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The map label for this gene is nhaA [H]

Identifier: 189424454

GI number: 189424454

Start: 1426430

End: 1427605

Strand: Reverse

Name: nhaA [H]

Synonym: Glov_1390

Alternate gene names: 189424454

Gene position: 1427605-1426430 (Counterclockwise)

Preceding gene: 189424458

Following gene: 189424453

Centisome position: 36.44

GC content: 56.63

Gene sequence:

>1176_bases
ATGCAACGACTCAAGGAATTTTACGAACAAGAATCATTCACCGGCATCCTGTTGATGCTGGTCACAATAGCGGCCCTGCT
GCTGAAAAACTCTCCCCTTGCCGAGGTCTACAACAGTTTTCTGCACACACCGGTAGCTGTTCAGTTCGGGGCCTTGAAGA
TTGCCAAGCCACTGCTGCTCTGGATCAATGACGGCCTGATGGCTGTTTTCTTCCTGCTGGTGGGGCTTGAGGTCAAGCGC
GAACTGATCCGGGGCAACCTCTCTTCCTGGAATCAAGCGGCCCTGCCGGTCATTGCCGCCATTGGCGGTATGCTGGTGCC
GGCCCTGATCTATGTCGGCTTCAATCACCAAGAACCAGCATCCCTGCATGGCTGGGCCATCCCCACGGCAACCGACATCG
CCTTTGCCCTGGGTATCCTGTCGTTATTGGGTAACCGGGTGCCGGCTTCATTGAAGATATTCCTGCTGGCGCTGGCAATT
ATTGACGATCTGGGCGCCATTGTGATCATCGCCCTCTTCTATACCTCTGACCTATCACTGGCTTCCATTGCCGTTGCCTC
AGTCACCTTGCTGGCCCTGTTTGCACTCAACCGCTTTGGCGTAGAACGCAGGGCGGCCTATATCCTTTTGGGTGCCGTAC
TATGGGTCAGTGTGCTGAAATCCGGTGTCCACGCCACCCTGGCCGGCGTGGCACTGGCCTTCATGATTCCCCTTGAGACC
CGTAGCGCAAAAACAGGCAAAAAGGCCCTGGCTGCCCAACTGGAACATGATCTGCACCCGTGGGTTTCGTTTATGATCCT
GCCGCTGTTCGCCTTTGTGAATGCCGGGATTGACCTGCGCGGCCTGTCGCTGAACCAGCTGGCCACCCCGGTGCCGCTGG
GGATCATGCTGGGGCTGTTCATTGGCAAGCAGGTCGGGGTCTTCGGGTTCAGCTGGCTTGCCATCAAAAGCGGGCTGGCA
CGCCTGCCGGCAACCAGTAACTGGCGCCAGCTGTATGGTGTCTGCCTGATGACCGGCATCGGCTTTACCATGAGCCTTTT
CATAGACTCACTGGCCTTTACTGACGATGCTATCTACCAGTACGCAGATAAACTGGCGATTGTGCTGGGATCACTGTTAT
CCGGCGTAGCGGGCTACCTTGTGCTGCGTTTTGGACCTTCAACACGTCAGACCTGA

Upstream 100 bases:

>100_bases
TATTTCATTTCTATCTGAGGTACCACACATCAAGACGTTGTCAAGGCGGGCCACTGAACTTATACTGCGTGCATTCAGCA
TCAATTCTGTCGGGGGAATC

Downstream 100 bases:

>100_bases
CCACCGGGGCTTGACGCCCAGTCGTCGCTATGGTATTGAGCAAACCTTCAAAATTCAACGGGTTACAAAACAAATTAATT
GCCCACACAAAACAAAAGTT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQRLKEFYEQESFTGILLMLVTIAALLLKNSPLAEVYNSFLHTPVAVQFGALKIAKPLLLWINDGLMAVFFLLVGLEVKR
ELIRGNLSSWNQAALPVIAAIGGMLVPALIYVGFNHQEPASLHGWAIPTATDIAFALGILSLLGNRVPASLKIFLLALAI
IDDLGAIVIIALFYTSDLSLASIAVASVTLLALFALNRFGVERRAAYILLGAVLWVSVLKSGVHATLAGVALAFMIPLET
RSAKTGKKALAAQLEHDLHPWVSFMILPLFAFVNAGIDLRGLSLNQLATPVPLGIMLGLFIGKQVGVFGFSWLAIKSGLA
RLPATSNWRQLYGVCLMTGIGFTMSLFIDSLAFTDDAIYQYADKLAIVLGSLLSGVAGYLVLRFGPSTRQT

Sequences:

>Translated_391_residues
MQRLKEFYEQESFTGILLMLVTIAALLLKNSPLAEVYNSFLHTPVAVQFGALKIAKPLLLWINDGLMAVFFLLVGLEVKR
ELIRGNLSSWNQAALPVIAAIGGMLVPALIYVGFNHQEPASLHGWAIPTATDIAFALGILSLLGNRVPASLKIFLLALAI
IDDLGAIVIIALFYTSDLSLASIAVASVTLLALFALNRFGVERRAAYILLGAVLWVSVLKSGVHATLAGVALAFMIPLET
RSAKTGKKALAAQLEHDLHPWVSFMILPLFAFVNAGIDLRGLSLNQLATPVPLGIMLGLFIGKQVGVFGFSWLAIKSGLA
RLPATSNWRQLYGVCLMTGIGFTMSLFIDSLAFTDDAIYQYADKLAIVLGSLLSGVAGYLVLRFGPSTRQT
>Mature_391_residues
MQRLKEFYEQESFTGILLMLVTIAALLLKNSPLAEVYNSFLHTPVAVQFGALKIAKPLLLWINDGLMAVFFLLVGLEVKR
ELIRGNLSSWNQAALPVIAAIGGMLVPALIYVGFNHQEPASLHGWAIPTATDIAFALGILSLLGNRVPASLKIFLLALAI
IDDLGAIVIIALFYTSDLSLASIAVASVTLLALFALNRFGVERRAAYILLGAVLWVSVLKSGVHATLAGVALAFMIPLET
RSAKTGKKALAAQLEHDLHPWVSFMILPLFAFVNAGIDLRGLSLNQLATPVPLGIMLGLFIGKQVGVFGFSWLAIKSGLA
RLPATSNWRQLYGVCLMTGIGFTMSLFIDSLAFTDDAIYQYADKLAIVLGSLLSGVAGYLVLRFGPSTRQT

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=392, Percent_Identity=55.6122448979592, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42053; Mature: 42053

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLKEFYEQESFTGILLMLVTIAALLLKNSPLAEVYNSFLHTPVAVQFGALKIAKPLLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WINDGLMAVFFLLVGLEVKRELIRGNLSSWNQAALPVIAAIGGMLVPALIYVGFNHQEPA
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SLHGWAIPTATDIAFALGILSLLGNRVPASLKIFLLALAIIDDLGAIVIIALFYTSDLSL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ASIAVASVTLLALFALNRFGVERRAAYILLGAVLWVSVLKSGVHATLAGVALAFMIPLET
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RSAKTGKKALAAQLEHDLHPWVSFMILPLFAFVNAGIDLRGLSLNQLATPVPLGIMLGLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCHHHHHHHHH
IGKQVGVFGFSWLAIKSGLARLPATSNWRQLYGVCLMTGIGFTMSLFIDSLAFTDDAIYQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADKLAIVLGSLLSGVAGYLVLRFGPSTRQT
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MQRLKEFYEQESFTGILLMLVTIAALLLKNSPLAEVYNSFLHTPVAVQFGALKIAKPLLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WINDGLMAVFFLLVGLEVKRELIRGNLSSWNQAALPVIAAIGGMLVPALIYVGFNHQEPA
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SLHGWAIPTATDIAFALGILSLLGNRVPASLKIFLLALAIIDDLGAIVIIALFYTSDLSL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ASIAVASVTLLALFALNRFGVERRAAYILLGAVLWVSVLKSGVHATLAGVALAFMIPLET
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RSAKTGKKALAAQLEHDLHPWVSFMILPLFAFVNAGIDLRGLSLNQLATPVPLGIMLGLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHCCCCHHHHHHHHH
IGKQVGVFGFSWLAIKSGLARLPATSNWRQLYGVCLMTGIGFTMSLFIDSLAFTDDAIYQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADKLAIVLGSLLSGVAGYLVLRFGPSTRQT
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA