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The map label for this gene is hpaG [H]

Identifier: 189352898

GI number: 189352898

Start: 1045647

End: 1046336

Strand: Direct

Name: hpaG [H]

Synonym: BMULJ_04132

Alternate gene names: 189352898

Gene position: 1045647-1046336 (Clockwise)

Preceding gene: 189352896

Following gene: 189352899

Centisome position: 42.28

GC content: 72.32

Gene sequence:

>690_bases
ATGGAGCTGTGTTGCACGACCGCTGCGGCGCCGCCGCTGCCGGTCGCGATCGGTACCGTTTATGGCGCACTGCTGAACGA
GCGCGCGGCGCTCGCCGCGCTCGGCGACGCAGTGCATGCGGCGCCTTACGGGCGTCCGCCGCAGGCGCCCGTGCTCTACA
TCAAGCCGGCCAATACGCATGCGCCCGACGGCGCGGCCGTCGTCGTGCCGGCCGGCGTCGAGGCGCTGGAGATCGGCGCG
TCGGTCGCCGTCGTCTTCGCGCGCCGTGCGACGCGCGTGCCGGCCGCCCGCGCGCTCGACTACGTGCACGGCTTCACGCT
CGCCAGCGACGTATCCGTTCCGCATCCCGACTACTATCGGCCAGCCGTGCGCTTCAAATGCCGCGACGGCTTTTGTCCGC
TGGGCCCGGCGATCGTGCCGGCCGCCGCGCTCGCCGAGGTCGACGCGATCGCGCTGAGCGTGCGGATCGACGGCGAAGTC
GTGGCGCGCACGGCCACCGCGACGCTGATTCGCCCGGTGCGCGAATTGATCGCCGACATCAGCGCGTTCATGTCGTTCGA
CGCCGGCGACGTGCTGTTGCTCGGCGTCGCGGGCGGCGCGCCGCATGCGCGCGTGGGCAGCACGATCGAGATCGCCGCCG
ACGGCATCGGCACGTTGCGCCACACGCTCGTCGCGGAGGATGCACGATGA

Upstream 100 bases:

>100_bases
AAATTCGTCTATCAGGGTAATCGAGGTTGTCAGCGTCGCTTTGTTTACTTAAGATGTTAAGTATTGACGATGCGCCGCGA
CGCGCGGCAGAGGAGTCCCG

Downstream 100 bases:

>100_bases
AGACGGCACGTGTCATCTACAACGGCGCCCTGCATGCGGCCGAACCGGCCGGCGACGGCGCGATCCGCCTCGATACCGGG
CGCGTGCTCGGCGAGGAGGC

Product: 5-carboxymethyl-2-hydroxymuconate isomerase

Products: NA

Alternate protein names: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; HHDD isomerase; 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; OPET decarboxylase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MELCCTTAAAPPLPVAIGTVYGALLNERAALAALGDAVHAAPYGRPPQAPVLYIKPANTHAPDGAAVVVPAGVEALEIGA
SVAVVFARRATRVPAARALDYVHGFTLASDVSVPHPDYYRPAVRFKCRDGFCPLGPAIVPAAALAEVDAIALSVRIDGEV
VARTATATLIRPVRELIADISAFMSFDAGDVLLLGVAGGAPHARVGSTIEIAADGIGTLRHTLVAEDAR

Sequences:

>Translated_229_residues
MELCCTTAAAPPLPVAIGTVYGALLNERAALAALGDAVHAAPYGRPPQAPVLYIKPANTHAPDGAAVVVPAGVEALEIGA
SVAVVFARRATRVPAARALDYVHGFTLASDVSVPHPDYYRPAVRFKCRDGFCPLGPAIVPAAALAEVDAIALSVRIDGEV
VARTATATLIRPVRELIADISAFMSFDAGDVLLLGVAGGAPHARVGSTIEIAADGIGTLRHTLVAEDAR
>Mature_229_residues
MELCCTTAAAPPLPVAIGTVYGALLNERAALAALGDAVHAAPYGRPPQAPVLYIKPANTHAPDGAAVVVPAGVEALEIGA
SVAVVFARRATRVPAARALDYVHGFTLASDVSVPHPDYYRPAVRFKCRDGFCPLGPAIVPAAALAEVDAIALSVRIDGEV
VARTATATLIRPVRELIADISAFMSFDAGDVLLLGVAGGAPHARVGSTIEIAADGIGTLRHTLVAEDAR

Specific function: Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5- tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate) [H]

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=156, Percent_Identity=32.0512820512821, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40786394, Length=156, Percent_Identity=32.0512820512821, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66348062, Length=180, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI215422413, Length=172, Percent_Identity=27.906976744186, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI13654274, Length=175, Percent_Identity=27.4285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17557057, Length=180, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28572127, Length=198, Percent_Identity=25.2525252525253, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571789, Length=185, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234
- InterPro:   IPR012684
- InterPro:   IPR012686 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =5.3.3.10; =4.1.1.68 [H]

Molecular weight: Translated: 23453; Mature: 23453

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELCCTTAAAPPLPVAIGTVYGALLNERAALAALGDAVHAAPYGRPPQAPVLYIKPANTH
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
APDGAAVVVPAGVEALEIGASVAVVFARRATRVPAARALDYVHGFTLASDVSVPHPDYYR
CCCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCEEEECCCCCCCCCCCC
PAVRFKCRDGFCPLGPAIVPAAALAEVDAIALSVRIDGEVVARTATATLIRPVRELIADI
CCEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHH
SAFMSFDAGDVLLLGVAGGAPHARVGSTIEIAADGIGTLRHTLVAEDAR
HHHHCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MELCCTTAAAPPLPVAIGTVYGALLNERAALAALGDAVHAAPYGRPPQAPVLYIKPANTH
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
APDGAAVVVPAGVEALEIGASVAVVFARRATRVPAARALDYVHGFTLASDVSVPHPDYYR
CCCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCEEEECCCCCCCCCCCC
PAVRFKCRDGFCPLGPAIVPAAALAEVDAIALSVRIDGEVVARTATATLIRPVRELIADI
CCEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHH
SAFMSFDAGDVLLLGVAGGAPHARVGSTIEIAADGIGTLRHTLVAEDAR
HHHHCCCCCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA