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The map label for this gene is ilvD [H]

Identifier: 189354070

GI number: 189354070

Start: 2403547

End: 2405298

Strand: Reverse

Name: ilvD [H]

Synonym: BMULJ_05323

Alternate gene names: 189354070

Gene position: 2405298-2403547 (Counterclockwise)

Preceding gene: 189354073

Following gene: 189354069

Centisome position: 97.26

GC content: 67.81

Gene sequence:

>1752_bases
ATGTCGGCAACGAAACCCAGGCTGCGCTCCGCTCAATGGTTCGGCACCAACGACAAGAACGGCTTCATGTACCGGAGCTG
GATGAAGAATCAGGGCATTCCCGATCACGAATTCGACGGCCGGCCGATCATCGGCATCTGCAATACGTGGTCCGAACTGA
CGCCGTGCAACGCGCATTTTCGCAAGCTCGCCGAGCATGTGAAGCGCGGGATTTTCGAGGCGGGCGGGTTCCCGGTCGAG
TTCCCGGTGTTCTCGAACGGCGAATCGAACCTGCGCCCGTCCGCGATGCTCACGCGCAATCTTGCATCGATGGACGTCGA
AGAGGCGATCCGCGGCAACCCGATCGACGCGGTCGTGCTGCTCGCCGGCTGCGACAAGACGACGCCCGCGCTGCTGATGG
GCGCCGCGAGCTGCGACGTGCCGGCGATCGTCGTATCGGGCGGCCCGATGCTGAACGGCAAGCTCGAAGGCAAGAACATC
GGTTCCGGCACGGCGGTCTGGCAACTGCATGAAGCGCTGAAGGCCGGCGAAATCGATCTGCATCACTTCCTGTCGGCCGA
AGCCGGGATGTCGCGCTCGGCCGGCACCTGCAACACGATGGGCACCGCGTCGACGATGGCCTGCATGGCCGAAGCGCTCG
GCGTCGCGCTGCCCCACAACGCGGCGATTCCCGCCGTCGATTCGCGCCGCTACGTGCTCGCGCACATGTCGGGCATCCGC
ATCGTCGAGATGGCGCTCGAAGGGCTCGTGCTGTCGAAGGTGCTCACGCGCGCGGCGTTCGAGAACGCGATTCGCGTGAA
CGCGGCGATCGGCGGATCGACGAACGCGGTGATCCATCTGAAGGCGATCGCGGGCCGCATCGGCGTGCCGCTCGAACTCG
AGGACTGGATGCGCATCGGCCGCGACACGCCGACGATCGTCGACCTGATGCCGTCCGGACGCTTCCTGATGGAGGAGTTC
TATTACGCGGGCGGCCTGCCGGCCGTGCTGCGCCGGCTCGGCGAAGGCGGCCTGCTGCCGCATCCGGATGCGCTGACGGT
CAACGGCAAGACGCTCTGGGACAACGTGCGCGAGGCGCCGAACTACGACGACGAAGTGATCCGTCCGCTCGACCGTCCGC
TGATCGCCGACGGCGGCATCCGCATCCTGCGCGGCAACCTCGCGCCGCGCGGCGCGGTGCTGAAGCCGTCCGCGGCGAGC
CCCGAGCTGCTCAAGCATCGCGGCCGCGCGGTGGTGTTCGAGAACTTCGACCACTACAAGGCGACGATCAACGACGAATC
GCTCGACGTCGACGCGAACTCGGTGCTCGTGCTGAAGAACTGCGGGCCGCGCGGTTATCCGGGAATGGCCGAGGTCGGCA
ACATGGGCCTGCCGCCGAAGCTGCTGCGGCAGGGCGTGAAGGACATGGTGCGGATCTCCGACGCACGGATGAGCGGCACG
GCCTACGGCACGGTGGTGCTGCACGTCGCGCCGGAAGCGGCCGCGGGCGGCCCGCTCGCGGCGGTGCGCAACGGCGACTG
GATCGAACTGGATTGCGAGGCCGGCACGCTGCATCTCGACATTCCGGACGACGAACTGCAGCGCCGGCTGTCCGACGTCG
ATCCGGCGGCTGCGCCGGGCGTCGCCGGGCAGGCGGGCAAGGGCGGCTATGCGCGGCTGTATCTCGATCACGTGCTGCAG
GCCGACGAAGGGTGCGACCTCGACTTCCTGGTCGGCACGCGCGGCGCGGAGGTGCCGAGCCACTCGCACTGA

Upstream 100 bases:

>100_bases
TCAATATCTGATTCGATATGGGAAACGGCGAAAACGTCATTGGTAGGTTATCAAAATTCTCCCTAGACTGCGCCGGTATC
TCGCCTCCACAGGATTGACG

Downstream 100 bases:

>100_bases
GCGCGGCGCGCGGCACGAGGCACGAGGCACGAGGCGGCACGAGCGGCACGAGGCGGCACGACCTGAACGACACAGACCGG
CGACGACGCCGGCACGCACA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSATKPRLRSAQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGIFEAGGFPVE
FPVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNI
GSGTAVWQLHEALKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIR
IVEMALEGLVLSKVLTRAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRDTPTIVDLMPSGRFLMEEF
YYAGGLPAVLRRLGEGGLLPHPDALTVNGKTLWDNVREAPNYDDEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAAS
PELLKHRGRAVVFENFDHYKATINDESLDVDANSVLVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDIPDDELQRRLSDVDPAAAPGVAGQAGKGGYARLYLDHVLQ
ADEGCDLDFLVGTRGAEVPSHSH

Sequences:

>Translated_583_residues
MSATKPRLRSAQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGIFEAGGFPVE
FPVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNI
GSGTAVWQLHEALKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIR
IVEMALEGLVLSKVLTRAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRDTPTIVDLMPSGRFLMEEF
YYAGGLPAVLRRLGEGGLLPHPDALTVNGKTLWDNVREAPNYDDEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAAS
PELLKHRGRAVVFENFDHYKATINDESLDVDANSVLVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDIPDDELQRRLSDVDPAAAPGVAGQAGKGGYARLYLDHVLQ
ADEGCDLDFLVGTRGAEVPSHSH
>Mature_582_residues
SATKPRLRSAQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHFRKLAEHVKRGIFEAGGFPVEF
PVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVLLAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNIG
SGTAVWQLHEALKAGEIDLHHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIRI
VEMALEGLVLSKVLTRAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIGRDTPTIVDLMPSGRFLMEEFY
YAGGLPAVLRRLGEGGLLPHPDALTVNGKTLWDNVREAPNYDDEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAASP
ELLKHRGRAVVFENFDHYKATINDESLDVDANSVLVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGTA
YGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDIPDDELQRRLSDVDPAAAPGVAGQAGKGGYARLYLDHVLQA
DEGCDLDFLVGTRGAEVPSHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=578, Percent_Identity=30.1038062283737, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI2367371, Length=457, Percent_Identity=33.6980306345733, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1786464, Length=452, Percent_Identity=33.1858407079646, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=29.0697674418605, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=580, Percent_Identity=32.2413793103448, Blast_Score=256, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62310; Mature: 62179

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATKPRLRSAQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCCCCCCCEECCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
RKLAEHVKRGIFEAGGFPVEFPVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEEEE
LAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNIGSGTAVWQLHEALKAGEIDL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHHCCCCHH
HHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCHH
IVEMALEGLVLSKVLTRAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIG
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCCEEHHHHHHHC
RDTPTIVDLMPSGRFLMEEFYYAGGLPAVLRRLGEGGLLPHPDALTVNGKTLWDNVREAP
CCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCC
NYDDEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAASPELLKHRGRAVVFENFDHYK
CCCHHHHHHCCCCEECCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEECCCCEE
ATINDESLDVDANSVLVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
EEECCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDIPDDELQRRLSDVDPAAAPG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCCCCC
VAGQAGKGGYARLYLDHVLQADEGCDLDFLVGTRGAEVPSHSH
CCCCCCCCCEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SATKPRLRSAQWFGTNDKNGFMYRSWMKNQGIPDHEFDGRPIIGICNTWSELTPCNAHF
CCCCCCCCCCEECCCCCCCCCEEHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
RKLAEHVKRGIFEAGGFPVEFPVFSNGESNLRPSAMLTRNLASMDVEEAIRGNPIDAVVL
HHHHHHHHHHHHHCCCCCEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEEEE
LAGCDKTTPALLMGAASCDVPAIVVSGGPMLNGKLEGKNIGSGTAVWQLHEALKAGEIDL
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHHCCCCHH
HHFLSAEAGMSRSAGTCNTMGTASTMACMAEALGVALPHNAAIPAVDSRRYVLAHMSGIR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHCCHH
IVEMALEGLVLSKVLTRAAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVPLELEDWMRIG
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCCEEHHHHHHHC
RDTPTIVDLMPSGRFLMEEFYYAGGLPAVLRRLGEGGLLPHPDALTVNGKTLWDNVREAP
CCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHCCC
NYDDEVIRPLDRPLIADGGIRILRGNLAPRGAVLKPSAASPELLKHRGRAVVFENFDHYK
CCCHHHHHHCCCCEECCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEEECCCCEE
ATINDESLDVDANSVLVLKNCGPRGYPGMAEVGNMGLPPKLLRQGVKDMVRISDARMSGT
EEECCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIELDCEAGTLHLDIPDDELQRRLSDVDPAAAPG
EEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHCCCCCCCC
VAGQAGKGGYARLYLDHVLQADEGCDLDFLVGTRGAEVPSHSH
CCCCCCCCCEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA