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The map label for this gene is lktD [H]

Identifier: 190894589

GI number: 190894589

Start: 255759

End: 257159

Strand: Reverse

Name: lktD [H]

Synonym: RHECIAT_PC0000252

Alternate gene names: 190894589

Gene position: 257159-255759 (Counterclockwise)

Preceding gene: 190894590

Following gene: 190894588

Centisome position: 23.56

GC content: 63.31

Gene sequence:

>1401_bases
TTGGACAGTGGCGGCTCGAACGAGAGCCACTCAGGCAAGGGGAGGGAGCTCATCGCCCGCCCGCCACTGCCGCCGGTCAT
TGCTGAATTCCAGTCCGATGCCGTCGAGCTGGAGGAACGCGCACCGCCACGGGTCGCACGCATGACTCTCTATTGCGTGA
CGGCGCTGATTGCTTCGGCGATCATCTGGGCTTCGGTCTCGTCGATCGATGAGGTGGTGATTGCGCCCGGCAAGCTCGTC
ACCACTCAGCCGACCATCGTCGTCCAGCCGCTCGAAACCTCGATCATCCGCACGATCGACGTCAAGGCCGGCGAAGTGGT
GCATGCCGGCCAGACGCTGGCGACGCTCGATGCCACCTTCAGCCAGGCTGATGTCGGTCAGTTGAAGACAAAGTTCTCCG
CTCTCGACGCGCAGGTGAAGCGGCTTGAGACCGAGCTGACCGGCGAGGACTATTCGAAGGTCGCCGGCAATACGCCGGAC
GAGCAGTTGCAGGTGCAGCTGTTCGGCCAACGGCGCGCCTTCTACACCGCGCAGCTGAAGAATTTCGAGCAGCAAATCGC
CGGCCAGTCCTCCGTCCTTGCGGCAAACCGCAACCAGGAGGCCGTGCTGAACGACCGGCGCGATAACCTCTCGCTGATCG
AGGCGACACGAAAGAAGCTCTATGACACGGAAAGCGGCTCGCTGCTGACCATGCTCGGCTCGCGCGACGCCCGCCTTGAT
GTCGAGGCCGATATCACTGCGGTGCGCGGCAAGGCCGACGAGGCAGCTCACACCTATGCCAAGCTGCTCGCCGACCGTCA
GGCCTTTATCGAGGATTTCCGCCGCGCCGCGATGGAGCAACTGGCGGACCTGCGCAGCCAGCGCGACATGGCGGGTGAGG
AGCTGAAGAAACTGGAGCTGCGCCGTAACATGGTCGCACTGACGGCGCCGGCCGATGCCGTCGTGCTCGATCTGGCGCAA
CGTTCGGTCGGTTCGGTGGTGCGGGAAGCCGAACCGGTTGTCACGCTGGTGCCGATCAACGTGCCGCTCGAAGCCGAAGT
GTCGATCAATACGCGCGATATCGGCCGGGTGGCCGTCGGCAAGGAAGCGCGCATCAAGCTCGATGCCTATCCCTTCCAGA
AATATGGCACCGCCTCCGGCGAGGTGAGAACCATCAGCCAGGACACTTTTCTGTCCGGTCAACAAGAGCAGGCCGCCACC
CCCGGCCAGCCGGCCGCTGCCCCCTTCTTCAAGGCGCGGATCCTGCTTGCCGATACCCGGTTGAATGCCGCCGATGTGCC
GGTGCGGCTGCTTCCAGGTATGACCGTGTCGACGGAAATCAAGGTCGGCAACCGCACGGTGATCTCCTATTTCCTGTATC
CGTTGCTGCGCGGACTCGATAACGCAATACGTGAACCATAG

Upstream 100 bases:

>100_bases
TATCGCGCTGCATGACCTATCGCCACCTGTGGTCCCAGCAGATGAGGCAGGTTGCATGAGCGCGCACGCGAGAAAACCCG
ACGAGAACCTGCCGGCCCCC

Downstream 100 bases:

>100_bases
GCTGACGGATCGGTTGGCCGACAACCACTTCCGTGTGCGCCTCGAGGCAGATGTCGCGTCTCATCGTCTGTGGTTTAGGC
CGCATAGTCGTGAAATCGGC

Product: putative HlyD family protein secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDSGGSNESHSGKGRELIARPPLPPVIAEFQSDAVELEERAPPRVARMTLYCVTALIASAIIWASVSSIDEVVIAPGKLV
TTQPTIVVQPLETSIIRTIDVKAGEVVHAGQTLATLDATFSQADVGQLKTKFSALDAQVKRLETELTGEDYSKVAGNTPD
EQLQVQLFGQRRAFYTAQLKNFEQQIAGQSSVLAANRNQEAVLNDRRDNLSLIEATRKKLYDTESGSLLTMLGSRDARLD
VEADITAVRGKADEAAHTYAKLLADRQAFIEDFRRAAMEQLADLRSQRDMAGEELKKLELRRNMVALTAPADAVVLDLAQ
RSVGSVVREAEPVVTLVPINVPLEAEVSINTRDIGRVAVGKEARIKLDAYPFQKYGTASGEVRTISQDTFLSGQQEQAAT
PGQPAAAPFFKARILLADTRLNAADVPVRLLPGMTVSTEIKVGNRTVISYFLYPLLRGLDNAIREP

Sequences:

>Translated_466_residues
MDSGGSNESHSGKGRELIARPPLPPVIAEFQSDAVELEERAPPRVARMTLYCVTALIASAIIWASVSSIDEVVIAPGKLV
TTQPTIVVQPLETSIIRTIDVKAGEVVHAGQTLATLDATFSQADVGQLKTKFSALDAQVKRLETELTGEDYSKVAGNTPD
EQLQVQLFGQRRAFYTAQLKNFEQQIAGQSSVLAANRNQEAVLNDRRDNLSLIEATRKKLYDTESGSLLTMLGSRDARLD
VEADITAVRGKADEAAHTYAKLLADRQAFIEDFRRAAMEQLADLRSQRDMAGEELKKLELRRNMVALTAPADAVVLDLAQ
RSVGSVVREAEPVVTLVPINVPLEAEVSINTRDIGRVAVGKEARIKLDAYPFQKYGTASGEVRTISQDTFLSGQQEQAAT
PGQPAAAPFFKARILLADTRLNAADVPVRLLPGMTVSTEIKVGNRTVISYFLYPLLRGLDNAIREP
>Mature_466_residues
MDSGGSNESHSGKGRELIARPPLPPVIAEFQSDAVELEERAPPRVARMTLYCVTALIASAIIWASVSSIDEVVIAPGKLV
TTQPTIVVQPLETSIIRTIDVKAGEVVHAGQTLATLDATFSQADVGQLKTKFSALDAQVKRLETELTGEDYSKVAGNTPD
EQLQVQLFGQRRAFYTAQLKNFEQQIAGQSSVLAANRNQEAVLNDRRDNLSLIEATRKKLYDTESGSLLTMLGSRDARLD
VEADITAVRGKADEAAHTYAKLLADRQAFIEDFRRAAMEQLADLRSQRDMAGEELKKLELRRNMVALTAPADAVVLDLAQ
RSVGSVVREAEPVVTLVPINVPLEAEVSINTRDIGRVAVGKEARIKLDAYPFQKYGTASGEVRTISQDTFLSGQQEQAAT
PGQPAAAPFFKARILLADTRLNAADVPVRLLPGMTVSTEIKVGNRTVISYFLYPLLRGLDNAIREP

Specific function: Involved in the transport of the Leukotoxin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50718; Mature: 50718

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGGSNESHSGKGRELIARPPLPPVIAEFQSDAVELEERAPPRVARMTLYCVTALIASA
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IIWASVSSIDEVVIAPGKLVTTQPTIVVQPLETSIIRTIDVKAGEVVHAGQTLATLDATF
HHHHHHHHCCCEEECCCEEEECCCEEEEECCCCCEEEEEECCCCCEEECCCCCEEHHHHH
SQADVGQLKTKFSALDAQVKRLETELTGEDYSKVAGNTPDEQLQVQLFGQRRAFYTAQLK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHEEEEEECCCHHHHHHHHH
NFEQQIAGQSSVLAANRNQEAVLNDRRDNLSLIEATRKKLYDTESGSLLTMLGSRDARLD
HHHHHHCCCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEE
VEADITAVRGKADEAAHTYAKLLADRQAFIEDFRRAAMEQLADLRSQRDMAGEELKKLEL
ECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRNMVALTAPADAVVLDLAQRSVGSVVREAEPVVTLVPINVPLEAEVSINTRDIGRVAVG
HCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEEC
KEARIKLDAYPFQKYGTASGEVRTISQDTFLSGQQEQAATPGQPAAAPFFKARILLADTR
CCCEEEEECCCCHHHCCCCCCEEEECCCHHCCCCHHHCCCCCCCCCCCHHHEEEEEEECC
LNAADVPVRLLPGMTVSTEIKVGNRTVISYFLYPLLRGLDNAIREP
CCCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSGGSNESHSGKGRELIARPPLPPVIAEFQSDAVELEERAPPRVARMTLYCVTALIASA
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IIWASVSSIDEVVIAPGKLVTTQPTIVVQPLETSIIRTIDVKAGEVVHAGQTLATLDATF
HHHHHHHHCCCEEECCCEEEECCCEEEEECCCCCEEEEEECCCCCEEECCCCCEEHHHHH
SQADVGQLKTKFSALDAQVKRLETELTGEDYSKVAGNTPDEQLQVQLFGQRRAFYTAQLK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHEEEEEECCCHHHHHHHHH
NFEQQIAGQSSVLAANRNQEAVLNDRRDNLSLIEATRKKLYDTESGSLLTMLGSRDARLD
HHHHHHCCCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEE
VEADITAVRGKADEAAHTYAKLLADRQAFIEDFRRAAMEQLADLRSQRDMAGEELKKLEL
ECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRNMVALTAPADAVVLDLAQRSVGSVVREAEPVVTLVPINVPLEAEVSINTRDIGRVAVG
HCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEEC
KEARIKLDAYPFQKYGTASGEVRTISQDTFLSGQQEQAATPGQPAAAPFFKARILLADTR
CCCEEEEECCCCHHHCCCCCCEEEECCCHHCCCCHHHCCCCCCCCCCCHHHEEEEEEECC
LNAADVPVRLLPGMTVSTEIKVGNRTVISYFLYPLLRGLDNAIREP
CCCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3040588; 2914876; 2707120 [H]