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The map label for this gene is purM [H]

Identifier: 190571273

GI number: 190571273

Start: 943228

End: 944265

Strand: Direct

Name: purM [H]

Synonym: WPa_0874

Alternate gene names: 190571273

Gene position: 943228-944265 (Clockwise)

Preceding gene: 190571269

Following gene: 190571275

Centisome position: 63.63

GC content: 34.01

Gene sequence:

>1038_bases
ATGAATACTTATGCTAAATCTGGAATAGACCTTAAACTATATAATGAACTAATAAAAAAAGTTAAACCTATTATTGAAAA
GACTAAAGGAGAAGAAGTAATTAGTGAAGTAGGATCATTTTCTGCATTGTTTGACTTTTCTTCGCTGAGTAAGAAATACG
ACCATCCAGTACTTGTTTCCTCAACTGATGGAGTGGGCACAAAACTATTAATAGCTCAAGAGGTGAATAAGCATGATACT
ATAGGTATAGACTTAGTTGCAATGTGTGTAAATGATCTACTTGCACAAGGAGCAACACCTTTATTTTTCCTTGATTACTT
TGCAACAGGCGTTTTAAACAAAAACGTTTTATTGTCTGTAATCCAGGGCATTGCAGAAGGGTGCAAGGAATCTAAAATAG
CATTAGTTGGTGGAGAAACTGCAGAAATGCCTGGAATGTATGGTAACAATCACTATGACCTTGCAGGGTTTGTGGTTGGT
GTTGTTGATCGAAAGCAAATTCTCCCAAATTGTAGTATAATGAAAGCAGGTGACTGTGTAGTTGGTTTAGAATCAAATGG
AATTCACTCAAATGGATTTTCTTTGGTGCGCCATATTTTTAAAAGCTTAGATATAAATTATAATGATATATCTCCATGGA
ATAATAAATCTTGGGGTGAAATATTACTTAAGCCAACAAAGATATATGTTGATTCTTTGTTGCCTATTATGCCAAAGGTA
AAAGGCATTGCGCATATAACAGGTGGCGGGTTAATAGACAATATTCCAAGAATTCTCTCAGGAAATTTATTTGTAGACAT
AAATATTAATTCTTGGAAATGGCCAGATATATTTTTATGGCTGAAAGAAGAAGGCAAAATAGAAAAGAGAGAAATGTTAA
AAACATTTAATTGCGGCATAGGTATAGTACTGATTGTAGATCCCGATAATATGAAGGATGTGGAAAGCCATTTCCAAAAG
CGTGGAGAAAAAATTGAGATTATTGGAAAACTTGATGAAGCATGTCAGCCTCCACTTGATAGAGTAGTATTTAGTTAG

Upstream 100 bases:

>100_bases
TGGTAGGCATGTAGTAGTCAATTTAAGAGAAAGTTTCGTTGCGCTTTTTGTGTCAAAGCATTAATGTAGTATTAATAATT
ATAAGATTTGTGAAGGCGTT

Downstream 100 bases:

>100_bases
TCTAACTTTACCGACAGTCTTTTTGCAACTTCTGAGTATGCTTCCTTTAAGTTTCCTAGATTTAAACGGAAAACATCTTT
GTCTAGCTTTTTATGAGTAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNTYAKSGIDLKLYNELIKKVKPIIEKTKGEEVISEVGSFSALFDFSSLSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLNKNVLLSVIQGIAEGCKESKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSIMKAGDCVVGLESNGIHSNGFSLVRHIFKSLDINYNDISPWNNKSWGEILLKPTKIYVDSLLPIMPKV
KGIAHITGGGLIDNIPRILSGNLFVDININSWKWPDIFLWLKEEGKIEKREMLKTFNCGIGIVLIVDPDNMKDVESHFQK
RGEKIEIIGKLDEACQPPLDRVVFS

Sequences:

