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The map label for this gene is lysA [H]

Identifier: 189353549

GI number: 189353549

Start: 1786529

End: 1787767

Strand: Direct

Name: lysA [H]

Synonym: BMULJ_04793

Alternate gene names: 189353549

Gene position: 1786529-1787767 (Clockwise)

Preceding gene: 189353546

Following gene: 189353551

Centisome position: 72.24

GC content: 67.72

Gene sequence:

>1239_bases
ATGTCCCTCGATTCCCGCCAGCTCGCTGCGCTCGCGCAGCAATACGGCACCCCGCTGTGGGTGTACGACGCCGACGTCAT
CCGCGACCGCATCGCGCAACTGCGCCAGTTCGACGTGATCCGCTATGCGCAGAAAGCGAACTCGAACGTCCATATCCTGA
AGCTGATGCGCGACGAAGGCGCGTGCGTCGACGCCGTGTCGCTCGGCGAAATCGAGCGCAGCCTCGCGGCCGGCTTCAGC
CCGGCGGGCGAGCCGGAAGGCGTCGTGTTCACCGCCGATCTCGTCGATCGTCCGACGCTCGCGGCCGTGCTGAAGCACGG
CGTGACCGTCAACGCGGGCTCGCTCGACATGCTCGAGCGCGTCGGCCAGCATGCGCCGGGCCATCGCGTGTGGCTGCGCG
TGAATCCGGGCTTCGGTCACGGGCACAGCAACAAGACCAACACCGGCGGCCCGCAGAGCAAGCACGGGATCTGGATCGAC
GACGTGCCGCGCGCGATCGCGCTCGTGCGTCAGTACGGGCTGAAGCTCGTCGGCATCCATATGCACATCGGCTCGGGCGT
CGACTACGGTCATCTGTCGCAGGTGTGCGACGCGATGGTCGACCTCGTCGCCTCGCTCGGCCACGACATCGACGCGATCT
CCGCGGGCGGCGGGCTGTCGATTCCGTATCGCGACGGCGAGCCGCGCGTCGACGTCGATCACTATTTCCGTCAATGGGAC
GCCGCGCGCAAGCGCATCGAACGCCATCTCGGCCATGCGGTGCGCATCGAGATCGAGCCGGGCCGCTTCCTGGTAGCCGA
AGCCGGTACGCTCGTCACCGAAGTGCAGGCCGTCAACCGCCGGCCGAAGCACGACTTCGTGCTGATCGATGCCGGCTTCA
ACGACCTGATGCGCCCGGCGATGTACGGCAGCTATCACGCGGTGTCCGTGCATGCGCACGACGGTGCGCTGCCCGAAGGG
CGGCCGCAGGTCGACATCGCGATCGCGGGGCCGCTGTGCGAGTCGGGCGACGTGTTTACGCAGGACGCGGGCGGCGTGGT
CACGCACCGCAAGCTCCCGCAGCCGCAGATCGGCGATCTGCTGTTCCTGCACGATGCGGGCGCGTACGGCGCGTCGATGT
CGTCGAACTACAATAGCCGGCCGCTCGCGCCGGAAGTGCTCGTCGATCGCGGTACGCCGCGGCTGATTCGCCGCCGGCAG
ACGATCGGCGAATTGCTCGCGCTCGAAACGTTCGAATAA

Upstream 100 bases:

>100_bases
ATATCCCGAATGAATTGAATGTCGATAAATCGGCATTTTACTGCATAGCAGATTGCGCGCATCATCGCGACTGTCCGTTC
AATCGACCGATCCATCCGTC

Downstream 100 bases:

>100_bases
GGCGCGCGCGCCGACTTACGGCCACACTCGCTGATGCAGGCGAGTGTGGCCGTTTTGCTTTTTGGCGGGCGGGCCGCACC
CTGCCCGTACGCGGGCGGCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSLDSRQLAALAQQYGTPLWVYDADVIRDRIAQLRQFDVIRYAQKANSNVHILKLMRDEGACVDAVSLGEIERSLAAGFS
PAGEPEGVVFTADLVDRPTLAAVLKHGVTVNAGSLDMLERVGQHAPGHRVWLRVNPGFGHGHSNKTNTGGPQSKHGIWID
DVPRAIALVRQYGLKLVGIHMHIGSGVDYGHLSQVCDAMVDLVASLGHDIDAISAGGGLSIPYRDGEPRVDVDHYFRQWD
AARKRIERHLGHAVRIEIEPGRFLVAEAGTLVTEVQAVNRRPKHDFVLIDAGFNDLMRPAMYGSYHAVSVHAHDGALPEG
RPQVDIAIAGPLCESGDVFTQDAGGVVTHRKLPQPQIGDLLFLHDAGAYGASMSSNYNSRPLAPEVLVDRGTPRLIRRRQ
TIGELLALETFE

Sequences:

>Translated_412_residues
MSLDSRQLAALAQQYGTPLWVYDADVIRDRIAQLRQFDVIRYAQKANSNVHILKLMRDEGACVDAVSLGEIERSLAAGFS
PAGEPEGVVFTADLVDRPTLAAVLKHGVTVNAGSLDMLERVGQHAPGHRVWLRVNPGFGHGHSNKTNTGGPQSKHGIWID
DVPRAIALVRQYGLKLVGIHMHIGSGVDYGHLSQVCDAMVDLVASLGHDIDAISAGGGLSIPYRDGEPRVDVDHYFRQWD
AARKRIERHLGHAVRIEIEPGRFLVAEAGTLVTEVQAVNRRPKHDFVLIDAGFNDLMRPAMYGSYHAVSVHAHDGALPEG
RPQVDIAIAGPLCESGDVFTQDAGGVVTHRKLPQPQIGDLLFLHDAGAYGASMSSNYNSRPLAPEVLVDRGTPRLIRRRQ
TIGELLALETFE
>Mature_411_residues
SLDSRQLAALAQQYGTPLWVYDADVIRDRIAQLRQFDVIRYAQKANSNVHILKLMRDEGACVDAVSLGEIERSLAAGFSP
AGEPEGVVFTADLVDRPTLAAVLKHGVTVNAGSLDMLERVGQHAPGHRVWLRVNPGFGHGHSNKTNTGGPQSKHGIWIDD
VPRAIALVRQYGLKLVGIHMHIGSGVDYGHLSQVCDAMVDLVASLGHDIDAISAGGGLSIPYRDGEPRVDVDHYFRQWDA
ARKRIERHLGHAVRIEIEPGRFLVAEAGTLVTEVQAVNRRPKHDFVLIDAGFNDLMRPAMYGSYHAVSVHAHDGALPEGR
PQVDIAIAGPLCESGDVFTQDAGGVVTHRKLPQPQIGDLLFLHDAGAYGASMSSNYNSRPLAPEVLVDRGTPRLIRRRQT
IGELLALETFE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=400, Percent_Identity=63.25, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24586472, Length=357, Percent_Identity=26.3305322128852, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44876; Mature: 44744

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDSRQLAALAQQYGTPLWVYDADVIRDRIAQLRQFDVIRYAQKANSNVHILKLMRDEG
CCCCHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
ACVDAVSLGEIERSLAAGFSPAGEPEGVVFTADLVDRPTLAAVLKHGVTVNAGSLDMLER
CEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCHHHHHHHHCCCEECCCCHHHHHH
VGQHAPGHRVWLRVNPGFGHGHSNKTNTGGPQSKHGIWIDDVPRAIALVRQYGLKLVGIH
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEE
MHIGSGVDYGHLSQVCDAMVDLVASLGHDIDAISAGGGLSIPYRDGEPRVDVDHYFRQWD
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
AARKRIERHLGHAVRIEIEPGRFLVAEAGTLVTEVQAVNRRPKHDFVLIDAGFNDLMRPA
HHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
MYGSYHAVSVHAHDGALPEGRPQVDIAIAGPLCESGDVFTQDAGGVVTHRKLPQPQIGDL
HCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCE
LFLHDAGAYGASMSSNYNSRPLAPEVLVDRGTPRLIRRRQTIGELLALETFE
EEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLDSRQLAALAQQYGTPLWVYDADVIRDRIAQLRQFDVIRYAQKANSNVHILKLMRDEG
CCCHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
ACVDAVSLGEIERSLAAGFSPAGEPEGVVFTADLVDRPTLAAVLKHGVTVNAGSLDMLER
CEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCHHHHHHHHCCCEECCCCHHHHHH
VGQHAPGHRVWLRVNPGFGHGHSNKTNTGGPQSKHGIWIDDVPRAIALVRQYGLKLVGIH
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEE
MHIGSGVDYGHLSQVCDAMVDLVASLGHDIDAISAGGGLSIPYRDGEPRVDVDHYFRQWD
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
AARKRIERHLGHAVRIEIEPGRFLVAEAGTLVTEVQAVNRRPKHDFVLIDAGFNDLMRPA
HHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
MYGSYHAVSVHAHDGALPEGRPQVDIAIAGPLCESGDVFTQDAGGVVTHRKLPQPQIGDL
HCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCE
LFLHDAGAYGASMSSNYNSRPLAPEVLVDRGTPRLIRRRQTIGELLALETFE
EEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]