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The map label for this gene is aroP [H]

Identifier: 189353003

GI number: 189353003

Start: 1167302

End: 1168687

Strand: Direct

Name: aroP [H]

Synonym: BMULJ_04237

Alternate gene names: 189353003

Gene position: 1167302-1168687 (Clockwise)

Preceding gene: 189353001

Following gene: 189353004

Centisome position: 47.2

GC content: 63.64

Gene sequence:

>1386_bases
ATGGTTTCTGGAAACGAGAAGGACGGCCTGAAGCGTGGGCTGAAGAACCGGCACATCCAGCTGATTGCGCTGGGTGGCGC
ACTGGGTACCGGGCTGTTCCTGGGCATTGCGCAGACGATCAAGATGGCCGGCCCGTCCGTGCTGCTCGGCTATGCGGTGG
CCGGCGTCGTCGCGTTTTTCATCATGCGCCAGCTCGGCGAGATGGTCGTCGACGAGCCCGTCGCCGGCTCGTTCAGCTAT
TTCGCGGACAAATACTGCGGCCACTTCACCGGTTTCCTGTCCGGCTGGAACTACTGGGTGCTCTACATCCTCGTCAGCAT
GGCCGAGCTGTCGGCCGTCGGCATCTACGTGCAGTACTGGTGGCCCGGCGTGCCGACATGGGTCTCCGCGCTCGTGTTCT
TCGTCGTCATCAACCTCGTCAACCTGACGAGCGTGAAGTCGTACGGCGAGACGGAATTCTGGTTCTCGATCATCAAGGTC
GCCGCGATCGTCGGCATGATCGGCTTCGGCGGCTGGCTGCTCGCGAGCGGGCATGCGGGGCCGGAAGCGAGCGTCGCGAA
CCTGTGGCAGCACGGCGGCTTCTTCCCGAACGGCGTGTCGGGCCTCGTGATGTCGATGGCCGCGATCATGTTCTCGTTCG
GCGGGCTCGAACTGGTCGGGATCACGGCGGCCGAAGCCGACGATCCGAAGCGCAGCATTCCGCGCGCGACGAACCAGGTC
ATCTACCGGATCCTGATTTTCTACATCGGCGCGCTCGGCGTGCTGCTGTCGCTCTATCCGTGGCAAAAGGTCGTGTCCGG
CGGCAGCCCGTTCGTGCTGATCTTCCATGCGCTGAGCAGCGACGTGGTCGCGAACGTGCTGAACGTCGTCGTGCTGACGG
CGGCGCTGTCGGTGTACAACAGCGGCGTCTACTGCAACAGCCGGATGCTGTTCGGCCTCGCGAAGCAGGGCAATGCGCCG
AAGGTGCTGTGCTCGGTCAACCGGCGCGGCATTCCGCTCGCCGCGCTCGGCGCGTCGGCACTCGCGACGGGCGTCTGCGT
TCTGGTCAACTACTTCATGCCGGGCAAGGCGTTCGAAGTGCTGATGGGGCTCGTCGTGTCGGCGCTGATCATCAACTGGG
CGATGATCACGCTGATCCATCTGAAGTTCCGTCAGGCCAAGCGGGCAGCCGGGGAGCAGACGTCCTTCCGCAGTCTGGGC
TATCCTTTTACGAATTATCTGTGCCTGGCGTTCATGGCCGGCATTCTCGTCGTGATGTACCTGACGCCGGATCTCCGCCT
GTCGGTGTACCTGATTCCCGTGTGGCTCGCGGTTCTCGCGGTCGGGTATCGCTTCCGTCAGAAGAATGCCGGCTATGCGC
TGCGTAACGGCGCATCCGCACGCTGA

Upstream 100 bases:

>100_bases
CAACCCGGCGGCTCCACGAACGGCCGCCGGCACAGCAAAACAGCGCCCGGCACCCCGAAGGCGCACCGCTTCCGGCGGAG
GCGGACAGAGTGGAGAAGAC

Downstream 100 bases:

>100_bases
CGCGCGCCGCGACCGATCATTCCTCCAAACGAGACCGACATAGCCATGTTCGAACACATCGAAGCGTATCCGGGCGACCC
GATCCTCACGCTGAACGAGA

Product: AAT family amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MVSGNEKDGLKRGLKNRHIQLIALGGALGTGLFLGIAQTIKMAGPSVLLGYAVAGVVAFFIMRQLGEMVVDEPVAGSFSY
FADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFVVINLVNLTSVKSYGETEFWFSIIKV
AAIVGMIGFGGWLLASGHAGPEASVANLWQHGGFFPNGVSGLVMSMAAIMFSFGGLELVGITAAEADDPKRSIPRATNQV
IYRILIFYIGALGVLLSLYPWQKVVSGGSPFVLIFHALSSDVVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAKQGNAP
KVLCSVNRRGIPLAALGASALATGVCVLVNYFMPGKAFEVLMGLVVSALIINWAMITLIHLKFRQAKRAAGEQTSFRSLG
YPFTNYLCLAFMAGILVVMYLTPDLRLSVYLIPVWLAVLAVGYRFRQKNAGYALRNGASAR

Sequences:

>Translated_461_residues
MVSGNEKDGLKRGLKNRHIQLIALGGALGTGLFLGIAQTIKMAGPSVLLGYAVAGVVAFFIMRQLGEMVVDEPVAGSFSY
FADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFVVINLVNLTSVKSYGETEFWFSIIKV
AAIVGMIGFGGWLLASGHAGPEASVANLWQHGGFFPNGVSGLVMSMAAIMFSFGGLELVGITAAEADDPKRSIPRATNQV
IYRILIFYIGALGVLLSLYPWQKVVSGGSPFVLIFHALSSDVVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAKQGNAP
KVLCSVNRRGIPLAALGASALATGVCVLVNYFMPGKAFEVLMGLVVSALIINWAMITLIHLKFRQAKRAAGEQTSFRSLG
YPFTNYLCLAFMAGILVVMYLTPDLRLSVYLIPVWLAVLAVGYRFRQKNAGYALRNGASAR
>Mature_461_residues
MVSGNEKDGLKRGLKNRHIQLIALGGALGTGLFLGIAQTIKMAGPSVLLGYAVAGVVAFFIMRQLGEMVVDEPVAGSFSY
FADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYWWPGVPTWVSALVFFVVINLVNLTSVKSYGETEFWFSIIKV
AAIVGMIGFGGWLLASGHAGPEASVANLWQHGGFFPNGVSGLVMSMAAIMFSFGGLELVGITAAEADDPKRSIPRATNQV
IYRILIFYIGALGVLLSLYPWQKVVSGGSPFVLIFHALSSDVVANVLNVVVLTAALSVYNSGVYCNSRMLFGLAKQGNAP
KVLCSVNRRGIPLAALGASALATGVCVLVNYFMPGKAFEVLMGLVVSALIINWAMITLIHLKFRQAKRAAGEQTSFRSLG
YPFTNYLCLAFMAGILVVMYLTPDLRLSVYLIPVWLAVLAVGYRFRQKNAGYALRNGASAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=68.5144124168514, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=63.5346756152125, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI48994972, Length=458, Percent_Identity=42.1397379912664, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=45.3333333333333, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1790653, Length=455, Percent_Identity=39.3406593406593, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=37.192118226601, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.6589327146172, Blast_Score=284, Evalue=8e-78,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=33.5616438356164, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1788480, Length=428, Percent_Identity=35.5140186915888, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082023, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87081869, Length=235, Percent_Identity=25.9574468085106, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=34.5211581291759, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=436, Percent_Identity=33.7155963302752, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=433, Percent_Identity=32.1016166281755, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=32.843137254902, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=34.1628959276018, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=418, Percent_Identity=32.2966507177034, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=414, Percent_Identity=30.9178743961353, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=395, Percent_Identity=32.6582278481013, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=435, Percent_Identity=29.6551724137931, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=412, Percent_Identity=29.6116504854369, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=415, Percent_Identity=30.6024096385542, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319608, Length=484, Percent_Identity=26.4462809917355, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=30.3398058252427, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=406, Percent_Identity=31.5270935960591, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=395, Percent_Identity=28.3544303797468, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=412, Percent_Identity=28.8834951456311, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=407, Percent_Identity=31.6953316953317, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=497, Percent_Identity=24.3460764587525, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221512776, Length=365, Percent_Identity=21.0958904109589, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=365, Percent_Identity=21.0958904109589, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667468, Length=275, Percent_Identity=25.8181818181818, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49701; Mature: 49701

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSGNEKDGLKRGLKNRHIQLIALGGALGTGLFLGIAQTIKMAGPSVLLGYAVAGVVAFF
CCCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGVPTWVSALVFFVVINLVNLTSVKSYGETEFWFSIIKVAAIVGMIGFGGWLLASGHAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCC
PEASVANLWQHGGFFPNGVSGLVMSMAAIMFSFGGLELVGITAAEADDPKRSIPRATNQV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYIGALGVLLSLYPWQKVVSGGSPFVLIFHALSSDVVANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLAKQGNAPKVLCSVNRRGIPLAALGASALATGVCVLVNYFMPGKAFEV
CCCEECCHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSALIINWAMITLIHLKFRQAKRAAGEQTSFRSLGYPFTNYLCLAFMAGILVVMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
LTPDLRLSVYLIPVWLAVLAVGYRFRQKNAGYALRNGASAR
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure
MVSGNEKDGLKRGLKNRHIQLIALGGALGTGLFLGIAQTIKMAGPSVLLGYAVAGVVAFF
CCCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVDEPVAGSFSYFADKYCGHFTGFLSGWNYWVLYILVSMAELSAVGIYVQYW
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEEEE
WPGVPTWVSALVFFVVINLVNLTSVKSYGETEFWFSIIKVAAIVGMIGFGGWLLASGHAG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCC
PEASVANLWQHGGFFPNGVSGLVMSMAAIMFSFGGLELVGITAAEADDPKRSIPRATNQV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYIGALGVLLSLYPWQKVVSGGSPFVLIFHALSSDVVANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLAKQGNAPKVLCSVNRRGIPLAALGASALATGVCVLVNYFMPGKAFEV
CCCEECCHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMGLVVSALIINWAMITLIHLKFRQAKRAAGEQTSFRSLGYPFTNYLCLAFMAGILVVMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
LTPDLRLSVYLIPVWLAVLAVGYRFRQKNAGYALRNGASAR
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]