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The map label for this gene is hutC [H]

Identifier: 189354043

GI number: 189354043

Start: 2370313

End: 2371050

Strand: Direct

Name: hutC [H]

Synonym: BMULJ_05296

Alternate gene names: 189354043

Gene position: 2370313-2371050 (Clockwise)

Preceding gene: 189354042

Following gene: 189354046

Centisome position: 95.84

GC content: 67.75

Gene sequence:

>738_bases
ATGGTCATGAAGACCACCGCGCCGTTCCAGCAGATCAAGACGCTCGTTCGCCAGAAAACCGAAGCGGGCGAATGGCGGCC
GGGCGACCGCATTCCGTCCGAACTCGATCTCGCCGCGCAGTTCGGCGTCGCACGCATGACGGTCAACCGCGCGCTGCGCG
AACTGACCGAGGAAGGCGTGCTGAAGCGGATCGCGGGCGTCGGCACGTTCGTCGCCGAATCGAAGCCGCAGTCGAACCTG
CTGATGATCGCGCATATCCGCGACGAGATCCGCGCGCGCGGGCACGCGTACCGATGCCGCGTGCTGAGCCAGTCGCGCGA
GCCGGCGTCGTTCGACGTCGCCGCGGCGTTCGGGCTGCCGGTCAATACGCCGGTGTTTCATGTGGTGTGCGTGCACGAGG
AAAACGGCCGCCCGATCCAGCTCGAGGACCGCTACGTGAACCCCGCCGCCGCGCCCGCCTTCATCGATCAGGACTTCCGC
CAGGAACCGCCGTCCGAGTATCTGTACAACAACGTGTCGCACGACGAGCTCGAGATCGAGCACGTCGTCGACGCGTCGCT
GCCGACGGCCGAGCAGGCGCGGCTGCTCGACATGCGCGCGGACGAACCGTGCCTGACGCTCACGCGCCGCACGTGGACGA
AGGGGTTGCCCGTCACGTTCGTGCACTTCCTGCATCCGGGCAACCGCTATCGGCTCGGTTCACGCTTCAAGCCGGGCGCG
GGGCGCCGCCAGACCTGA

Upstream 100 bases:

>100_bases
GAGCGACGCGTTCGGCGCGACGCCGACGGCCGACGTGCGCGAGTTGCCGCCCGCCTGATCCGCTAGAATCCGTCGATCGC
CTTTGCCCGAGAGTTCCCCG

Downstream 100 bases:

>100_bases
GCGCACGCGGCCGCGCGGGTGCCGCGTGCACCGCATACGCGTGTGCGTGCGCGTTCACGTTCGCGTTCAGATCGCGCTCG
CCTGCCCCGCATCGCGCGAC

Product: GntR family histidine utilization transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MVMKTTAPFQQIKTLVRQKTEAGEWRPGDRIPSELDLAAQFGVARMTVNRALRELTEEGVLKRIAGVGTFVAESKPQSNL
LMIAHIRDEIRARGHAYRCRVLSQSREPASFDVAAAFGLPVNTPVFHVVCVHEENGRPIQLEDRYVNPAAAPAFIDQDFR
QEPPSEYLYNNVSHDELEIEHVVDASLPTAEQARLLDMRADEPCLTLTRRTWTKGLPVTFVHFLHPGNRYRLGSRFKPGA
GRRQT

Sequences:

>Translated_245_residues
MVMKTTAPFQQIKTLVRQKTEAGEWRPGDRIPSELDLAAQFGVARMTVNRALRELTEEGVLKRIAGVGTFVAESKPQSNL
LMIAHIRDEIRARGHAYRCRVLSQSREPASFDVAAAFGLPVNTPVFHVVCVHEENGRPIQLEDRYVNPAAAPAFIDQDFR
QEPPSEYLYNNVSHDELEIEHVVDASLPTAEQARLLDMRADEPCLTLTRRTWTKGLPVTFVHFLHPGNRYRLGSRFKPGA
GRRQT
>Mature_245_residues
MVMKTTAPFQQIKTLVRQKTEAGEWRPGDRIPSELDLAAQFGVARMTVNRALRELTEEGVLKRIAGVGTFVAESKPQSNL
LMIAHIRDEIRARGHAYRCRVLSQSREPASFDVAAAFGLPVNTPVFHVVCVHEENGRPIQLEDRYVNPAAAPAFIDQDFR
QEPPSEYLYNNVSHDELEIEHVVDASLPTAEQARLLDMRADEPCLTLTRRTWTKGLPVTFVHFLHPGNRYRLGSRFKPGA
GRRQT

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=212, Percent_Identity=27.8301886792453, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082252, Length=213, Percent_Identity=26.2910798122066, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27652; Mature: 27652

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMKTTAPFQQIKTLVRQKTEAGEWRPGDRIPSELDLAAQFGVARMTVNRALRELTEEGV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRIAGVGTFVAESKPQSNLLMIAHIRDEIRARGHAYRCRVLSQSREPASFDVAAAFGLP
HHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCC
VNTPVFHVVCVHEENGRPIQLEDRYVNPAAAPAFIDQDFRQEPPSEYLYNNVSHDELEIE
CCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHH
HVVDASLPTAEQARLLDMRADEPCLTLTRRTWTKGLPVTFVHFLHPGNRYRLGSRFKPGA
HHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEHEEECCCCCEECCCCCCCCC
GRRQT
CCCCC
>Mature Secondary Structure
MVMKTTAPFQQIKTLVRQKTEAGEWRPGDRIPSELDLAAQFGVARMTVNRALRELTEEGV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKRIAGVGTFVAESKPQSNLLMIAHIRDEIRARGHAYRCRVLSQSREPASFDVAAAFGLP
HHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCC
VNTPVFHVVCVHEENGRPIQLEDRYVNPAAAPAFIDQDFRQEPPSEYLYNNVSHDELEIE
CCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHH
HVVDASLPTAEQARLLDMRADEPCLTLTRRTWTKGLPVTFVHFLHPGNRYRLGSRFKPGA
HHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEHEEECCCCCEECCCCCCCCC
GRRQT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]