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The map label for this gene is hmuV [H]

Identifier: 189353939

GI number: 189353939

Start: 2255542

End: 2256384

Strand: Direct

Name: hmuV [H]

Synonym: BMULJ_05192

Alternate gene names: 189353939

Gene position: 2255542-2256384 (Clockwise)

Preceding gene: 189353938

Following gene: 189353942

Centisome position: 91.2

GC content: 71.17

Gene sequence:

>843_bases
ATGCTGACCGTCCAACATCTCCGTGTCGCGCGCCGACATCGCGTCATCCTTCACGATCTGTCGCTGACGATCGAACCGGG
CCGCGTCACCGCGCTGCTCGGCCGCAACGGCGCGGGCAAGAGCACATTGCTGAAAGCGCTGGCCGGCGAGCTGACCGGCA
GTGCCGCGCCGAACGGCGTGCGCGTCACCGGCCGCATCGCGCTGAACGGCGAACCGCTCGCGCAGATCGACGCGCAGCGG
CTCGCGCGGCTGCGCGCGGTGCTGCCGCAAGCCGCGCAACCGGCCTTTCCGTTCAGTGTCGACGAGATCGTGCTGCTCGG
CCGCTATCCGCATGCACGTAGCCGCGGCGGCGCGCTGTCGCGACGCGATCGCGGCATCGCGTGGCACGCGCTCGCGCGTG
CCGGCGCGGAGACGCTGCTCGGCCGCGACGTGACGACGCTGTCCGGCGGCGAACTCGCGCGGGTGCAGTTCGCGCGCGTG
CTGGCGCAGCTGTGGCCGTCCGACGACGAAGCGGGCCGCGACGCTCGCGACGCGTCGCCGACGCGCTATCTGCTGCTCGA
CGAACCGACCGCCGCGCTCGATCTCGCGCATCAGCATCGGCTGCTCGAGACGGTGCGCACGATCGCACGCGAATGGCGGC
TCGGCGTGCTCGCGATCGTCCACGATCCGAATCTCGCCGCGCGGCATGCGGACACGATCGCGATGCTCGCGGACGGCATG
ATCGTCGCGCACGGCACGCCGCACGATGTGATGACGCCCGAACACATTGCACGCTGCTACGGGTTCGCGGTGAAGCGGAT
CGACAGCGGCGACGGTACGCCGCCCGTGATGGTGCCGGCATAG

Upstream 100 bases:

>100_bases
CTCGGCGTGCTGACCGCGCTGCTCGGCGCACCGTTCTTTCTCGCGCTGCTGTGGAAAAGCCGCGGCTCGCTCGGCGCTTA
GTCGTGCCTCCGTCTCGATC

Downstream 100 bases:

>100_bases
CGCGCGGCCCGTACGCGCGACCGATGGACGAAGTGCGCCCCATGTAGTCAACCCACGCGTCGTATGCGCACTCAATGCTC
GACGTCCGCGAGCATCCGCA

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MLTVQHLRVARRHRVILHDLSLTIEPGRVTALLGRNGAGKSTLLKALAGELTGSAAPNGVRVTGRIALNGEPLAQIDAQR
LARLRAVLPQAAQPAFPFSVDEIVLLGRYPHARSRGGALSRRDRGIAWHALARAGAETLLGRDVTTLSGGELARVQFARV
LAQLWPSDDEAGRDARDASPTRYLLLDEPTAALDLAHQHRLLETVRTIAREWRLGVLAIVHDPNLAARHADTIAMLADGM
IVAHGTPHDVMTPEHIARCYGFAVKRIDSGDGTPPVMVPA

Sequences:

