Click here to switch to the map view.

The map label for this gene is hisD2 [H]

Identifier: 190895132

GI number: 190895132

Start: 862076

End: 863479

Strand: Reverse

Name: hisD2 [H]

Synonym: RHECIAT_PC0000802

Alternate gene names: 190895132

Gene position: 863479-862076 (Counterclockwise)

Preceding gene: 190895133

Following gene: 190895131

Centisome position: 79.11

GC content: 59.97

Gene sequence:

>1404_bases
TTGGGGCGCCGCCTGGCGCCCCGCCAACCACAGTCTCTCCAAACCCAGAATGCGGGGCACGGCTTCCGCAAACGAAGAGT
TATTGTCATGATCAGACACATCAAAACGGCCCAAGCCTCGACGGCGGGCGCTTCCGATAGCGCGATAACGAAAGCTGTCG
AGGAGCTCCTTTCTAAGGTGGAAGCCGGCGGCGACAAAGCGGTCCGGGAACTCTCCGTTAAGTTCGACAAATTCGACCGC
GAGTCCTATCGCCTGACAAAAGACGAAATCGCTGCCGCGATTAATTCCCTGACCAAGCAGGAGCGCGAGGACCTGGACTT
TGCCCAGGATCAGGTCCGCCGCTTCGCACAGGCACAAAGAGATGCGCTGCAGGATCTCGAAGTCGAGACGATCCCGGGCG
TGGTTCTGGGCCATCGCAATGTGCCGATCGAAAATGTCGGCTGCTACGTGCCGGGTGGAAAATATCCGCTGCTTGCATCG
GCACATATGACTGTGCTGACAGCGCGTGTGGCGGGCTGCGACCGCGTCATTACCTGTGCTCCCCCGTTCAACGGACAGAT
ATCCAACAAGATCGTCGCCGCACAGGCTCTCGCCGGTGCAGACGAGATCTACTGCATCGGCGGTGTTCAGGCGATCGCGG
CGATGGGCTATGGCACCGAAACGATCGAAGCCGTCGACATGCTTGCCGGTCCGGGCAATGCCTATGTGGCAGAGGCCAAG
CGTCTCTTGTTCGGCAAGGTCGGTATCGACCTGTTTGCCGGCCCGACCGAAACGCTGGTGATTGCTGACGAAAGCGTCGA
CGGTGAAATCGTTGCAACGGACCTGCTCGGCCAAGCCGAACATGGTGCCAACTCTCCGGCAGTGCTCATCACCAATTCCG
AGAAGCTCGCCAAGGATACACTTGCCGAAATCGACCGGCTCCTGCAGATCCTTCCGACGGCCGCCGTCGCAGGAAAGGCC
TGGAACGACTGCGGAGAGATCATCCTCTGCGACACGATCGAGGAAATGGTGTCCGAAGCTGACCGCGTCGCTTCGGAACA
CGTTCAGGTCATGACGAGCGACCCGAACTACTTTCTCGAGAACATGAAAAACTATGGAGCGCTGTTCCTTGGCGCCCGCA
CCAATGTCGCCTTCGGCGACAAGGTCATCGGCACGAACCACACACTGCCGACGAACAAGGCCGCGCGCTACACCGGCGGT
CTGTGGGTGGGGAAATTCCTCAAGACCTGCACCTATCAGCGCATAGAGACCGATGAGGCATCAGCCCTTATCGGTGCCTA
TAGCTCTCGTCTCTGCCTGATGGAAGGCTTCGCGGGTCACGCCGAGCAAGCCAACATTCGTGTCCGCCGCTTCGGTGGCC
GCAACATTCCTTACGCGGGGGCCGCCGGCCCGCGCGACGCATAA

Upstream 100 bases:

>100_bases
GCTGGTGGGACTTCCCGTCGCCGGCCTATTACGAGAAGGAACAGGCTGCCTACGCAAAGATGCGCGAACTCGAGCAGCAT
CTATAGAGCCAACTTCAGGC

Downstream 100 bases:

>100_bases
GCAACCGGCGGCTTCGACACCCTCTTGTCGAGACTGCCCGCAATCCACCAACCGCTGAGGCAAAAAAGGGGAACTACAAT
GAAACTGAAAATGCTTCTTA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MGRRLAPRQPQSLQTQNAGHGFRKRRVIVMIRHIKTAQASTAGASDSAITKAVEELLSKVEAGGDKAVRELSVKFDKFDR
ESYRLTKDEIAAAINSLTKQEREDLDFAQDQVRRFAQAQRDALQDLEVETIPGVVLGHRNVPIENVGCYVPGGKYPLLAS
AHMTVLTARVAGCDRVITCAPPFNGQISNKIVAAQALAGADEIYCIGGVQAIAAMGYGTETIEAVDMLAGPGNAYVAEAK
RLLFGKVGIDLFAGPTETLVIADESVDGEIVATDLLGQAEHGANSPAVLITNSEKLAKDTLAEIDRLLQILPTAAVAGKA
WNDCGEIILCDTIEEMVSEADRVASEHVQVMTSDPNYFLENMKNYGALFLGARTNVAFGDKVIGTNHTLPTNKAARYTGG
LWVGKFLKTCTYQRIETDEASALIGAYSSRLCLMEGFAGHAEQANIRVRRFGGRNIPYAGAAGPRDA

Sequences:

>Translated_467_residues
MGRRLAPRQPQSLQTQNAGHGFRKRRVIVMIRHIKTAQASTAGASDSAITKAVEELLSKVEAGGDKAVRELSVKFDKFDR
ESYRLTKDEIAAAINSLTKQEREDLDFAQDQVRRFAQAQRDALQDLEVETIPGVVLGHRNVPIENVGCYVPGGKYPLLAS
AHMTVLTARVAGCDRVITCAPPFNGQISNKIVAAQALAGADEIYCIGGVQAIAAMGYGTETIEAVDMLAGPGNAYVAEAK
RLLFGKVGIDLFAGPTETLVIADESVDGEIVATDLLGQAEHGANSPAVLITNSEKLAKDTLAEIDRLLQILPTAAVAGKA
WNDCGEIILCDTIEEMVSEADRVASEHVQVMTSDPNYFLENMKNYGALFLGARTNVAFGDKVIGTNHTLPTNKAARYTGG
LWVGKFLKTCTYQRIETDEASALIGAYSSRLCLMEGFAGHAEQANIRVRRFGGRNIPYAGAAGPRDA
>Mature_466_residues
GRRLAPRQPQSLQTQNAGHGFRKRRVIVMIRHIKTAQASTAGASDSAITKAVEELLSKVEAGGDKAVRELSVKFDKFDRE
SYRLTKDEIAAAINSLTKQEREDLDFAQDQVRRFAQAQRDALQDLEVETIPGVVLGHRNVPIENVGCYVPGGKYPLLASA
HMTVLTARVAGCDRVITCAPPFNGQISNKIVAAQALAGADEIYCIGGVQAIAAMGYGTETIEAVDMLAGPGNAYVAEAKR
LLFGKVGIDLFAGPTETLVIADESVDGEIVATDLLGQAEHGANSPAVLITNSEKLAKDTLAEIDRLLQILPTAAVAGKAW
NDCGEIILCDTIEEMVSEADRVASEHVQVMTSDPNYFLENMKNYGALFLGARTNVAFGDKVIGTNHTLPTNKAARYTGGL
WVGKFLKTCTYQRIETDEASALIGAYSSRLCLMEGFAGHAEQANIRVRRFGGRNIPYAGAAGPRDA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=35.4523227383863, Blast_Score=246, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=36.4734299516908, Blast_Score=223, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 50154; Mature: 50022

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRLAPRQPQSLQTQNAGHGFRKRRVIVMIRHIKTAQASTAGASDSAITKAVEELLSKV
CCCCCCCCCCCCCCCCCCCCCHHHCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EAGGDKAVRELSVKFDKFDRESYRLTKDEIAAAINSLTKQEREDLDFAQDQVRRFAQAQR
HCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALQDLEVETIPGVVLGHRNVPIENVGCYVPGGKYPLLASAHMTVLTARVAGCDRVITCA
HHHHHCCHHHCCCEEECCCCCCCCCCCEECCCCCCCEEEHHHHHHHHHHHCCCCEEEEEC
PPFNGQISNKIVAAQALAGADEIYCIGGVQAIAAMGYGTETIEAVDMLAGPGNAYVAEAK
CCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
RLLFGKVGIDLFAGPTETLVIADESVDGEIVATDLLGQAEHGANSPAVLITNSEKLAKDT
HHHHHHCCCEEECCCCCEEEEECCCCCCCEEEHHHHCCCCCCCCCCEEEEECCHHHHHHH
LAEIDRLLQILPTAAVAGKAWNDCGEIILCDTIEEMVSEADRVASEHVQVMTSDPNYFLE
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCEEEEECCCHHHHH
NMKNYGALFLGARTNVAFGDKVIGTNHTLPTNKAARYTGGLWVGKFLKTCTYQRIETDEA
HHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHH
SALIGAYSSRLCLMEGFAGHAEQANIRVRRFGGRNIPYAGAAGPRDA
HHHHHHHHCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRRLAPRQPQSLQTQNAGHGFRKRRVIVMIRHIKTAQASTAGASDSAITKAVEELLSKV
CCCCCCCCCCCCCCCCCCCCHHHCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EAGGDKAVRELSVKFDKFDRESYRLTKDEIAAAINSLTKQEREDLDFAQDQVRRFAQAQR
HCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALQDLEVETIPGVVLGHRNVPIENVGCYVPGGKYPLLASAHMTVLTARVAGCDRVITCA
HHHHHCCHHHCCCEEECCCCCCCCCCCEECCCCCCCEEEHHHHHHHHHHHCCCCEEEEEC
PPFNGQISNKIVAAQALAGADEIYCIGGVQAIAAMGYGTETIEAVDMLAGPGNAYVAEAK
CCCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
RLLFGKVGIDLFAGPTETLVIADESVDGEIVATDLLGQAEHGANSPAVLITNSEKLAKDT
HHHHHHCCCEEECCCCCEEEEECCCCCCCEEEHHHHCCCCCCCCCCEEEEECCHHHHHHH
LAEIDRLLQILPTAAVAGKAWNDCGEIILCDTIEEMVSEADRVASEHVQVMTSDPNYFLE
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCEEEEECCCHHHHH
NMKNYGALFLGARTNVAFGDKVIGTNHTLPTNKAARYTGGLWVGKFLKTCTYQRIETDEA
HHHCCCEEEEECCCCCCCCCEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCHH
SALIGAYSSRLCLMEGFAGHAEQANIRVRRFGGRNIPYAGAAGPRDA
HHHHHHHHCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]