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The map label for this gene is hmuU [H]

Identifier: 189353938

GI number: 189353938

Start: 2254431

End: 2255522

Strand: Direct

Name: hmuU [H]

Synonym: BMULJ_05191

Alternate gene names: 189353938

Gene position: 2254431-2255522 (Clockwise)

Preceding gene: 189353937

Following gene: 189353939

Centisome position: 91.16

GC content: 75.73

Gene sequence:

>1092_bases
ATGTCCGCTCGTCTCTCGTCGATTCGCGCGTCGTCGGCCGCCGCGGCTGCGCCCGGCGCACGACGCATCGGTACGCAGCG
CCGTTTTGCGCCCGTCGCGCTCGGCGTGCTCGCCGTGCTCGTCGGCGCGATGTCGGTCGTCGCGCTCTGTGTCGGCGCGT
ACCGCATTTCGCCGGCCGACGCGTGGGCCGCGCTCGCCGGCGACCCCGCCGCGCAGCAGGCGCGCGCGGTGCTGCTCGGC
ATCCGGGCGCCGCGCGCAGTGCTGGCGCTGCTCGTCGGCGGCGGCTTCGGCGCCGCCGGCGCCGCGATGCAGGCGCTGTT
TCGCAATCCGCTCGCCGATCCGGGGCTCGTCGGCGTGTCGAGCGGCGCGGCGCTCGGTGCGACGGCCGCGATCGTGCTCG
GCCCCGCGCTGTTCGCCGCGCATGCCGGCGCGGCCGCGCTGCCGGCCGCGGCCTTCGTCGGCGCGCTCGCAATCGCGGCG
CTCGTCTACCGGCTCGCCGCGTCGCGCGGGCGGCTCGCACTGCCGCTGCTGCTGCTCGCCGGCATCGCGATCAACGCGCT
CGTCGGCGCGGCGATCGGGCTGCTCACGTTCGTCGCCGACGACGCGCAGTTGCGCTCGCTGACGTTCTGGAGCCTCGGCA
GCCTCGGCGGCGCGCAATGGTCGACGCTCGCGGCCGTCGCGCCGTGCGCGGTGCTCGGCTGCGCACTGCTCGTGCGCGAA
CGCGATGCGCTGAACGCGCTGCAGCTCGGCGAAACCGAAGCGCTGCACCTCGGCGTGCCGGTTCAGCGGCTCAAGCGGCG
CGTGCTCGTCGCGGTCGCGCTCGCGGTCGGCGCGCTCGTGTCGTGCGCGGGAATCGTCGGCTTCATCGGGCTCGTCGCGC
CGCATTGCGTGCGTCTCGCGTGCGGGCCGGACCAGCGCATCGTGCTGCCCGGCGCCGCGTTGCTCGGTGCGCTGCTGACG
CTCGCGGCCGATCTTGCCGCACGCACGCTCGCCGCGCCGGCCGAGATTCCGCTCGGCGTGCTGACCGCGCTGCTCGGCGC
ACCGTTCTTTCTCGCGCTGCTGTGGAAAAGCCGCGGCTCGCTCGGCGCTTAG

Upstream 100 bases:

>100_bases
TCGACGCGCTGCTGCTGCTCGGCTTCGGCCCGCGGCTGCCGCTCGCGGTCACGACGCTGCATCGGCGTCTGTCGGACACG
CTCGCGTAATGGGATCGTCG

Downstream 100 bases:

>100_bases
TCGTGCCTCCGTCTCGATCATGCTGACCGTCCAACATCTCCGTGTCGCGCGCCGACATCGCGTCATCCTTCACGATCTGT
CGCTGACGATCGAACCGGGC

Product: iron complex transport system permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSARLSSIRASSAAAAAPGARRIGTQRRFAPVALGVLAVLVGAMSVVALCVGAYRISPADAWAALAGDPAAQQARAVLLG
IRAPRAVLALLVGGGFGAAGAAMQALFRNPLADPGLVGVSSGAALGATAAIVLGPALFAAHAGAAALPAAAFVGALAIAA
LVYRLAASRGRLALPLLLLAGIAINALVGAAIGLLTFVADDAQLRSLTFWSLGSLGGAQWSTLAAVAPCAVLGCALLVRE
RDALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCAGIVGFIGLVAPHCVRLACGPDQRIVLPGAALLGALLT
LAADLAARTLAAPAEIPLGVLTALLGAPFFLALLWKSRGSLGA

Sequences:

>Translated_363_residues
MSARLSSIRASSAAAAAPGARRIGTQRRFAPVALGVLAVLVGAMSVVALCVGAYRISPADAWAALAGDPAAQQARAVLLG
IRAPRAVLALLVGGGFGAAGAAMQALFRNPLADPGLVGVSSGAALGATAAIVLGPALFAAHAGAAALPAAAFVGALAIAA
LVYRLAASRGRLALPLLLLAGIAINALVGAAIGLLTFVADDAQLRSLTFWSLGSLGGAQWSTLAAVAPCAVLGCALLVRE
RDALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCAGIVGFIGLVAPHCVRLACGPDQRIVLPGAALLGALLT
LAADLAARTLAAPAEIPLGVLTALLGAPFFLALLWKSRGSLGA
>Mature_362_residues
SARLSSIRASSAAAAAPGARRIGTQRRFAPVALGVLAVLVGAMSVVALCVGAYRISPADAWAALAGDPAAQQARAVLLGI
RAPRAVLALLVGGGFGAAGAAMQALFRNPLADPGLVGVSSGAALGATAAIVLGPALFAAHAGAAALPAAAFVGALAIAAL
VYRLAASRGRLALPLLLLAGIAINALVGAAIGLLTFVADDAQLRSLTFWSLGSLGGAQWSTLAAVAPCAVLGCALLVRER
DALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCAGIVGFIGLVAPHCVRLACGPDQRIVLPGAALLGALLTL
AADLAARTLAAPAEIPLGVLTALLGAPFFLALLWKSRGSLGA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=311, Percent_Identity=40.1929260450161, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1790740, Length=299, Percent_Identity=36.7892976588629, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1790741, Length=313, Percent_Identity=35.1437699680511, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=40.2061855670103, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786804, Length=309, Percent_Identity=36.5695792880259, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786347, Length=295, Percent_Identity=31.864406779661, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35810; Mature: 35679

Theoretical pI: Translated: 11.70; Mature: 11.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARLSSIRASSAAAAAPGARRIGTQRRFAPVALGVLAVLVGAMSVVALCVGAYRISPAD
CCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AWAALAGDPAAQQARAVLLGIRAPRAVLALLVGGGFGAAGAAMQALFRNPLADPGLVGVS
HHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEECC
SGAALGATAAIVLGPALFAAHAGAAALPAAAFVGALAIAALVYRLAASRGRLALPLLLLA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GIAINALVGAAIGLLTFVADDAQLRSLTFWSLGSLGGAQWSTLAAVAPCAVLGCALLVRE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RDALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCAGIVGFIGLVAPHCVRLA
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHC
CGPDQRIVLPGAALLGALLTLAADLAARTLAAPAEIPLGVLTALLGAPFFLALLWKSRGS
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGA
CCC
>Mature Secondary Structure 
SARLSSIRASSAAAAAPGARRIGTQRRFAPVALGVLAVLVGAMSVVALCVGAYRISPAD
CCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AWAALAGDPAAQQARAVLLGIRAPRAVLALLVGGGFGAAGAAMQALFRNPLADPGLVGVS
HHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEECC
SGAALGATAAIVLGPALFAAHAGAAALPAAAFVGALAIAALVYRLAASRGRLALPLLLLA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GIAINALVGAAIGLLTFVADDAQLRSLTFWSLGSLGGAQWSTLAAVAPCAVLGCALLVRE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RDALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCAGIVGFIGLVAPHCVRLA
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHC
CGPDQRIVLPGAALLGALLTLAADLAARTLAAPAEIPLGVLTALLGAPFFLALLWKSRGS
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]