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The map label for this gene is oxyR [H]

Identifier: 190894346

GI number: 190894346

Start: 5793

End: 6707

Strand: Reverse

Name: oxyR [H]

Synonym: RHECIAT_PC0000006

Alternate gene names: 190894346

Gene position: 6707-5793 (Counterclockwise)

Preceding gene: 190894348

Following gene: 190894343

Centisome position: 0.61

GC content: 64.92

Gene sequence:

>915_bases
ATGAAAAATCTTACCCTGAAACAGCTACGTTATTTTGAAGCCTTGGCAAGGGACGGCCGTTTTCGCCGTGCCGCCGATGC
CTGCGCCATCTCCCAGCCGGCGCTCTCCATGCAGATCAAAGAACTTGAGCAGGAGTTGGGCAGCGAACTCTTCGAGCGCG
GCGCCCGCGAGGTGAAGCTCACCCCGTTCGGCCAGACCTTCGCGCTGCGCGTTCGCGATATCCTGCGCGCCGTGGACGAG
CTCGGCGAGTTTGCCCGCGCCTCGCGCGACAGTTTCCTCACGCGCCTGCGCATCGGCATCATCCCGACGATCGCGCCTTA
TCTGCTGCCGGCGATTATAAACGATCTCAACAAAAGCTTCGCGGGAATTCAGATCGAGGTGCGCGAGACGCAGACGGGCA
AGCTGGTCCAGGAGCTGGCGCAGGGCCAGCTCGATATGGCGATCGTCGCGCTGCCGGTGTCGGAACCCTCGCTGACCGAG
CTCGAACTGTTCAAGGAGGAGTTCGTGCTGGTCCGGCGGCACGAGGATGGCGGCAAGCCGGTGCCCGAACGCGAGGCGCT
ACGCGAAATGCGGCTGCTGCTGCTCGAAGAGGGCCACTGCTTCCGCGACCAGGCCCTGTCATTCTGCAAGGTGGGGCCCG
CCCGCCCGCGGGAAATCATGGAAGGCAGCTCGCTCTCCACCCTCGTCCAGATGGTCGGCGCCGGCATCGGCGTCACTTTG
ATCCCGGAGATGGCCGTTCCGGTCGAAACGCGCTCGGCCCATGTCTCGATCTCCCGCTTCCCGTCGCCGCAGCCATCGCG
AACCATCGGCATGGTCTGGCGCAATTCCACGCCGATGGCCAAGCAGTTGCAGGAGGTCGCCGAGGCGGTGCGCCGCTCGG
CGGAGGCGATGCGGGAGCAGTATGCCGAGGGGTGA

Upstream 100 bases:

>100_bases
GAGCCGAGCTGGCGCCCCACTCTCTCCCTTGCAGTCTTCATATCGGAAGCGTTCAATAATTTTAAGTTGGATTTACTGAT
TGCTGCGATAAGCTGAGCTT

Downstream 100 bases:

>100_bases
CGAACGACGGCTGTCGCAGTCGGTGCCCAACACTTGCCTTTGTGGGGAAGGTTGAGGATCGATAAGTGCCAGCGCCTTCG
CGTTACGGCCTTCGCTTGAA

Product: LysR family hydrogen peroxide sensing transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERGAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPAIINDLNKSFAGIQIEVRETQTGKLVQELAQGQLDMAIVALPVSEPSLTE
LELFKEEFVLVRRHEDGGKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGPARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVAEAVRRSAEAMREQYAEG

Sequences:

>Translated_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERGAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPAIINDLNKSFAGIQIEVRETQTGKLVQELAQGQLDMAIVALPVSEPSLTE
LELFKEEFVLVRRHEDGGKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGPARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVAEAVRRSAEAMREQYAEG
>Mature_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERGAREVKLTPFGQTFALRVRDILRAVDE
LGEFARASRDSFLTRLRIGIIPTIAPYLLPAIINDLNKSFAGIQIEVRETQTGKLVQELAQGQLDMAIVALPVSEPSLTE
LELFKEEFVLVRRHEDGGKPVPEREALREMRLLLLEEGHCFRDQALSFCKVGPARPREIMEGSSLSTLVQMVGAGIGVTL
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVAEAVRRSAEAMREQYAEG

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=293, Percent_Identity=40.6143344709898, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=31.9502074688797, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI145693105, Length=276, Percent_Identity=27.8985507246377, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788748, Length=308, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787806, Length=273, Percent_Identity=24.9084249084249, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787879, Length=268, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788297, Length=311, Percent_Identity=26.0450160771704, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788887, Length=278, Percent_Identity=28.0575539568345, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=301, Percent_Identity=27.2425249169435, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=32.1917808219178, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789506, Length=246, Percent_Identity=26.0162601626016, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787530, Length=254, Percent_Identity=26.7716535433071, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693193, Length=122, Percent_Identity=35.2459016393443, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789173, Length=165, Percent_Identity=30.9090909090909, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=244, Percent_Identity=26.6393442622951, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788626, Length=255, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790783, Length=268, Percent_Identity=24.6268656716418, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789492, Length=285, Percent_Identity=26.6666666666667, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33985; Mature: 33985

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERGAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TPFGQTFALRVRDILRAVDELGEFARASRDSFLTRLRIGIIPTIAPYLLPAIINDLNKSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTGKLVQELAQGQLDMAIVALPVSEPSLTELELFKEEFVLVRRHEDGGKP
CCEEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKVGPARPREIMEGSSLSTLVQMVGAGIGVTL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCEEE
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVAEAVRRSAEAMREQ
CCCCCCCCCCCCCEEEHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YAEG
HCCC
>Mature Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGSELFERGAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TPFGQTFALRVRDILRAVDELGEFARASRDSFLTRLRIGIIPTIAPYLLPAIINDLNKSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTGKLVQELAQGQLDMAIVALPVSEPSLTELELFKEEFVLVRRHEDGGKP
CCEEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKVGPARPREIMEGSSLSTLVQMVGAGIGVTL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCEEE
IPEMAVPVETRSAHVSISRFPSPQPSRTIGMVWRNSTPMAKQLQEVAEAVRRSAEAMREQ
CCCCCCCCCCCCCEEEHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
YAEG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]