>Translated_345_residues
MNTYAKSGIDLKLYNELIKKVKPIIEKTKGEEVISEVGSFSALFDFSSLSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLNKNVLLSVIQGIAEGCKESKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSIMKAGDCVVGLESNGIHSNGFSLVRHIFKSLDINYNDISPWNNKSWGEILLKPTKIYVDSLLPIMPKV
KGIAHITGGGLIDNIPRILSGNLFVDININSWKWPDIFLWLKEEGKIEKREMLKTFNCGIGIVLIVDPDNMKDVESHFQK
RGEKIEIIGKLDEACQPPLDRVVFS
>Mature_345_residues
MNTYAKSGIDLKLYNELIKKVKPIIEKTKGEEVISEVGSFSALFDFSSLSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLNKNVLLSVIQGIAEGCKESKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSIMKAGDCVVGLESNGIHSNGFSLVRHIFKSLDINYNDISPWNNKSWGEILLKPTKIYVDSLLPIMPKV
KGIAHITGGGLIDNIPRILSGNLFVDININSWKWPDIFLWLKEEGKIEKREMLKTFNCGIGIVLIVDPDNMKDVESHFQK
RGEKIEIIGKLDEACQPPLDRVVFS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=48.3483483483483, Blast_Score=330, Evalue=9e-91,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=48.3483483483483, Blast_Score=330, Evalue=9e-91,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=48.3483483483483, Blast_Score=330, Evalue=9e-91,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=47.4320241691843, Blast_Score=301, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17567511, Length=338, Percent_Identity=40.8284023668639, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=47.1641791044776, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=40.4761904761905, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38069; Mature: 38069

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYAKSGIDLKLYNELIKKVKPIIEKTKGEEVISEVGSFSALFDFSSLSKKYDHPVLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
STDGVGTKLLIAQEVNKHDTIGIDLVAMCVNDLLAQGATPLFFLDYFATGVLNKNVLLSV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHH
IQGIAEGCKESKIALVGGETAEMPGMYGNNHYDLAGFVVGVVDRKQILPNCSIMKAGDCV
HHHHHHCCCCCCEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEECCCEE
VGLESNGIHSNGFSLVRHIFKSLDINYNDISPWNNKSWGEILLKPTKIYVDSLLPIMPKV
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHH
KGIAHITGGGLIDNIPRILSGNLFVDININSWKWPDIFLWLKEEGKIEKREMLKTFNCGI
CCEEEECCCCHHHHHHHHHCCCEEEEEECCCEECCEEEEEECCCCCCHHHHHHHHHCCCE
GIVLIVDPDNMKDVESHFQKRGEKIEIIGKLDEACQPPLDRVVFS
EEEEEECCCCCHHHHHHHHHCCCEEEEEECHHHHHCCCHHHHCCC
>Mature Secondary Structure
MNTYAKSGIDLKLYNELIKKVKPIIEKTKGEEVISEVGSFSALFDFSSLSKKYDHPVLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
STDGVGTKLLIAQEVNKHDTIGIDLVAMCVNDLLAQGATPLFFLDYFATGVLNKNVLLSV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHH
IQGIAEGCKESKIALVGGETAEMPGMYGNNHYDLAGFVVGVVDRKQILPNCSIMKAGDCV
HHHHHHCCCCCCEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEECCCEE
VGLESNGIHSNGFSLVRHIFKSLDINYNDISPWNNKSWGEILLKPTKIYVDSLLPIMPKV
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHH
KGIAHITGGGLIDNIPRILSGNLFVDININSWKWPDIFLWLKEEGKIEKREMLKTFNCGI
CCEEEECCCCHHHHHHHHHCCCEEEEEECCCEECCEEEEEECCCCCCHHHHHHHHHCCCE
GIVLIVDPDNMKDVESHFQKRGEKIEIIGKLDEACQPPLDRVVFS
EEEEEECCCCCHHHHHHHHHCCCEEEEEECHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA