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The map label for this gene is fdh [H]

Identifier: 189353203

GI number: 189353203

Start: 1429712

End: 1432036

Strand: Direct

Name: fdh [H]

Synonym: BMULJ_04439

Alternate gene names: 189353203

Gene position: 1429712-1432036 (Clockwise)

Preceding gene: 189353201

Following gene: 189353204

Centisome position: 57.81

GC content: 67.61

Gene sequence:

>2325_bases
ATGAGAAAGAAATCCGCCACCGCGCGCATCGAGCCGTACACTCACCCCGCCGCCGGCTGGGGCGCGCTGAAAGCCGTCAC
GATCAACCTGATCAAGGAGAAGGTCGCCGGCGGCAACTACCGCACGCTGCTGCGCCAGAACCAGCCCGACGGCTTCGACT
GCCCGGGCTGCGCCTGGCCCGACCGCCAGCACGCGTCCACGTTCGAGTTCTGCGAGAACGGCGTGAAGGCCGTTGCGGCC
GAAGCGACGAGCAAGCGCGTGACGCCGGCGTTCTTCGCCGAACACACGGTGACCGAACTGCTCGAACAGTCGGACTTCGA
GCTGGAACAGCACGGCCGGCTCACCGATCCGATGGTGTACGACGCACAGAGCGACCGCTACGTGCCGATCGCGTGGGACG
ACGCGTTCGCGCTGATCGCGCGGCATCTGCGCGCGCTGCCCGACCCGAATCAGGCCGCGTTCTACACGTCCGGCCGCGCG
AGCAACGAAGCGGCGTTCCTGTATCAGCTGCTCGTGCGGATGTACGGGACCAACAACTTTCCCGACTGCTCGAACATGTG
CCACGAGGCGACGAGCCGCGGGCTGCCGGCGTCGGTCGGCGTCGGCAAGGGCACCGTCACGCTCGACGATTTCGAGCATG
CGGACACGTTGCTGATCTTCGGCCAGAACCCGGCGACCAACCATCCGCGCATGCTCGGCGAACTGCGCGAATGCGCGAAG
CGCGGCGCGACGATCGTGTCGATCAATCCGCTGAAGGAGCGCGGGCTGGAACGTTTCGCCGATCCGCAAAGCCCGCTCGA
GATGCTGACGATGTCGGGCACGCGGATCGCCTCGACCTTCATCCAGCCGACGCTCGGCGGCGACTTCGCGCTGATCAAGG
GTGTCGCGAAACGCGTGCTCGAGCTCGACGACGCGGCGCGCGCCGCCGGTGCGCCGCGCGTGCTCGACACCGCGTTCATC
GACGCGCACACGGCCGGCTTCGACGCGTTCGCCGACGATCTGCGCGCCGAAAACTGGGCCGCGCTGACCGCCGAAAGCGG
CGTGCCGTACGAGCAGATCGACGCGCTCGCGCAGCTTTACGCGCGCAGCGAGCGCGTGATCGCGACGTGGGGCATGGGGA
TCACGCAGCACAAGCATTCGGTCGCGACCGTGCAGATGCTGACGAACCTGATGCTGATGCGCGGCAACATCGGCCGGCCC
GGCGCGGGGCTGTGTCCGGTGCGCGGCCATTCGAACGTGCAGGGCAACCGCACGGTCGGCATCGAGGAAAAGCCGACGCT
GTCGTTCCTCGAACGGCTCGGCCGCGTATTCGACTTCGAGCCGCCGCGCGAACACGGGTACGACGTCGTCGAGACGATCG
AGGCGATGCTCGACGGCCGCGTGAAGGTCCTGATCGGCCTCGGCGGCAACTTCGCGATGGCGACGCCCGACACGCCGCGC
ACGTGGGAAGGGATGCGCCGCTGCAACCTGACCGTGCACATCACGACGAAGCTGAACCGCAGCCATCTGATCCACGGCCG
CGACGCGCTGATCCTGCCGACGCTCGGCCGCACCGAGGTCGACCTGCAGGGCAACGTGCCGCAAGGCGTCACCGTCGAGG
ATTCGATGAGCATGGTGCACGTCTCGTACGGGATGAACCGGCCCGCGTCGCCGAACCTGATGTCGGAGCCCGCGATCGTC
GCGCATATCGGCCATGCGCTGTTCGGCAGCGACAAGGTCGATTGGCTCGCGTACAAGAACGACTACGCGAAGATTCGCGA
CGCGATCGAAGCGACGCTCGACGGCTTCTACGACTACAACGCGCGCATCGCGCGGCCGGGCGGCTTTCATTTGCGTGTCG
CGTCGCGCGACCGCGAGTGGCTGACGCCGAACGGCAAGGCAAACTTCATCGCGCACGCGCTGCCGACCGACACGCCGATC
CAACGCGCACGCGCCCTGCACGGCGAGCGGCTGATGACGCTGATGACCACGCGCTCGCACGACCAGTACAACACGACCGT
CTACGGGCTCGACGACCGCTATCGCGGCGTGTTCGGCCAGCGTCGCGTCGTGTTCGCGAACCGCGACGATCTCGCGATGC
TCGGCCTGAAGGCCGGCGACTGGGTCGACATGGAAACGGTGTGGCACGACGGCATCGAGCGGCGCGCGAACGGCTTCCTG
CTCGTCGAATACGACATTCCGCGCGGCTGCATCGGCGCGTACTACCCGGAAACGAATCCGCTCGTGCCGCTCGACAGCGT
CGGCGACGTCTGCAACACGCCGACCTCGAAATCGATTCCGGTGCTGCTGCATCGCGCCGCCGCGCCGGTCTCGGCGGCCG
CGTGA

Upstream 100 bases:

>100_bases
GAAACGCCGCAACTGTACTCTTTTTTGAAGTGAACAGGTGTACACACAGCGCATGCGGTGCGGCGCGTACTCTGCACGCA
TCGATCCCGACAGACGCATC

Downstream 100 bases:

>100_bases
CGGAGTGCCGCGATGATCGTTCGTCCGCGCGAGCACTGGCTGCGCATGCTGCTGGTGTGGAACGGCTCGGTGCTGCTGAC
GATCCTGCCGCAGCTCGTGC

Product: formate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 774; Mature: 774

Protein sequence:

>774_residues
MRKKSATARIEPYTHPAAGWGALKAVTINLIKEKVAGGNYRTLLRQNQPDGFDCPGCAWPDRQHASTFEFCENGVKAVAA
EATSKRVTPAFFAEHTVTELLEQSDFELEQHGRLTDPMVYDAQSDRYVPIAWDDAFALIARHLRALPDPNQAAFYTSGRA
SNEAAFLYQLLVRMYGTNNFPDCSNMCHEATSRGLPASVGVGKGTVTLDDFEHADTLLIFGQNPATNHPRMLGELRECAK
RGATIVSINPLKERGLERFADPQSPLEMLTMSGTRIASTFIQPTLGGDFALIKGVAKRVLELDDAARAAGAPRVLDTAFI
DAHTAGFDAFADDLRAENWAALTAESGVPYEQIDALAQLYARSERVIATWGMGITQHKHSVATVQMLTNLMLMRGNIGRP
GAGLCPVRGHSNVQGNRTVGIEEKPTLSFLERLGRVFDFEPPREHGYDVVETIEAMLDGRVKVLIGLGGNFAMATPDTPR
TWEGMRRCNLTVHITTKLNRSHLIHGRDALILPTLGRTEVDLQGNVPQGVTVEDSMSMVHVSYGMNRPASPNLMSEPAIV
AHIGHALFGSDKVDWLAYKNDYAKIRDAIEATLDGFYDYNARIARPGGFHLRVASRDREWLTPNGKANFIAHALPTDTPI
QRARALHGERLMTLMTTRSHDQYNTTVYGLDDRYRGVFGQRRVVFANRDDLAMLGLKAGDWVDMETVWHDGIERRANGFL
LVEYDIPRGCIGAYYPETNPLVPLDSVGDVCNTPTSKSIPVLLHRAAAPVSAAA

Sequences:

>Translated_774_residues
MRKKSATARIEPYTHPAAGWGALKAVTINLIKEKVAGGNYRTLLRQNQPDGFDCPGCAWPDRQHASTFEFCENGVKAVAA
EATSKRVTPAFFAEHTVTELLEQSDFELEQHGRLTDPMVYDAQSDRYVPIAWDDAFALIARHLRALPDPNQAAFYTSGRA
SNEAAFLYQLLVRMYGTNNFPDCSNMCHEATSRGLPASVGVGKGTVTLDDFEHADTLLIFGQNPATNHPRMLGELRECAK
RGATIVSINPLKERGLERFADPQSPLEMLTMSGTRIASTFIQPTLGGDFALIKGVAKRVLELDDAARAAGAPRVLDTAFI
DAHTAGFDAFADDLRAENWAALTAESGVPYEQIDALAQLYARSERVIATWGMGITQHKHSVATVQMLTNLMLMRGNIGRP
GAGLCPVRGHSNVQGNRTVGIEEKPTLSFLERLGRVFDFEPPREHGYDVVETIEAMLDGRVKVLIGLGGNFAMATPDTPR
TWEGMRRCNLTVHITTKLNRSHLIHGRDALILPTLGRTEVDLQGNVPQGVTVEDSMSMVHVSYGMNRPASPNLMSEPAIV
AHIGHALFGSDKVDWLAYKNDYAKIRDAIEATLDGFYDYNARIARPGGFHLRVASRDREWLTPNGKANFIAHALPTDTPI
QRARALHGERLMTLMTTRSHDQYNTTVYGLDDRYRGVFGQRRVVFANRDDLAMLGLKAGDWVDMETVWHDGIERRANGFL
LVEYDIPRGCIGAYYPETNPLVPLDSVGDVCNTPTSKSIPVLLHRAAAPVSAAA
>Mature_774_residues
MRKKSATARIEPYTHPAAGWGALKAVTINLIKEKVAGGNYRTLLRQNQPDGFDCPGCAWPDRQHASTFEFCENGVKAVAA
EATSKRVTPAFFAEHTVTELLEQSDFELEQHGRLTDPMVYDAQSDRYVPIAWDDAFALIARHLRALPDPNQAAFYTSGRA
SNEAAFLYQLLVRMYGTNNFPDCSNMCHEATSRGLPASVGVGKGTVTLDDFEHADTLLIFGQNPATNHPRMLGELRECAK
RGATIVSINPLKERGLERFADPQSPLEMLTMSGTRIASTFIQPTLGGDFALIKGVAKRVLELDDAARAAGAPRVLDTAFI
DAHTAGFDAFADDLRAENWAALTAESGVPYEQIDALAQLYARSERVIATWGMGITQHKHSVATVQMLTNLMLMRGNIGRP
GAGLCPVRGHSNVQGNRTVGIEEKPTLSFLERLGRVFDFEPPREHGYDVVETIEAMLDGRVKVLIGLGGNFAMATPDTPR
TWEGMRRCNLTVHITTKLNRSHLIHGRDALILPTLGRTEVDLQGNVPQGVTVEDSMSMVHVSYGMNRPASPNLMSEPAIV
AHIGHALFGSDKVDWLAYKNDYAKIRDAIEATLDGFYDYNARIARPGGFHLRVASRDREWLTPNGKANFIAHALPTDTPI
QRARALHGERLMTLMTTRSHDQYNTTVYGLDDRYRGVFGQRRVVFANRDDLAMLGLKAGDWVDMETVWHDGIERRANGFL
LVEYDIPRGCIGAYYPETNPLVPLDSVGDVCNTPTSKSIPVLLHRAAAPVSAAA

Specific function: Probably involved in acid resistance [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787778, Length=757, Percent_Identity=50.9907529722589, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=371, Percent_Identity=27.2237196765499, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788534, Length=387, Percent_Identity=27.390180878553, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI87081994, Length=314, Percent_Identity=23.5668789808917, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR010046 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: NA

Molecular weight: Translated: 85160; Mature: 85160

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKSATARIEPYTHPAAGWGALKAVTINLIKEKVAGGNYRTLLRQNQPDGFDCPGCAWP
CCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCCCC
DRQHASTFEFCENGVKAVAAEATSKRVTPAFFAEHTVTELLEQSDFELEQHGRLTDPMVY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEE
DAQSDRYVPIAWDDAFALIARHLRALPDPNQAAFYTSGRASNEAAFLYQLLVRMYGTNNF
ECCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PDCSNMCHEATSRGLPASVGVGKGTVTLDDFEHADTLLIFGQNPATNHPRMLGELRECAK
CCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
RGATIVSINPLKERGLERFADPQSPLEMLTMSGTRIASTFIQPTLGGDFALIKGVAKRVL
CCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
ELDDAARAAGAPRVLDTAFIDAHTAGFDAFADDLRAENWAALTAESGVPYEQIDALAQLY
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
ARSERVIATWGMGITQHKHSVATVQMLTNLMLMRGNIGRPGAGLCPVRGHSNVQGNRTVG
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEC
IEEKPTLSFLERLGRVFDFEPPREHGYDVVETIEAMLDGRVKVLIGLGGNFAMATPDTPR
CCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEEEEECCCEEECCCCCCH
TWEGMRRCNLTVHITTKLNRSHLIHGRDALILPTLGRTEVDLQGNVPQGVTVEDSMSMVH
HHHHHHHCCEEEEEEEECCCCEEECCCCEEEEECCCCEEEEECCCCCCCCEECCCCCEEE
VSYGMNRPASPNLMSEPAIVAHIGHALFGSDKVDWLAYKNDYAKIRDAIEATLDGFYDYN
EECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCC
ARIARPGGFHLRVASRDREWLTPNGKANFIAHALPTDTPIQRARALHGERLMTLMTTRSH
CEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
DQYNTTVYGLDDRYRGVFGQRRVVFANRDDLAMLGLKAGDWVDMETVWHDGIERRANGFL
CCCCCEEEECCHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
LVEYDIPRGCIGAYYPETNPLVPLDSVGDVCNTPTSKSIPVLLHRAAAPVSAAA
EEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRKKSATARIEPYTHPAAGWGALKAVTINLIKEKVAGGNYRTLLRQNQPDGFDCPGCAWP
CCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCCCC
DRQHASTFEFCENGVKAVAAEATSKRVTPAFFAEHTVTELLEQSDFELEQHGRLTDPMVY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCEEE
DAQSDRYVPIAWDDAFALIARHLRALPDPNQAAFYTSGRASNEAAFLYQLLVRMYGTNNF
ECCCCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PDCSNMCHEATSRGLPASVGVGKGTVTLDDFEHADTLLIFGQNPATNHPRMLGELRECAK
CCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
RGATIVSINPLKERGLERFADPQSPLEMLTMSGTRIASTFIQPTLGGDFALIKGVAKRVL
CCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
ELDDAARAAGAPRVLDTAFIDAHTAGFDAFADDLRAENWAALTAESGVPYEQIDALAQLY
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
ARSERVIATWGMGITQHKHSVATVQMLTNLMLMRGNIGRPGAGLCPVRGHSNVQGNRTVG
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEC
IEEKPTLSFLERLGRVFDFEPPREHGYDVVETIEAMLDGRVKVLIGLGGNFAMATPDTPR
CCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEEEEECCCEEECCCCCCH
TWEGMRRCNLTVHITTKLNRSHLIHGRDALILPTLGRTEVDLQGNVPQGVTVEDSMSMVH
HHHHHHHCCEEEEEEEECCCCEEECCCCEEEEECCCCEEEEECCCCCCCCEECCCCCEEE
VSYGMNRPASPNLMSEPAIVAHIGHALFGSDKVDWLAYKNDYAKIRDAIEATLDGFYDYN
EECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCC
ARIARPGGFHLRVASRDREWLTPNGKANFIAHALPTDTPIQRARALHGERLMTLMTTRSH
CEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
DQYNTTVYGLDDRYRGVFGQRRVVFANRDDLAMLGLKAGDWVDMETVWHDGIERRANGFL
CCCCCEEEECCHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEE
LVEYDIPRGCIGAYYPETNPLVPLDSVGDVCNTPTSKSIPVLLHRAAAPVSAAA
EEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]