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The map label for this gene is kbl [C]

Identifier: 189424599

GI number: 189424599

Start: 1620489

End: 1621826

Strand: Reverse

Name: kbl [C]

Synonym: Glov_1540

Alternate gene names: 189424599

Gene position: 1621826-1620489 (Counterclockwise)

Preceding gene: 189424600

Following gene: 189424571

Centisome position: 41.4

GC content: 50.82

Gene sequence:

>1338_bases
ATGCCTCGTAAAGGATTGCACGGACTTACCGCCCAACTTAAAGATGCACTGATTTTGCAGGCTCTTGAGCGGCGGTTACA
AACTGCAGAACGCCAGGAAACCGCTACAAGCGGCAGCACACGACCAGAGTCAGCAACAATTCCTGAAAAATTCTATCGTT
TTCATCTGCATCCCGGTTATCAGCAACTCCGCATAATAAATGATGGCGGTGTCCGTCTTGGCATCAGCAATCCTTTTTTT
AAACTGCATGAAGGTATTGCAGGCGCCACCACGGTTATTAACGGCAAAGAATACATCAACTATTCCAGCTACAACTATCT
TGGGCTTGTGGGCCACCCCGCAGTGGCCGAAGCATCCAAACAGGCGATTGACCAGTACGGCACCTCTGTTTCTGCCAGCC
GCCCCGTATCAGGGGAACGTCCTGTCCACCGGCAACTTGAAAAAGCCCTTGCAGAGACCTATCAGGTTGATGATGCCATT
GCATTTGTCAGTGGTCACGCCACCAACGTATCCACCATCGGTTACCTGTTCGGCCCCAAAGATCTCGTACTCCACGATGA
ACTGATTCACAACAGTATCCTGCAGGGTATACAGCTTTCAGGCGCCAAACGGCTGTCATTTCCCCACAATGATTATACCG
CTCTGGATCAGATCCTGAAAAATCAACGACACCAGTTTGAACGGGTATTGATCGTACTTGAAGGAATCTACAGCATGGAT
GGCGATTATCCCGATCTGCCTGCTTTTGTTGAGATAAAAAAACGCTATTGCGCCTTTTTGATGGTGGATGAAGCCCATTC
GTTCGGCATTATGGGAGAAAAAGGACTTGGCATTCGGGAACATTTTGCTTTGCAGGGGAGCGACGTTGATATCTGGATGG
GGACGTTAAGCAAGGCACTGGCAGGGTGTGGTGGCTATATCGCAGGGGAAACCGCACTGATCGAACATCTCAAGTTCCTT
GCTCCCGGCTTTCTCTACAGTGTCGGCATGCCGCCTTCAGTTGCTGCCTCGTCACTGGCAGCCCTTGAGCTTATACGTCA
AACACCTGAACTTACAGCAACCTTGAAAGCGCGGGGCCAACTTTTTTTAAAACTGGCACAGGAGGCAGGGATCAATACCG
GCAGCAGCGCCGGACTTGCCATCATACCGGCAATTACCGGCAGTTCTCTGAAGGCTGCCCGGCTTGCTGAGGCGCTCTTT
GAGCGTGGCATTAATGTTCAGCCGATCATCTATCCAGCAGTGCCGGAGAAATCTGCACGGCTGCGTTTTTTCATCTCATG
CCTGCATACGGAAGAGCAGATCAGGAAAACCGTTGCCATCCTTGCGGAAGAGATCTGA

Upstream 100 bases:

>100_bases
TCTCAGCATGGCGCAGAGGTCACGGAGGAGATTATTGAGCAGATTGTACATGATGTGTATGCTACTCCAGCAACGGACGA
AAAAAGGATGATCCAGTAAT

Downstream 100 bases:

>100_bases
ACAGGTGACGTTATTCCAGGCTGTTGCCCCGTAGACAAACCCAAAACAACCTTACACCTATTAACCTCCTGCCAGAGCTC
CTCAGCCGCCCCACCAAACC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MPRKGLHGLTAQLKDALILQALERRLQTAERQETATSGSTRPESATIPEKFYRFHLHPGYQQLRIINDGGVRLGISNPFF
KLHEGIAGATTVINGKEYINYSSYNYLGLVGHPAVAEASKQAIDQYGTSVSASRPVSGERPVHRQLEKALAETYQVDDAI
AFVSGHATNVSTIGYLFGPKDLVLHDELIHNSILQGIQLSGAKRLSFPHNDYTALDQILKNQRHQFERVLIVLEGIYSMD
GDYPDLPAFVEIKKRYCAFLMVDEAHSFGIMGEKGLGIREHFALQGSDVDIWMGTLSKALAGCGGYIAGETALIEHLKFL
APGFLYSVGMPPSVAASSLAALELIRQTPELTATLKARGQLFLKLAQEAGINTGSSAGLAIIPAITGSSLKAARLAEALF
ERGINVQPIIYPAVPEKSARLRFFISCLHTEEQIRKTVAILAEEI

Sequences:

>Translated_445_residues
MPRKGLHGLTAQLKDALILQALERRLQTAERQETATSGSTRPESATIPEKFYRFHLHPGYQQLRIINDGGVRLGISNPFF
KLHEGIAGATTVINGKEYINYSSYNYLGLVGHPAVAEASKQAIDQYGTSVSASRPVSGERPVHRQLEKALAETYQVDDAI
AFVSGHATNVSTIGYLFGPKDLVLHDELIHNSILQGIQLSGAKRLSFPHNDYTALDQILKNQRHQFERVLIVLEGIYSMD
GDYPDLPAFVEIKKRYCAFLMVDEAHSFGIMGEKGLGIREHFALQGSDVDIWMGTLSKALAGCGGYIAGETALIEHLKFL
APGFLYSVGMPPSVAASSLAALELIRQTPELTATLKARGQLFLKLAQEAGINTGSSAGLAIIPAITGSSLKAARLAEALF
ERGINVQPIIYPAVPEKSARLRFFISCLHTEEQIRKTVAILAEEI
>Mature_444_residues
PRKGLHGLTAQLKDALILQALERRLQTAERQETATSGSTRPESATIPEKFYRFHLHPGYQQLRIINDGGVRLGISNPFFK
LHEGIAGATTVINGKEYINYSSYNYLGLVGHPAVAEASKQAIDQYGTSVSASRPVSGERPVHRQLEKALAETYQVDDAIA
FVSGHATNVSTIGYLFGPKDLVLHDELIHNSILQGIQLSGAKRLSFPHNDYTALDQILKNQRHQFERVLIVLEGIYSMDG
DYPDLPAFVEIKKRYCAFLMVDEAHSFGIMGEKGLGIREHFALQGSDVDIWMGTLSKALAGCGGYIAGETALIEHLKFLA
PGFLYSVGMPPSVAASSLAALELIRQTPELTATLKARGQLFLKLAQEAGINTGSSAGLAIIPAITGSSLKAARLAEALFE
RGINVQPIIYPAVPEKSARLRFFISCLHTEEQIRKTVAILAEEI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=462, Percent_Identity=31.6017316017316, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=35.1585014409222, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=35.1585014409222, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4758668, Length=456, Percent_Identity=30.0438596491228, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI5454084, Length=388, Percent_Identity=30.1546391752577, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=30.7042253521127, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=30.7042253521127, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=30.7042253521127, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4502025, Length=352, Percent_Identity=28.9772727272727, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI40316939, Length=352, Percent_Identity=28.9772727272727, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=36.2857142857143, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=32.3119777158774, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=353, Percent_Identity=34.8441926345609, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17560914, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=377, Percent_Identity=32.6259946949602, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982625, Length=284, Percent_Identity=31.3380281690141, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71982617, Length=284, Percent_Identity=31.3380281690141, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=33.5227272727273, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320438, Length=356, Percent_Identity=29.7752808988764, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323954, Length=266, Percent_Identity=26.6917293233083, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24662918, Length=349, Percent_Identity=34.9570200573066, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI17136286, Length=352, Percent_Identity=32.3863636363636, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=30.4597701149425, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=27.5510204081633, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=27.5510204081633, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=27.5510204081633, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48549; Mature: 48418

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKGLHGLTAQLKDALILQALERRLQTAERQETATSGSTRPESATIPEKFYRFHLHPGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCC
QQLRIINDGGVRLGISNPFFKLHEGIAGATTVINGKEYINYSSYNYLGLVGHPAVAEASK
EEEEEEECCCEEEECCCCHHHHHCCCCCCEEEECCHHHEEECCCCEEEEECCCHHHHHHH
QAIDQYGTSVSASRPVSGERPVHRQLEKALAETYQVDDAIAFVSGHATNVSTIGYLFGPK
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCC
DLVLHDELIHNSILQGIQLSGAKRLSFPHNDYTALDQILKNQRHQFERVLIVLEGIYSMD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDYPDLPAFVEIKKRYCAFLMVDEAHSFGIMGEKGLGIREHFALQGSDVDIWMGTLSKAL
CCCCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHEECCCCCHHHHHHHHHHH
AGCGGYIAGETALIEHLKFLAPGFLYSVGMPPSVAASSLAALELIRQTPELTATLKARGQ
HCCCCCCCCHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LFLKLAQEAGINTGSSAGLAIIPAITGSSLKAARLAEALFERGINVQPIIYPAVPEKSAR
HHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LRFFISCLHTEEQIRKTVAILAEEI
HHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRKGLHGLTAQLKDALILQALERRLQTAERQETATSGSTRPESATIPEKFYRFHLHPGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCC
QQLRIINDGGVRLGISNPFFKLHEGIAGATTVINGKEYINYSSYNYLGLVGHPAVAEASK
EEEEEEECCCEEEECCCCHHHHHCCCCCCEEEECCHHHEEECCCCEEEEECCCHHHHHHH
QAIDQYGTSVSASRPVSGERPVHRQLEKALAETYQVDDAIAFVSGHATNVSTIGYLFGPK
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEECCC
DLVLHDELIHNSILQGIQLSGAKRLSFPHNDYTALDQILKNQRHQFERVLIVLEGIYSMD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GDYPDLPAFVEIKKRYCAFLMVDEAHSFGIMGEKGLGIREHFALQGSDVDIWMGTLSKAL
CCCCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHEECCCCCHHHHHHHHHHH
AGCGGYIAGETALIEHLKFLAPGFLYSVGMPPSVAASSLAALELIRQTPELTATLKARGQ
HCCCCCCCCHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LFLKLAQEAGINTGSSAGLAIIPAITGSSLKAARLAEALFERGINVQPIIYPAVPEKSAR
HHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LRFFISCLHTEEQIRKTVAILAEEI
HHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA