Click here to switch to the map view.

The map label for this gene is uraA [H]

Identifier: 189424143

GI number: 189424143

Start: 1123910

End: 1125187

Strand: Reverse

Name: uraA [H]

Synonym: Glov_1077

Alternate gene names: 189424143

Gene position: 1125187-1123910 (Counterclockwise)

Preceding gene: 189424144

Following gene: 189424142

Centisome position: 28.72

GC content: 63.69

Gene sequence:

>1278_bases
ATGTCAACCACTCCCGAACCGGTCTGGCGTACCGCCCTTTCCGGCGCACAGATCCTGTTTGTCGCCTTCGGGGCAACCGT
ACTCGTTCCGCTGTTGACCGGTCTGAACCCCAGTCTGGCGCTGCTGGGGGCCGGGATCGGCACCCTGGTCTTCCAGATCT
GCACCGGGCGTCAGGTGCCGATCTACCTCGGCTCTTCGTTCGCCTTTATCGCCCCGGTGATCTATTCGGTCAAGAGTTGG
GGCATGCCGGCCACCCTGGGGGCGCTGGCAGCGGCCAGTCTGTTCTACTATATCGCCGCGGCTCTGGTAAAATGGCGCGG
GGTTGGCTTCATACATCACCTGCTGCCGCCGGTGGTGATCGGGCCGGTGGTAATGGTTATCGGCCTGGGACTGGCCCAGG
TGGCGATCAACATGGCCACCGGCAAGGCCGGCGACAGCCAGGTCGTCCCCTATGGCACGGCCCTGGGTATTGCCGCAATT
TCACTGACCGCCACCATGCTGACCGCCATCCATGCCCGCGGCCTGCTCAAACTGGTGCCGATCCTGGTGGGTGTGGCAGC
CGGCTACGGCAGCTCCCTTTTCCTCGGTCTGGTTGACTTCAGCAAGGTGATCAACGCCCCCTGGCTGGCAGTGCCGCAGT
TCGGCCATCCTGAGTTCAATCTGGCGGCAATCCTGTTCATGATCCCGGTGGCCATAGCCCCGATTGTCGAGCATGTGGGC
GGCATTCTGGCCATCGGTTCGGTGGTCGGCCGTGATTACACGGAGCAGCCCGGCCTGCACCGTACCCTGCTGGGTGACGG
CCTGGCGGTCACCATTGCCGGCCTCTTTGGCGGCCCGCCGGTAACCACCTACGGCGAGGTAACCGGGGCGGTCATGCTGA
CCCGTAACTACAACCCGGTGGTCATGACCTGGGCGGCCGGCTTTGCCATTCTGATGGCGTTTGTCGGCAAGTTCGGCGCC
CTGTTGCAGACGATCCCCATGCCGGTCATGGGAGGGATCATGGTCCTGCTTTTCGGCTCCATCGCAGGCATCGGCCTGAA
GACCATTATTGACGGCAGGGTTGACCTGATGAAACCACGCAACCTCTGCCTGGTCTCAGTCACCCTGGTGACCGGTATCG
GCGGCCTGGGCGTCACCATCGGCAGCTTCAGTCTTCAGGGAATCAGCCTCTGCGGTGTGCTGGCGGTCATACTGAACCTG
CTGCTTCCCCGCGGTGAGCAGCAGGGAGAAGACAGCCCGGTGGGCAGCGGCAGCGAACAGGGCGGACACTCCGGCTAG

Upstream 100 bases:

>100_bases
TGCCTCCATTGATGAACGGCTCAATGAGCATGGCTACATCCTTCCTGGCCTCGGCGATGCCGGGGATAAAATCTTCGGTA
CCAAATAGGAGACCAGCGCA

Downstream 100 bases:

>100_bases
CCTCTGGACCTGCCCGGCAAAGCTGCTACACTGGGCACTGTGATACTCAAGCCATGTTGCCGTTTGCAACTAATCCGCTT
ATGCTGGTATTTTCCTGCAG

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSTTPEPVWRTALSGAQILFVAFGATVLVPLLTGLNPSLALLGAGIGTLVFQICTGRQVPIYLGSSFAFIAPVIYSVKSW
GMPATLGALAAASLFYYIAAALVKWRGVGFIHHLLPPVVIGPVVMVIGLGLAQVAINMATGKAGDSQVVPYGTALGIAAI
SLTATMLTAIHARGLLKLVPILVGVAAGYGSSLFLGLVDFSKVINAPWLAVPQFGHPEFNLAAILFMIPVAIAPIVEHVG
GILAIGSVVGRDYTEQPGLHRTLLGDGLAVTIAGLFGGPPVTTYGEVTGAVMLTRNYNPVVMTWAAGFAILMAFVGKFGA
LLQTIPMPVMGGIMVLLFGSIAGIGLKTIIDGRVDLMKPRNLCLVSVTLVTGIGGLGVTIGSFSLQGISLCGVLAVILNL
LLPRGEQQGEDSPVGSGSEQGGHSG

Sequences:

>Translated_425_residues
MSTTPEPVWRTALSGAQILFVAFGATVLVPLLTGLNPSLALLGAGIGTLVFQICTGRQVPIYLGSSFAFIAPVIYSVKSW
GMPATLGALAAASLFYYIAAALVKWRGVGFIHHLLPPVVIGPVVMVIGLGLAQVAINMATGKAGDSQVVPYGTALGIAAI
SLTATMLTAIHARGLLKLVPILVGVAAGYGSSLFLGLVDFSKVINAPWLAVPQFGHPEFNLAAILFMIPVAIAPIVEHVG
GILAIGSVVGRDYTEQPGLHRTLLGDGLAVTIAGLFGGPPVTTYGEVTGAVMLTRNYNPVVMTWAAGFAILMAFVGKFGA
LLQTIPMPVMGGIMVLLFGSIAGIGLKTIIDGRVDLMKPRNLCLVSVTLVTGIGGLGVTIGSFSLQGISLCGVLAVILNL
LLPRGEQQGEDSPVGSGSEQGGHSG
>Mature_424_residues
STTPEPVWRTALSGAQILFVAFGATVLVPLLTGLNPSLALLGAGIGTLVFQICTGRQVPIYLGSSFAFIAPVIYSVKSWG
MPATLGALAAASLFYYIAAALVKWRGVGFIHHLLPPVVIGPVVMVIGLGLAQVAINMATGKAGDSQVVPYGTALGIAAIS
LTATMLTAIHARGLLKLVPILVGVAAGYGSSLFLGLVDFSKVINAPWLAVPQFGHPEFNLAAILFMIPVAIAPIVEHVGG
ILAIGSVVGRDYTEQPGLHRTLLGDGLAVTIAGLFGGPPVTTYGEVTGAVMLTRNYNPVVMTWAAGFAILMAFVGKFGAL
LQTIPMPVMGGIMVLLFGSIAGIGLKTIIDGRVDLMKPRNLCLVSVTLVTGIGGLGVTIGSFSLQGISLCGVLAVILNLL
LPRGEQQGEDSPVGSGSEQGGHSG

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=448, Percent_Identity=23.6607142857143, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI44680143, Length=449, Percent_Identity=23.8307349665924, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI44680148, Length=453, Percent_Identity=23.841059602649, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI40316845, Length=453, Percent_Identity=23.841059602649, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1788843, Length=417, Percent_Identity=40.5275779376499, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI87081818, Length=411, Percent_Identity=39.6593673965937, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI87082181, Length=438, Percent_Identity=29.4520547945205, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082178, Length=332, Percent_Identity=28.3132530120482, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790087, Length=386, Percent_Identity=25.9067357512953, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=173, Percent_Identity=28.3236994219653, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=28.8888888888889, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=376, Percent_Identity=22.0744680851064, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17542260, Length=189, Percent_Identity=26.4550264550265, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356175, Length=373, Percent_Identity=25.4691689008043, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43555; Mature: 43423

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCC
>Mature Secondary Structure 
STTPEPVWRTALSGAQILFVAFGATVLVPLLTGLNPSLALLGAGIGTLVFQICTGRQVP
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCE
IYLGSSFAFIAPVIYSVKSWGMPATLGALAAASLFYYIAAALVKWRGVGFIHHLLPPVVI
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GPVVMVIGLGLAQVAINMATGKAGDSQVVPYGTALGIAAISLTATMLTAIHARGLLKLVP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVGVAAGYGSSLFLGLVDFSKVINAPWLAVPQFGHPEFNLAAILFMIPVAIAPIVEHVG
HHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GILAIGSVVGRDYTEQPGLHRTLLGDGLAVTIAGLFGGPPVTTYGEVTGAVMLTRNYNPV
HHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEHHCCCCCCCCCCCCCEEEEEEECCCCE
VMTWAAGFAILMAFVGKFGALLQTIPMPVMGGIMVLLFGSIAGIGLKTIIDGRVDLMKPR
EEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCCC
NLCLVSVTLVTGIGGLGVTIGSFSLQGISLCGVLAVILNLLLPRGEQQGEDSPVGSGSEQ
CEEEEEEHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGHSG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]