGVNRLPEQRPALDGKCGKCGHRLFEGHPADVSGDQFDKQVSRSSVPVL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEE
VDVWAPWCGPCRAMAPAYEQAARELEPNVRLIKLNSDNEQQVAGRLGIQGIPTMILFDNG
EEECCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCC
RERARTSGAMPAGEIVRWVRQHLPA
HHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDHLVVCTHCGGVNRLPEQRPALDGKCGKCGHRLFEGHPADVSGDQFDKQVSRSSVPVL
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEE
VDVWAPWCGPCRAMAPAYEQAARELEPNVRLIKLNSDNEQQVAGRLGIQGIPTMILFDNG
EEECCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCC
RERARTSGAMPAGEIVRWVRQHLPA
HHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]