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The map label for this gene is pdhA [H]

Identifier: 190570556

GI number: 190570556

Start: 83219

End: 84199

Strand: Direct

Name: pdhA [H]

Synonym: WPa_0086

Alternate gene names: 190570556

Gene position: 83219-84199 (Clockwise)

Preceding gene: 190570548

Following gene: 190570557

Centisome position: 5.61

GC content: 36.29

Gene sequence:

>981_bases
ATGAAAGCAGGAAATTTCACTAAAGAGCAAGTGATTGGGTTCTACAGAAAAATGCTTCTAATACGCAGATTTGAGGAAAA
AGCAGGACAATTATACGGAATGGGATTAATAGGCGGATTCTGTCACTTATCAATAGGGCAAGAAGCAGTTGCAGTTGGGA
CTCAAGCTGCATCAAAACCTGGTGATGCTTTTATCACAAGCTATAGAGACCATGGCTTAATGCTTGCATGTAATTCTGAT
CCAAATGTTGTGATGGCAGAACTAAACGGCAAAGAAACAGGGTGTTCAAAAGGTAAAGGTGGCTCCATGCACATATTTGA
TGTTGAAAAAAATTTCTTTGGTGGACATGGAATAGTAGGTGCACAAGTCCCAATTGGTACAGGAATAGCATTTGCTAATA
AATACAAGAAAAAAGATAACGTTGTATTCACATATTTTGGTGACGGTGCTGCAAATCAAGGACAAGTATATGAATCATTT
AATATGGCATCTTTGTGGAAGTTACCTGTGGTTTATATCATAGAAAATAACGAATACGCAATGGGAACTTCTGTGCAAAG
ATCAACTTTAGTAACTGAACTATATAAAAGAGGAGAGAGTTTTGGTATTCCTGGAAAACAAGTTGATGGAATGGATTTTT
TCTCTGTCTATGAGGTAACAAGTGAAATAGCTGAGCACGTACGTGGGGGAAAAGGACCTCTCTTGCTTGAAATGAAGACA
TATCGATATCGTGGCCATTCGATGTCAGATCCTGCTACTTATCGCACAAAAGAAGAAGTTGAAGATATGAAGCAAAATCA
TGATCCTATAAGTAATTTAAAGCAGTATATGAAAGATAATAAAATAGCTTCTGATGAAGAATGCAAAGCTATTGATAAGG
AAATACGAGACTTAGTAAAAAAGTCAGAAGATTTTGCTAAAAGTAGTAAAGAGCCAGAGATTGATGAGCTGTATACTGAT
GTTTATAAATTTGTTAGCTAA

Upstream 100 bases:

>100_bases
ACGTGAAAAGCTTCAAGCCAGTGATAGTAGTCCATATAGATAGTATTATAAAATGTTAAAGATTTCTGGTATGATCTCAG
TTTAATAAAAGAAAGTCAAT

Downstream 100 bases:

>100_bases
TCAGTTGCCATCAAAATTATGTTTTGGCCTACTATAGATATTTTTTGGCAGCACTTAACTTTATTATATAACAGCCTAGT
CAATAGAAACTGTAGTAACT

Product: pyruvate dehydrogenase complex, E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKAGNFTKEQVIGFYRKMLLIRRFEEKAGQLYGMGLIGGFCHLSIGQEAVAVGTQAASKPGDAFITSYRDHGLMLACNSD
PNVVMAELNGKETGCSKGKGGSMHIFDVEKNFFGGHGIVGAQVPIGTGIAFANKYKKKDNVVFTYFGDGAANQGQVYESF
NMASLWKLPVVYIIENNEYAMGTSVQRSTLVTELYKRGESFGIPGKQVDGMDFFSVYEVTSEIAEHVRGGKGPLLLEMKT
YRYRGHSMSDPATYRTKEEVEDMKQNHDPISNLKQYMKDNKIASDEECKAIDKEIRDLVKKSEDFAKSSKEPEIDELYTD
VYKFVS

Sequences:

>Translated_326_residues
MKAGNFTKEQVIGFYRKMLLIRRFEEKAGQLYGMGLIGGFCHLSIGQEAVAVGTQAASKPGDAFITSYRDHGLMLACNSD
PNVVMAELNGKETGCSKGKGGSMHIFDVEKNFFGGHGIVGAQVPIGTGIAFANKYKKKDNVVFTYFGDGAANQGQVYESF
NMASLWKLPVVYIIENNEYAMGTSVQRSTLVTELYKRGESFGIPGKQVDGMDFFSVYEVTSEIAEHVRGGKGPLLLEMKT
YRYRGHSMSDPATYRTKEEVEDMKQNHDPISNLKQYMKDNKIASDEECKAIDKEIRDLVKKSEDFAKSSKEPEIDELYTD
VYKFVS
>Mature_326_residues
MKAGNFTKEQVIGFYRKMLLIRRFEEKAGQLYGMGLIGGFCHLSIGQEAVAVGTQAASKPGDAFITSYRDHGLMLACNSD
PNVVMAELNGKETGCSKGKGGSMHIFDVEKNFFGGHGIVGAQVPIGTGIAFANKYKKKDNVVFTYFGDGAANQGQVYESF
NMASLWKLPVVYIIENNEYAMGTSVQRSTLVTELYKRGESFGIPGKQVDGMDFFSVYEVTSEIAEHVRGGKGPLLLEMKT
YRYRGHSMSDPATYRTKEEVEDMKQNHDPISNLKQYMKDNKIASDEECKAIDKEIRDLVKKSEDFAKSSKEPEIDELYTD
VYKFVS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=50.314465408805, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=51.2578616352201, Blast_Score=314, Evalue=6e-86,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=51.2578616352201, Blast_Score=314, Evalue=7e-86,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=50.1538461538461, Blast_Score=307, Evalue=8e-84,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=44.9685534591195, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI11386135, Length=320, Percent_Identity=29.6875, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI258645172, Length=325, Percent_Identity=30.1538461538462, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=319, Percent_Identity=49.2163009404389, Blast_Score=319, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17536047, Length=319, Percent_Identity=49.2163009404389, Blast_Score=318, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI86563355, Length=320, Percent_Identity=30, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI86563357, Length=320, Percent_Identity=30, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=49.2163009404389, Blast_Score=315, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=48.4276729559748, Blast_Score=311, Evalue=3e-85,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=48.4276729559748, Blast_Score=311, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=48.4276729559748, Blast_Score=311, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=49.0196078431373, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=46.8553459119497, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI21355903, Length=318, Percent_Identity=28.6163522012579, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36299; Mature: 36299

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAGNFTKEQVIGFYRKMLLIRRFEEKAGQLYGMGLIGGFCHLSIGQEAVAVGTQAASKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHEECCCCHHHHHCCHHCCCC
GDAFITSYRDHGLMLACNSDPNVVMAELNGKETGCSKGKGGSMHIFDVEKNFFGGHGIVG
CCHHEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEE
AQVPIGTGIAFANKYKKKDNVVFTYFGDGAANQGQVYESFNMASLWKLPVVYIIENNEYA
CCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHEECCCEEEEEECCCEE
MGTSVQRSTLVTELYKRGESFGIPGKQVDGMDFFSVYEVTSEIAEHVRGGKGPLLLEMKT
ECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
YRYRGHSMSDPATYRTKEEVEDMKQNHDPISNLKQYMKDNKIASDEECKAIDKEIRDLVK
EEECCCCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KSEDFAKSSKEPEIDELYTDVYKFVS
HHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKAGNFTKEQVIGFYRKMLLIRRFEEKAGQLYGMGLIGGFCHLSIGQEAVAVGTQAASKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHEECCCCHHHHHCCHHCCCC
GDAFITSYRDHGLMLACNSDPNVVMAELNGKETGCSKGKGGSMHIFDVEKNFFGGHGIVG
CCHHEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEE
AQVPIGTGIAFANKYKKKDNVVFTYFGDGAANQGQVYESFNMASLWKLPVVYIIENNEYA
CCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHEECCCEEEEEECCCEE
MGTSVQRSTLVTELYKRGESFGIPGKQVDGMDFFSVYEVTSEIAEHVRGGKGPLLLEMKT
ECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
YRYRGHSMSDPATYRTKEEVEDMKQNHDPISNLKQYMKDNKIASDEECKAIDKEIRDLVK
EEECCCCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KSEDFAKSSKEPEIDELYTDVYKFVS
HHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]