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The map label for this gene is upp

Identifier: 189424144

GI number: 189424144

Start: 1125200

End: 1125826

Strand: Reverse

Name: upp

Synonym: Glov_1078

Alternate gene names: 189424144

Gene position: 1125826-1125200 (Counterclockwise)

Preceding gene: 189424145

Following gene: 189424143

Centisome position: 28.74

GC content: 56.14

Gene sequence:

>627_bases
GTGGCCATTTACGAAGTCAAACACCCGCTGATCCAGCACAAGCTCGGCCTGCTGCGCAAGGCTGATCTCAGCACCAAGCA
GTTTCGTGAGCTTGCCTCTGAAGTTGCCCGTCTGTTGACCTATGAAGCGACCAAGGATCTTGAAACCGAGAGTATCACGA
TCAACGGTTGGGCCGGGCCGGTCACCGTCCAGCAGATCAAGGGCAAGAAAATTACGATTGTGCCGATTTTGCGGGCTGGT
CTGGGGATGATGAACGGGGTGCTTGATATGATTCCCAGTGCCAAGGTCAGCGTGGTCGGCCTGTACCGTAACGAGGAGAC
CCTGGAACCGGTGGCCTACTACGAGAAATTTACCACGGACATGGAGGAGCGTACCGCCTTGATCATTGATCCGATGCTGG
CGACCGGCGGTTCACTGCTGGCCACCATCGAGATGCTGAAGGCAACCGGTTGCCGACGGATCAAGGGCCTGTTTCTGGTG
GCCGTCCCCGAGGGTCTTGAGAAGATCAGCAGCGCCCACCCTGATGTTGAAATCTACGTTGCCTCCATTGATGAACGGCT
CAATGAGCATGGCTACATCCTTCCTGGCCTCGGCGATGCCGGGGATAAAATCTTCGGTACCAAATAG

Upstream 100 bases:

>100_bases
GCGTCAGCCTGTGCTCTGTTCTCACCGCTTGACCTGCCGGACGTTGAACTATATGTATAGCTGACTCGCTCAAACCAAAC
CTGTCCCAAGGAGCTCTGAC

Downstream 100 bases:

>100_bases
GAGACCAGCGCAATGTCAACCACTCCCGAACCGGTCTGGCGTACCGCCCTTTCCGGCGCACAGATCCTGTTTGTCGCCTT
CGGGGCAACCGTACTCGTTC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAIYEVKHPLIQHKLGLLRKADLSTKQFRELASEVARLLTYEATKDLETESITINGWAGPVTVQQIKGKKITIVPILRAG
LGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFTTDMEERTALIIDPMLATGGSLLATIEMLKATGCRRIKGLFLV
AVPEGLEKISSAHPDVEIYVASIDERLNEHGYILPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MAIYEVKHPLIQHKLGLLRKADLSTKQFRELASEVARLLTYEATKDLETESITINGWAGPVTVQQIKGKKITIVPILRAG
LGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFTTDMEERTALIIDPMLATGGSLLATIEMLKATGCRRIKGLFLV
AVPEGLEKISSAHPDVEIYVASIDERLNEHGYILPGLGDAGDKIFGTK
>Mature_207_residues
AIYEVKHPLIQHKLGLLRKADLSTKQFRELASEVARLLTYEATKDLETESITINGWAGPVTVQQIKGKKITIVPILRAGL
GMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFTTDMEERTALIIDPMLATGGSLLATIEMLKATGCRRIKGLFLVA
VPEGLEKISSAHPDVEIYVASIDERLNEHGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=25.2475247524752, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=25.2475247524752, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=71.1538461538462, Blast_Score=320, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=21.2871287128713, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=21.2871287128713, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=207, Percent_Identity=34.2995169082126, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=25.9615384615385, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573516, Length=208, Percent_Identity=25.9615384615385, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573514, Length=208, Percent_Identity=25.9615384615385, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573512, Length=208, Percent_Identity=25.9615384615385, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_GEOLS (B3E677)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001951321.1
- ProteinModelPortal:   B3E677
- SMR:   B3E677
- GeneID:   6368195
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_1078
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22826; Mature: 22695

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYEVKHPLIQHKLGLLRKADLSTKQFRELASEVARLLTYEATKDLETESITINGWAGP
CCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
VTVQQIKGKKITIVPILRAGLGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFTTD
EEHEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
MEERTALIIDPMLATGGSLLATIEMLKATGCRRIKGLFLVAVPEGLEKISSAHPDVEIYV
HHHCEEEEECCHHHCCCHHHHHHHHHHHCCCHHHCCEEEEECCHHHHHHHCCCCCEEEEE
ASIDERLNEHGYILPGLGDAGDKIFGTK
EEHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AIYEVKHPLIQHKLGLLRKADLSTKQFRELASEVARLLTYEATKDLETESITINGWAGP
CEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
VTVQQIKGKKITIVPILRAGLGMMNGVLDMIPSAKVSVVGLYRNEETLEPVAYYEKFTTD
EEHEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCC
MEERTALIIDPMLATGGSLLATIEMLKATGCRRIKGLFLVAVPEGLEKISSAHPDVEIYV
HHHCEEEEECCHHHCCCHHHHHHHHHHHCCCHHHCCEEEEECCHHHHHHHCCCCCEEEEE
ASIDERLNEHGYILPGLGDAGDKIFGTK
EEHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA