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The map label for this gene is uvrC

Identifier: 189423649

GI number: 189423649

Start: 563833

End: 565647

Strand: Reverse

Name: uvrC

Synonym: Glov_0579

Alternate gene names: 189423649

Gene position: 565647-563833 (Counterclockwise)

Preceding gene: 189423653

Following gene: 189423645

Centisome position: 14.44

GC content: 60.99

Gene sequence:

>1815_bases
ATGGAACTTCGCGACAGCATCCGCAGCTTTCCCACCGCCCCCGGCGTCTACCTGATGCGGGATGCAACCGGCACGATCCT
CTATGTCGGCAAGGCCCGTAATCTGCGGCAGCGGGTCAGCAACTATTTCGGTGCGACCGATGGACGCCCCCAGGTCCGTT
TCCTGATGGCACGGGTAACCTCGATTGAATTCACCATCACCGACACTGAAAAAGAGGCCCTGCTGCTTGAAAACACCCTG
ATCAAGCAACATCAGCCCCGCTACAACCTCAACCTCAAGGACGACAAGACCTTTTTTTCGCTGCGCATCGACCTCACTGA
GCGTTTTCCCCGCTTCACGGTGGTACGCAAGGTCAGCCGTGACGGCGCGCGCTACTTCGGTCCCTACGCCTCTGCCAGTG
CGGCACGGGAGGTGCTGCGTCAACTGCAGCGGATGTTTCCGCTGCGCCACTACCCGTTGAAAACCTGCCTGAACCGTTCC
CGACCCTGCCTGTATCACCAGATCGGCCAGTGCAGCGCCCCCTGCCATAACCTGATCACAGCCGAAGAATACAACCTGCT
GGTGGAGGGGGCCGTCCTGTTTCTGGAAGGAAAGAACAAAGATCTGGTGAGCGGCTTCAGACAACGGATGAAGGAGGCCG
CCGAGGGGCTGCACTATGAGGAGGCTGCCCGCTGGCGCGATCTGCTCAAGGCAATTGATACCACCCTGGAACACCAGAAG
ATGGTCAGCCAGGGGGGCGACAGCGACATCCTCGGGCTGGCCGGCAACGAAGACAGTCTGGCTATTGCCGTACTGTTCGT
GCGGGGCGGCAGCCTGTCCGGCAGCACGGTCCTGCATGGCTCGGGCGGACTTGATACCAGCGACACCCTGGCAACCTTTA
TCCAGTATTATTACGGCAACGAGCGTTTTATCCCCGACGAACTGCTGCTGCCGCTCAGCCTTGACGCCGGGCAGTCCCTG
GAAGAGTGGCTGAGCGAGCTGAAGGGCAAAAAGGTACGTTTGCAGCAGCCCAAACGTGGCGACAAACTCAACCTGGTCAA
TCTGGCAACCCGCAATGCCCAGGCGGCGTTGGCTGAAAAATCAGCAACCCGGCAGGGCATTGAGCGAACCCTTGCAGAGC
TGCAGCAGAAACTCGCATTGCCCCGGCTGCCCCGCCGGATTGAGTGCTACGACATCTCCACCCTGCAGGGGCGTCATTCC
GTCGGTAGCGGCGTCGCCTTCCTGGATGGCTTGCCTGACAAGGAACGCTACCGGCGCTACCGGATCAGGGAGAGCCAGGG
GCAGGACGACTTCGGGATGCTGCAGGAGGTCTTTGCCCGGCGCTTCAGCCCGGAACGGATTGAACAATGGGGCCTGCCGG
ATCTGGTGGTGGTGGATGGCGGCATCGGACAGCTGAACAGCACCCTGTCCGTACTCGCCGAGTTGGGACTCTCGGAACGG
CCGGCAGTTGTCTCACTGGCAAAAAGCAGGGTCAAAGGTGACGGCAAAGATATTCATGTCGAGCGGACTGAAGAACGGGT
CTTTCTGCCGGGCCGCCGCAACCCGGTCAGGTTGCGCCAGGACTCGGCCCCGCTGAAGCTGCTGGCAGCTATCCGGGACG
AGGCGCACCGTTTTGCCATCGGCTATCACCGCCGCCTGCGGGACAGGGAAACGCTACGCTCAGCCCTGCGGGAGATACCC
GGTGTCGGGCCGAAACTGGAGCGGCTGCTCCTGACGCGGTTTGGTTCTTTGGAAGGGATACAAAATGCCACGGTTGAGGA
ACTTGCCACCGTGGCAGGGGTCAGCCAGGAACTGGCGCGATTGATTAAGGCCTAA

Upstream 100 bases:

>100_bases
TTTAAGGCAGCCATGTCTGCATAATTTTAGCGCATCAATGCACGATAATTAATCAGAACAGCACGCTTTTCTTTTTCAAC
GGCAATGTTACAATCGCCCC

Downstream 100 bases:

>100_bases
TCAGCCTGGAACGACTACATCTTCCCATCCTGCACAATCACCTGCCGCATTTCATCATGCAGCAGTTTCAGATCAATCGG
CTTTGAAACATAGCCGTCAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MELRDSIRSFPTAPGVYLMRDATGTILYVGKARNLRQRVSNYFGATDGRPQVRFLMARVTSIEFTITDTEKEALLLENTL
IKQHQPRYNLNLKDDKTFFSLRIDLTERFPRFTVVRKVSRDGARYFGPYASASAAREVLRQLQRMFPLRHYPLKTCLNRS
RPCLYHQIGQCSAPCHNLITAEEYNLLVEGAVLFLEGKNKDLVSGFRQRMKEAAEGLHYEEAARWRDLLKAIDTTLEHQK
MVSQGGDSDILGLAGNEDSLAIAVLFVRGGSLSGSTVLHGSGGLDTSDTLATFIQYYYGNERFIPDELLLPLSLDAGQSL
EEWLSELKGKKVRLQQPKRGDKLNLVNLATRNAQAALAEKSATRQGIERTLAELQQKLALPRLPRRIECYDISTLQGRHS
VGSGVAFLDGLPDKERYRRYRIRESQGQDDFGMLQEVFARRFSPERIEQWGLPDLVVVDGGIGQLNSTLSVLAELGLSER
PAVVSLAKSRVKGDGKDIHVERTEERVFLPGRRNPVRLRQDSAPLKLLAAIRDEAHRFAIGYHRRLRDRETLRSALREIP
GVGPKLERLLLTRFGSLEGIQNATVEELATVAGVSQELARLIKA

Sequences:

>Translated_604_residues
MELRDSIRSFPTAPGVYLMRDATGTILYVGKARNLRQRVSNYFGATDGRPQVRFLMARVTSIEFTITDTEKEALLLENTL
IKQHQPRYNLNLKDDKTFFSLRIDLTERFPRFTVVRKVSRDGARYFGPYASASAAREVLRQLQRMFPLRHYPLKTCLNRS
RPCLYHQIGQCSAPCHNLITAEEYNLLVEGAVLFLEGKNKDLVSGFRQRMKEAAEGLHYEEAARWRDLLKAIDTTLEHQK
MVSQGGDSDILGLAGNEDSLAIAVLFVRGGSLSGSTVLHGSGGLDTSDTLATFIQYYYGNERFIPDELLLPLSLDAGQSL
EEWLSELKGKKVRLQQPKRGDKLNLVNLATRNAQAALAEKSATRQGIERTLAELQQKLALPRLPRRIECYDISTLQGRHS
VGSGVAFLDGLPDKERYRRYRIRESQGQDDFGMLQEVFARRFSPERIEQWGLPDLVVVDGGIGQLNSTLSVLAELGLSER
PAVVSLAKSRVKGDGKDIHVERTEERVFLPGRRNPVRLRQDSAPLKLLAAIRDEAHRFAIGYHRRLRDRETLRSALREIP
GVGPKLERLLLTRFGSLEGIQNATVEELATVAGVSQELARLIKA
>Mature_604_residues
MELRDSIRSFPTAPGVYLMRDATGTILYVGKARNLRQRVSNYFGATDGRPQVRFLMARVTSIEFTITDTEKEALLLENTL
IKQHQPRYNLNLKDDKTFFSLRIDLTERFPRFTVVRKVSRDGARYFGPYASASAAREVLRQLQRMFPLRHYPLKTCLNRS
RPCLYHQIGQCSAPCHNLITAEEYNLLVEGAVLFLEGKNKDLVSGFRQRMKEAAEGLHYEEAARWRDLLKAIDTTLEHQK
MVSQGGDSDILGLAGNEDSLAIAVLFVRGGSLSGSTVLHGSGGLDTSDTLATFIQYYYGNERFIPDELLLPLSLDAGQSL
EEWLSELKGKKVRLQQPKRGDKLNLVNLATRNAQAALAEKSATRQGIERTLAELQQKLALPRLPRRIECYDISTLQGRHS
VGSGVAFLDGLPDKERYRRYRIRESQGQDDFGMLQEVFARRFSPERIEQWGLPDLVVVDGGIGQLNSTLSVLAELGLSER
PAVVSLAKSRVKGDGKDIHVERTEERVFLPGRRNPVRLRQDSAPLKLLAAIRDEAHRFAIGYHRRLRDRETLRSALREIP
GVGPKLERLLLTRFGSLEGIQNATVEELATVAGVSQELARLIKA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=605, Percent_Identity=37.5206611570248, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788037, Length=190, Percent_Identity=30.5263157894737, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_GEOLS (B3E394)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001950826.1
- ProteinModelPortal:   B3E394
- GeneID:   6367938
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_0579
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68007; Mature: 68007

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRDSIRSFPTAPGVYLMRDATGTILYVGKARNLRQRVSNYFGATDGRPQVRFLMARVT
CCHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SIEFTITDTEKEALLLENTLIKQHQPRYNLNLKDDKTFFSLRIDLTERFPRFTVVRKVSR
EEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEHHHCCCHHHHHHHHHH
DGARYFGPYASASAAREVLRQLQRMFPLRHYPLKTCLNRSRPCLYHQIGQCSAPCHNLIT
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHCCC
AEEYNLLVEGAVLFLEGKNKDLVSGFRQRMKEAAEGLHYEEAARWRDLLKAIDTTLEHQK
HHHHCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MVSQGGDSDILGLAGNEDSLAIAVLFVRGGSLSGSTVLHGSGGLDTSDTLATFIQYYYGN
HHHCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC
ERFIPDELLLPLSLDAGQSLEEWLSELKGKKVRLQQPKRGDKLNLVNLATRNAQAALAEK
CCCCCHHHEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCHHHHHHHH
SATRQGIERTLAELQQKLALPRLPRRIECYDISTLQGRHSVGSGVAFLDGLPDKERYRRY
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHH
RIRESQGQDDFGMLQEVFARRFSPERIEQWGLPDLVVVDGGIGQLNSTLSVLAELGLSER
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCC
PAVVSLAKSRVKGDGKDIHVERTEERVFLPGRRNPVRLRQDSAPLKLLAAIRDEAHRFAI
CHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
GYHRRLRDRETLRSALREIPGVGPKLERLLLTRFGSLEGIQNATVEELATVAGVSQELAR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LIKA
HHCC
>Mature Secondary Structure
MELRDSIRSFPTAPGVYLMRDATGTILYVGKARNLRQRVSNYFGATDGRPQVRFLMARVT
CCHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SIEFTITDTEKEALLLENTLIKQHQPRYNLNLKDDKTFFSLRIDLTERFPRFTVVRKVSR
EEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEHHHCCCHHHHHHHHHH
DGARYFGPYASASAAREVLRQLQRMFPLRHYPLKTCLNRSRPCLYHQIGQCSAPCHNLIT
CCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHCCC
AEEYNLLVEGAVLFLEGKNKDLVSGFRQRMKEAAEGLHYEEAARWRDLLKAIDTTLEHQK
HHHHCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MVSQGGDSDILGLAGNEDSLAIAVLFVRGGSLSGSTVLHGSGGLDTSDTLATFIQYYYGN
HHHCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC
ERFIPDELLLPLSLDAGQSLEEWLSELKGKKVRLQQPKRGDKLNLVNLATRNAQAALAEK
CCCCCHHHEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCHHHHHHHH
SATRQGIERTLAELQQKLALPRLPRRIECYDISTLQGRHSVGSGVAFLDGLPDKERYRRY
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCHHHCCCCCHHHHHHH
RIRESQGQDDFGMLQEVFARRFSPERIEQWGLPDLVVVDGGIGQLNSTLSVLAELGLSER
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCC
PAVVSLAKSRVKGDGKDIHVERTEERVFLPGRRNPVRLRQDSAPLKLLAAIRDEAHRFAI
CHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
GYHRRLRDRETLRSALREIPGVGPKLERLLLTRFGSLEGIQNATVEELATVAGVSQELAR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
LIKA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA