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The map label for this gene is glmS [H]

Identifier: 189424571

GI number: 189424571

Start: 1582413

End: 1584242

Strand: Reverse

Name: glmS [H]

Synonym: Glov_1512

Alternate gene names: 189424571

Gene position: 1584242-1582413 (Counterclockwise)

Preceding gene: 189424599

Following gene: 189424570

Centisome position: 40.44

GC content: 58.63

Gene sequence:

>1830_bases
ATGTGTGGTATTGTTGGTTATATCGGTGAACAAGAGGCAACCTCGATCATTTTTGAGGGACTGCGCAAGCTGGAATACCG
CGGCTATGATTCTGCCGGTATCGCAACACTGCAGCCGGATGGTATTGCGGTGCGTCGCAGTGAAGGCAAGTTGCTTAATC
TGGAGAAACTGCTGCGGGAGCAGCCGCTGGCCGGCTCCATCGGCATCGGCCATACCCGCTGGGCCACCCATGGCCGTCCC
TCCGAGACCAACGCCCATCCCCACCGGGCCGGTTCCATTGTGGTGGTACATAACGGTATTATTGAAAACTACCTTGGCCT
GAAGGAACAGCTGCAGGCAGCAGGACACAAATTTTCCAGCCAGACCGATACCGAGGTGATCGCCCATCTGGTGGAGGAAC
GTCTGAAAACAGCCGGTTCCTTTGAGGTCGCGGTCCGTACCGCCCTGCAGGAGCTGCAGGGGGCCTTTGCGGTCTGCATC
CTCTGCAAGGATCAACCTGATACCCTGATTGCGGCCAAGGTCGGTTCACCGATGGTGGTCGGGCTGGGGCAGGGTGAGTT
TTTTGTCGCCTCCGATATCCCTGCCATCCTGGCCCATACCCGTGAGATGGTCTTCATGGAGGATGGCGAACTGGCGGTCT
TTAACGGCCGGTCAGCCTGTTTCTCCACCATTGCCGGAGCGCCGCTGGAGAAGAAGGCACGGCATATCGACTGGTCGCCC
CTGATGGCGGAAAAGGGGGGCTACAAGCATTTCATGCTGAAGGAGATCCACGAGCAGCCCCGGGCGGTGCGGGATACGAT
TGCCGGGCGTTTGCAGGAGCAGCAGGGGGATGTCTACTTGGAGGACCTGGGCTACGCTGACGCTGCTTTGCAGACCGTGC
AGCGGATGGTCATCGTGGCCTGCGGCACCTCCTGGCATGCTGCCCTGACCGGCAAGTTTCTGATCGAGGGGCATTGCCGT
ATCCCGGTTGAGATCGATATCGCCTCGGAATTCCGCTACCGCAGTCCGGTGATTGATGAGAAAACGCTGGTGATGGTCAT
CTCCCAATCAGGCGAAACCGCCGATACCCTGGCAGCCCTGCGGGAGGCCAAGAAGCTGGGGGCCATGAATCTGGCCATCT
GCAACGTGCTGGATTCCTCCATTGCCCGTGACGCCGCCGGGGTGATCTATACCCATGCCGGTCCTGAGATCGGGGTGGCC
TCCACCAAGGCCTTTGTGACCCAGTTAACCGCGCTCTATCTGTTTACCATCCGTCTTGGCCGGGCCATCGGCCGGTTGAG
TGTGTCAGAGGGGCAGCAGATGATTGCCGATCTGAAGAAGGTGCCGGAACTGCTGGAACAGACCCTGAAACTGAACGGCC
AGACCGAAAAGATCGCCCGCCAGTACATGAACGCCCGCGATTTTCTCTACCTGGGACGGGGCAGGAACTTCCCGATCGCC
TTGGAAGGTGCACTCAAGCTGAAGGAGATCTCCTACATCCACGCGGAAGGGTATCCCGCCGGCGAGATGAAGCATGGTCC
GATCGCCCTGATTGATGAGCATGTGCCGGTGGTGGTGCTGGTGCCGAAGAACAGCACCTACGAAAAGACCGTCTCCAACA
TGGAAGAGGTGATCGCACGAAGCGGCCGGGTGATCGCCCTCTGCAGTGAAGGTGACCATGAGGTGCAGGATAAGGCCGAG
GCAACGCTGGAACTGCCTGAGCTCAGTGACGACCTTGATCCGATCCTGCTGTCGGTACCGTTGCAGTTGTTGGCCTACCA
TATTGCCGTATTAAAAGGTACCGACGTGGATCAACCACGTAATCTTGCCAAGAGTGTGACGGTAGAATAG

Upstream 100 bases:

>100_bases
CAATTCTTAATACCATAAGAAAAGCATAAAGCAAAAAAAAACCGCGACAACCAAACAAACATTTGATTTTATTAACACAA
GGAGCATACCAGTTAATTCT

Downstream 100 bases:

>100_bases
ACGATGCAGTGCTTCTTTGAAGAAAAACTGGAGAACATTTGATGATTTTTCCATATAAACATCCCGCTTGCCAGAACACC
ATCCATACAGTATACAGATA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGYIGEQEATSIIFEGLRKLEYRGYDSAGIATLQPDGIAVRRSEGKLLNLEKLLREQPLAGSIGIGHTRWATHGRP
SETNAHPHRAGSIVVVHNGIIENYLGLKEQLQAAGHKFSSQTDTEVIAHLVEERLKTAGSFEVAVRTALQELQGAFAVCI
LCKDQPDTLIAAKVGSPMVVGLGQGEFFVASDIPAILAHTREMVFMEDGELAVFNGRSACFSTIAGAPLEKKARHIDWSP
LMAEKGGYKHFMLKEIHEQPRAVRDTIAGRLQEQQGDVYLEDLGYADAALQTVQRMVIVACGTSWHAALTGKFLIEGHCR
IPVEIDIASEFRYRSPVIDEKTLVMVISQSGETADTLAALREAKKLGAMNLAICNVLDSSIARDAAGVIYTHAGPEIGVA
STKAFVTQLTALYLFTIRLGRAIGRLSVSEGQQMIADLKKVPELLEQTLKLNGQTEKIARQYMNARDFLYLGRGRNFPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEHVPVVVLVPKNSTYEKTVSNMEEVIARSGRVIALCSEGDHEVQDKAE
ATLELPELSDDLDPILLSVPLQLLAYHIAVLKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGYIGEQEATSIIFEGLRKLEYRGYDSAGIATLQPDGIAVRRSEGKLLNLEKLLREQPLAGSIGIGHTRWATHGRP
SETNAHPHRAGSIVVVHNGIIENYLGLKEQLQAAGHKFSSQTDTEVIAHLVEERLKTAGSFEVAVRTALQELQGAFAVCI
LCKDQPDTLIAAKVGSPMVVGLGQGEFFVASDIPAILAHTREMVFMEDGELAVFNGRSACFSTIAGAPLEKKARHIDWSP
LMAEKGGYKHFMLKEIHEQPRAVRDTIAGRLQEQQGDVYLEDLGYADAALQTVQRMVIVACGTSWHAALTGKFLIEGHCR
IPVEIDIASEFRYRSPVIDEKTLVMVISQSGETADTLAALREAKKLGAMNLAICNVLDSSIARDAAGVIYTHAGPEIGVA
STKAFVTQLTALYLFTIRLGRAIGRLSVSEGQQMIADLKKVPELLEQTLKLNGQTEKIARQYMNARDFLYLGRGRNFPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEHVPVVVLVPKNSTYEKTVSNMEEVIARSGRVIALCSEGDHEVQDKAE
ATLELPELSDDLDPILLSVPLQLLAYHIAVLKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGYIGEQEATSIIFEGLRKLEYRGYDSAGIATLQPDGIAVRRSEGKLLNLEKLLREQPLAGSIGIGHTRWATHGRP
SETNAHPHRAGSIVVVHNGIIENYLGLKEQLQAAGHKFSSQTDTEVIAHLVEERLKTAGSFEVAVRTALQELQGAFAVCI
LCKDQPDTLIAAKVGSPMVVGLGQGEFFVASDIPAILAHTREMVFMEDGELAVFNGRSACFSTIAGAPLEKKARHIDWSP
LMAEKGGYKHFMLKEIHEQPRAVRDTIAGRLQEQQGDVYLEDLGYADAALQTVQRMVIVACGTSWHAALTGKFLIEGHCR
IPVEIDIASEFRYRSPVIDEKTLVMVISQSGETADTLAALREAKKLGAMNLAICNVLDSSIARDAAGVIYTHAGPEIGVA
STKAFVTQLTALYLFTIRLGRAIGRLSVSEGQQMIADLKKVPELLEQTLKLNGQTEKIARQYMNARDFLYLGRGRNFPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEHVPVVVLVPKNSTYEKTVSNMEEVIARSGRVIALCSEGDHEVQDKAE
ATLELPELSDDLDPILLSVPLQLLAYHIAVLKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=36.6959064327485, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=36.0058309037901, Blast_Score=426, Evalue=1e-119,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=49.1830065359477, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=24.1269841269841, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788651, Length=172, Percent_Identity=28.4883720930233, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=441, Percent_Identity=39.6825396825397, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=41.0672853828306, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17532897, Length=441, Percent_Identity=39.6825396825397, Blast_Score=305, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=39.8648648648649, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.9633027522936, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=36.4077669902913, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=38.3941605839416, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66380; Mature: 66380

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGEQEATSIIFEGLRKLEYRGYDSAGIATLQPDGIAVRRSEGKLLNLEKLLRE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEECHHHHHHC
QPLAGSIGIGHTRWATHGRPSETNAHPHRAGSIVVVHNGIIENYLGLKEQLQAAGHKFSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCC
QTDTEVIAHLVEERLKTAGSFEVAVRTALQELQGAFAVCILCKDQPDTLIAAKVGSPMVV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEE
GLGQGEFFVASDIPAILAHTREMVFMEDGELAVFNGRSACFSTIAGAPLEKKARHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEECCCHHHHHHHCCCCHHHHHCCCCCCC
LMAEKGGYKHFMLKEIHEQPRAVRDTIAGRLQEQQGDVYLEDLGYADAALQTVQRMVIVA
HHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHEEEE
CGTSWHAALTGKFLIEGHCRIPVEIDIASEFRYRSPVIDEKTLVMVISQSGETADTLAAL
ECCCCCHHEEEEEEEECCEECEEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
REAKKLGAMNLAICNVLDSSIARDAAGVIYTHAGPEIGVASTKAFVTQLTALYLFTIRLG
HHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RAIGRLSVSEGQQMIADLKKVPELLEQTLKLNGQTEKIARQYMNARDFLYLGRGRNFPIA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEHVPVVVLVPKNSTYEKTVSNMEEVIAR
EECCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
SGRVIALCSEGDHEVQDKAEATLELPELSDDLDPILLSVPLQLLAYHIAVLKGTDVDQPR
CCCEEEEECCCCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGEQEATSIIFEGLRKLEYRGYDSAGIATLQPDGIAVRRSEGKLLNLEKLLRE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCEECHHHHHHC
QPLAGSIGIGHTRWATHGRPSETNAHPHRAGSIVVVHNGIIENYLGLKEQLQAAGHKFSS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCC
QTDTEVIAHLVEERLKTAGSFEVAVRTALQELQGAFAVCILCKDQPDTLIAAKVGSPMVV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEE
GLGQGEFFVASDIPAILAHTREMVFMEDGELAVFNGRSACFSTIAGAPLEKKARHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEECCCHHHHHHHCCCCHHHHHCCCCCCC
LMAEKGGYKHFMLKEIHEQPRAVRDTIAGRLQEQQGDVYLEDLGYADAALQTVQRMVIVA
HHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHEEEE
CGTSWHAALTGKFLIEGHCRIPVEIDIASEFRYRSPVIDEKTLVMVISQSGETADTLAAL
ECCCCCHHEEEEEEEECCEECEEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
REAKKLGAMNLAICNVLDSSIARDAAGVIYTHAGPEIGVASTKAFVTQLTALYLFTIRLG
HHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RAIGRLSVSEGQQMIADLKKVPELLEQTLKLNGQTEKIARQYMNARDFLYLGRGRNFPIA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDEHVPVVVLVPKNSTYEKTVSNMEEVIAR
EECCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
SGRVIALCSEGDHEVQDKAEATLELPELSDDLDPILLSVPLQLLAYHIAVLKGTDVDQPR
CCCEEEEECCCCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA