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The map label for this gene is fumC [H]

Identifier: 189424137

GI number: 189424137

Start: 1117058

End: 1118455

Strand: Reverse

Name: fumC [H]

Synonym: Glov_1071

Alternate gene names: 189424137

Gene position: 1118455-1117058 (Counterclockwise)

Preceding gene: 189424138

Following gene: 189424136

Centisome position: 28.55

GC content: 63.02

Gene sequence:

>1398_bases
ATGCCATCGACACGTACTGAAACCGACTCCATGGGAGCGATTGAGGTAGCGGCTGACCGCTACTGGGGTGCCCAGACCCA
GCGTTCCATCCTGCATTTTCCGATCGGAGTTGACCGCTTCCGCTGGCAGCGGCCCATCATCCGCGCACTGGGCATCCTCA
AAAAGGCCGCGGCCCAGGCCAATGCCGAGTTGGGGGAACTGCCCCCTGATCTGGCCCGGCTGATCAGTGCCGCCAGCAGT
GAGGTGATTGAGGGCAGGCTGGATGACCACTTTCCACTGGTGGTGTTTCAGACCGGCTCCGGCACCCAGTCCAACATGAA
TGCCAATGAGGTGATCAGCAACCGGGCCATTGAGCTGGCAGGCGGCGTACCCGGCAGCAAGAAACCGGTCCACCCCAACG
ATCATGTCAACCGGGGACAATCCTCCAACGACACCTTTCCCACCGCCATGCATATTGCCGTGGTGGAACAGCTGCAACAG
CGGCTGCTGCCGGACGTGAGCAGCCTGAGAGACAGACTGGCCTCAAAGGCGGAAGAGTACCGCACGGTGGTCAAGACCGG
CCGGACCCACCTGCAGGACGCCACCCCGATCACCCTCGGGCAAGAAATCGGCGGCTGGGTTGCCCAGCTTGATTTCGGGC
TTGCTGCGGTGCGGGCCTGTCTGCCCGGTCTGTACGAACTTGCCATTGGCGGTACGGCCGTAGGTACCGGACTGAACGCC
CATCCCCGTTTTGGCGACCTGGCTGCGGCAAAGATTGCCCAACTGACCGGCCAGCCGTTTATCAGCGCCCCCAACAAATT
CTTTGCCCTGGCTGCCCACGATGCCCTGGTGCAGACCTCGGCCGGCCTGCGGACCCTGGCCGGCGGGCTGATGAAGCTGG
CCAACGATATCCGCTGGCTGGCAAGCGGCCCCCGCTGCGGGATCGGTGAGTTGCAGATCCCGGAAAACGAGCCGGGATCA
TCGATCATGCCGGGCAAGATCAACCCCACCCAGTGCGAGGCCCTGACCATGGTCTGCGTCCAGGTCTTTGGCAACGATGC
CGCGGTTGCCCTGGCCGGCAGTCAGGGCAATTTCCAGCTGAACGTCTTCAAGCCGGTCATGGTGCATAACGTACTGGAGA
GCATCCAGCTCCTTGCTGACGCCTGCAGCGCCTTTAACGAGCATTGCGCCGGCGGCATCACCCCCAACCTGCCCCGCATC
GCAGAACATCTTGCCGGCAACCTGATGCTGGTCACCGCCCTGACCCGCCATATCGGCTACGACGCGGCAGCCGGAATTGC
CAAAGAGGCCGATCACAAGGGGCTTACCCTGCGTGAGGCAGCCCTGGCCTCCGGTCTGGTAACAGCGGAACAGTATGATG
CCTGGATTGTGCCGCTGGCCATGACCCGGCCGGGTTAA

Upstream 100 bases:

>100_bases
GAAAAAGATCAGAAAAGACCCGGCGGCCCGGACCACTGCTCTGTTGCGCAGGGTGTTCGGGGGTACATAGCAGAGCCAAT
CATCTTATCGGGAGCCAGAG

Downstream 100 bases:

>100_bases
CAGACCGTAAAGAGGCATCCGTCGCCGGTCCTTTCTCACCCTTGGGCTGTTGAAGATCACGCTTGACTTCGCGTGGTAGT
CATTTGGTAACCTCTGTTCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPSTRTETDSMGAIEVAADRYWGAQTQRSILHFPIGVDRFRWQRPIIRALGILKKAAAQANAELGELPPDLARLISAASS
EVIEGRLDDHFPLVVFQTGSGTQSNMNANEVISNRAIELAGGVPGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVEQLQQ
RLLPDVSSLRDRLASKAEEYRTVVKTGRTHLQDATPITLGQEIGGWVAQLDFGLAAVRACLPGLYELAIGGTAVGTGLNA
HPRFGDLAAAKIAQLTGQPFISAPNKFFALAAHDALVQTSAGLRTLAGGLMKLANDIRWLASGPRCGIGELQIPENEPGS
SIMPGKINPTQCEALTMVCVQVFGNDAAVALAGSQGNFQLNVFKPVMVHNVLESIQLLADACSAFNEHCAGGITPNLPRI
AEHLAGNLMLVTALTRHIGYDAAAGIAKEADHKGLTLREAALASGLVTAEQYDAWIVPLAMTRPG

Sequences:

>Translated_465_residues
MPSTRTETDSMGAIEVAADRYWGAQTQRSILHFPIGVDRFRWQRPIIRALGILKKAAAQANAELGELPPDLARLISAASS
EVIEGRLDDHFPLVVFQTGSGTQSNMNANEVISNRAIELAGGVPGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVEQLQQ
RLLPDVSSLRDRLASKAEEYRTVVKTGRTHLQDATPITLGQEIGGWVAQLDFGLAAVRACLPGLYELAIGGTAVGTGLNA
HPRFGDLAAAKIAQLTGQPFISAPNKFFALAAHDALVQTSAGLRTLAGGLMKLANDIRWLASGPRCGIGELQIPENEPGS
SIMPGKINPTQCEALTMVCVQVFGNDAAVALAGSQGNFQLNVFKPVMVHNVLESIQLLADACSAFNEHCAGGITPNLPRI
AEHLAGNLMLVTALTRHIGYDAAAGIAKEADHKGLTLREAALASGLVTAEQYDAWIVPLAMTRPG
>Mature_464_residues
PSTRTETDSMGAIEVAADRYWGAQTQRSILHFPIGVDRFRWQRPIIRALGILKKAAAQANAELGELPPDLARLISAASSE
VIEGRLDDHFPLVVFQTGSGTQSNMNANEVISNRAIELAGGVPGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVEQLQQR
LLPDVSSLRDRLASKAEEYRTVVKTGRTHLQDATPITLGQEIGGWVAQLDFGLAAVRACLPGLYELAIGGTAVGTGLNAH
PRFGDLAAAKIAQLTGQPFISAPNKFFALAAHDALVQTSAGLRTLAGGLMKLANDIRWLASGPRCGIGELQIPENEPGSS
IMPGKINPTQCEALTMVCVQVFGNDAAVALAGSQGNFQLNVFKPVMVHNVLESIQLLADACSAFNEHCAGGITPNLPRIA
EHLAGNLMLVTALTRHIGYDAAAGIAKEADHKGLTLREAALASGLVTAEQYDAWIVPLAMTRPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.2251082251082, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=45.4545454545455, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.4837310195228, Blast_Score=540, Evalue=1e-154,
Organism=Escherichia coli, GI87082375, Length=452, Percent_Identity=38.9380530973451, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=59.2672413793103, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=58.1538461538462, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=59.7402597402597, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=57.7006507592191, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=57.7006507592191, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.1428571428571, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=56.5874730021598, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24583245, Length=466, Percent_Identity=50, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49332; Mature: 49201

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTRTETDSMGAIEVAADRYWGAQTQRSILHFPIGVDRFRWQRPIIRALGILKKAAAQA
CCCCCCCCCCCCEEEEHHHHHCCCHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NAELGELPPDLARLISAASSEVIEGRLDDHFPLVVFQTGSGTQSNMNANEVISNRAIELA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEE
GGVPGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVEQLQQRLLPDVSSLRDRLASKAEEY
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RTVVKTGRTHLQDATPITLGQEIGGWVAQLDFGLAAVRACLPGLYELAIGGTAVGTGLNA
HHHHHHCHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
HPRFGDLAAAKIAQLTGQPFISAPNKFFALAAHDALVQTSAGLRTLAGGLMKLANDIRWL
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ASGPRCGIGELQIPENEPGSSIMPGKINPTQCEALTMVCVQVFGNDAAVALAGSQGNFQL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEE
NVFKPVMVHNVLESIQLLADACSAFNEHCAGGITPNLPRIAEHLAGNLMLVTALTRHIGY
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
DAAAGIAKEADHKGLTLREAALASGLVTAEQYDAWIVPLAMTRPG
HHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCCEEEEEEECCCC
>Mature Secondary Structure 
PSTRTETDSMGAIEVAADRYWGAQTQRSILHFPIGVDRFRWQRPIIRALGILKKAAAQA
CCCCCCCCCCCEEEEHHHHHCCCHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
NAELGELPPDLARLISAASSEVIEGRLDDHFPLVVFQTGSGTQSNMNANEVISNRAIELA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEE
GGVPGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVEQLQQRLLPDVSSLRDRLASKAEEY
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RTVVKTGRTHLQDATPITLGQEIGGWVAQLDFGLAAVRACLPGLYELAIGGTAVGTGLNA
HHHHHHCHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
HPRFGDLAAAKIAQLTGQPFISAPNKFFALAAHDALVQTSAGLRTLAGGLMKLANDIRWL
CCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ASGPRCGIGELQIPENEPGSSIMPGKINPTQCEALTMVCVQVFGNDAAVALAGSQGNFQL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEE
NVFKPVMVHNVLESIQLLADACSAFNEHCAGGITPNLPRIAEHLAGNLMLVTALTRHIGY
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
DAAAGIAKEADHKGLTLREAALASGLVTAEQYDAWIVPLAMTRPG
HHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]