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The map label for this gene is pyrC [H]

Identifier: 190570588

GI number: 190570588

Start: 127701

End: 129071

Strand: Reverse

Name: pyrC [H]

Synonym: WPa_0123

Alternate gene names: 190570588

Gene position: 129071-127701 (Counterclockwise)

Preceding gene: 190570589

Following gene: 190570587

Centisome position: 8.71

GC content: 38.0

Gene sequence:

>1371_bases
TTGTATTTTACTAAAAAAACTTTAGATTTATTTTATAATCGATACTCAAATATGATTTGGAATTTATTGCAGACAGGGCA
AAAGGAAGGCTATAAAATTGCGTATACCAATGCTCGTATTATTGACCCGGAAACTAAACTTGATATAAAAGGTTCATTAT
TGACTGAAGGGGGTAAAATTGTTGATTTTGGCGAATCATTATTTTCAACAAGTGGAGTTGATGAAATAATAGACTGTAAA
GGGCTTGTTCTAATGCCAGGCCTTATTGACATTCACGTACATTTTCGTGAACCAGGTCAAGAGCATAAAGAAACTATACA
TACAGGCAGCAAATCTGCAGCTGCAGGGGGCGCTACAACTGTAGTTTGTCAGCCAAACACTGTTCCAGCGATTGATAGTG
TTGTCTTGGCTCAGTATTTGAAATATAGAGCATTTGAAACTTCGCATGTGAATGTGGAATTTTACGCTAAAATCACCACT
TCGGAAGAAAAATTAACTGAAATGGCACTCTTAAAGGAAGCAGGTGCAGTTGGTTTCACCGATGATGGTATGCCAGTTAT
GAATCCAATGATTATGAGACAGGCACTGCTTTATTCAAGTATGCTTGGTGTTCCTATTGCTCAACACGCAGAGGATTTAA
ATCTATCTGCTGGTGGCGCAATCAATGCAGGTAAAATTTCTGAAGAATTGGGAATAAAGGGAATCTTGAGTGCGTCAGAG
TCGGTTATGGTAAATCGTGATATACTGCTAATGAAGGACATAGAAAATGTACACTACCATATTTTACATGTCTCTTCAAA
AGATTCACTTGATGCTATTAAACGTGCAAAAGATTTGGGATTAAATGTTACATGTGAAGTAACTCCTCATCACTTTACTT
TAACTGAAGATATAGTAAAACAACACGGAGCAATCGCAAAAATGAACCCGCCGCTTCGCACTGAAGAGGATCGTTTAGCT
ATGATTGAAGGTTTAAAGACAGGTGTGATTGATTGCATTGCAACCGATCATGCTCCGCATGATCTTAGTTCTAAAGATTT
GCCACTTGAAAATGCTGCATTTGGTATTGTTGGCCTTGAAACAATGCTGCCCATTTCACTTGAACTATATCACAGTGGAC
AAATGGGTCTACTTGATGTGCTTGCAAAATTGACATATAAGCCTGCAGATATCATACATGTGCCACGTGGCCGCATACAG
AAAAACCTTGCAGCGGACTTAATTTTAGTTGATTTGGATCATGAATGGAAAATTAAAGTTGACAACTTTGCTAGTAAATC
AAAAAATTCCCCTTTCGATGGACGCAAAGTGAAAGGGCGCGTAATACGTACCGTTGTGTCTGGCAAAACTGTATATTTAC
AGAAGGATTAG

Upstream 100 bases:

>100_bases
TTAATAACGTTGAAATCGAAAATGGTAGTTATAGAATAGCTGCTTGAGTATTAATTTAAATATTCTTTATTGCTAGTTTT
ATATCATCACTTTAATTTGG

Downstream 100 bases:

>100_bases
TTATCATACAGTTGCGTTCTCAATTTCAATCAATTGTAAATATTCAATATAAGTGGTAAAATATAGCCACTGAATAAAAA
ATATATGCTAATTAGTACGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MYFTKKTLDLFYNRYSNMIWNLLQTGQKEGYKIAYTNARIIDPETKLDIKGSLLTEGGKIVDFGESLFSTSGVDEIIDCK
GLVLMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGATTVVCQPNTVPAIDSVVLAQYLKYRAFETSHVNVEFYAKITT
SEEKLTEMALLKEAGAVGFTDDGMPVMNPMIMRQALLYSSMLGVPIAQHAEDLNLSAGGAINAGKISEELGIKGILSASE
SVMVNRDILLMKDIENVHYHILHVSSKDSLDAIKRAKDLGLNVTCEVTPHHFTLTEDIVKQHGAIAKMNPPLRTEEDRLA
MIEGLKTGVIDCIATDHAPHDLSSKDLPLENAAFGIVGLETMLPISLELYHSGQMGLLDVLAKLTYKPADIIHVPRGRIQ
KNLAADLILVDLDHEWKIKVDNFASKSKNSPFDGRKVKGRVIRTVVSGKTVYLQKD

Sequences:

>Translated_456_residues
MYFTKKTLDLFYNRYSNMIWNLLQTGQKEGYKIAYTNARIIDPETKLDIKGSLLTEGGKIVDFGESLFSTSGVDEIIDCK
GLVLMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGATTVVCQPNTVPAIDSVVLAQYLKYRAFETSHVNVEFYAKITT
SEEKLTEMALLKEAGAVGFTDDGMPVMNPMIMRQALLYSSMLGVPIAQHAEDLNLSAGGAINAGKISEELGIKGILSASE
SVMVNRDILLMKDIENVHYHILHVSSKDSLDAIKRAKDLGLNVTCEVTPHHFTLTEDIVKQHGAIAKMNPPLRTEEDRLA
MIEGLKTGVIDCIATDHAPHDLSSKDLPLENAAFGIVGLETMLPISLELYHSGQMGLLDVLAKLTYKPADIIHVPRGRIQ
KNLAADLILVDLDHEWKIKVDNFASKSKNSPFDGRKVKGRVIRTVVSGKTVYLQKD
>Mature_456_residues
MYFTKKTLDLFYNRYSNMIWNLLQTGQKEGYKIAYTNARIIDPETKLDIKGSLLTEGGKIVDFGESLFSTSGVDEIIDCK
GLVLMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGATTVVCQPNTVPAIDSVVLAQYLKYRAFETSHVNVEFYAKITT
SEEKLTEMALLKEAGAVGFTDDGMPVMNPMIMRQALLYSSMLGVPIAQHAEDLNLSAGGAINAGKISEELGIKGILSASE
SVMVNRDILLMKDIENVHYHILHVSSKDSLDAIKRAKDLGLNVTCEVTPHHFTLTEDIVKQHGAIAKMNPPLRTEEDRLA
MIEGLKTGVIDCIATDHAPHDLSSKDLPLENAAFGIVGLETMLPISLELYHSGQMGLLDVLAKLTYKPADIIHVPRGRIQ
KNLAADLILVDLDHEWKIKVDNFASKSKNSPFDGRKVKGRVIRTVVSGKTVYLQKD

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=390, Percent_Identity=33.0769230769231, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI19923821, Length=431, Percent_Identity=24.1299303944316, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786722, Length=451, Percent_Identity=28.159645232816, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193204318, Length=385, Percent_Identity=32.4675324675325, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322218, Length=387, Percent_Identity=26.3565891472868, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=30.9895833333333, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI18859883, Length=421, Percent_Identity=26.8408551068884, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50148; Mature: 50148

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFTKKTLDLFYNRYSNMIWNLLQTGQKEGYKIAYTNARIIDPETKLDIKGSLLTEGGKI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCEEECCEEECCCCEE
VDFGESLFSTSGVDEIIDCKGLVLMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGATT
EECCHHHHCCCCCHHHHCCCCEEEECCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEE
VVCQPNTVPAIDSVVLAQYLKYRAFETSHVNVEFYAKITTSEEKLTEMALLKEAGAVGFT
EEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCCC
DDGMPVMNPMIMRQALLYSSMLGVPIAQHAEDLNLSAGGAINAGKISEELGIKGILSASE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEECCCC
SVMVNRDILLMKDIENVHYHILHVSSKDSLDAIKRAKDLGLNVTCEVTPHHFTLTEDIVK
CEEECCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEECHHHHHH
QHGAIAKMNPPLRTEEDRLAMIEGLKTGVIDCIATDHAPHDLSSKDLPLENAAFGIVGLE
HCCCEEECCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
TMLPISLELYHSGQMGLLDVLAKLTYKPADIIHVPRGRIQKNLAADLILVDLDHEWKIKV
HHCCEEEEEEECCCCCHHHHHHHHCCCCCCEEECCCHHHHHCCCEEEEEEECCCCEEEEE
DNFASKSKNSPFDGRKVKGRVIRTVVSGKTVYLQKD
CCCCCCCCCCCCCCCHHCCCEEEEEECCCEEEEECC
>Mature Secondary Structure
MYFTKKTLDLFYNRYSNMIWNLLQTGQKEGYKIAYTNARIIDPETKLDIKGSLLTEGGKI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCEEECCEEECCCCEE
VDFGESLFSTSGVDEIIDCKGLVLMPGLIDIHVHFREPGQEHKETIHTGSKSAAAGGATT
EECCHHHHCCCCCHHHHCCCCEEEECCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEE
VVCQPNTVPAIDSVVLAQYLKYRAFETSHVNVEFYAKITTSEEKLTEMALLKEAGAVGFT
EEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCCC
DDGMPVMNPMIMRQALLYSSMLGVPIAQHAEDLNLSAGGAINAGKISEELGIKGILSASE
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEECCCC
SVMVNRDILLMKDIENVHYHILHVSSKDSLDAIKRAKDLGLNVTCEVTPHHFTLTEDIVK
CEEECCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCEEECHHHHHH
QHGAIAKMNPPLRTEEDRLAMIEGLKTGVIDCIATDHAPHDLSSKDLPLENAAFGIVGLE
HCCCEEECCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
TMLPISLELYHSGQMGLLDVLAKLTYKPADIIHVPRGRIQKNLAADLILVDLDHEWKIKV
HHCCEEEEEEECCCCCHHHHHHHHCCCCCCEEECCCHHHHHCCCEEEEEEECCCCEEEEE
DNFASKSKNSPFDGRKVKGRVIRTVVSGKTVYLQKD
CCCCCCCCCCCCCCCHHCCCEEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA