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The map label for this gene is capL [H]

Identifier: 189424567

GI number: 189424567

Start: 1577921

End: 1579225

Strand: Reverse

Name: capL [H]

Synonym: Glov_1508

Alternate gene names: 189424567

Gene position: 1579225-1577921 (Counterclockwise)

Preceding gene: 189424568

Following gene: 189424566

Centisome position: 40.31

GC content: 55.02

Gene sequence:

>1305_bases
ATGCTTGCACCGCTAGTGGAAAAACTCACCCAAAAAACCGCCACCATCGGTATTGTCGGCCTGGGCTACGTCGGACTGCC
ACTGATGCTGCGCTATACAGAAGTCGGCTACAAGGTACTGGGACTTGATATTGACGCAGCTAAAACTGAGAAGCTCAATC
GCGGCGAGAGTTACATCGAGCATATCCCTGCTTCAGCCATTGCTCAAGCGGTCAGCAATGGCTTTGAGGCCACCACTGAC
TTCTCTCGCAGCAACGAGGCCGATGCCCTGATCGTCTGCGTCCCCACACCGCTCAACAAATACCGCGAGCCCGACCTCAG
TTTCGTTACCGACACCACCGATGCCCTGGTGCCGCACCTGCGGGCAGGCCAGGTGGTTTCACTGGAGAGCACCACTTATC
CCGGCACTACTGATGAAGAGCTCAAGCCGCGTGTTGAGTCCAGGGGACTGGTGGTTGGCAAAGATGTTTTTCTGGTATAT
TCACCAGAGCGGGAAGACCCGGGCAACCCCAACTTCCACACCCGCACCATTCCCAAGGTCTGCGGCGGCTGCACCACGGC
CTGCCAGCAGGCAGGTCTGGCGCTGTATGGCCAGGTGATCGACACGGTCGTACCGGTCAGCAGCACCCGTGTGGCAGAAA
TGACCAAGCTGTTGGAAAACATCCATCGGGCGGTCAATATCGGCCTGGTTAATGAGATGAAGATCGTTGCCGACAAAATG
GGGATTGACATCCATGAAGTCATCCGGGCTGCAGCCACCAAACCGTTCGGGTTTACCGCCTACTACCCCGGCCCCGGCCT
GGGTGGTCACTGTATCCCAATTGACCCGTTCTATTTAACTTGGAAGGCCCGCGAATACGGCCTGCACACCCGCTTTATCG
AACTGGCCGGCGAAGTCAACAGTTCCATGCCGGAATGGGTGTTAACCAAAGTAGCTGAAGGGCTCAACAACCACTGCAAA
TCGATCAAAGGCAGCAAGGTGCTGGTGCTGGGGATCGCCTACAAAAAGAATGTGGACGACATGCGCGAGTCTCCCTCGGT
TGAGATCATGGAACAACTGCGGGATAAAGGCGCGCTTATCTCCTACGCCGACCCCCACGTGCCGGTCTTTCCCCAGATGC
GGGAACACCGCTTTGAGCTCTCCAGTGTTGACGTAACCGAACAATCGCTAAAAGGGTATGATTGTGTTATTGTGGCTACC
AACCATGACAAGTTTGATTATGCATTAATCAAACAACATGCGGCCTTGATTGTCGATACCCGTGGGGTTTACCTGGAACC
GGCAGAGAATATCATAAAAGCGTAA

Upstream 100 bases:

>100_bases
GTCTTTCGGGTAATGATCTGATCTTCACATTTTTTATACGCTGCGTCGTCGCGCCGTTGCGTAAAATGTTTTTTAGAGGA
CAACAGGAAGGAAACGAGTA

Downstream 100 bases:

>100_bases
AGGCAGTCTCGCACAGAGGCGCGGAGTTGCACAGAGAAAGTCAAAAATGTTAGAAGCATGATAGGTTCTTTTTTGTCATT
ATTATCATTAGGTAATCAGG

Product: nucleotide sugar dehydrogenase

Products: UDP-glucuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLAPLVEKLTQKTATIGIVGLGYVGLPLMLRYTEVGYKVLGLDIDAAKTEKLNRGESYIEHIPASAIAQAVSNGFEATTD
FSRSNEADALIVCVPTPLNKYREPDLSFVTDTTDALVPHLRAGQVVSLESTTYPGTTDEELKPRVESRGLVVGKDVFLVY
SPEREDPGNPNFHTRTIPKVCGGCTTACQQAGLALYGQVIDTVVPVSSTRVAEMTKLLENIHRAVNIGLVNEMKIVADKM
GIDIHEVIRAAATKPFGFTAYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELAGEVNSSMPEWVLTKVAEGLNNHCK
SIKGSKVLVLGIAYKKNVDDMRESPSVEIMEQLRDKGALISYADPHVPVFPQMREHRFELSSVDVTEQSLKGYDCVIVAT
NHDKFDYALIKQHAALIVDTRGVYLEPAENIIKA

Sequences:

>Translated_434_residues
MLAPLVEKLTQKTATIGIVGLGYVGLPLMLRYTEVGYKVLGLDIDAAKTEKLNRGESYIEHIPASAIAQAVSNGFEATTD
FSRSNEADALIVCVPTPLNKYREPDLSFVTDTTDALVPHLRAGQVVSLESTTYPGTTDEELKPRVESRGLVVGKDVFLVY
SPEREDPGNPNFHTRTIPKVCGGCTTACQQAGLALYGQVIDTVVPVSSTRVAEMTKLLENIHRAVNIGLVNEMKIVADKM
GIDIHEVIRAAATKPFGFTAYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELAGEVNSSMPEWVLTKVAEGLNNHCK
SIKGSKVLVLGIAYKKNVDDMRESPSVEIMEQLRDKGALISYADPHVPVFPQMREHRFELSSVDVTEQSLKGYDCVIVAT
NHDKFDYALIKQHAALIVDTRGVYLEPAENIIKA
>Mature_434_residues
MLAPLVEKLTQKTATIGIVGLGYVGLPLMLRYTEVGYKVLGLDIDAAKTEKLNRGESYIEHIPASAIAQAVSNGFEATTD
FSRSNEADALIVCVPTPLNKYREPDLSFVTDTTDALVPHLRAGQVVSLESTTYPGTTDEELKPRVESRGLVVGKDVFLVY
SPEREDPGNPNFHTRTIPKVCGGCTTACQQAGLALYGQVIDTVVPVSSTRVAEMTKLLENIHRAVNIGLVNEMKIVADKM
GIDIHEVIRAAATKPFGFTAYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELAGEVNSSMPEWVLTKVAEGLNNHCK
SIKGSKVLVLGIAYKKNVDDMRESPSVEIMEQLRDKGALISYADPHVPVFPQMREHRFELSSVDVTEQSLKGYDCVIVAT
NHDKFDYALIKQHAALIVDTRGVYLEPAENIIKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=455, Percent_Identity=24.1758241758242, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI296040438, Length=364, Percent_Identity=24.7252747252747, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=427, Percent_Identity=33.2552693208431, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=23.0263157894737, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.22

Molecular weight: Translated: 47616; Mature: 47616

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00720 RASGEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAPLVEKLTQKTATIGIVGLGYVGLPLMLRYTEVGYKVLGLDIDAAKTEKLNRGESYIE
CCCHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCHHHHH
HIPASAIAQAVSNGFEATTDFSRSNEADALIVCVPTPLNKYREPDLSFVTDTTDALVPHL
HCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCEEEECCHHHHHCCC
RAGQVVSLESTTYPGTTDEELKPRVESRGLVVGKDVFLVYSPEREDPGNPNFHTRTIPKV
CCCCEEEEECCCCCCCCCHHHCCHHHHCCEEEECEEEEEECCCCCCCCCCCCCCCCHHHH
CGGCTTACQQAGLALYGQVIDTVVPVSSTRVAEMTKLLENIHRAVNIGLVNEMKIVADKM
HCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GIDIHEVIRAAATKPFGFTAYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELAGEVN
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHHC
SSMPEWVLTKVAEGLNNHCKSIKGSKVLVLGIAYKKNVDDMRESPSVEIMEQLRDKGALI
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHHHCCCEE
SYADPHVPVFPQMREHRFELSSVDVTEQSLKGYDCVIVATNHDKFDYALIKQHAALIVDT
EECCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHCCEEEEEC
RGVYLEPAENIIKA
CCEEECCHHHHHCC
>Mature Secondary Structure
MLAPLVEKLTQKTATIGIVGLGYVGLPLMLRYTEVGYKVLGLDIDAAKTEKLNRGESYIE
CCCHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCHHHHH
HIPASAIAQAVSNGFEATTDFSRSNEADALIVCVPTPLNKYREPDLSFVTDTTDALVPHL
HCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCEEEECCHHHHHCCC
RAGQVVSLESTTYPGTTDEELKPRVESRGLVVGKDVFLVYSPEREDPGNPNFHTRTIPKV
CCCCEEEEECCCCCCCCCHHHCCHHHHCCEEEECEEEEEECCCCCCCCCCCCCCCCHHHH
CGGCTTACQQAGLALYGQVIDTVVPVSSTRVAEMTKLLENIHRAVNIGLVNEMKIVADKM
HCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GIDIHEVIRAAATKPFGFTAYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELAGEVN
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCEEEEEECHHHCCHHHHHHHHHHHC
SSMPEWVLTKVAEGLNNHCKSIKGSKVLVLGIAYKKNVDDMRESPSVEIMEQLRDKGALI
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHHHCCCEE
SYADPHVPVFPQMREHRFELSSVDVTEQSLKGYDCVIVATNHDKFDYALIKQHAALIVDT
EECCCCCCCCCCHHHHCCCCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHCCEEEEEC
RGVYLEPAENIIKA
CCEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose; NAD+; H2O

Specific reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]