>Translated_280_residues
MLTVQHLRVARRHRVILHDLSLTIEPGRVTALLGRNGAGKSTLLKALAGELTGSAAPNGVRVTGRIALNGEPLAQIDAQR
LARLRAVLPQAAQPAFPFSVDEIVLLGRYPHARSRGGALSRRDRGIAWHALARAGAETLLGRDVTTLSGGELARVQFARV
LAQLWPSDDEAGRDARDASPTRYLLLDEPTAALDLAHQHRLLETVRTIAREWRLGVLAIVHDPNLAARHADTIAMLADGM
IVAHGTPHDVMTPEHIARCYGFAVKRIDSGDGTPPVMVPA
>Mature_280_residues
MLTVQHLRVARRHRVILHDLSLTIEPGRVTALLGRNGAGKSTLLKALAGELTGSAAPNGVRVTGRIALNGEPLAQIDAQR
LARLRAVLPQAAQPAFPFSVDEIVLLGRYPHARSRGGALSRRDRGIAWHALARAGAETLLGRDVTTLSGGELARVQFARV
LAQLWPSDDEAGRDARDASPTRYLLLDEPTAALDLAHQHRLLETVRTIAREWRLGVLAIVHDPNLAARHADTIAMLADGM
IVAHGTPHDVMTPEHIARCYGFAVKRIDSGDGTPPVMVPA

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system [H]

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1786345, Length=266, Percent_Identity=39.0977443609023, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786803, Length=279, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790739, Length=255, Percent_Identity=34.5098039215686, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788002, Length=254, Percent_Identity=33.0708661417323, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790544, Length=247, Percent_Identity=30.3643724696356, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789890, Length=247, Percent_Identity=31.1740890688259, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788165, Length=258, Percent_Identity=28.6821705426357, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786253, Length=234, Percent_Identity=31.6239316239316, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789593, Length=262, Percent_Identity=30.5343511450382, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789891, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787112, Length=247, Percent_Identity=31.1740890688259, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788210, Length=252, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787370, Length=238, Percent_Identity=27.3109243697479, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081791, Length=252, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081709, Length=240, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787029, Length=237, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789864, Length=259, Percent_Identity=25.8687258687259, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788506, Length=294, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788053, Length=227, Percent_Identity=30.3964757709251, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693107, Length=269, Percent_Identity=26.3940520446097, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787712, Length=233, Percent_Identity=24.4635193133047, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786703, Length=234, Percent_Identity=29.9145299145299, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=248, Percent_Identity=27.8225806451613, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565938, Length=265, Percent_Identity=27.5471698113208, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=241, Percent_Identity=29.045643153527, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323959, Length=193, Percent_Identity=29.0155440414508, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24659289, Length=251, Percent_Identity=29.0836653386454, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 30170; Mature: 30170

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVQHLRVARRHRVILHDLSLTIEPGRVTALLGRNGAGKSTLLKALAGELTGSAAPNGV
CCCHHHHHHHHHHEEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCE
RVTGRIALNGEPLAQIDAQRLARLRAVLPQAAQPAFPFSVDEIVLLGRYPHARSRGGALS
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
RRDRGIAWHALARAGAETLLGRDVTTLSGGELARVQFARVLAQLWPSDDEAGRDARDASP
CCCCCHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TRYLLLDEPTAALDLAHQHRLLETVRTIAREWRLGVLAIVHDPNLAARHADTIAMLADGM
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCE
IVAHGTPHDVMTPEHIARCYGFAVKRIDSGDGTPPVMVPA
EEECCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCEEECC
>Mature Secondary Structure
MLTVQHLRVARRHRVILHDLSLTIEPGRVTALLGRNGAGKSTLLKALAGELTGSAAPNGV
CCCHHHHHHHHHHEEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCE
RVTGRIALNGEPLAQIDAQRLARLRAVLPQAAQPAFPFSVDEIVLLGRYPHARSRGGALS
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
RRDRGIAWHALARAGAETLLGRDVTTLSGGELARVQFARVLAQLWPSDDEAGRDARDASP
CCCCCHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TRYLLLDEPTAALDLAHQHRLLETVRTIAREWRLGVLAIVHDPNLAARHADTIAMLADGM
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCE
IVAHGTPHDVMTPEHIARCYGFAVKRIDSGDGTPPVMVPA
EEECCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA