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The map label for this gene is maeB [H]

Identifier: 189424327

GI number: 189424327

Start: 1309950

End: 1312208

Strand: Reverse

Name: maeB [H]

Synonym: Glov_1262

Alternate gene names: 189424327

Gene position: 1312208-1309950 (Counterclockwise)

Preceding gene: 189424336

Following gene: 189424326

Centisome position: 33.49

GC content: 55.95

Gene sequence:

>2259_bases
ATGGCAAAGATCAAGGACGCTCTTGAGTACCATTCAATGGGTCGTAAAGGAAAAATTGAGGTTATCTCAACCAAACCGTG
TCAAACTGCAGCAGACCTCTCGCTGGCCTATTCTCCGGGTGTGGCTGAGCCCTGCCTGGCAATAGAAAAAAATCCGGATG
ATGCCTACAAGTACACCGCCAAAGGAAACCTGGTGGCCGTTGTCTCCAACGGTACTGCCGTCCTGGGCCTCGGCAATCTG
GGTGCGCTGGCCGGCAAGCCGGTCATGGAAGGCAAAGGGATTCTTTTCAAGCGTTTTGCCGATATCGACGTCTTTGACAT
CGAGCTTGACACCGAAAATCCGGACGAGATCATCAAGGCCTGCCAGCTGCTGGAGCCGACCTTTGGCGGTATCAACCTGG
AAGATATCAAGGCACCAGAATGTTTCTACATTGAAGAAGAGCTGAAAAAGACCATGAAGATCCCGGTCTTCCACGATGAC
CAGCATGGCACCGCCATCATTTCATCGGCAGCCCTGCTCAACGCACTGGAGCTGGTTGGCAAGAATATTGAGGATATCAG
GATCGTGGTGAACGGTGCCGGTGCTTCTGCCAACTCCTGCGCCAAGCTGGCGATTGCCCTGGGAGTCAAGCCGAACAACA
TGATCATGTGCGACACCAAGGGGGTCATTTATAAGGGAAGGGTTGAGGGGATGAACCCCTACAAGGCACTGTTTGCGGCT
GACACTCCTTTCCGCACCTTGGAGGAGGCTGCCAGGGGGGCTGACGTCCTGTTCGGTCTTTCCGCCAAAGGGGCCTTCAC
TGCCGACATGGTGCGCAGCATGGCCCCCAACCCGATCATCTTCGCCATGGCCAACCCGGACCCGGAGATTACCCCCGACG
AGGCCCGCGCAGCCAGAGGCGATGTGATCATTGCCACCGGACGTTCCGACTATCCCAATCAGGTCAATAACGTGCTGGGC
TTCCCCTTTATCTTCCGTGGCGCCCTGGATGTACGGGCCAGCTGCATCAATGAAGAGATGAAGCTGGCAGCGGTCAAGGC
CCTGGCCAAGCTGGCCCGTGAAGAAGTACCCGACTCGGTCAGCAAGGCCTACGGCAACGTCAAGTTTTCATTCGGCAGGG
AGTACATCATCCCCAAACCGTTTGACCCGCGGGTACTGCTGCATGTTGCCCCGGCCATTGCCCAGGCAGCCATGGACAGC
GGTGTTGCCCGGCAACCTATCGAGGATATGGAAAAGTATATCGAACACCTCGAATCGACCCAGGGCAAGTCAAAAGAGAT
CATGCGCTACATCATCAACAAGGCCAAGACCGACCCGAAACGGGTTGCCTTCCCTGAAGGAGACAACGAGAAGATGCTGC
GGGCGGCCCAGATTCTTGTGGATGAAGGAATCGCCAAGCCGATCCTGATCGGTAACAGCATCAAGATCCGCAACAAAATC
GACGAACTGGGACTCAATCTGGATGACGTGCAGATCGTTGATACTGAGCACTCAAAGTTTACCGAGCCCTATGCTCAGGA
GCTTTACCGCCTCAGACAGCGCAAAGGGATCACCGAGACCGAGGCTGGACGGATCATCCGCCGTAAATCCCGCAACCATT
TCGGCGCCATGATGGTCAGAATGGGTGACGCCGACGCCATGCTGTCCGGTATTGACGCCCACTACCCGGAGACTATCCGC
CCGGCACTGGAAGTTGTCGGAAAACAGCCGAATCTGACCTCGGTGCACGGCATGTACATGATGGTCTTCAAGAAGGGTGT
CTACTTCATGGCCGACACCACGGTTGAAATCGACCCGTCTGCTGAAGAACTGGCTGAAACAGCCATACTGGCAGCTCAAA
ACGTCAAGGTGTTTGACATTGACCCACGGGTGGCCATGCTCTCTTTCTCAAACTTCGGCTCAGTCCGCCACCCCCTCTCA
GACAAGGTGCGGCGTGCCGTTGAGATCGTCAAGGAGCGGGAGCCGGATCTGATTATCGATGGGGAAATGCAGGCCGATAC
GGCAGTGGTACAGGAGCTGCTGGATCACTTCAAATTCTCCAAACTGAAGAACACGGCCAATGTCCTGATCTTTCCTGACC
TCAACTCAGGCAACATCGCCTATAAACTGTTGGCCCGCCTGGGGGGGGCTGAGGCGATCGGACCGATCCTGATGGGGATG
CAGAAGCCGGTCCATGTCCTCCAGCGGGGTGATGACGTCAGTGACATCGTCAACATGGCTGCCATCGCCGTAGTAGATGC
ACAGGGTCGCAACAGCTGA

Upstream 100 bases:

>100_bases
CATATATGTCTTTAGTCATAATAAACACAAGCCAGTGTAATCAGGACATTATTAACTATTTTTTTATCATCACTAAATTA
ATTCTGGAGGAATGTCGACC

Downstream 100 bases:

>100_bases
CACACCAGCAGTCCGTATGCCGGGGCTGTCCGTCATACGGACTGCCCCGGCAGCAGATTCCCCTGATGTCCAAACATTCT
TTTGACATTCAGCAATGCCT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MAKIKDALEYHSMGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIEKNPDDAYKYTAKGNLVAVVSNGTAVLGLGNL
GALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMKIPVFHDD
QHGTAIISSAALLNALELVGKNIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKALFAA
DTPFRTLEEAARGADVLFGLSAKGAFTADMVRSMAPNPIIFAMANPDPEITPDEARAARGDVIIATGRSDYPNQVNNVLG
FPFIFRGALDVRASCINEEMKLAAVKALAKLAREEVPDSVSKAYGNVKFSFGREYIIPKPFDPRVLLHVAPAIAQAAMDS
GVARQPIEDMEKYIEHLESTQGKSKEIMRYIINKAKTDPKRVAFPEGDNEKMLRAAQILVDEGIAKPILIGNSIKIRNKI
DELGLNLDDVQIVDTEHSKFTEPYAQELYRLRQRKGITETEAGRIIRRKSRNHFGAMMVRMGDADAMLSGIDAHYPETIR
PALEVVGKQPNLTSVHGMYMMVFKKGVYFMADTTVEIDPSAEELAETAILAAQNVKVFDIDPRVAMLSFSNFGSVRHPLS
DKVRRAVEIVKEREPDLIIDGEMQADTAVVQELLDHFKFSKLKNTANVLIFPDLNSGNIAYKLLARLGGAEAIGPILMGM
QKPVHVLQRGDDVSDIVNMAAIAVVDAQGRNS

Sequences:

>Translated_752_residues
MAKIKDALEYHSMGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIEKNPDDAYKYTAKGNLVAVVSNGTAVLGLGNL
GALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMKIPVFHDD
QHGTAIISSAALLNALELVGKNIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKALFAA
DTPFRTLEEAARGADVLFGLSAKGAFTADMVRSMAPNPIIFAMANPDPEITPDEARAARGDVIIATGRSDYPNQVNNVLG
FPFIFRGALDVRASCINEEMKLAAVKALAKLAREEVPDSVSKAYGNVKFSFGREYIIPKPFDPRVLLHVAPAIAQAAMDS
GVARQPIEDMEKYIEHLESTQGKSKEIMRYIINKAKTDPKRVAFPEGDNEKMLRAAQILVDEGIAKPILIGNSIKIRNKI
DELGLNLDDVQIVDTEHSKFTEPYAQELYRLRQRKGITETEAGRIIRRKSRNHFGAMMVRMGDADAMLSGIDAHYPETIR
PALEVVGKQPNLTSVHGMYMMVFKKGVYFMADTTVEIDPSAEELAETAILAAQNVKVFDIDPRVAMLSFSNFGSVRHPLS
DKVRRAVEIVKEREPDLIIDGEMQADTAVVQELLDHFKFSKLKNTANVLIFPDLNSGNIAYKLLARLGGAEAIGPILMGM
QKPVHVLQRGDDVSDIVNMAAIAVVDAQGRNS
>Mature_751_residues
AKIKDALEYHSMGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIEKNPDDAYKYTAKGNLVAVVSNGTAVLGLGNLG
ALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKACQLLEPTFGGINLEDIKAPECFYIEEELKKTMKIPVFHDDQ
HGTAIISSAALLNALELVGKNIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKALFAAD
TPFRTLEEAARGADVLFGLSAKGAFTADMVRSMAPNPIIFAMANPDPEITPDEARAARGDVIIATGRSDYPNQVNNVLGF
PFIFRGALDVRASCINEEMKLAAVKALAKLAREEVPDSVSKAYGNVKFSFGREYIIPKPFDPRVLLHVAPAIAQAAMDSG
VARQPIEDMEKYIEHLESTQGKSKEIMRYIINKAKTDPKRVAFPEGDNEKMLRAAQILVDEGIAKPILIGNSIKIRNKID
ELGLNLDDVQIVDTEHSKFTEPYAQELYRLRQRKGITETEAGRIIRRKSRNHFGAMMVRMGDADAMLSGIDAHYPETIRP
ALEVVGKQPNLTSVHGMYMMVFKKGVYFMADTTVEIDPSAEELAETAILAAQNVKVFDIDPRVAMLSFSNFGSVRHPLSD
KVRRAVEIVKEREPDLIIDGEMQADTAVVQELLDHFKFSKLKNTANVLIFPDLNSGNIAYKLLARLGGAEAIGPILMGMQ
KPVHVLQRGDDVSDIVNMAAIAVVDAQGRNS

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=349, Percent_Identity=28.9398280802292, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI62420880, Length=349, Percent_Identity=28.9398280802292, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI239049447, Length=349, Percent_Identity=28.9398280802292, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI4505145, Length=353, Percent_Identity=27.7620396600567, Blast_Score=71, Evalue=5e-12,
Organism=Homo sapiens, GI4505143, Length=347, Percent_Identity=25.3602305475504, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1788806, Length=751, Percent_Identity=53.2623169107856, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=36.7052023121387, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=35.8730158730159, Blast_Score=199, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17537199, Length=425, Percent_Identity=25.1764705882353, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=27.9850746268657, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=30.3724928366762, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646386, Length=349, Percent_Identity=30.3724928366762, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356279, Length=464, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362672, Length=464, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281362674, Length=464, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI78707242, Length=409, Percent_Identity=26.8948655256724, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI78707238, Length=409, Percent_Identity=26.8948655256724, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI78707240, Length=347, Percent_Identity=27.6657060518732, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82089; Mature: 81958

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKDALEYHSMGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIEKNPDDAYKYTA
CCCHHHHHHHHHCCCCCCEEEEECCCCCCHHCCEEEECCCCCCCCEEEECCCCHHEEEEE
KGNLVAVVSNGTAVLGLGNLGALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKA
CCCEEEEEECCEEEEEECCCCHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEELKKTMKIPVFHDDQHGTAIISSAALLNALELVG
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHC
KNIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKALFAA
CCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEECCCCCCCHHHHEEEC
DTPFRTLEEAARGADVLFGLSAKGAFTADMVRSMAPNPIIFAMANPDPEITPDEARAARG
CCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCC
DVIIATGRSDYPNQVNNVLGFPFIFRGALDVRASCINEEMKLAAVKALAKLAREEVPDSV
CEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SKAYGNVKFSFGREYIIPKPFDPRVLLHVAPAIAQAAMDSGVARQPIEDMEKYIEHLEST
HHHHCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QGKSKEIMRYIINKAKTDPKRVAFPEGDNEKMLRAAQILVDEGIAKPILIGNSIKIRNKI
CCCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECHHH
DELGLNLDDVQIVDTEHSKFTEPYAQELYRLRQRKGITETEAGRIIRRKSRNHFGAMMVR
HHHCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEE
MGDADAMLSGIDAHYPETIRPALEVVGKQPNLTSVHGMYMMVFKKGVYFMADTTVEIDPS
ECCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECEEEECCC
AEELAETAILAAQNVKVFDIDPRVAMLSFSNFGSVRHPLSDKVRRAVEIVKEREPDLIID
HHHHHHHHHHEECCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GEMQADTAVVQELLDHFKFSKLKNTANVLIFPDLNSGNIAYKLLARLGGAEAIGPILMGM
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCC
QKPVHVLQRGDDVSDIVNMAAIAVVDAQGRNS
HHHHHHHHCCCCHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure 
AKIKDALEYHSMGRKGKIEVISTKPCQTAADLSLAYSPGVAEPCLAIEKNPDDAYKYTA
CCHHHHHHHHHCCCCCCEEEEECCCCCCHHCCEEEECCCCCCCCEEEECCCCHHEEEEE
KGNLVAVVSNGTAVLGLGNLGALAGKPVMEGKGILFKRFADIDVFDIELDTENPDEIIKA
CCCEEEEEECCEEEEEECCCCHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHH
CQLLEPTFGGINLEDIKAPECFYIEEELKKTMKIPVFHDDQHGTAIISSAALLNALELVG
HHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHC
KNIEDIRIVVNGAGASANSCAKLAIALGVKPNNMIMCDTKGVIYKGRVEGMNPYKALFAA
CCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEECCCCCCCHHHHEEEC
DTPFRTLEEAARGADVLFGLSAKGAFTADMVRSMAPNPIIFAMANPDPEITPDEARAARG
CCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCC
DVIIATGRSDYPNQVNNVLGFPFIFRGALDVRASCINEEMKLAAVKALAKLAREEVPDSV
CEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SKAYGNVKFSFGREYIIPKPFDPRVLLHVAPAIAQAAMDSGVARQPIEDMEKYIEHLEST
HHHHCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
QGKSKEIMRYIINKAKTDPKRVAFPEGDNEKMLRAAQILVDEGIAKPILIGNSIKIRNKI
CCCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECHHH
DELGLNLDDVQIVDTEHSKFTEPYAQELYRLRQRKGITETEAGRIIRRKSRNHFGAMMVR
HHHCCCCCCEEEEECCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEE
MGDADAMLSGIDAHYPETIRPALEVVGKQPNLTSVHGMYMMVFKKGVYFMADTTVEIDPS
ECCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECEEEECCC
AEELAETAILAAQNVKVFDIDPRVAMLSFSNFGSVRHPLSDKVRRAVEIVKEREPDLIID
HHHHHHHHHHEECCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEC
GEMQADTAVVQELLDHFKFSKLKNTANVLIFPDLNSGNIAYKLLARLGGAEAIGPILMGM
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCC
QKPVHVLQRGDDVSDIVNMAAIAVVDAQGRNS
HHHHHHHHCCCCHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]