Click here to switch to the map view.

The map label for this gene is trpF

Identifier: 189424277

GI number: 189424277

Start: 1258367

End: 1258984

Strand: Reverse

Name: trpF

Synonym: Glov_1212

Alternate gene names: 189424277

Gene position: 1258984-1258367 (Counterclockwise)

Preceding gene: 189424278

Following gene: 189424276

Centisome position: 32.14

GC content: 58.25

Gene sequence:

>618_bases
ATGATCAAAGTAAAAATCTGTGGCATAACCAGCCCCGAGGATGCCCTGACCGCCGTTGAAGCGGGCGCGGATGCCTTGGG
GTTTGTCTTTTACAAGGAATCCCCCCGCCATATCTTCCCTGAAGAGGCGGCCCGGATCATCAACCTGCTGCCCCCCTTTG
TGCAGGCAGTGGGGCTGTTCGTGAACGAGGCGCCGGAAATCGTCAACCAGGTCAGCCGCAACTGCAGGCTGGGACTGGTG
CAGTTGCATGGCGACGAGACACCGGACTACTGCAGAAAGATTGAGCAGCGGGTCATGAAGGCCTTTCGGGTCCGTTCCCT
GACCTGTCTTGATCCGATCGCCGACTACCGTATGTCCGGTTGCCTGCTGGATGCCTATTCACCCTCATTCTATGGCGGCA
CCGGCAAGAGCTTTAACTGGGAGATCGCCCGTGAGGCGATGACACGTGGCCACCGGATTGTACTGGCGGGCGGGCTGACC
CCGGACAACGTGGCTGAGGCGATCCGCCAGGTACGTCCCTATGCCGTTGATGTCTCCAGCGGCGTGGAATCAGCACCCGG
CAGAAAAGATGCAGACAAGGTACGAGAGTTTATACGCAATGCAAAGGAAGCCTTATAA

Upstream 100 bases:

>100_bases
GTCATTAAAGCATCTGCCGAAGGTGAAACTCTAGGTTGAGATCGAGGTTAAGGTTGAGCAATTTCCTTAACCTCAACCTT
AACCTTCATCTGGTGTTTCT

Downstream 100 bases:

>100_bases
TGAAACAACCCGATAAACACGGCCACTTCGGTATCCACGGCGGACGCTATGTGCCTGAAACCCTGATGCCTGCCCTGAAG
GAGCTGGAAGAGGCCTATGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLFVNEAPEIVNQVSRNCRLGLV
QLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSGCLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLT
PDNVAEAIRQVRPYAVDVSSGVESAPGRKDADKVREFIRNAKEAL

Sequences:

>Translated_205_residues
MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLFVNEAPEIVNQVSRNCRLGLV
QLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSGCLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLT
PDNVAEAIRQVRPYAVDVSSGVESAPGRKDADKVREFIRNAKEAL
>Mature_205_residues
MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLFVNEAPEIVNQVSRNCRLGLV
QLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSGCLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLT
PDNVAEAIRQVRPYAVDVSSGVESAPGRKDADKVREFIRNAKEAL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=191, Percent_Identity=32.4607329842932, Blast_Score=80, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320210, Length=217, Percent_Identity=32.258064516129, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_GEOLS (B3E754)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951454.1
- ProteinModelPortal:   B3E754
- SMR:   B3E754
- GeneID:   6368107
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1212
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22614; Mature: 22614

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLF
CEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VNEAPEIVNQVSRNCRLGLVQLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSG
HCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLTPDNVAEAIRQVRPYAVDVSS
EEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCEEEECCC
GVESAPGRKDADKVREFIRNAKEAL
CCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLF
CEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VNEAPEIVNQVSRNCRLGLVQLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSG
HCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLTPDNVAEAIRQVRPYAVDVSS
EEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCEEEECCC
GVESAPGRKDADKVREFIRNAKEAL
CCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA