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The map label for this gene is fcl [H]

Identifier: 189424551

GI number: 189424551

Start: 1558742

End: 1559011

Strand: Reverse

Name: fcl [H]

Synonym: Glov_1490

Alternate gene names: 189424551

Gene position: 1559011-1558742 (Counterclockwise)

Preceding gene: 189424552

Following gene: 189424550

Centisome position: 39.79

GC content: 50.37

Gene sequence:

>270_bases
ATGAATAAGACTACAAAAATATTCATCGCCGGTTCCAAAGGGCTGGTAGGCTCTGCTCTTGTACGGTGCCTGCAAGCGGC
CAGCTACTTGAACCTGCTTACCCCTGAAATGGATAAACTGGACCTTACCAACCAGCAGGCAGTGGCAAAATTCTTTGCCC
AAGAAAAACCGGAGTATGTCTTTCTGGCAGCGGCCAAGGTGAGGGGCATCCACGCCAACAACACCTATCCGGCTGAGTTC
ATCTACACCAACCTGGCAATCCAAAACTGA

Upstream 100 bases:

>100_bases
AGCTTTAAGGAACTGGTTGCCGAAATGGTTCGTGAAGATCTGAAGGCGGCTGAACGGGATGAACTGGTCAAAAAGCACGG
CTACCGGGCGTTTGACTATA

Downstream 100 bases:

>100_bases
AGTGGTTGCGGTTTTTGAGACATGAGTATAAGCAATGAACCGATCCCTTTGAAAGGAGAGGTCCCATGCGGCACCGCAAC
CGTTACAGTTTAGAATTCAA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 89; Mature: 89

Protein sequence:

>89_residues
MNKTTKIFIAGSKGLVGSALVRCLQAASYLNLLTPEMDKLDLTNQQAVAKFFAQEKPEYVFLAAAKVRGIHANNTYPAEF
IYTNLAIQN

Sequences:

>Translated_89_residues
MNKTTKIFIAGSKGLVGSALVRCLQAASYLNLLTPEMDKLDLTNQQAVAKFFAQEKPEYVFLAAAKVRGIHANNTYPAEF
IYTNLAIQN
>Mature_89_residues
MNKTTKIFIAGSKGLVGSALVRCLQAASYLNLLTPEMDKLDLTNQQAVAKFFAQEKPEYVFLAAAKVRGIHANNTYPAEF
IYTNLAIQN

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Escherichia coli, GI1788365, Length=84, Percent_Identity=50, Blast_Score=87, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 9809; Mature: 9809

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTTKIFIAGSKGLVGSALVRCLQAASYLNLLTPEMDKLDLTNQQAVAKFFAQEKPEYV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
FLAAAKVRGIHANNTYPAEFIYTNLAIQN
EEEEEEECEEECCCCCCHHEEEEEEEECC
>Mature Secondary Structure
MNKTTKIFIAGSKGLVGSALVRCLQAASYLNLLTPEMDKLDLTNQQAVAKFFAQEKPEYV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
FLAAAKVRGIHANNTYPAEFIYTNLAIQN
EEEEEEECEEECCCCCCHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]