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The map label for this gene is metC [H]

Identifier: 190570600

GI number: 190570600

Start: 144593

End: 145825

Strand: Reverse

Name: metC [H]

Synonym: WPa_0138

Alternate gene names: 190570600

Gene position: 145825-144593 (Counterclockwise)

Preceding gene: 190570601

Following gene: 190570599

Centisome position: 9.84

GC content: 36.66

Gene sequence:

>1233_bases
GTGAGAGAAGAGTCTTTATTAGTTAAAGCAGGAAGAAAATTTAATGATTATAAAGGATCGATGAACCCACCAGTTTATCA
TTCTTCTACCATATTATTTCCTACTTACAAGGATTACTTAAATGCAGCAAATGGAGAAAGTATATACGATGTAATCAATG
ATGGTGTTGCAAGGGATTACAGTTACAGTAATGTTGGTACGCCTACTGTTCATTATTTTTCAAATGCACTGGCTGAAATT
GAGGGTAGGGGACAAGCACTCATCTACCCTTCTGGATTATTTGCACTTACTTTTGCTATTTTGACTTTCACTAAAGCAGG
TTCACATGTCCTGATACAAGATAATAGTTATTATAGGCTAAAGAGATTTGCCGAAAATGAGCTACCAAAAAGAGGAGTAG
AAGTAACTTTTTATAATCCGACACAGGATATAACTGATTTAGTTCAGAGTAATACTTCACTCATCATGATTGAGACTCCT
GGTTCTATAACGTTTGAGATTTCAAATATAGAGCATATAGTAAAAGTTGCTAAAGCACGTGGAATCGTAACCGTTTGTGA
CAATTCATGGGCCACTCCTTTGTTGTTTAAGCCGCTTGATTATGGAATTGATGTTGCACTATACGCGGTGACAAAGTATC
TAGCCGGTCACTCAGATTTAGTGATGGGAGCTATGGTTGCTGAAGGTAAAATTTTTAAATTGCTTTATGAGAGCTATAAA
AATTATGGAGTCACCATTCAATCGCATGACTGTTACCTTGCACACAGGGGACTTAGAACACTGCAAACACGCATGAGGAA
GCATCAAAGTACAGCAATGCAAGTAGCAAAGTGGCTGGAAAAACATCCAAAAATCAAAAAAGTCTTATACCCCGCACTTT
TTTCCTATTCTCAGCATGATTTATGGAAAAGTTATTTCAAAGGGGCAAGTAGCGTATTTAGTATAGTACTCGATAGAGAA
TATTCATGTGAGGAACTAAGCTGCATGGTTGATCACATGAAAATTTTTGGCATCGGTGCTTCTTGGGGAGGATGTGACAG
TTTGATATTACCAATAGAACATAGATCTATGTCAAGATCTGTAATGAATTCAGATTATGGTGGAAGTTTTGTGCGAATAT
TTTGCGGACTAGAAGATCCTGAAGATTTGATTTTTGACTTGAATACTGCATTAATAAGACTGCCATGTTCAAGTGTTAAA
GATGATTGTGAGACTGAAAGAGCTACTGCATAA

Upstream 100 bases:

>100_bases
ATCTATGAATTATTAAAGAGTGAAATAGAGCGATTACATGCGATTTCTCTTCACTTGTATACGCAAAGCGAATACAATCT
AAAAAATAAATAGTAGAAAC

Downstream 100 bases:

>100_bases
CATTGTAAATGCTGACTTTGATATTGAAATCAAAGGCGTCACATGTAATCCTAAGAGAGTTAAAGAAGGTTACCTTTTTG
TTTGTGTGTCAGAAAGGAGT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MREESLLVKAGRKFNDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDGVARDYSYSNVGTPTVHYFSNALAEI
EGRGQALIYPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPKRGVEVTFYNPTQDITDLVQSNTSLIMIETP
GSITFEISNIEHIVKVAKARGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLVMGAMVAEGKIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLQTRMRKHQSTAMQVAKWLEKHPKIKKVLYPALFSYSQHDLWKSYFKGASSVFSIVLDRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIEHRSMSRSVMNSDYGGSFVRIFCGLEDPEDLIFDLNTALIRLPCSSVK
DDCETERATA

Sequences:

>Translated_410_residues
MREESLLVKAGRKFNDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDGVARDYSYSNVGTPTVHYFSNALAEI
EGRGQALIYPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPKRGVEVTFYNPTQDITDLVQSNTSLIMIETP
GSITFEISNIEHIVKVAKARGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLVMGAMVAEGKIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLQTRMRKHQSTAMQVAKWLEKHPKIKKVLYPALFSYSQHDLWKSYFKGASSVFSIVLDRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIEHRSMSRSVMNSDYGGSFVRIFCGLEDPEDLIFDLNTALIRLPCSSVK
DDCETERATA
>Mature_410_residues
MREESLLVKAGRKFNDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDGVARDYSYSNVGTPTVHYFSNALAEI
EGRGQALIYPSGLFALTFAILTFTKAGSHVLIQDNSYYRLKRFAENELPKRGVEVTFYNPTQDITDLVQSNTSLIMIETP
GSITFEISNIEHIVKVAKARGIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLVMGAMVAEGKIFKLLYESYK
NYGVTIQSHDCYLAHRGLRTLQTRMRKHQSTAMQVAKWLEKHPKIKKVLYPALFSYSQHDLWKSYFKGASSVFSIVLDRE
YSCEELSCMVDHMKIFGIGASWGGCDSLILPIEHRSMSRSVMNSDYGGSFVRIFCGLEDPEDLIFDLNTALIRLPCSSVK
DDCETERATA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=298, Percent_Identity=31.5436241610738, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI299473759, Length=239, Percent_Identity=31.3807531380753, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI25453487, Length=295, Percent_Identity=28.135593220339, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789383, Length=403, Percent_Identity=35.2357320099256, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1790375, Length=397, Percent_Identity=29.9748110831234, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17538055, Length=340, Percent_Identity=33.2352941176471, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=343, Percent_Identity=32.9446064139942, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=382, Percent_Identity=29.3193717277487, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=37.202380952381, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319307, Length=349, Percent_Identity=28.9398280802292, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=338, Percent_Identity=27.5147928994083, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321254, Length=421, Percent_Identity=26.3657957244656, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323333, Length=419, Percent_Identity=24.1050119331742, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=350, Percent_Identity=34.5714285714286, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 46106; Mature: 46106

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREESLLVKAGRKFNDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDGVARDY
CCCCHHHHHCCCCCCCCCCCCCCCCEECCEEEECCHHHHHCCCCCCHHHHHHCCCCCCCC
SYSNVGTPTVHYFSNALAEIEGRGQALIYPSGLFALTFAILTFTKAGSHVLIQDNSYYRL
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
KRFAENELPKRGVEVTFYNPTQDITDLVQSNTSLIMIETPGSITFEISNIEHIVKVAKAR
HHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHC
GIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLVMGAMVAEGKIFKLLYESYK
CEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
NYGVTIQSHDCYLAHRGLRTLQTRMRKHQSTAMQVAKWLEKHPKIKKVLYPALFSYSQHD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
LWKSYFKGASSVFSIVLDREYSCEELSCMVDHMKIFGIGASWGGCDSLILPIEHRSMSRS
HHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEECHHHHHHH
VMNSDYGGSFVRIFCGLEDPEDLIFDLNTALIRLPCSSVKDDCETERATA
HHCCCCCCCEEEEEECCCCHHHHHHHCCHHEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MREESLLVKAGRKFNDYKGSMNPPVYHSSTILFPTYKDYLNAANGESIYDVINDGVARDY
CCCCHHHHHCCCCCCCCCCCCCCCCEECCEEEECCHHHHHCCCCCCHHHHHHCCCCCCCC
SYSNVGTPTVHYFSNALAEIEGRGQALIYPSGLFALTFAILTFTKAGSHVLIQDNSYYRL
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHH
KRFAENELPKRGVEVTFYNPTQDITDLVQSNTSLIMIETPGSITFEISNIEHIVKVAKAR
HHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHHHC
GIVTVCDNSWATPLLFKPLDYGIDVALYAVTKYLAGHSDLVMGAMVAEGKIFKLLYESYK
CEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
NYGVTIQSHDCYLAHRGLRTLQTRMRKHQSTAMQVAKWLEKHPKIKKVLYPALFSYSQHD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
LWKSYFKGASSVFSIVLDREYSCEELSCMVDHMKIFGIGASWGGCDSLILPIEHRSMSRS
HHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEECHHHHHHH
VMNSDYGGSFVRIFCGLEDPEDLIFDLNTALIRLPCSSVKDDCETERATA
HHCCCCCCCEEEEEECCCCHHHHHHHCCHHEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]