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The map label for this gene is tyrB [H]

Identifier: 189353004

GI number: 189353004

Start: 1168733

End: 1169935

Strand: Direct

Name: tyrB [H]

Synonym: BMULJ_04238

Alternate gene names: 189353004

Gene position: 1168733-1169935 (Clockwise)

Preceding gene: 189353003

Following gene: 189353005

Centisome position: 47.26

GC content: 66.5

Gene sequence:

>1203_bases
ATGTTCGAACACATCGAAGCGTATCCGGGCGACCCGATCCTCACGCTGAACGAGAACTTCCAGAAAGATCCGCGCGACCG
CAAGGTCAACCTCAGCATCGGCATCTATTTCGATGCCGAAGGGCGGATTCCCGTGATGGGCGCGGTACGCGAAGCCGAAA
CGGCGCTGCAGCGCGAGAGCGGCCCGAAGCCGTACCTGCCGATGGTCGGTCTGGCCGCGTATCGCGACGCGGTGCAGGCG
CTCGTGTTCGGCGCCGATCATCCGGCGCGCGCGGCCGGTCGCATCGCGACCGTGCAGACGCTCGGCGGCTCGGGCGCGTT
GAAGGTCGGCGCCGATTTCCTGAAGCGCTATTTCCCCGACGCGCAGGTATGGCTCAGCGATCCGAGCTGGGAAAACCACC
GCTTCATCTTCGAGCGTGCGGGTTTCACCGTCAACACGTATCCGTACTACGACGAAGCGACGGGCGGCCTTAAGTTCGAC
GCGATGCTCGCGGCGATCGACGCGCTGCCGGCGCGCAGCGTCGTGCTGCTGCATGCGTGCTGCCATAACCCGACCGGCGT
CGATCTCGACGAAGGTCAGTGGGAGAAGCTGATCGACGTGATCGAGGCGCGCGAACTGCTGCCGTTCGTCGACATGGCCT
ACCAGGGCTTCGGCGCGGGGCTCGACGCCGATGCGTTCGCGGTGCGCGAACTCGCGCGGCGCGGCGTTCCGGCGCTCGTC
GCGAATTCGTTCTCGAAGAACTTCTCGCTGTATGGCGAACGCGTCGGCGGGCTCAGCGTCGTCTGCGAAGATGCGGCCGC
CGCCGAGCGCGTGCTCGGCCAGCTCGCCGGCGCCGTGCGCTCGAACTACAGCAACCCGCAAACGTACGGCGCGAAGGTCG
TGTCGGCCGTGCTGAATACGCCCGCGCTGCGCAAGCAGTGGGAAGAAGAACTCGCGGCGATGTGCCGCCGCATCGCGCGC
ATGCGTCAGGCGATCCACGACGGGCTGCGCGATCACGTCAGCGGCGAAGCGCTCACGCGCTACGTGAAGCAGCGCGGGAT
GTTCACGTACACGGGCCTGACCGAATCGCAGGTCGAAGCGCTGCGCGAAGTGCACGGCGTGTACATCCTGCGTTCGGGCC
GCATGTGCGTGGCCGGGCTGAACGATTCGAACGTCGGCATCGTCGCGGATGCGATCGGCAAGGTGCTGAAGAGCGGCGTC
TGA

Upstream 100 bases:

>100_bases
CTTCCGTCAGAAGAATGCCGGCTATGCGCTGCGTAACGGCGCATCCGCACGCTGACGCGCGCCGCGACCGATCATTCCTC
CAAACGAGACCGACATAGCC

Downstream 100 bases:

>100_bases
ACGCGCTTGCACGCGTCGCGAAAACCGGCTGTCTCCTCGATGGAGGCAGCCGTTTCTTTTATGCTGCCGTCCGGCGCCGC
ACCCCTGTCGCGGTCGCAGG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFEHIEAYPGDPILTLNENFQKDPRDRKVNLSIGIYFDAEGRIPVMGAVREAETALQRESGPKPYLPMVGLAAYRDAVQA
LVFGADHPARAAGRIATVQTLGGSGALKVGADFLKRYFPDAQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPARSVVLLHACCHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARRGVPALV
ANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVSAVLNTPALRKQWEEELAAMCRRIAR
MRQAIHDGLRDHVSGEALTRYVKQRGMFTYTGLTESQVEALREVHGVYILRSGRMCVAGLNDSNVGIVADAIGKVLKSGV

Sequences:

>Translated_400_residues
MFEHIEAYPGDPILTLNENFQKDPRDRKVNLSIGIYFDAEGRIPVMGAVREAETALQRESGPKPYLPMVGLAAYRDAVQA
LVFGADHPARAAGRIATVQTLGGSGALKVGADFLKRYFPDAQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPARSVVLLHACCHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARRGVPALV
ANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVSAVLNTPALRKQWEEELAAMCRRIAR
MRQAIHDGLRDHVSGEALTRYVKQRGMFTYTGLTESQVEALREVHGVYILRSGRMCVAGLNDSNVGIVADAIGKVLKSGV
>Mature_400_residues
MFEHIEAYPGDPILTLNENFQKDPRDRKVNLSIGIYFDAEGRIPVMGAVREAETALQRESGPKPYLPMVGLAAYRDAVQA
LVFGADHPARAAGRIATVQTLGGSGALKVGADFLKRYFPDAQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFD
AMLAAIDALPARSVVLLHACCHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARRGVPALV
ANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVSAVLNTPALRKQWEEELAAMCRRIAR
MRQAIHDGLRDHVSGEALTRYVKQRGMFTYTGLTESQVEALREVHGVYILRSGRMCVAGLNDSNVGIVADAIGKVLKSGV

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=43.21608040201, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI4504067, Length=388, Percent_Identity=38.9175257731959, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI117414139, Length=385, Percent_Identity=28.051948051948, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=59.1939546599496, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=43.1818181818182, Blast_Score=335, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=40.3022670025189, Blast_Score=324, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=40.8060453400504, Blast_Score=310, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17569539, Length=401, Percent_Identity=38.9027431421446, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17569537, Length=387, Percent_Identity=32.5581395348837, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17550384, Length=270, Percent_Identity=37.4074074074074, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI25147136, Length=211, Percent_Identity=38.3886255924171, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=39.4088669950739, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6322743, Length=427, Percent_Identity=34.6604215456674, Blast_Score=248, Evalue=9e-67,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=43.6692506459948, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=43.6692506459948, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=39.4472361809045, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=39.4472361809045, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=39.8976982097187, Blast_Score=298, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43629; Mature: 43629

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHIEAYPGDPILTLNENFQKDPRDRKVNLSIGIYFDAEGRIPVMGAVREAETALQRES
CCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
GPKPYLPMVGLAAYRDAVQALVFGADHPARAAGRIATVQTLGGSGALKVGADFLKRYFPD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCC
AQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPARSVVLLHAC
CEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
CHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARRGVPALV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
ANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVSAVLNT
HHHHHCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PALRKQWEEELAAMCRRIARMRQAIHDGLRDHVSGEALTRYVKQRGMFTYTGLTESQVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCHHHHHH
LREVHGVYILRSGRMCVAGLNDSNVGIVADAIGKVLKSGV
HHHHHCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEHIEAYPGDPILTLNENFQKDPRDRKVNLSIGIYFDAEGRIPVMGAVREAETALQRES
CCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
GPKPYLPMVGLAAYRDAVQALVFGADHPARAAGRIATVQTLGGSGALKVGADFLKRYFPD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCC
AQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPARSVVLLHAC
CEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
CHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARRGVPALV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
ANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVSAVLNT
HHHHHCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PALRKQWEEELAAMCRRIARMRQAIHDGLRDHVSGEALTRYVKQRGMFTYTGLTESQVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCHHHHHH
LREVHGVYILRSGRMCVAGLNDSNVGIVADAIGKVLKSGV
HHHHHCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]