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The map label for this gene is mdtN [H]

Identifier: 189353287

GI number: 189353287

Start: 1524020

End: 1525069

Strand: Direct

Name: mdtN [H]

Synonym: BMULJ_04527

Alternate gene names: 189353287

Gene position: 1524020-1525069 (Clockwise)

Preceding gene: 189353286

Following gene: 189353288

Centisome position: 61.62

GC content: 71.05

Gene sequence:

>1050_bases
ATGAAGGCCGCCGGACTCTCCCGCCCGTCCGCGAAAGGCCGCGCGATCGCGATCACGATCGTCGCACTCGGCATCGCGGC
TCTCGCGTACGCGTATCACCGCACCACCGCCTACCCGTCCACCGACGACGCGTCGATCGACGCGGACGTCGTGCACGTCG
CGTCGCCCGTCGGCGGACGCATCGTGCGGCTCGCGGTGCACGAGAACCAGCGCGTCGCAAAAGGCGACCTGCTCTATGAA
ATCGATCCGGTGCCGTACCGGCTCGCCGTTGCGCAGGCACAGGCCGACGTCGAGCTCGCGCGCGCGTCGCTCGACACGCG
CCGCCGTTCGCTGATCGGCGAGCGCTCGAATGCGGCGGTGGCGGCCGAGCAGGTCAAGCGCGCGAAGCAGAATCACGATC
TCGCGACGCGCGACGTCGAGCGGCTGGCGCCGCTCGCCGCGCAGGGCTATGTCAGCGCGCAGCAGTTCGACCAGGCCAAG
GTCCGGCAGCGCGACGCGGCCGTGTCGCTCGCGCAGGCGCAGGAGCAGCAGCGCGCGTCCGCGCAGACGATCGGCGACGA
AGCCGACGCGATCGCGACGCTGCATGCACGCGAAGCCGCGCTGGCCCGCGCGCAGCACGCGCTCGAGGACACCGTCGTGC
GCGCGCCACACGACGGGCTCGTGACGGGCCTGACCGTGCTCGCCGGCGAAACGCTCGCGCCGAACCAGTCGATCTTCACG
CTGATCGATGCGAGCGAATGGTTCGCCGTCGGCAATTTCCGCGAGACGTCGCTGAACCGCATCGCCGTCGGCGACTGCGC
GACCGTCTATTCGATGATCGACCGCGGCCGCCCGATGACGGGCAAGGTCGTCGGCATCGGCGCCGGCATCGCCGACAGCG
ATCGCATCAACCTGCCGCGCTCGCTGCCGATCGTGCAGCGTTCGGTGAACTGGGTGCATGTCGCGCAGCGCTTCCCCGTG
CGCGTGAAGCTCGACGAACCCGACGCGGGGCTCGTGCGCGTCGGCGCCAGCGCGATCGTCGAGGTCCGGCATGGCGCAGC
CTGCCGCTGA

Upstream 100 bases:

>100_bases
CCGGTTGGGCCACCGTCGTGCCTTATCAGTTGGCCGTCTGCACCGCGATCGGCCTCGTGATCGCCGTGATCGTCTGGCTC
GCCGGCACGGGGCCGTTCGC

Downstream 100 bases:

>100_bases
GGTCCGCTCGCCCGGCCTGCGCGAAGTCCTGCGACTGCTCGCGCCGTTTCCGGGACGCACGGCGATCGCCGTGCGCGTCG
CGCTGATCTGCACGCTGACC

Product: multidrug resistance protein MdtN

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKAAGLSRPSAKGRAIAITIVALGIAALAYAYHRTTAYPSTDDASIDADVVHVASPVGGRIVRLAVHENQRVAKGDLLYE
IDPVPYRLAVAQAQADVELARASLDTRRRSLIGERSNAAVAAEQVKRAKQNHDLATRDVERLAPLAAQGYVSAQQFDQAK
VRQRDAAVSLAQAQEQQRASAQTIGDEADAIATLHAREAALARAQHALEDTVVRAPHDGLVTGLTVLAGETLAPNQSIFT
LIDASEWFAVGNFRETSLNRIAVGDCATVYSMIDRGRPMTGKVVGIGAGIADSDRINLPRSLPIVQRSVNWVHVAQRFPV
RVKLDEPDAGLVRVGASAIVEVRHGAACR

Sequences:

>Translated_349_residues
MKAAGLSRPSAKGRAIAITIVALGIAALAYAYHRTTAYPSTDDASIDADVVHVASPVGGRIVRLAVHENQRVAKGDLLYE
IDPVPYRLAVAQAQADVELARASLDTRRRSLIGERSNAAVAAEQVKRAKQNHDLATRDVERLAPLAAQGYVSAQQFDQAK
VRQRDAAVSLAQAQEQQRASAQTIGDEADAIATLHAREAALARAQHALEDTVVRAPHDGLVTGLTVLAGETLAPNQSIFT
LIDASEWFAVGNFRETSLNRIAVGDCATVYSMIDRGRPMTGKVVGIGAGIADSDRINLPRSLPIVQRSVNWVHVAQRFPV
RVKLDEPDAGLVRVGASAIVEVRHGAACR
>Mature_349_residues
MKAAGLSRPSAKGRAIAITIVALGIAALAYAYHRTTAYPSTDDASIDADVVHVASPVGGRIVRLAVHENQRVAKGDLLYE
IDPVPYRLAVAQAQADVELARASLDTRRRSLIGERSNAAVAAEQVKRAKQNHDLATRDVERLAPLAAQGYVSAQQFDQAK
VRQRDAAVSLAQAQEQQRASAQTIGDEADAIATLHAREAALARAQHALEDTVVRAPHDGLVTGLTVLAGETLAPNQSIFT
LIDASEWFAVGNFRETSLNRIAVGDCATVYSMIDRGRPMTGKVVGIGAGIADSDRINLPRSLPIVQRSVNWVHVAQRFPV
RVKLDEPDAGLVRVGASAIVEVRHGAACR

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=310, Percent_Identity=38.7096774193548, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87081951, Length=310, Percent_Identity=29.3548387096774, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789637, Length=328, Percent_Identity=28.0487804878049, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789041, Length=334, Percent_Identity=26.6467065868263, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788711, Length=333, Percent_Identity=25.2252252252252, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790024, Length=256, Percent_Identity=27.734375, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790012, Length=272, Percent_Identity=29.7794117647059, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37256; Mature: 37256

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAGLSRPSAKGRAIAITIVALGIAALAYAYHRTTAYPSTDDASIDADVVHVASPVGGR
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCE
IVRLAVHENQRVAKGDLLYEIDPVPYRLAVAQAQADVELARASLDTRRRSLIGERSNAAV
EEEEEEECCCCEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AAEQVKRAKQNHDLATRDVERLAPLAAQGYVSAQQFDQAKVRQRDAAVSLAQAQEQQRAS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTIGDEADAIATLHAREAALARAQHALEDTVVRAPHDGLVTGLTVLAGETLAPNQSIFT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEE
LIDASEWFAVGNFRETSLNRIAVGDCATVYSMIDRGRPMTGKVVGIGAGIADSDRINLPR
EEECCHHEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
SLPIVQRSVNWVHVAQRFPVRVKLDEPDAGLVRVGASAIVEVRHGAACR
CCHHHHHCCCEEEEECCCCEEEEECCCCCCEEEECHHHHHEECCCCCCC
>Mature Secondary Structure
MKAAGLSRPSAKGRAIAITIVALGIAALAYAYHRTTAYPSTDDASIDADVVHVASPVGGR
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCE
IVRLAVHENQRVAKGDLLYEIDPVPYRLAVAQAQADVELARASLDTRRRSLIGERSNAAV
EEEEEEECCCCEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AAEQVKRAKQNHDLATRDVERLAPLAAQGYVSAQQFDQAKVRQRDAAVSLAQAQEQQRAS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTIGDEADAIATLHAREAALARAQHALEDTVVRAPHDGLVTGLTVLAGETLAPNQSIFT
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEE
LIDASEWFAVGNFRETSLNRIAVGDCATVYSMIDRGRPMTGKVVGIGAGIADSDRINLPR
EEECCHHEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
SLPIVQRSVNWVHVAQRFPVRVKLDEPDAGLVRVGASAIVEVRHGAACR
CCHHHHHCCCEEEEECCCCEEEEECCCCCCEEEECHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]