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The map label for this gene is mscM [H]

Identifier: 189353201

GI number: 189353201

Start: 1426826

End: 1428100

Strand: Direct

Name: mscM [H]

Synonym: BMULJ_04437

Alternate gene names: 189353201

Gene position: 1426826-1428100 (Clockwise)

Preceding gene: 189353200

Following gene: 189353203

Centisome position: 57.69

GC content: 66.27

Gene sequence:

>1275_bases
ATGACTTTGAATGAATCCTGGTTTGCGCCGCTCGTCGGCACGCTCATCCTGCTCGCTGCCGCCGGCGTCGTCACCGCGGC
CGTCCATTTCCTGCTGTTTCGCGTCGTCGCACGGCTCGCGCGGCGCTCGGCCACGCGCATCGACGATGCGCTGTTCCAGT
TCGGCGCGTTCAAGTGGCTGAACCGCATCGTCCCGTTCGTCGTGATCAAGCTCGGGCTCGGCGCCGTGCCCGGCCTGCCG
GACGCCGCCGCGCAGGCCGCCGACAAGGTGCTGTTCGCGCTGATCGTGTTCGTCGTCACGATGACGATCAGCGCGACGCT
GTCCGCGCTCGAGCATACGTACCGCACGACGCGCCGCGAACAGCCGCGCCTGTCGCTGAAAGGCGCGATGCAGCTCGTCA
AGCTCGTGATGTTCATCACGGCCGCGCTCGTCGTGATCGGCGATGCGACCGGCAAGCAGATCGGCCTGCTGCTGTCCGGC
ATCGGCGCGATGTCGGCGGTGCTGATGCTGATCTTCAAGGACACGCTGCTCGGGCTCGTCGCCGGCGTGCAGCTGTCGTC
GAACGACATGCTGCGGATCGGCGACTGGATCACGATGCCGTCCGCCGGCGCGGACGGCACGGTGATCGACATCACGCTGA
ACACGGTAAAAGTCGCGAACTTCGATCACACGATCATCACCGTGCCGACCTGGAAGCTCATCACCGAGAGCTACCAGAAC
TGGCGCGGGATGACCGAAGCCGGCGGCCGCCGGATCAAGCGCGCGCTCTTCATCGACGCGACGAGCGTGCGCTTTCTGAC
GAACGACGAGATCGCGCGGCTCGAACGGCTCACGCTGCTGAAGGATTATCTGGACGAAAAGGTCGACGCGATCGCGCAAT
GGAACGGCGCGCTCGGCCCAGCGGCCGAGTGCCCGGCGAACCGCCGCCAGCTGACGAACCTCGGCACGTTTCGCGCCTAC
GTCGCGAACTATCTGCAGTGGCATCCGCGCATCCGCCGCGACATGACCTGCATGGCGCGCCAGCTGCCGCTCACCGCCGA
GGGCATTCCGCTCGAGCTGTACTGCTTCACCGACACGACGACGTGGGTCGACTATGAAGCGATCCAGTCCGATCTGTTCG
ACCATCTGATCGCGATCCTGCCGGAATTCGGGCTGCGCGTGTACCAGCATCCGTCGGGGTTCGACATGCGCGAGATGACG
GGCGCCGTGCGCGCCGATGCACGCCGCGCCGCCGCCGAACCGACCGACGATCCGGAAACTGCGATCGCCGCCTAG

Upstream 100 bases:

>100_bases
CCCGATGGCACAATCGCTGTCCCTTTCAAGTGCCCTTCAGCGGGCACGCGCCGCATCGCGGCGCCGATTCCAATGCAACA
GAAGGACCGCACCACCCGCT

Downstream 100 bases:

>100_bases
CGGGCCGCCGCGCCGCGCGCGACGCCGCGCGGCGTGCTCACGCGGCCGCGCATTCGGCCGCGAGCCGCCCGAGCACCTTC
AGCGCCTCCTCCATCTGCCG

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTLNESWFAPLVGTLILLAAAGVVTAAVHFLLFRVVARLARRSATRIDDALFQFGAFKWLNRIVPFVVIKLGLGAVPGLP
DAAAQAADKVLFALIVFVVTMTISATLSALEHTYRTTRREQPRLSLKGAMQLVKLVMFITAALVVIGDATGKQIGLLLSG
IGAMSAVLMLIFKDTLLGLVAGVQLSSNDMLRIGDWITMPSAGADGTVIDITLNTVKVANFDHTIITVPTWKLITESYQN
WRGMTEAGGRRIKRALFIDATSVRFLTNDEIARLERLTLLKDYLDEKVDAIAQWNGALGPAAECPANRRQLTNLGTFRAY
VANYLQWHPRIRRDMTCMARQLPLTAEGIPLELYCFTDTTTWVDYEAIQSDLFDHLIAILPEFGLRVYQHPSGFDMREMT
GAVRADARRAAAEPTDDPETAIAA

Sequences:

>Translated_424_residues
MTLNESWFAPLVGTLILLAAAGVVTAAVHFLLFRVVARLARRSATRIDDALFQFGAFKWLNRIVPFVVIKLGLGAVPGLP
DAAAQAADKVLFALIVFVVTMTISATLSALEHTYRTTRREQPRLSLKGAMQLVKLVMFITAALVVIGDATGKQIGLLLSG
IGAMSAVLMLIFKDTLLGLVAGVQLSSNDMLRIGDWITMPSAGADGTVIDITLNTVKVANFDHTIITVPTWKLITESYQN
WRGMTEAGGRRIKRALFIDATSVRFLTNDEIARLERLTLLKDYLDEKVDAIAQWNGALGPAAECPANRRQLTNLGTFRAY
VANYLQWHPRIRRDMTCMARQLPLTAEGIPLELYCFTDTTTWVDYEAIQSDLFDHLIAILPEFGLRVYQHPSGFDMREMT
GAVRADARRAAAEPTDDPETAIAA
>Mature_423_residues
TLNESWFAPLVGTLILLAAAGVVTAAVHFLLFRVVARLARRSATRIDDALFQFGAFKWLNRIVPFVVIKLGLGAVPGLPD
AAAQAADKVLFALIVFVVTMTISATLSALEHTYRTTRREQPRLSLKGAMQLVKLVMFITAALVVIGDATGKQIGLLLSGI
GAMSAVLMLIFKDTLLGLVAGVQLSSNDMLRIGDWITMPSAGADGTVIDITLNTVKVANFDHTIITVPTWKLITESYQNW
RGMTEAGGRRIKRALFIDATSVRFLTNDEIARLERLTLLKDYLDEKVDAIAQWNGALGPAAECPANRRQLTNLGTFRAYV
ANYLQWHPRIRRDMTCMARQLPLTAEGIPLELYCFTDTTTWVDYEAIQSDLFDHLIAILPEFGLRVYQHPSGFDMREMTG
AVRADARRAAAEPTDDPETAIAA

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=282, Percent_Identity=53.9007092198582, Blast_Score=330, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 46637; Mature: 46506

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNESWFAPLVGTLILLAAAGVVTAAVHFLLFRVVARLARRSATRIDDALFQFGAFKWL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRIVPFVVIKLGLGAVPGLPDAAAQAADKVLFALIVFVVTMTISATLSALEHTYRTTRRE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPRLSLKGAMQLVKLVMFITAALVVIGDATGKQIGLLLSGIGAMSAVLMLIFKDTLLGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVQLSSNDMLRIGDWITMPSAGADGTVIDITLNTVKVANFDHTIITVPTWKLITESYQN
HCCEECCCCCEEECCEEECCCCCCCCEEEEEEEEEEEEECCCCEEEECCHHHHHHHHHHH
WRGMTEAGGRRIKRALFIDATSVRFLTNDEIARLERLTLLKDYLDEKVDAIAQWNGALGP
CCCCHHHHHHHHHHHHEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAECPANRRQLTNLGTFRAYVANYLQWHPRIRRDMTCMARQLPLTAEGIPLELYCFTDTT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
TWVDYEAIQSDLFDHLIAILPEFGLRVYQHPSGFDMREMTGAVRADARRAAAEPTDDPET
CHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
AIAA
HCCC
>Mature Secondary Structure 
TLNESWFAPLVGTLILLAAAGVVTAAVHFLLFRVVARLARRSATRIDDALFQFGAFKWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRIVPFVVIKLGLGAVPGLPDAAAQAADKVLFALIVFVVTMTISATLSALEHTYRTTRRE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPRLSLKGAMQLVKLVMFITAALVVIGDATGKQIGLLLSGIGAMSAVLMLIFKDTLLGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVQLSSNDMLRIGDWITMPSAGADGTVIDITLNTVKVANFDHTIITVPTWKLITESYQN
HCCEECCCCCEEECCEEECCCCCCCCEEEEEEEEEEEEECCCCEEEECCHHHHHHHHHHH
WRGMTEAGGRRIKRALFIDATSVRFLTNDEIARLERLTLLKDYLDEKVDAIAQWNGALGP
CCCCHHHHHHHHHHHHEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAECPANRRQLTNLGTFRAYVANYLQWHPRIRRDMTCMARQLPLTAEGIPLELYCFTDTT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
TWVDYEAIQSDLFDHLIAILPEFGLRVYQHPSGFDMREMTGAVRADARRAAAEPTDDPET
CHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
AIAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]