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The map label for this gene is ubiE [H]

Identifier: 192288519

GI number: 192288519

Start: 95702

End: 96463

Strand: Reverse

Name: ubiE [H]

Synonym: Rpal_0086

Alternate gene names: 192288519

Gene position: 96463-95702 (Counterclockwise)

Preceding gene: 192288521

Following gene: 192288518

Centisome position: 1.68

GC content: 62.34

Gene sequence:

>762_bases
ATGACTGAGCCGGGCGAGACCACGCATTTCGGCTATCGCGACGTTCCGCTGGACGAGAAGCAGACGCTGGTCAACGACGT
GTTTCACAGCGTCGCCGGCCGCTACGACCTGATGAACGATCTGATGTCGGGCGGCATGCACCGGTTGTGGAAGGACGTGA
TGATCACGACCCTCAACCCGCCGCGTGACGACACGCCGTTCCGGCTGCTCGACGTTGCCGGCGGCACCGGCGACATCTCG
TTCCGTGCCGCCAAAGCCTCGGGCGCCGGCTTTCACTCCACCGTCTGCGACATCAACACCGATATGCTCGAAGTCGGCCG
CCAGCGTGCGGTCGAGCGCAATCTCGACGACAAGGTTGATTTCGTCGAGGGCAATGCCGAGAGCCTGCAGTTCGACGATC
GCAGCTTCGACGCCTACACTATCGCGTTCGGCATCCGGAACGTGCCGCGGATCGATCTGGCGCTGAAGGAGGCCTATCGC
GTTTTGAAGCCGGGCAGCCGTTTCCTGTGCCTGGAGTTCTCGTCCGTCGATGTGCCCGGCCTGTCCAAGCTGTACGATCT
GTTCTCATTCAAGGTGATCCCGGAGATCGGCCGCGTCGTCACCGGCGATGCCGACAGCTATCAGTACCTGGTCGAATCGA
TCCGCAAATTCCCTAAGCCGTATGATTTCGCCGAGATGATGCGCGACGCCGGCTTTGCGCGCGCCAACTGGCAGGTGATG
AGCGGCGGCATCGTCGCGCTGCATTCGGGCTGGCGTTTGTGA

Upstream 100 bases:

>100_bases
CTCCGCACCAAGCGCGCTATATGGTCCGCCGCGGACCGCCGTTTTCGTGTTTCGGGCGGCAATCGGCCTGAAAAACCGTC
CGCGCGCAGGAGTTGAAGGC

Downstream 100 bases:

>100_bases
TCGCAGCACTCACTCATGTGGCGCGGCTCGGCCGCGCCGCCTTCGTGTTCGCGCGCGAGGGTGTGTTCGGCGTGGTCGAT
CCGGCGTTGATTCCGCCCGC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTEPGETTHFGYRDVPLDEKQTLVNDVFHSVAGRYDLMNDLMSGGMHRLWKDVMITTLNPPRDDTPFRLLDVAGGTGDIS
FRAAKASGAGFHSTVCDINTDMLEVGRQRAVERNLDDKVDFVEGNAESLQFDDRSFDAYTIAFGIRNVPRIDLALKEAYR
VLKPGSRFLCLEFSSVDVPGLSKLYDLFSFKVIPEIGRVVTGDADSYQYLVESIRKFPKPYDFAEMMRDAGFARANWQVM
SGGIVALHSGWRL

Sequences:

>Translated_253_residues
MTEPGETTHFGYRDVPLDEKQTLVNDVFHSVAGRYDLMNDLMSGGMHRLWKDVMITTLNPPRDDTPFRLLDVAGGTGDIS
FRAAKASGAGFHSTVCDINTDMLEVGRQRAVERNLDDKVDFVEGNAESLQFDDRSFDAYTIAFGIRNVPRIDLALKEAYR
VLKPGSRFLCLEFSSVDVPGLSKLYDLFSFKVIPEIGRVVTGDADSYQYLVESIRKFPKPYDFAEMMRDAGFARANWQVM
SGGIVALHSGWRL
>Mature_252_residues
TEPGETTHFGYRDVPLDEKQTLVNDVFHSVAGRYDLMNDLMSGGMHRLWKDVMITTLNPPRDDTPFRLLDVAGGTGDISF
RAAKASGAGFHSTVCDINTDMLEVGRQRAVERNLDDKVDFVEGNAESLQFDDRSFDAYTIAFGIRNVPRIDLALKEAYRV
LKPGSRFLCLEFSSVDVPGLSKLYDLFSFKVIPEIGRVVTGDADSYQYLVESIRKFPKPYDFAEMMRDAGFARANWQVMS
GGIVALHSGWRL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=279, Percent_Identity=49.1039426523297, Blast_Score=259, Evalue=1e-69,
Organism=Escherichia coli, GI48994983, Length=248, Percent_Identity=47.1774193548387, Blast_Score=230, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17557039, Length=253, Percent_Identity=45.0592885375494, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=258, Percent_Identity=46.1240310077519, Blast_Score=213, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24641702, Length=261, Percent_Identity=47.1264367816092, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28394; Mature: 28263

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPGETTHFGYRDVPLDEKQTLVNDVFHSVAGRYDLMNDLMSGGMHRLWKDVMITTLNP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHEEEECCC
PRDDTPFRLLDVAGGTGDISFRAAKASGAGFHSTVCDINTDMLEVGRQRAVERNLDDKVD
CCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHECCCCHHHHHHHHHHHHHCCCCCCCE
FVEGNAESLQFDDRSFDAYTIAFGIRNVPRIDLALKEAYRVLKPGSRFLCLEFSSVDVPG
EECCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
LSKLYDLFSFKVIPEIGRVVTGDADSYQYLVESIRKFPKPYDFAEMMRDAGFARANWQVM
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEE
SGGIVALHSGWRL
CCCEEEECCCCCC
>Mature Secondary Structure 
TEPGETTHFGYRDVPLDEKQTLVNDVFHSVAGRYDLMNDLMSGGMHRLWKDVMITTLNP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHEEEECCC
PRDDTPFRLLDVAGGTGDISFRAAKASGAGFHSTVCDINTDMLEVGRQRAVERNLDDKVD
CCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHECCCCHHHHHHHHHHHHHCCCCCCCE
FVEGNAESLQFDDRSFDAYTIAFGIRNVPRIDLALKEAYRVLKPGSRFLCLEFSSVDVPG
EECCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
LSKLYDLFSFKVIPEIGRVVTGDADSYQYLVESIRKFPKPYDFAEMMRDAGFARANWQVM
HHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEE
SGGIVALHSGWRL
CCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA